-
1
-
-
0001639195
-
Some speculations on the myeloproliferative syndromes
-
Dameshek W. Some speculations on the myeloproliferative syndromes. Blood 1951, 6:372-375.
-
(1951)
Blood
, vol.6
, pp. 372-375
-
-
Dameshek, W.1
-
2
-
-
33845436745
-
The myeloproliferative disorders
-
Campbell P.J., Green A.R. The myeloproliferative disorders. N Engl J Med 2006, 355:2452-2466.
-
(2006)
N Engl J Med
, vol.355
, pp. 2452-2466
-
-
Campbell, P.J.1
Green, A.R.2
-
3
-
-
34548240698
-
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
-
Levine R.L., Pardanani A., Tefferi A., et al. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat Rev Cancer 2007, 7:673-683.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 673-683
-
-
Levine, R.L.1
Pardanani, A.2
Tefferi, A.3
-
4
-
-
0016391236
-
Letter: bone-marrow responses in polycythemia vera
-
Prchal J.F., Axelrad A.A. Letter: bone-marrow responses in polycythemia vera. N Engl J Med 1974, 290:1382.
-
(1974)
N Engl J Med
, vol.290
, pp. 1382
-
-
Prchal, J.F.1
Axelrad, A.A.2
-
5
-
-
0020083461
-
Erythroid progenitors in polycythemia vera: demonstration of their hypersensitivity to erythropoietin using serum free cultures
-
Casadevall N., Vainchenker W., Lacombe C., et al. Erythroid progenitors in polycythemia vera: demonstration of their hypersensitivity to erythropoietin using serum free cultures. Blood 1982, 59:447-451.
-
(1982)
Blood
, vol.59
, pp. 447-451
-
-
Casadevall, N.1
Vainchenker, W.2
Lacombe, C.3
-
6
-
-
0020522444
-
Individual BFU-E in polycythemia vera produce both erythropoietin dependent and independent progeny
-
Cashman J., Henkelman D., Humphries K., et al. Individual BFU-E in polycythemia vera produce both erythropoietin dependent and independent progeny. Blood 1983, 61:876-884.
-
(1983)
Blood
, vol.61
, pp. 876-884
-
-
Cashman, J.1
Henkelman, D.2
Humphries, K.3
-
7
-
-
0018163444
-
Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera
-
Eaves C.J., Eaves A.C. Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera. Blood 1978, 52:1196-1210.
-
(1978)
Blood
, vol.52
, pp. 1196-1210
-
-
Eaves, C.J.1
Eaves, A.C.2
-
8
-
-
0028146159
-
Anti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera
-
Fisher M.J., Prchal J.F., Prchal J.T., et al. Anti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera. Blood 1994, 84:1982-1991.
-
(1994)
Blood
, vol.84
, pp. 1982-1991
-
-
Fisher, M.J.1
Prchal, J.F.2
Prchal, J.T.3
-
9
-
-
0017755475
-
Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin
-
Zanjani E.D., Lutton J.D., Hoffman R., et al. Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin. J Clin Invest 1977, 59:841-848.
-
(1977)
J Clin Invest
, vol.59
, pp. 841-848
-
-
Zanjani, E.D.1
Lutton, J.D.2
Hoffman, R.3
-
10
-
-
0028045069
-
Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium
-
Correa P.N., Eskinazi D., Axelrad A.A. Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium. Blood 1994, 83:99-112.
-
(1994)
Blood
, vol.83
, pp. 99-112
-
-
Correa, P.N.1
Eskinazi, D.2
Axelrad, A.A.3
-
11
-
-
0026667283
-
Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor
-
Dai C.H., Krantz S.B., Dessypris E.N., et al. Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor. Blood 1992, 80:891-899.
-
(1992)
Blood
, vol.80
, pp. 891-899
-
-
Dai, C.H.1
Krantz, S.B.2
Dessypris, E.N.3
-
12
-
-
0028261196
-
Polycythaemia vera. III. Burst-forming units-erythroid (BFU-E) response to stem cell factor and c-kit receptor expression
-
Dai C.H., Krantz S.B., Green W.F., et al. Polycythaemia vera. III. Burst-forming units-erythroid (BFU-E) response to stem cell factor and c-kit receptor expression. Br J Haematol 1994, 86:12-21.
