메뉴 건너뛰기




Volumn 51, Issue 38, 2012, Pages 7433-7443

Measurement and modeling of signaling at the single-cell level

Author keywords

[No Author keywords available]

Indexed keywords

CELL FUNCTIONS; EXTRACELLULAR ENVIRONMENTS; INDIVIDUAL CELLS; MOLECULAR PROCESS; PHENOTYPIC BEHAVIOR; RECEPTOR-MEDIATED SIGNALING; SINGLE-CELL LEVEL;

EID: 84866673361     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300846p     Document Type: Article
Times cited : (27)

References (94)
  • 1
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler, I. J. and Kripke, M. L. (1977) Metastasis results from preexisting variant cells within a malignant tumor Science 197, 893-895
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 2
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan, S. and Weinberg, R. A. (2011) Tumor metastasis: Molecular insights and evolving paradigms Cell 147, 275-292
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 3
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., and Sorger, P. K. (2009) Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis Nature 459, 428-432
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 6
    • 65549121943 scopus 로고    scopus 로고
    • Notch signaling: The core pathway and its posttranslational regulation
    • Fortini, M. E. (2009) Notch signaling: The core pathway and its posttranslational regulation Dev. Cell 16, 633-647
    • (2009) Dev. Cell , vol.16 , pp. 633-647
    • Fortini, M.E.1
  • 8
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz, M. B., Levine, A. J., Siggia, E. D., and Swain, P. S. (2002) Stochastic gene expression in a single cell Science 297, 1183-1186
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 9
    • 77952474987 scopus 로고    scopus 로고
    • Cellular heterogeneity: Do differences make a difference?
    • Altschuler, S. J. and Wu, L. F. (2010) Cellular heterogeneity: Do differences make a difference? Cell 141, 559-563
    • (2010) Cell , vol.141 , pp. 559-563
    • Altschuler, S.J.1    Wu, L.F.2
  • 10
    • 78951470515 scopus 로고    scopus 로고
    • Origins of regulated cell-to-cell variability
    • Snijder, B. and Pelkmans, L. (2011) Origins of regulated cell-to-cell variability Nat. Rev. Mol. Cell Biol. 12, 119-125
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 119-125
    • Snijder, B.1    Pelkmans, L.2
  • 12
    • 79651474934 scopus 로고    scopus 로고
    • Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations
    • Yuan, T. L., Wulf, G., Burga, L., and Cantley, L. C. (2011) Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations Curr. Biol. 21, 173-183
    • (2011) Curr. Biol. , vol.21 , pp. 173-183
    • Yuan, T.L.1    Wulf, G.2    Burga, L.3    Cantley, L.C.4
  • 13
    • 0032496358 scopus 로고    scopus 로고
    • The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
    • Ferrell, J. E., Jr. and Machleder, E. M. (1998) The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes Science 280, 895-898
    • (1998) Science , vol.280 , pp. 895-898
    • Ferrell Jr., J.E.1    MacHleder, E.M.2
  • 15
    • 34248586312 scopus 로고    scopus 로고
    • Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    • Wang, W., Wyckoff, J. B., Goswami, S., Wang, Y., Sidani, M., Segall, J. E., and Condeelis, J. S. (2007) Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors Cancer Res. 67, 3505-3511
    • (2007) Cancer Res. , vol.67 , pp. 3505-3511
    • Wang, W.1    Wyckoff, J.B.2    Goswami, S.3    Wang, Y.4    Sidani, M.5    Segall, J.E.6    Condeelis, J.S.7
  • 16
