Physiological levels of TNFα stimulation induce stochastic dynamics of NF-κB responses in single living cells

Journal of Cell Science

Volumn 123, Issue 16, 2010, Pages 2834-2843

  Turner, David A ^a   Paszek, Pawel ^a   Woodcock, Dan J ^b   Nelson, David E ^a   Horton, Caroline A ^a   Wang, Yunjiao ^c   Spiller, David G ^a   Rand, David A ^b   White, Michael R H ^a   Harper, Claire V ^a  

^a Center for Cell Imaging   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Live cell imaging; Mathematical modelling; NF B; Stochastic processes; Systems biology; TNF

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; RELA PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

ARTICLE; CELL ACTIVATION; CELL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR DYNAMICS; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; STOCHASTIC MODEL; SYSTEMS BIOLOGY; BIOLOGICAL MODEL; BIOSYNTHESIS; CONFOCAL MICROSCOPY; DOSE RESPONSE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; STATISTICS; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; I-KAPPA B PROTEINS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; NF-KAPPA B; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955986202     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.069641     Document Type: Article

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