-
(1994)
Br J Haematol
, vol.86
, pp. 12-21
-
-
Dai, C.H.1
Krantz, S.B.2
Green, W.F.3
-
13
-
-
0025975727
-
Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3
-
Dai C.H., Krantz S.B., Means R.T., et al. Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3. J Clin Invest 1991, 87:391-396.
-
(1991)
J Clin Invest
, vol.87
, pp. 391-396
-
-
Dai, C.H.1
Krantz, S.B.2
Means, R.T.3
-
14
-
-
0026683635
-
Familial and congenital polycythemia in three unrelated families
-
Emanuel P.D., Eaves C.J., Broudy V.C., et al. Familial and congenital polycythemia in three unrelated families. Blood 1992, 79:3019-3030.
-
(1992)
Blood
, vol.79
, pp. 3019-3030
-
-
Emanuel, P.D.1
Eaves, C.J.2
Broudy, V.C.3
-
15
-
-
0024457155
-
Erythropoietin receptors in polycythemia vera
-
Means R.T., Krantz S.B., Sawyer S.T., et al. Erythropoietin receptors in polycythemia vera. J Clin Invest 1989, 84:1340-1344.
-
(1989)
J Clin Invest
, vol.84
, pp. 1340-1344
-
-
Means, R.T.1
Krantz, S.B.2
Sawyer, S.T.3
-
16
-
-
0028034396
-
Molecular analysis of the erythropoietin receptor system in patients with polycythaemia vera
-
Hess G., Rose P., Gamm H., et al. Molecular analysis of the erythropoietin receptor system in patients with polycythaemia vera. Br J Haematol 1994, 88:794-802.
-
(1994)
Br J Haematol
, vol.88
, pp. 794-802
-
-
Hess, G.1
Rose, P.2
Gamm, H.3
-
17
-
-
0030021792
-
Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies
-
Le Couedic J.P., Mitjavila M.T., Villeval J.L., et al. Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies. Blood 1996, 87:1502-1511.
-
(1996)
Blood
, vol.87
, pp. 1502-1511
-
-
Le Couedic, J.P.1
Mitjavila, M.T.2
Villeval, J.L.3
-
18
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter E.J., Scott L.M., Campbell P.J., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005, 365:1054-1061.
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
19
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C., Ugo V., Le Couedic J.P., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434:1144-1148.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
20
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R., Passamonti F., Buser A.S., et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005, 352:1779-1790.
-
(2005)
N Engl J Med
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
-
21
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine R.L., Wadleigh M., Cools J., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7:387-397.
-
(2005)
Cancer Cell
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
22
-
-
0034693871
-
Janus kinases: components of multiple signaling pathways
-
Rane S.G., Reddy E.P. Janus kinases: components of multiple signaling pathways. Oncogene 2000, 19:5662-5679.
-
(2000)
Oncogene
, vol.19
, pp. 5662-5679
-
-
Rane, S.G.1
Reddy, E.P.2
-
23
-
-
0037071409
-
JAKs, STATs and Src kinases in hematopoiesis
-
Rane S.G., Reddy E.P. JAKs, STATs and Src kinases in hematopoiesis. Oncogene 2002, 21:3334-3358.
-
(2002)
Oncogene
, vol.21
, pp. 3334-3358
-
-
Rane, S.G.1
Reddy, E.P.2
-
24
-
-
2442642830
-
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
-
Feener E.P., Rosario F., Dunn S.L., et al. Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol 2004, 24:4968-4978.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 4968-4978
-
-
Feener, E.P.1
Rosario, F.2
Dunn, S.L.3
-
25
-
-
0037033012
-
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
-
Saharinen P., Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 2002, 277:47954-47963.
-
(2002)
J Biol Chem
, vol.277
, pp. 47954-47963
-
-
Saharinen, P.1
Silvennoinen, O.2
-
26
-
-
80052492285
-
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
-
Ungureanu D., Wu J., Pekkala T., et al. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol 2011, 18:971-976.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 971-976
-
-
Ungureanu, D.1
Wu, J.2
Pekkala, T.3
-
27
-
-
35348850734
-
Hematopoietic cytokine receptor signaling
-
Baker S.J., Rane S.G., Reddy E.P. Hematopoietic cytokine receptor signaling. Oncogene 2007, 26:6724-6737.