    • 71549116711 scopus 로고    scopus 로고
    • Trait variability of cancer cells quantified by high-content automated microscopy of single cells
    • Quaranta, V., Tyson, D. R., Garbett, S. P., Weidow, B., Harris, M. P., and Georgescu, W. (2009) Trait variability of cancer cells quantified by high-content automated microscopy of single cells Methods Enzymol. 467, 23-57
    • (2009) Methods Enzymol. , vol.467 , pp. 23-57
    • Quaranta, V.1    Tyson, D.R.2    Garbett, S.P.3    Weidow, B.4    Harris, M.P.5    Georgescu, W.6
  • 17
    • 79959451416 scopus 로고    scopus 로고
    • Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems
    • Mehta, S. and Zhang, J. (2011) Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems Annu. Rev. Biochem. 80, 375-401
    • (2011) Annu. Rev. Biochem. , vol.80 , pp. 375-401
    • Mehta, S.1    Zhang, J.2
  • 18
    • 77953383994 scopus 로고    scopus 로고
    • Measurement of single-cell dynamics
    • Spiller, D. G., Wood, C. D., Rand, D. A., and White, M. R. (2010) Measurement of single-cell dynamics Nature 465, 736-745
    • (2010) Nature , vol.465 , pp. 736-745
    • Spiller, D.G.1    Wood, C.D.2    Rand, D.A.3    White, M.R.4
  • 19
    • 77956150923 scopus 로고    scopus 로고
    • Cellular imaging: Taking a long, hard look
    • Baker, M. (2010) Cellular imaging: Taking a long, hard look Nature 466, 1137-1140
    • (2010) Nature , vol.466 , pp. 1137-1140
    • Baker, M.1
  • 21
    • 79953266898 scopus 로고    scopus 로고
    • Single-cell genomics
    • Kalisky, T. and Quake, S. R. (2011) Single-cell genomics Nat. Methods 8, 311-314
    • (2011) Nat. Methods , vol.8 , pp. 311-314
    • Kalisky, T.1    Quake, S.R.2
  • 22
    • 79953288433 scopus 로고    scopus 로고
    • Development and applications of single-cell transcriptome analysis
    • Tang, F., Lao, K., and Surani, M. A. (2011) Development and applications of single-cell transcriptome analysis Nat. Methods 8, S6-S11
    • (2011) Nat. Methods , vol.8
    • Tang, F.1    Lao, K.2    Surani, M.A.3
  • 23
    • 32444435330 scopus 로고    scopus 로고
    • Parallel picoliter rt-PCR assays using microfluidics
    • Marcus, J. S., Anderson, W. F., and Quake, S. R. (2006) Parallel picoliter rt-PCR assays using microfluidics Anal. Chem. 78, 956-958
    • (2006) Anal. Chem. , vol.78 , pp. 956-958
    • Marcus, J.S.1    Anderson, W.F.2    Quake, S.R.3
  • 24
    • 77956116622 scopus 로고    scopus 로고
    • Massively parallel detection of gene expression in single cells using subnanolitre wells
    • Gong, Y., Ogunniyi, A. O., and Love, J. C. (2010) Massively parallel detection of gene expression in single cells using subnanolitre wells Lab Chip 10, 2334-2337
    • (2010) Lab Chip , vol.10 , pp. 2334-2337
    • Gong, Y.1    Ogunniyi, A.O.2    Love, J.C.3
  • 25
    • 77956412152 scopus 로고    scopus 로고
    • Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis
    • Tang, F., Barbacioru, C., Bao, S., Lee, C., Nordman, E., Wang, X., Lao, K., and Surani, M. A. (2010) Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis Cell Stem Cell 6, 468-478
    • (2010) Cell Stem Cell , vol.6 , pp. 468-478
    • Tang, F.1    Barbacioru, C.2    Bao, S.3    Lee, C.4    Nordman, E.5    Wang, X.6    Lao, K.7    Surani, M.A.8
  • 28
    • 44049106680 scopus 로고    scopus 로고
    • High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets
    • Kumaresan, P., Yang, C. J., Cronier, S. A., Blazej, R. G., and Mathies, R. A. (2008) High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets Anal. Chem. 80, 3522-3529
    • (2008) Anal. Chem. , vol.80 , pp. 3522-3529
