-
1
-
-
0027459198
-
mdm2 Expression is induced by wild type p53 activity
-
Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468 (Pubitemid 23073692)
-
(1993)
EMBO Journal
, vol.12
, Issue.2
, pp. 461-468
-
-
Barak, Y.1
Juven, T.2
Haffner, R.3
Oren, M.4
-
2
-
-
42949171936
-
Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage
-
DOI 10.1016/j.molcel.2008.03.016, PII S1097276508002402
-
Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G (2008) Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell 30: 277-289 (Pubitemid 351615316)
-
(2008)
Molecular Cell
, vol.30
, Issue.3
, pp. 277-289
-
-
Batchelor, E.1
Mock, C.S.2
Bhan, I.3
Loewer, A.4
Lahav, G.5
-
3
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
DOI 10.1038/nrc1455
-
Bode AM, Dong Z (2004) Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 4: 793-805 (Pubitemid 39331151)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.10
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
4
-
-
0037377060
-
Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
-
DOI 10.1016/S0955-0674(03)00003-6
-
Brooks CL, Gu W (2003) Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 15: 164-171 (Pubitemid 36332191)
-
(2003)
Current Opinion in Cell Biology
, vol.15
, Issue.2
, pp. 164-171
-
-
Brooks, C.L.1
Gu, W.2
-
5
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
DOI 10.1038/nrm2450, PII NRM2450
-
Cimprich KA, Cortez D (2008) ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 9: 616-627 (Pubitemid 352032926)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.8
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
6
-
-
0030925222
-
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
-
DOI 10.1073/pnas.94.12.6048
-
Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E (1997) Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci USA 94: 6048-6053 (Pubitemid 27270633)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.12
, pp. 6048-6053
-
-
Fiscella, M.1
Zhang, H.2
Fan, S.3
Sakaguchi, K.4
Shen, S.5
Mercer, W.E.6
Vande Woude, G.F.7
O'Connor, P.M.8
Appella, E.9
-
7
-
-
33745451921
-
Oscillations and variability in the p53 system
-
Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U (2006) Oscillations and variability in the p53 system. Mol Syst Biol 2: 2006.0033
-
(2006)
Mol Syst Biol
, vol.2
, Issue.2006
, pp. 0033
-
-
Geva-Zatorsky, N.1
Rosenfeld, N.2
Itzkovitz, S.3
Milo, R.4
Sigal, A.5
Dekel, E.6
Yarnitzky, T.7
Liron, Y.8
Polak, P.9
Lahav, G.10
Alon, U.11
-
8
-
-
44449091966
-
Regulation of cell signaling dynamics by the protein kinase-scaffold ste5
-
DOI 10.1016/j.molcel.2008.04.016, PII S1097276508003006
-
Hao N, Nayak S, Behar M, Shanks RH, Nagiec MJ, Errede B, Hasty J, Elston TC, Dohlman HG (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell 30: 649-656 (Pubitemid 351755062)
-
(2008)
Molecular Cell
, vol.30
, Issue.5
, pp. 649-656
-
-
Hao, N.1
Nayak, S.2
Behar, M.3
Shanks, R.H.4
Nagiec, M.J.5
Errede, B.6
Hasty, J.7
Elston, T.C.8
Dohlman, H.G.9
-
9
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
DOI 10.1038/sj.onc.1208615
-
Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908 (Pubitemid 40638098)
-
(2005)
Oncogene
, vol.24
, Issue.17
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
10
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
DOI 10.1038/387296a0
-
Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299 (Pubitemid 27220766)
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
11
-
-
35649001607
-
A quantitative description of membrane current and its application to conduction and excitation in nerve
-
Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: 500-544
-
(1952)
J Physiol
, vol.117
, pp. 500-544
-
-
Hodgkin, A.L.1
Huxley, A.F.2
-
12
-
-
33847271089
-
Coping with stress: Multiple ways to activate p53
-