-
(2007)
Oncogene
, vol.26
, pp. 6724-6737
-
-
Baker, S.J.1
Rane, S.G.2
Reddy, E.P.3
-
28
-
-
0035694582
-
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
-
Huang L.J., Constantinescu S.N., Lodish H.F. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 2001, 8:1327-1338.
-
(2001)
Mol Cell
, vol.8
, pp. 1327-1338
-
-
Huang, L.J.1
Constantinescu, S.N.2
Lodish, H.F.3
-
29
-
-
22844438893
-
Janus kinases affect thrombopoietin receptor cell surface localization and stability
-
Royer Y., Staerk J., Costuleanu M., et al. Janus kinases affect thrombopoietin receptor cell surface localization and stability. J Biol Chem 2005, 280:27251-27261.
-
(2005)
J Biol Chem
, vol.280
, pp. 27251-27261
-
-
Royer, Y.1
Staerk, J.2
Costuleanu, M.3
-
30
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell J.E., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415-1421.
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell, J.E.1
Kerr, I.M.2
Stark, G.R.3
-
31
-
-
0029348007
-
The Janus protein tyrosine kinases in hematopoietic cytokine signaling
-
Ihle J.N. The Janus protein tyrosine kinases in hematopoietic cytokine signaling. Semin Immunol 1995, 7:247-254.
-
(1995)
Semin Immunol
, vol.7
, pp. 247-254
-
-
Ihle, J.N.1
-
32
-
-
20744460045
-
Identification of an acquired JAK2 mutation in polycythemia vera
-
Zhao R., Xing S., Li Z., et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem 2005, 280:22788-22792.
-
(2005)
J Biol Chem
, vol.280
, pp. 22788-22792
-
-
Zhao, R.1
Xing, S.2
Li, Z.3
-
33
-
-
41949118675
-
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F
-
Lu X., Huang L.J., Lodish H.F. Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem 2008, 283:5258-5266.
-
(2008)
J Biol Chem
, vol.283
, pp. 5258-5266
-
-
Lu, X.1
Huang, L.J.2
Lodish, H.F.3
-
34
-
-
30044437118
-
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
-
Lu X., Levine R., Tong W., et al. Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. Proc Natl Acad Sci U S A 2005, 102:18962-18967.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18962-18967
-
-
Lu, X.1
Levine, R.2
Tong, W.3
-
35
-
-
33846660947
-
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
-
Scott L.M., Tong W., Levine R.L., et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 2007, 356:459-468.
-
(2007)
N Engl J Med
, vol.356
, pp. 459-468
-
-
Scott, L.M.1
Tong, W.2
Levine, R.L.3
-
36
-
-
79960347715
-
The JAK2 exon 12 mutations: a comprehensive review
-
Scott L.M. The JAK2 exon 12 mutations: a comprehensive review. Am J Hematol 2011, 86:668-676.
-
(2011)
Am J Hematol
, vol.86
, pp. 668-676
-
-
Scott, L.M.1
-
37
-
-
0030718597
-
High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice
-
Villeval J.L., Cohen-Solal K., Tulliez M., et al. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood 1997, 90:4369-4383.
-
(1997)
Blood
, vol.90
, pp. 4369-4383
-
-
Villeval, J.L.1
Cohen-Solal, K.2
Tulliez, M.3
-
38
-
-
0028843848
-
Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice
-
Yan X.Q., Lacey D., Fletcher F., et al. Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 1995, 86:4025-4033.
-
(1995)
Blood
, vol.86
, pp. 4025-4033
-
-
Yan, X.Q.1
Lacey, D.2
Fletcher, F.3
-
39
-
-
0029956149
-
A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation
-
Yan X.Q., Lacey D., Hill D., et al. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood 1996, 88:402-409.
-
(1996)
Blood
, vol.88
, pp. 402-409
-
-
Yan, X.Q.1
Lacey, D.2
Hill, D.3
-
40
-
-
6844250789
-
The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats
-
Yanagida M., Ide Y., Imai A., et al. The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats. Br J Haematol 1997, 99:739-745.