    • Kumaresan, P.1    Yang, C.J.2    Cronier, S.A.3    Blazej, R.G.4    Mathies, R.A.5
  • 30
    • 77951643590 scopus 로고    scopus 로고
    • Identifying single-cell molecular programs by stochastic profiling
    • Janes, K. A., Wang, C. C., Holmberg, K. J., Cabral, K., and Brugge, J. S. (2010) Identifying single-cell molecular programs by stochastic profiling Nat. Methods 7, 311-317
    • (2010) Nat. Methods , vol.7 , pp. 311-317
    • Janes, K.A.1    Wang, C.C.2    Holmberg, K.J.3    Cabral, K.4    Brugge, J.S.5
  • 31
    • 80053645783 scopus 로고    scopus 로고
    • Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression
    • Wang, L., Brugge, J. S., and Janes, K. A. (2011) Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression Proc. Natl. Acad. Sci. U.S.A. 108, E803-E812
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108
    • Wang, L.1    Brugge, J.S.2    Janes, K.A.3
  • 32
    • 84859641038 scopus 로고    scopus 로고
    • Using gene expression noise to understand gene regulation
    • Munsky, B., Neuert, G., and van Oudenaarden, A. (2012) Using gene expression noise to understand gene regulation Science 336, 183-187
    • (2012) Science , vol.336 , pp. 183-187
    • Munsky, B.1    Neuert, G.2    Van Oudenaarden, A.3
  • 33
    • 77956520011 scopus 로고    scopus 로고
    • Functional roles for noise in genetic circuits
    • Eldar, A. and Elowitz, M. B. (2010) Functional roles for noise in genetic circuits Nature 467, 167-173
    • (2010) Nature , vol.467 , pp. 167-173
    • Eldar, A.1    Elowitz, M.B.2
  • 34
    • 34347260600 scopus 로고    scopus 로고
    • Living with noisy genes: How cells function reliably with inherent variability in gene expression
    • Maheshri, N. and O'Shea, E. K. (2007) Living with noisy genes: How cells function reliably with inherent variability in gene expression Annu. Rev. Biophys. Biomol. Struct. 36, 413-434
    • (2007) Annu. Rev. Biophys. Biomol. Struct. , vol.36 , pp. 413-434
    • Maheshri, N.1    O'Shea, E.K.2
  • 35
    • 84857437687 scopus 로고    scopus 로고
    • Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae
    • Stewart-Ornstein, J., Weissman, J. S., and El-Samad, H. (2012) Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae Mol. Cell 45, 483-493
    • (2012) Mol. Cell , vol.45 , pp. 483-493
    • Stewart-Ornstein, J.1    Weissman, J.S.2    El-Samad, H.3
  • 36
    • 38349043669 scopus 로고    scopus 로고
    • High-content single-cell drug screening with phosphospecific flow cytometry
    • Krutzik, P. O., Crane, J. M., Clutter, M. R., and Nolan, G. P. (2008) High-content single-cell drug screening with phosphospecific flow cytometry Nat. Chem. Biol. 4, 132-142
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 132-142
    • Krutzik, P.O.1    Crane, J.M.2    Clutter, M.R.3    Nolan, G.P.4
  • 37
    • 79956275308 scopus 로고    scopus 로고
    • Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples
    • Krutzik, P. O., Trejo, A., Schulz, K. R., and Nolan, G. P. (2011) Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples Methods Mol. Biol. 699, 179-202
    • (2011) Methods Mol. Biol. , vol.699 , pp. 179-202
    • Krutzik, P.O.1    Trejo, A.2    Schulz, K.R.3    Nolan, G.P.4
  • 38
    • 0036173143 scopus 로고    scopus 로고
    • Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry
    • Perez, O. D. and Nolan, G. P. (2002) Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry Nat. Biotechnol. 20, 155-162
    • (2002) Nat. Biotechnol. , vol.20 , pp. 155-162
    • Perez, O.D.1    Nolan, G.P.2