DOI 10.1038/sj.onc.1210263, PII 1210263
-
Horn HF, Vousden KH (2007) Coping with stress: multiple ways to activate p53. Oncogene 26: 1306-1316 (Pubitemid 46328472)
-
(2007)
Oncogene
, vol.26
, Issue.9
, pp. 1306-1316
-
-
Horn, H.F.1
Vousden, K.H.2
-
13
-
-
57149117828
-
A PI3-kinase-mediated negative feedback regulates neuronal excitability
-
Howlett E, Lin CC, Lavery W, Stern M (2008) A PI3-kinase-mediated negative feedback regulates neuronal excitability. PLoS Genet 4: e1000277
-
(2008)
PLoS Genet
, vol.4
-
-
Howlett, E.1
Lin, C.C.2
Lavery, W.3
Stern, M.4
-
14
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
DOI 10.1038/ncb1337, PII N1337
-
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8: 37-45 (Pubitemid 43064795)
-
(2006)
Nature Cell Biology
, vol.8
, Issue.1
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.M.5
Lukas, J.6
Jackson, S.P.7
-
15
-
-
0033592868
-
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
-
DOI 10.1073/pnas.96.26.14973
-
Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D (1999) Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci USA 96: 14973-14977 (Pubitemid 30019749)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.26
, pp. 14973-14977
-
-
Khosravi, R.1
Maya, R.2
Gottlieb, T.3
Oren, M.4
Shiloh, Y.5
Shkedy, D.6
-
16
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
DOI 10.1038/387299a0
-
Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303 (Pubitemid 27220767)
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 299-303
-
-
Kubbutat, M.H.G.1
Jones, S.N.2
Vousden, K.H.3
-
17
-
-
0842332406
-
Dynamics of the p53-Mdm2 feedback loop in individual cells
-
DOI 10.1038/ng1293
-
Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U (2004) Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet 36: 147-150 (Pubitemid 38174372)
-
(2004)
Nature Genetics
, vol.36
, Issue.2
, pp. 147-150
-
-
Lahav, G.1
Rosenfeld, N.2
Sigal, A.3
Geva-Zatorsky, N.4
Levine, A.J.5
Elowitz, M.B.6
Alon, U.7
-
18
-
-
77954312224
-
Basal dynamicsof p53 reveal transcriptionally attenuated pulses in cycling cells
-
LoewerA, Batchelor E, Gaglia G, Lahav G (2010) Basal dynamicsof p53 reveal transcriptionally attenuated pulses in cycling cells. Cell 142: 89-100
-
(2010)
Cell
, vol.142
, pp. 89-100
-
-
Loewera Batchelor, E.1
Gaglia, G.2
Lahav, G.3
-
19
-
-
18844405191
-
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
-
DOI 10.1101/gad.1291305
-
Lu X, Nannenga B, Donehower LA (2005) PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 19: 1162-1174 (Pubitemid 40696183)
-
(2005)
Genes and Development
, vol.19
, Issue.10
, pp. 1162-1174
-
-
Lu, X.1
Nannenga, B.2
Donehower, L.A.3
-
20
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
21
-
-
0035339357
-
ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
-
DOI 10.1101/gad.886901
-
Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M (2001) ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev 15: 1067-1077 (Pubitemid 32417300)
-
(2001)
Genes and Development
, vol.15
, Issue.9
, pp. 1067-1077
-
-
Maya, R.1
Balass, M.2
Kim, S.-T.3
Shkedy, D.4
Martinez Leal, J.-F.5
Shifman, O.6
Moas, M.7
Buschmann, T.8
Ronai, Z.9
Shiloh, Y.10
Kastan, M.B.11
Katzir, E.12
Oren, M.13
-
22
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
DOI 10.1016/S1044-579X(02)00099-8, PII S1044579X02000998
-
Michael D, Oren M (2003) The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13: 49-58 (Pubitemid 36269180)
-
(2003)
Seminars in Cancer Biology
, vol.13
, Issue.1
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
23
-
-
33847355217
-
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
-
DOI 10.1038/ncb1543, PII NCB1543
-
Santos SD, Verveer PJ, Bastiaens PI (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 9: 324-330 (Pubitemid 46344612)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.3
