SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 21, 2012, Pages 6523-6532

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells

(7) Rennhack, Andreas a Jumpertz, Thorsten b Ness, Julia b Baches, Sandra b Pietrzik, Claus U c Weggen, Sascha b Bulic, Bruno a

a CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR (Germany)

b HEINRICH HEINE UNIVERSITY (Germany)

c UNIVERSITY MEDICAL CENTER MAINZ (Germany)

Author keywords

Alzheime s disease; Diazirine; Drug development; Photoreactive probes; Proteases; Secretase inhibitors; Secretase modulators; Target identification

Indexed keywords

2 (1 (7 ((5 (2 OXOHEXAHYDRO 1H THIENO [3,4 D]IMIDAZOL 4 YL)PENTANOYL)OXY) 1 (4 (3 (TRILUOROMETHYL) 3H DIAZIRIN 3 YL)PHENYL)HEPT 2 YN 1 YL) 2 (4 (TRIFLUOROMETHYL)PHENYL)PIPERIDIN 4 YL)ACETIC ACID; 4 (3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL)BENZALDEHYDE; AR 243; AR 366; E 2010; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GAMMA SECRETASE MODULATOR; JNJ 40418677; METHYL 2 (1 (7 (5 (2 OXOHEXAHYDRO 1H THIENO [3,4 D]IMIDAZOL 4 YL)PENTANAMIDO) 1 (4 (3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL)PHENYL)HEPT 2 YN 1 YL) 2 (4 (TRIFLUOROMETHYL)PHENYL)PIPERIDIN 4 YL)ACETIC ACID; METHYL 4 (2,2,2 TRIFLUORO 1 ((TOSYLOXY)IMINO)ETHYL)BENZOIC ACID; METHYL 4 (2,2,2 TRIFLUOROACETYL)BENZOIC ACID; PHENYLPIPERIDINE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME BINDING; ENZYME DEGRADATION; ENZYME SPECIFICITY; ESTERIFICATION; LIPOPHILICITY; MASS SPECTROMETRY; PHOTOAFFINITY LABELING; PHOTOREACTIVITY; PROTEIN CLEAVAGE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AZIRINES; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOTOCHEMICAL PROCESSES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867580136 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.08.034 Document Type: Article

Times cited : (12)

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