  • 39
    • 3543069879 scopus 로고    scopus 로고
    • Seventeen-colour flow cytometry: Unravelling the immune system
    • Perfetto, S. P., Chattopadhyay, P. K., and Roederer, M. (2004) Seventeen-colour flow cytometry: Unravelling the immune system Nat. Rev. Immunol. 4, 648-655
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 648-655
    • Perfetto, S.P.1    Chattopadhyay, P.K.2    Roederer, M.3
  • 44
    • 77954541844 scopus 로고    scopus 로고
    • Single-cell NF-κB dynamics reveal digital activation and analogue information processing
    • Tay, S., Hughey, J. J., Lee, T. K., Lipniacki, T., Quake, S. R., and Covert, M. W. (2010) Single-cell NF-κB dynamics reveal digital activation and analogue information processing Nature 466, 267-271
    • (2010) Nature , vol.466 , pp. 267-271
    • Tay, S.1    Hughey, J.J.2    Lee, T.K.3    Lipniacki, T.4    Quake, S.R.5    Covert, M.W.6
  • 45
    • 0037044575 scopus 로고    scopus 로고
    • The IκB-NF-κB signaling module: Temporal control and selective gene activation
    • Hoffmann, A., Levchenko, A., Scott, M. L., and Baltimore, D. (2002) The IκB-NF-κB signaling module: Temporal control and selective gene activation Science 298, 1241-1245
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 47
    • 33646382406 scopus 로고    scopus 로고
    • Transient IκB kinase activity mediates temporal NF-κB dynamics in response to a wide range of tumor necrosis factor-α doses
    • Cheong, R., Bergmann, A., Werner, S. L., Regal, J., Hoffmann, A., and Levchenko, A. (2006) Transient IκB kinase activity mediates temporal NF-κB dynamics in response to a wide range of tumor necrosis factor-α doses J. Biol. Chem. 281, 2945-2950
    • (2006) J. Biol. Chem. , vol.281 , pp. 2945-2950
    • Cheong, R.1    Bergmann, A.2    Werner, S.L.3    Regal, J.4    Hoffmann, A.5    Levchenko, A.6
  • 50
    • 80054829921 scopus 로고    scopus 로고
    • Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images
    • Kalita, M. K., Sargsyan, K., Tian, B., Paulucci-Holthauzen, A., Najm, H. N., Debusschere, B. J., and Brasier, A. R. (2011) Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images J. Biol. Chem. 286, 37741-37757
    • (2011) J. Biol. Chem. , vol.286 , pp. 37741-37757
    • Kalita, M.K.1    Sargsyan, K.2    Tian, B.3    Paulucci-Holthauzen, A.4    Najm, H.N.5    Debusschere, B.J.6    Brasier, A.R.7
  • 51
    • 43249116959 scopus 로고    scopus 로고
    • Understanding NF-κB signaling via mathematical modeling
    • Cheong, R., Hoffmann, A., and Levchenko, A. (2008) Understanding NF-κB signaling via mathematical modeling Mol. Syst. Biol. 4, 192
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 192
    • Cheong, R.1    Hoffmann, A.2    Levchenko, A.3
  • 52
  • 53
    • 42949171936 scopus 로고    scopus 로고
    • Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage
    • Batchelor, E., Mock, C. S., Bhan, I., Loewer, A., and Lahav, G. (2008) Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage Mol. Cell 30, 277-289
    • (2008) Mol. Cell , vol.30 , pp. 277-289
    • Batchelor, E.1    Mock, C.S.2    Bhan, I.3    Loewer, A.4    Lahav, G.5
  • 58
    • 18744408814 scopus 로고    scopus 로고
    • A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates
    • Shults, M. D., Janes, K. A., Lauffenburger, D. A., and Imperiali, B. (2005) A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates Nat. Methods 2, 277-283
    • (2005) Nat. Methods , vol.2 , pp. 277-283
    • Shults, M.D.1    Janes, K.A.2    Lauffenburger, D.A.3    Imperiali, B.4
  • 59
