The time course of hydroxyl radical formation following spinal cord injury: The possible role of the iron-catalyzed Haber-Weiss reaction

Journal of Neurotrauma

Volumn 21, Issue 6, 2004, Pages 805-816

  Liu, Danxia ^a,b   Liu, Jing ^a   Sun, Dachuan ^a   Wen, Jing ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Hydrogen peroxide; Hydroxyl radical; Iron catalyzed Haber Weiss Fenton reaction; Microdialysis sampling and administration; Reactive oxygen species; Secondary spinal cord injury; Superoxide anion

Indexed keywords

HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL DEATH; CELL LOSS; CONTROLLED STUDY; DISEASE COURSE; FENTON REACTION; GRAY MATTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MICRODIALYSIS; NONHUMAN; RAT; SPIN TRAPPING; SPINAL CORD INJURY;

ANIMALS; CELL DEATH; FERROUS COMPOUNDS; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; MALE; METALLOPORPHYRINS; OXIDANTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES; TIME FACTORS; XANTHINE;

EID: 2942695288     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/0897715041269650     Document Type: Article

References (64)

1. AKSENOVA, M., BUTTERFIELD, D.A., ZHANG, S.X., et al. (2002). Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury. J. Neurotrauma 19, 491-502.
2. ALLEN, A.R. (1911). Surgery of experimental spinal cord injury equivalent to crush injury of fracture dislocation of spinal column. JAMA 57, 878-880.
3. ALTHAUS, J.S., ANDRUS, P.K., WILLIAMS, C.M., et al. (1993). The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury. Reversal by tirilazad mesylate (U-74006F). Mol. Chem. Neuropathol. 20, 147-162.
4. ANDERSON, D.K., SAUNDERS, R.D., and DEMEDIUK, P. et al. (1985). Lipid hydrolysis and peroxidation in injured spinal cord: Partial protection with methylprednisolone or vitamin E and selenium. Central Nerv. Sys. Trauma 2, 257-267.
5. ANDERSON, D.K., and MEANS, E.D. (1985) Iron-induced lipid peroxidation in spinal cord: protection with mannitol and methylprednisolone. J. Free Rad. Biol. Med. 1, 59-64.
6. BALENTINE, J.D. (1985). Hypotheses in spinal cord trauma research, in: Central Nervous System Trauma Status Report. D.P. Becker and J.T. Povlishock (eds), NIH: Bethesda, MD, pps. 455-461.
7. BECKMAN, J.S., BECKMAN, T.W., CHEN, J., et al. (1990). Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87, 1620-1624.
8. BRUMBY, P.E., and MASSEY, V. (1967). Determination of non-heme iron, total iron, and copper, in: Methods in Enzymology. R. W. Estrabrook and M. E. Pullman (eds), Academic Press: New York, pps 463-475.
9. CAO, W., CARNEY, J.M., DUCHON, A., et al. (1988). Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci. Lett. 88, 233-238.
10. CHOPP, M., CHAN, P.H., HSU, C.Y., et al. (1996). DNA damage and repair in central nervous system injury: National Institute of Neurological Disorders and Stroke workshop Summary. Stroke 27, 363-369.
11. CLARK, R.S.B., CHEN, M., KOCHANEK, P.M., et al. (2001). Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase. J. Neurotrauma 18, 675-689
12. CROW, J.P. (2000). Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Rad. Biol. Med. 28, 1487-1494.
13. DAY, B.J., FRIDOVICH, I., and CRAPO, J.D. (1997). Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch. Biochem. Biophys. 347, 256-262.
14. DEMEDIUK, P., SAUNDERS, R.D., ANDERSON, D.K., et al. (1985). Membrane lipid changes in laminectomized and traumatized cat spinal cord. Proc. Natl. Acad. Sci. USA 82, 7071-7075.
15. DEMOPOULOS, H.B., FLAMM, E.S., PIETRONIGRO, D.D., et al. (1980). The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol. Scand. 492, 91-119.
