Training signaling pathway maps to biochemical data with constrained fuzzy logic: Quantitative analysis of liver cell responses to inflammatory stimuli

PLoS Computational Biology

Volumn 7, Issue 3, 2011, Pages

  Morris, Melody K ^a,b   Saez Rodriguez, Julio ^a,b,c,d   Clarke, David C ^a,b   Sorger, Peter K ^a,b,c   Lauffenburger, Douglas A ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SIGNALING; CHEMICAL ACTIVATION; COMPUTER CIRCUITS; FORECASTING; PROTEINS; SIGNALING;

BIOCHEMICAL DATA; CELL RESPONSE; CELLS SIGNALING; COMPUTABLE MODELS; FUZZY-LOGIC; INFLAMMATORY STIMULI; LIVER CELLS; PRIOR-KNOWLEDGE; PROTEIN ACTIVATION; SIGNALLING PATHWAYS;

FUZZY LOGIC;

CYTOKINE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR ALPHA; AUTACOID; PROTEIN;

ARTICLE; CELL ACTIVITY; CELL COMMUNICATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; FEASIBILITY STUDY; FUZZY LOGIC; INFLAMMATION; LIVER CELL; MATHEMATICAL MODEL; MOLECULAR INTERACTION; PHENOTYPE; PREDICTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; THEORY VALIDATION; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; COMPUTER SIMULATION; HUMAN; LIVER; METABOLISM; METHODOLOGY; PHOSPHORYLATION; RAT; REPRODUCIBILITY;

ALGORITHMS; ANIMALS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CYTOKINES; FUZZY LOGIC; HEP G2 CELLS; HUMANS; INFLAMMATION MEDIATORS; LIVER; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEINS; RATS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 79953668247     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001099     Document Type: Article

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