Enantioselective, Copper(I)-Catalyzed Three-Component Reaction for the Preparation of Propargylamines

Angewandte Chemie - International Edition

Volumn 42, Issue 46, 2003, Pages 5763-5766

  Gommermann, Nina ^a   Koradin, Christopher ^a   Polborn, Kurt ^a   Knochel, Paul ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alkynes; Asymmetric catalysis; C H activation; Multicomponent reactions; Propargylamines

Indexed keywords

AMINES; CATALYSIS; COPPER;

ONE POT REACTION;

ALDEHYDES;

ALDEHYDE; ALKYNE DERIVATIVE; AMINE; COPPER DERIVATIVE; PROPARGYLAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; HYDROGEN BOND; REACTION ANALYSIS;

EID: 0346243940     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352578     Document Type: Article

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44. The absolute configuration was determined by comparison to a known compound (see the Supporting Information).
45. The crystal structure is shown in the Supporting Information. CCDC 216200 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving. html (or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB21EZ, UK; fax: (+44)1223-336-033; or deposit@ ccdc.cam.ac.uk).
46. An X-ray analysis of quinap-CuBr shows that the complex is dimeric (see ref. [4]).