, pp. 324-330
-
-
Santos, S.D.M.1
Verveer, P.J.2
Bastiaens, P.I.H.3
-
24
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT (1998) Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res 58: 4375-4382 (Pubitemid 28450040)
-
(1998)
Cancer Research
, vol.58
, Issue.19
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
Kennedy, A.P.4
Hill, D.E.5
Abraham, R.T.6
-
25
-
-
0020955161
-
Induction and repair of DNA damage in normal and ataxia-telangiectasia skin fibroblasts treated with neocarzinostatin
-
Shiloh Y, van der Schans GP, Lohman PH, Becker Y (1983) Induction and repair of DNA damage in normal and ataxia-telangiectasia skin fibroblasts treated with neocarzinostatin. Carcinogenesis 4: 917-921 (Pubitemid 13010789)
-
(1983)
Carcinogenesis
, vol.4
, Issue.7
, pp. 917-921
-
-
Shiloh, Y.1
Van Der Schans, G.P.2
Lohman, P.H.M.3
Becker, Y.4
-
26
-
-
0347363827
-
Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export
-
DOI 10.1038/sj.onc.1207176
-
Shinozaki T, Nota A, Taya Y, Okamoto K (2003) Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export. Oncogene 22: 8870-8880 (Pubitemid 38021503)
-
(2003)
Oncogene
, vol.22
, Issue.55
, pp. 8870-8880
-
-
Shinozaki, T.1
Nota, A.2
Taya, Y.3
Okamoto, K.4
-
27
-
-
33748150967
-
Wip1 phosphatase modulates ATM-dependent signaling pathways
-
DOI 10.1016/j.molcel.2006.07.010, PII S1097276506004904
-
Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV (2006) Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell 23: 757-764 (Pubitemid 44308587)
-
(2006)
Molecular Cell
, vol.23
, Issue.5
, pp. 757-764
-
-
Shreeram, S.1
Demidov, O.N.2
Hee, W.K.3
Yamaguchi, H.4
Onishi, N.5
Kek, C.6
Timofeev, O.N.7
Dudgeon, C.8
Fornace, A.J.9
Anderson, C.W.10
Minami, Y.11
Appella, E.12
Bulavin, D.V.13
-
28
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
DOI 10.1038/sj.emboj.7600145
-
Stommel JM, Wahl GM (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 23: 1547-1556 (Pubitemid 38579515)
-
(2004)
EMBO Journal
, vol.23
, Issue.7
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
29
-
-
33645293152
-
An excitable gene regulatory circuit induces transient cellular differentiation
-
Suel GM, Garcia-Ojalvo J, Liberman LM, Elowitz MB (2006) An excitable gene regulatory circuit induces transient cellular differentiation. Nature 440: 545-550
-
(2006)
Nature
, vol.440
, pp. 545-550
-
-
Suel, G.M.1
Garcia-Ojalvo, J.2
Liberman, L.M.3
Elowitz, M.B.4
-
30
-
-
77954541844
-
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing
-
Tay S, Hughey JJ, Lee TK, Lipniacki T, Quake SR, Covert MW (2010) Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature 466: 267-271
-
(2010)
Nature
, vol.466
, pp. 267-271
-
-
Tay, S.1
Hughey, J.J.2
Lee, T.K.3
Lipniacki, T.4
Quake, S.R.5
Covert, M.W.6
-
31
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu X, Bayle JH, Olson D, Levine AJ (1993) The p53-mdm-2 autoregulatory feedback loop. Genes Dev 7: 1126-1132 (Pubitemid 23207405)
-
(1993)
Genes and Development
, vol.7
, Issue.7
, pp. 1126-1132
-
-
Wu, X.1
Bayle, J.H.2
Olson, D.3
Levine, A.J.4
-
32
-
-
58149122647
-
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases
-
Yajima H, Lee KJ, Zhang S, Kobayashi J, Chen BP (2009) DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol 385: 800-810
-
(2009)
J Mol Biol
, vol.385
, pp. 800-810
-
-
Yajima, H.1
Lee, K.J.2
Zhang, S.3
Kobayashi, J.4
Chen, B.P.5
-
33
-
-
0034656243
-
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
-
Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH, Levine AJ (2000) Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 14: 981-993 (Pubitemid 30253006)
-
(2000)
Genes and Development
, vol.14
, Issue.8
, pp. 981-993
-
-
Zhao, R.1
Gish, K.2
Murphy, M.3
Yin, Y.4
Notterman, D.5
Hoffman, W.H.6
Tom, E.7
Mack, D.H.8
Levine, A.J.9
|