16. ELLERBY, L.M., and BREDESEN, D.E. (2000). Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis. Method Enzymol. 322, 413-421.
17. FLOYD, R.A., and CARNEY, J.M. (1992). Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32, S22-S27.
18. FLOYD, R.A., HENDERSON, R., WATSON, J.J., et al. (1986). Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats. Free Rad. Biol. Med. 2, 13-18.
19. HALL, E.D., ANDRUS, P.K., ALTHAUS, J.S., et al. (1993a). Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain. J. Neurosci. Res. 34, 107-112.
20. HALL, E.D., ANDRUS, P.K., and YONKERS, P.A. (1993b). Brain hydroxyl radical generation in acute experimental head injury. J. Neurochem. 60, 588-594.
21. HALL, E.D., ANDRUS, P.K., YONKERS, P.A., et al. (1994). Generation and detection of hydroxyl radical following experimental head injury. Ann. NY Acad. Sci. 738, 15-24.
22. HALLIWELL, B. (1989). Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke? Acta Neurol. Scand. 126, 23-33.
23. HOGG, N., DARLEY-USMAR, M., WILSON, M.T., et al. (1992). Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem. J. 281, 419-424.
24. IKEDA, Y., and LONG, D.M. (1990). The molecular basis of brain injury and brain edema: The role of oxygen free radicals. Neurosurg. 27, 1-11.
25. IKEDA, Y., BRELSFORD, K.L., IKEDA, K.D., et al. (1989). Oxygen-free radicals in traumatic brain edema. Neurol. Res. 11, 213-216.
26. IMLAY, J.A., and LINN, S. (1988). DNA damage and oxygen radical toxicity. Science 240, 1302-1309.
27. KONTOS, H.A., and WEI, E.P. (1986). Superoxide production in experimental brain injury. J. Neurosurg. 64, 803-807.
28. KRAUSE, G.S., NAYINI, N.R., and WHITE, B.C., et al. (1987). Natural course of iron delocalization and lipid peroxidation during the first eight hours following a 15-minute cardiac arrest in dogs. Ann. Emerg. Med. 16, 1200-1205.
29. LANDER, H.M. (1997). An essential role for free radicals and derived species in signal transduction. FASEB J. 11, 118-124.
30. LESKI, M.L., BAO, F., WU, L., et al. (2001). Protein and DNA oxidation in spinal injury: Neurofilaments-an oxidation target. Free Rad. Biol. Med. 30, 613-624.
31. LEWEN, A., MATZ, P., and CHAN, P.H. (2000). Free radical pathways in CNS injury. J. Neurotrauma 17, 871-890.
32. LIANG, L.P., HO, Y.S., and PATEL, M. (2000). Mitochondrial superoxide production in kainate-induced hippocampal damage. Neurosci. 101, 563-570.
33. LIPSCOMB, D.C., GORMAN, L.G., TRAYSTMAN, R.J., et al. (1998). Low molecular weight iron in cerebral ischemic acidosis in vivo. Stroke 29, 487-492.
34. LIU, D. (1993). Generation and detection of hydroxyl radical in vivo in rat spinal cord by microdialysis administration of Fenton's reagents and microdialysis sampling. J. Biochem. Biophys. Meth. 27, 281-291.
35. LIU, D. (1994). An experimental model combining microdialysis with electrophysiology, histology, and neurochemistry for studying excitotoxicity in spinal cord injury: Effect of NMDA and kainate. Mol. Chem. Neuropath. 23, 77-92.
36. 2a rises in extracellular fluid in response to hydroxyl radical generated in vivo in rat spinal cord. Free Rad. Biol. Med. 18, 571-576.
37. LIU, D., LI, L., and AUGUSTUS, L. (2001). Prostaglandin released by spinal cord injury mediates hydroxyl radical and malondialdehyde production and cell death: A site of the neuroprotective action of methylprednisolone. J. Neurochem. 77, 1036-1047.
38. LIU, D., LING, X., WEN, J., et al. (2000). The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J. Neurochem. 75, 2144-2154.
39. LIU, D., LIU, J., and WEN, J. (1999). Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction. Free Radic. Biol. Med. 27, 478-482.
