The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators

Biochemistry

Volumn 50, Issue 5, 2011, Pages 828-835

  Botev, Anne ^a   Munter, Lisa Marie ^a   Wenzel, Ringo ^a   Richter, Luise ^a   Althoff, Veit ^a   Ismer, Jochen ^b   Gerling, Ulla ^a   Weise, Christoph ^a   Koksch, Beate ^a   Hildebrand, Peter W ^b   Bittl, Robert ^a   Multhaup, Gerd ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; BINDING PROPERTIES; C-TERMINAL FRAGMENTS; CIRCULAR DICHROISM; CONTINUOUS WAVES; ELECTRON SPIN RESONANCE MEASUREMENTS; HELICAL CONFORMATION; IN-VITRO ASSAYS; IN-VIVO; INCLUSION BODIES; OLIGOMERIC STATE; REFOLDING; SECONDARY STRUCTURES; SECRETASES; SMALL MOLECULES; SURFACE PLASMONS; SYNTHETIC SUBSTRATES; TRANSMEMBRANE SEQUENCES;

BINDING ENERGY; DICHROISM; DIMERS; GLYCOPROTEINS; PURIFICATION; SPIN DYNAMICS; SURFACE PLASMON RESONANCE;

CONFORMATIONS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DIMER; GAMMA SECRETASE; GAMMA SECRETASE MODULATOR; MONOMER; SULINDAC SULFIDE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; DIMERIZATION; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY;

EID: 79952079871     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1014002     Document Type: Article

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