-
(1997)
Br J Haematol
, vol.99
, pp. 739-745
-
-
Yanagida, M.1
Ide, Y.2
Imai, A.3
-
41
-
-
79953890796
-
Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms
-
Pietra D., Brisci A., Rumi E., et al. Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms. Haematologica 2011, 96:607-611.
-
(2011)
Haematologica
, vol.96
, pp. 607-611
-
-
Pietra, D.1
Brisci, A.2
Rumi, E.3
-
42
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y., Lee B.H., Mercher T., et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 2006, 3:e270.
-
(2006)
PLoS Med
, vol.3
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
-
43
-
-
33344455687
-
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor
-
Staerk J., Lacout C., Sato T., et al. An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. Blood 2006, 107:1864-1871.
-
(2006)
Blood
, vol.107
, pp. 1864-1871
-
-
Staerk, J.1
Lacout, C.2
Sato, T.3
-
44
-
-
66449120900
-
Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity
-
Marty C., Chaligne R., Lacout C., et al. Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity. J Biol Chem 2009, 284:11781-11791.
-
(2009)
J Biol Chem
, vol.284
, pp. 11781-11791
-
-
Marty, C.1
Chaligne, R.2
Lacout, C.3
-
45
-
-
47249092413
-
MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort
-
Beer P.A., Campbell P.J., Scott L.M., et al. MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort. Blood 2008, 112:141-149.
-
(2008)
Blood
, vol.112
, pp. 141-149
-
-
Beer, P.A.1
Campbell, P.J.2
Scott, L.M.3
-
46
-
-
77949810252
-
Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis
-
Boyd E.M., Bench A.J., Goday-Fernandez A., et al. Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis. Br J Haematol 2010, 149:250-257.
-
(2010)
Br J Haematol
, vol.149
, pp. 250-257
-
-
Boyd, E.M.1
Bench, A.J.2
Goday-Fernandez, A.3
-
47
-
-
49449094277
-
New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition
-
Chaligne R., Tonetti C., Besancenot R., et al. New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition. Leukemia 2008, 22:1557-1566.
-
(2008)
Leukemia
, vol.22
, pp. 1557-1566
-
-
Chaligne, R.1
Tonetti, C.2
Besancenot, R.3
-
48
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients
-
Pardanani A.D., Levine R.L., Lasho T., et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006, 108:3472-3476.
-
(2006)
Blood
, vol.108
, pp. 3472-3476
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.3
-
49
-
-
4544277651
-
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
-
Tong W., Lodish H.F. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med 2004, 200:569-580.
-
(2004)
J Exp Med
, vol.200
, pp. 569-580
-
-
Tong, W.1
Lodish, H.F.2
-
50
-
-
20444426803
-
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
-
Tong W., Zhang J., Lodish H.F. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 2005, 105:4604-4612.
-
(2005)
Blood
, vol.105
, pp. 4604-4612
-
-
Tong, W.1
Zhang, J.2
Lodish, H.F.3
-
51
-
-
0037124306
-
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
-
Velazquez L., Cheng A.M., Fleming H.E., et al. Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med 2002, 195:1599-1611.
-
(2002)
J Exp Med
, vol.195
, pp. 1599-1611
-
-
Velazquez, L.1
Cheng, A.M.2
Fleming, H.E.3
-
52
-
-
48749084130
-
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
-
Bersenev A., Wu C., Balcerek J., et al. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J Clin Invest 2008, 118:2832-2844.
-
(2008)
J Clin Invest
, vol.118
, pp. 2832-2844
-
-
Bersenev, A.1
Wu, C.2
Balcerek, J.3
-
53
-
-
36148995898
-
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
-
Gery S., Gueller S., Chumakova K., et al. Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders. Blood 2007, 110:3360-3364.
-
(2007)
Blood
, vol.110
, pp. 3360-3364
-
-
Gery, S.1
Gueller, S.2
Chumakova, K.3
-
54
-
-
78650279826
-
Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms
-
Baran-Marszak F., Magdoud H., Desterke C., et al. Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms. Blood 2010, 116:5961-5971.