40. LIU, D., LIU, J., SUN, D., et al. (2003). Spinal injury increases iron: Catalytic production of hydroxyl radicals. Free Rad. Biol. Med., 34, 64-71.
41. LIU, D., and McADOO, D.J. (1993a). Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury. Brain Res. 609, 293-297.
42. LIU, D., and McADOO, D.J. (1993b). An experimental model combining microdialysis with electrophysiology, histology, and neurochemistry for exploring mechanisms of secondary damage in spinal cord injury: the effect of potassium. J. Neurotrauma 10, 349-362.
43. LIU, D., SYBERT, T.E., QIAN, H., et al. (1998). Superoxide production after spinal injury detected by microperfusion of cytochrome c. Free Rad. Biol. Med. 25, 298-304.
44. LIU, D., THANGNIPON, W., and McADOO, D.J. (1991). Excitatory amino acids rise to toxic levels upon impact injury to rat spinal cord. Brain Res. 547, 344-348.
45. LIU, D., YANG, J., LI, L., et al. (1995). Paraquat-a superoxide generator-kills neurons in the rat spinal cord. Free Rad. Biol. Med. 18, 861-867.
46. LIU, D., YANG, R., YAN, X., et al. (1994). Hydroxyl radicals generated in vivo kill neurons in spinal cord: electrophysiological, histological, and neurochemical results. J. Neurochem. 62, 37-44.
47. LUCAS, J.H., WHEELER, D.G., GUAN, Z., et al. (2002). Effect of glutathione augmentation on lipid peroxidation after spinal cord injury. J. Neurotrauma 19, 763-775.
48. MAITY, S., LU, D., RUSSEL, J.C., et al. (1992). Protection from cold injury by deferoxamine, an iron chelator. Angiol. 43, 781-790.
49. MARSALA, M., MALMBERG, A.B., and YAKSH, T.L. (1995). The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. J. Neurosci. Meth. 62, 43-53.
50. McCORD, J.M. (1985). Oxygen-derived free radicals in postischemic tissue injury. New Engl. J. Med. 312, 159-163.
51. OLIVER, C.N., STARKE-REED, P.E., STADTMAN, E.R., et al. (1990). Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. USA 87, 5144-5147.
52. PATEL, M., and DAY, B.J. (1999). Metalloporphyrin class of therapeutic catalytic antioxidants. TiPS 20, 359-364.
53. PATEL, M., DAY, B.J., CRAPO, J.D., et al. (1996). Requirement for superoxide in excitotoxic cell death. Neuron 16, 345-355.
54. QIAN, H., and LIU, D. (1997). The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography. Neurochem. Res. 22, 1231-1236.
55. SHACTER, E. (2000a). Quantification and significance of protein oxidation in biological samples. Drug Met. Rev. 32, 307-326.
56. SHACTER, E. (2000b). Protein oxidative damage. Meth. Enzymol. 319, 428-436.
57. SMITH, S.L., ANDRUS, P.K., ZHANG, J.R., et al. (1994). Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J. Neurotrauma 11, 393-404.
58. SORKIN, L.S., STEINMAN, J.L., HUGHES, M.G., et al. (1988). Microdialysis recovery of serotonin released in spinal cord dorsal horn. J. Neurosci. Methods 23, 131-138.
59. STADTMAN, E.R., and OLIVER, C.N. (1991). Metal-catalyzed oxidation of proteins. J. Biol. Chem. 266, 2005-2008.
60. SUBBARAO, K.V., and RICHARDSON, J.S. (1990). Iron-dependent peroxidation of rat brain: A regional study. J. Neurosci. Res. 26, 224-232.
61. TRAYSTMAN, R.J., KIRSCH, J.R., and KOEHLER, R.C. (1991). Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71, 1185-1195.
62. WATSON, B.D., and GINSBERG, M.D. (1989). Ischemic injury in the brain. Role of oxygen radical-mediated processes. Ann. New York Acad. Sci. 559, 269-281.
63. WILLMORE, L.J., TRIGGS, W.J., and GRAY, J.D. (1986). The role of iron-induced hippocampal peroxidation in acute epileptogenesis. Brain Res. 382, 422-426.
64. ZINGARELLI, B., DAY, B., CRAPO, J.D., et al. (1997). The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br. J. Pharmacol. 120, 259-267.