    • 68049099384 scopus 로고    scopus 로고
    • Microfluidic concentration-enhanced cellular kinase activity assay
    • Lee, J. H., Cosgrove, B. D., Lauffenburger, D. A., and Han, J. (2009) Microfluidic concentration-enhanced cellular kinase activity assay J. Am. Chem. Soc. 131, 10340-10341
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 10340-10341
    • Lee, J.H.1    Cosgrove, B.D.2    Lauffenburger, D.A.3    Han, J.4
  • 62
    • 67650886056 scopus 로고    scopus 로고
    • A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry
    • Yu, Y., Anjum, R., Kubota, K., Rush, J., Villen, J., and Gygi, S. P. (2009) A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry Proc. Natl. Acad. Sci. U.S.A. 106, 11606-11611
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 11606-11611
    • Yu, Y.1    Anjum, R.2    Kubota, K.3    Rush, J.4    Villen, J.5    Gygi, S.P.6
  • 63
    • 18044378410 scopus 로고    scopus 로고
    • Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling
    • Jessani, N., Young, J. A., Diaz, S. L., Patricelli, M. P., Varki, A., and Cravatt, B. F. (2005) Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling Angew. Chem., Int. Ed. 44, 2400-2403
    • (2005) Angew. Chem., Int. Ed. , vol.44 , pp. 2400-2403
    • Jessani, N.1    Young, J.A.2    Diaz, S.L.3    Patricelli, M.P.4    Varki, A.5    Cravatt, B.F.6
  • 65
    • 77950434011 scopus 로고    scopus 로고
    • Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor
    • Fosbrink, M., Aye-Han, N. N., Cheong, R., Levchenko, A., and Zhang, J. (2010) Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor Proc. Natl. Acad. Sci. U.S.A. 107, 5459-5464
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 5459-5464
    • Fosbrink, M.1    Aye-Han, N.N.2    Cheong, R.3    Levchenko, A.4    Zhang, J.5
  • 66
    • 80054930783 scopus 로고    scopus 로고
    • Imaging the coordination of multiple signalling activities in living cells
    • Welch, C. M., Elliott, H., Danuser, G., and Hahn, K. M. (2011) Imaging the coordination of multiple signalling activities in living cells Nat. Rev. Mol. Cell Biol. 12, 749-756
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 749-756
    • Welch, C.M.1    Elliott, H.2    Danuser, G.3    Hahn, K.M.4
  • 68
    • 33845218548 scopus 로고    scopus 로고
    • Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
    • Warren, L., Bryder, D., Weissman, I. L., and Quake, S. R. (2006) Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR Proc. Natl. Acad. Sci. U.S.A. 103, 17807-17812
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 17807-17812
    • Warren, L.1    Bryder, D.2    Weissman, I.L.3    Quake, S.R.4
  • 69
    • 77951067248 scopus 로고    scopus 로고
    • Increasing the sensitivity of enzyme-linked immunosorbent assay using multiplexed electrokinetic concentrator
    • Cheow, L. F., Ko, S. H., Kim, S. J., Kang, K. H., and Han, J. (2010) Increasing the sensitivity of enzyme-linked immunosorbent assay using multiplexed electrokinetic concentrator Anal. Chem. 82, 3383-3388
    • (2010) Anal. Chem. , vol.82 , pp. 3383-3388
    • Cheow, L.F.1    Ko, S.H.2    Kim, S.J.3    Kang, K.H.4    Han, J.5
  • 70
    • 79959677297 scopus 로고    scopus 로고
    • Protein signaling networks from single cell fluctuations and information theory profiling
    • Shin, Y. S., Remacle, F., Fan, R., Hwang, K., Wei, W., Ahmad, H., Levine, R. D., and Heath, J. R. (2011) Protein signaling networks from single cell fluctuations and information theory profiling Biophys. J. 100, 2378-2386
    • (2011) Biophys. J. , vol.100 , pp. 2378-2386
