Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 12, 2010, Pages 5459-5464

  Fosbrink, Matthew ^a   Aye Han, Nwe Nwe ^a   Cheong, Raymond ^a   Levchenko, Andre ^a   Zhang, Jin ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bistable; FRET; Kinase; MAPK; Subcellular

Indexed keywords

ANISOMYCIN; CYAN FLUORESCENT PROTEIN; FLUORESCENT DYE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; YELLOW FLUORESCENT PROTEIN;

ARTICLE; BIOSENSOR; CELL CULTURE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELL; MITOCHONDRION; PRIORITY JOURNAL; SIGNAL PROCESSING;

AMINO ACID SEQUENCE; BIOSENSING TECHNIQUES; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; GENES, REPORTER; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUMINESCENT PROTEINS; MAP KINASE SIGNALING SYSTEM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; STRESS, PHYSIOLOGICAL; SUBCELLULAR FRACTIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950434011     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909671107     Document Type: Article

References (30)

1. Weston CR, Davis RJ (2007) The JNK signal transduction pathway. Curr Opin Cell Biol 19:142-149.
2. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
3. Xia Y, Wu Z, Su B, Murray B, Karin M (1998) JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev 12:3369-3381. (Pubitemid 28520985)
4. Bagowski CP, Ferrell JE, Jr (2001) Bistability in the JNK cascade. Curr Biol 11:1176-1182.
5. Bagowski CP, Besser J, Frey CR, Ferrell JE, Jr (2003) The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. Curr Biol 13:315-320. (Pubitemid 36230022)
6. Ni Q, Titov DV, Zhang J (2006) Analyzing protein kinase dynamics in living cells with FRET reporters. Methods 40:279-286. (Pubitemid 44635295)
7. Bogoyevitch MA, Kobe B (2006) Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev 70:1061-1095.
8. Dérijard B, et al. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037. (Pubitemid 24106383)
9. Katz S, Heinrich R, Aronheim A (2001) The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase. FEBS Lett 506:196-200. (Pubitemid 32964812)
10. Barr RK, Boehm I, Attwood PV, Watt PM, Bogoyevitch MA (2004) The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK. J Biol Chem 279:36327-36338. (Pubitemid 39128970)
11. Katz S, Aronheim A (2002) Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2. Biochem J 368:939-945. (Pubitemid 36042697)
12. Durocher D, et al. (2000) The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell 6:1169-1182.
13. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY (2005) Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature 437:569-573. (Pubitemid 41613556)
14. Ouyang DY, Wang YY, Zheng YT (2005) Activation of c-Jun N-terminal kinases by ribotoxic stresses. Cell Mol Immunol 2:419-425.
15. Ma Y, Taylor S (2002) A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. J Biol Chem 277:27328-27336.
16. Zhou Q, Lam PY, Han D, Cadenas E (2008) c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J Neurochem 104:325-335. (Pubitemid 350293865)
17. Zacharias DA, Violin JD, Newton AC, Tsien RY (2002) Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296:913-916.
18. Ferrell JE, Jr (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14:140-148.
19. Ninfa AJ, Mayo AE (2004) Hysteresis vs. graded responses: the connections make all the difference. Sci STKE 2004:pe20.
20. Pomerening JR (2008) Uncovering mechanisms of bistability in biological systems. Curr Opin Biotechnol 19:381-388.
21. Cheong R, Wang CJ, Levchenko A (2009) High content cell screening in a microfluidic device. Mol Cell Proteomics 8:433-442.
22. Sato M, Kawai Y, Umezawa Y (2007) Genetically encoded fluorescent indicators to visualize protein phosphorylation by extracellular signal-regulated kinase in single living cells. Anal Chem 79:2570-2575. (Pubitemid 46449042)
23. Harvey CD, et al. (2008) A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci USA 105:19264-19269.
24. Liu J, Lin A (2005) Role of JNK activation in apoptosis: a double-edged sword. Cell Res 15:36-42. (Pubitemid 41653963)
25. Eminel S, Klettner A, Roemer L, Herdegen T, Waetzig V (2004) JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. J Biol Chem 279:55385-55392. (Pubitemid 40066538)
26. Aguirre V, Uchida T, Yenush L, Davis R, White MF (2000) The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054.
27. Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K (2003) JNK phosphorylates paxillin and regulates cell migration. Nature 424:219-223. (Pubitemid 36858692)
28. Ferrell JE, Jr, Machleder EM (1998) The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280:895-898.
29. Pomerening JR, Sontag ED, Ferrell JE, Jr (2003) Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol 5:346-351.
30. Whitehurst A, Cobb MH, White MA (2004) Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol Cell Biol 24:10145-10150. (Pubitemid 39507854)