    • Shin, Y.S.1    Remacle, F.2    Fan, R.3    Hwang, K.4    Wei, W.5    Ahmad, H.6    Levine, R.D.7    Heath, J.R.8
  • 72
    • 36048959493 scopus 로고    scopus 로고
    • Self- and super-organizing maps in R: The Kohonen package
    • Wehrens, R. and Buydens, L. M. C. (2007) Self- and super-organizing maps in R: The Kohonen package Journal of Statistical Software 21, 1-19
    • (2007) Journal of Statistical Software , vol.21 , pp. 1-19
    • Wehrens, R.1    Buydens, L.M.C.2
  • 74
    • 70449526719 scopus 로고    scopus 로고
    • Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility
    • Giampieri, S., Manning, C., Hooper, S., Jones, L., Hill, C. S., and Sahai, E. (2009) Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility Nat. Cell Biol. 11, 1287-1296
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1287-1296
    • Giampieri, S.1    Manning, C.2    Hooper, S.3    Jones, L.4    Hill, C.S.5    Sahai, E.6
  • 75
    • 77951728283 scopus 로고    scopus 로고
    • Intravital imaging illuminates transforming growth factor β signaling switches during metastasis
    • Giampieri, S., Pinner, S., and Sahai, E. (2010) Intravital imaging illuminates transforming growth factor β signaling switches during metastasis Cancer Res. 70, 3435-3439
    • (2010) Cancer Res. , vol.70 , pp. 3435-3439
    • Giampieri, S.1    Pinner, S.2    Sahai, E.3
  • 76
    • 79953668247 scopus 로고    scopus 로고
    • Training signaling pathway maps to biochemical data with constrained fuzzy logic: Quantitative analysis of liver cell responses to inflammatory stimuli
    • Morris, M. K., Saez-Rodriguez, J., Clarke, D. C., Sorger, P. K., and Lauffenburger, D. A. (2011) Training signaling pathway maps to biochemical data with constrained fuzzy logic: Quantitative analysis of liver cell responses to inflammatory stimuli PLoS Comput. Biol. 7, e1001099
    • (2011) PLoS Comput. Biol. , vol.7 , pp. 1001099
    • Morris, M.K.1    Saez-Rodriguez, J.2    Clarke, D.C.3    Sorger, P.K.4    Lauffenburger, D.A.5
  • 77
    • 84859994220 scopus 로고    scopus 로고
    • Computational approaches for analyzing information flow in biological networks
    • Kholodenko, B., Yaffe, M. B., and Kolch, W. (2012) Computational approaches for analyzing information flow in biological networks Sci. Signaling 5, re1
    • (2012) Sci. Signaling , vol.5 , pp. 1
    • Kholodenko, B.1    Yaffe, M.B.2    Kolch, W.3
  • 80
    • 79952635820 scopus 로고    scopus 로고
    • Measuring and modeling apoptosis in single cells
    • Spencer, S. L. and Sorger, P. K. (2011) Measuring and modeling apoptosis in single cells Cell 144, 926-939
    • (2011) Cell , vol.144 , pp. 926-939
    • Spencer, S.L.1    Sorger, P.K.2
  • 81
    • 33750351769 scopus 로고    scopus 로고
    • Data-driven modelling of signal-transduction networks
    • Janes, K. A. and Yaffe, M. B. (2006) Data-driven modelling of signal-transduction networks Nat. Rev. Mol. Cell Biol. 7, 820-828
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 820-828
    • Janes, K.A.1    Yaffe, M.B.2
  • 82
    • 79953175640 scopus 로고    scopus 로고
    • Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers
    • Rivet, C. A., Hill, A. S., Lu, H., and Kemp, M. L. (2011) Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers Mol. Cell. Proteomics 10, M110-003921
    • (2011) Mol. Cell. Proteomics , vol.10 , pp. 110-003921
    • Rivet, C.A.1    Hill, A.S.2    Lu, H.3    Kemp, M.L.4
  • 84
    • 17644427718 scopus 로고    scopus 로고
    • Causal protein-signaling networks derived from multiparameter single-cell data
    • Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D. A., and Nolan, G. P. (2005) Causal protein-signaling networks derived from multiparameter single-cell data Science 308, 523-529
    • (2005) Science , vol.308 , pp. 523-529
    • Sachs, K.1    Perez, O.2    Pe'Er, D.3    Lauffenburger, D.A.4    Nolan, G.P.5
  • 85
    • 84866688958 scopus 로고    scopus 로고
    • Bayesian Hierarchical Modeling for Signaling Pathway Inference from Single Cell Interventional Data
    • Luo, R. and Zhao, H. (2011) Bayesian Hierarchical Modeling for Signaling Pathway Inference from Single Cell Interventional Data Annals of Applied Statistics 5, 725-745
    • (2011) Annals of Applied Statistics , vol.5 , pp. 725-745
    • Luo, R.1    Zhao, H.2
  • 86
    • 80054841161 scopus 로고    scopus 로고
    • Information transduction capacity of noisy biochemical signaling networks
    • Cheong, R., Rhee, A., Wang, C. J., Nemenman, I., and Levchenko, A. (2011) Information transduction capacity of noisy biochemical signaling networks Science 334, 354-358
    • (2011) Science , vol.334 , pp. 354-358
    • Cheong, R.1    Rhee, A.2    Wang, C.J.3    Nemenman, I.4    Levchenko, A.5
  • 87
    • 34250216344 scopus 로고    scopus 로고
    • Image-based multivariate profiling of drug responses from single cells
    • Loo, L. H., Wu, L. F., and Altschuler, S. J. (2007) Image-based multivariate profiling of drug responses from single cells Nat. Methods 4, 445-453
    • (2007) Nat. Methods , vol.4 , pp. 445-453
    • Loo, L.H.1    Wu, L.F.2    Altschuler, S.J.3
  • 88
    • 1642463417 scopus 로고    scopus 로고
    • Analysis of protein phosphorylation and cellular signaling events by flow cytometry: Techniques and clinical applications
    • Krutzik, P. O., Irish, J. M., Nolan, G. P., and Perez, O. D. (2004) Analysis of protein phosphorylation and cellular signaling events by flow cytometry: Techniques and clinical applications Clin. Immunol. 110, 206-221
    • (2004) Clin. Immunol. , vol.110 , pp. 206-221
    • Krutzik, P.O.1    Irish, J.M.2    Nolan, G.P.3    Perez, O.D.4
  • 89
    • 79955135865 scopus 로고    scopus 로고
    • Identification of models of heterogeneous cell populations from population snapshot data
    • Hasenauer, J., Waldherr, S., Doszczak, M., Radde, N., Scheurich, P., and Allgower, F. (2011) Identification of models of heterogeneous cell populations from population snapshot data BMC Bioinf. 12, 125
    • (2011) BMC Bioinf. , vol.12 , pp. 125
    • Hasenauer, J.1    Waldherr, S.2    Doszczak, M.3    Radde, N.4    Scheurich, P.5    Allgower, F.6
  • 91
    • 77952257945 scopus 로고    scopus 로고
    • Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities
    • Singh, D. K., Ku, C. J., Wichaidit, C., Steininger, R. J., III, Wu, L. F., and Altschuler, S. J. (2010) Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities Mol. Syst. Biol. 6, 369
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 369
    • Singh, D.K.1    Ku, C.J.2    Wichaidit, C.3    Steininger III, R.J.4    Wu, L.F.5    Altschuler, S.J.6
  • 92
    • 75549087566 scopus 로고    scopus 로고
    • Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes
    • Loo, L. H., Lin, H. J., Singh, D. K., Lyons, K. M., Altschuler, S. J., and Wu, L. F. (2009) Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes J. Cell Biol. 187, 375-384
    • (2009) J. Cell Biol. , vol.187 , pp. 375-384
    • Loo, L.H.1    Lin, H.J.2    Singh, D.K.3    Lyons, K.M.4    Altschuler, S.J.5    Wu, L.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.