-
(2010)
Blood
, vol.116
, pp. 5961-5971
-
-
Baran-Marszak, F.1
Magdoud, H.2
Desterke, C.3
-
55
-
-
67149083222
-
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
-
Gery S., Cao Q., Gueller S., et al. Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F. J Leukoc Biol 2009, 85:957-965.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 957-965
-
-
Gery, S.1
Cao, Q.2
Gueller, S.3
-
56
-
-
77953485892
-
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
-
Oh S.T., Simonds E.F., Jones C., et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood 2010, 116:988-992.
-
(2010)
Blood
, vol.116
, pp. 988-992
-
-
Oh, S.T.1
Simonds, E.F.2
Jones, C.3
-
57
-
-
77956670899
-
LNK mutations in JAK2 mutation-negative erythrocytosis
-
Lasho T.L., Pardanani A., Tefferi A. LNK mutations in JAK2 mutation-negative erythrocytosis. N Engl J Med 2010, 363:1189-1190.
-
(2010)
N Engl J Med
, vol.363
, pp. 1189-1190
-
-
Lasho, T.L.1
Pardanani, A.2
Tefferi, A.3
-
58
-
-
77958021645
-
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
-
Pardanani A., Lasho T., Finke C., et al. LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia 2010, 24:1713-1718.
-
(2010)
Leukemia
, vol.24
, pp. 1713-1718
-
-
Pardanani, A.1
Lasho, T.2
Finke, C.3
-
59
-
-
84860412097
-
Possible new LNK mutations in myeloproliferative neoplasms
-
Ha J.S., Jeon D.S. Possible new LNK mutations in myeloproliferative neoplasms. Am J Hematol 2011, 86:866-868.
-
(2011)
Am J Hematol
, vol.86
, pp. 866-868
-
-
Ha, J.S.1
Jeon, D.S.2
-
60
-
-
80053969987
-
LNK can also be mutated outside PH and SH2 domains in myeloproliferative neoplasms with and without V617FJAK2 mutation
-
Hurtado C., Erquiaga I., Aranaz P., et al. LNK can also be mutated outside PH and SH2 domains in myeloproliferative neoplasms with and without V617FJAK2 mutation. Leuk Res 2011, 35:1537-1539.
-
(2011)
Leuk Res
, vol.35
, pp. 1537-1539
-
-
Hurtado, C.1
Erquiaga, I.2
Aranaz, P.3
-
61
-
-
79958126723
-
Clonal hierarchy and allelic mutation segregation in a myelofibrosis patient with two distinct LNK mutations
-
Lasho T.L., Tefferi A., Finke C., et al. Clonal hierarchy and allelic mutation segregation in a myelofibrosis patient with two distinct LNK mutations. Leukemia 2011, 25:1056-1058.
-
(2011)
Leukemia
, vol.25
, pp. 1056-1058
-
-
Lasho, T.L.1
Tefferi, A.2
Finke, C.3
-
62
-
-
77953193307
-
Lnk constrains myeloproliferative diseases in mice
-
Bersenev A., Wu C., Balcerek J., et al. Lnk constrains myeloproliferative diseases in mice. J Clin Invest 2010, 120:2058-2069.
-
(2010)
J Clin Invest
, vol.120
, pp. 2058-2069
-
-
Bersenev, A.1
Wu, C.2
Balcerek, J.3
-
63
-
-
0037148516
-
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
-
Takaki S., Morita H., Tezuka Y., et al. Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J Exp Med 2002, 195:151-160.
-
(2002)
J Exp Med
, vol.195
, pp. 151-160
-
-
Takaki, S.1
Morita, H.2
Tezuka, Y.3
-
64
-
-
77953768742
-
Cbl and human myeloid neoplasms: the Cbl oncogene comes of age
-
Kales S.C., Ryan P.E., Nau M.M., et al. Cbl and human myeloid neoplasms: the Cbl oncogene comes of age. Cancer Res 2010, 70:4789-4794.
-
(2010)
Cancer Res
, vol.70
, pp. 4789-4794
-
-
Kales, S.C.1
Ryan, P.E.2
Nau, M.M.3
-
65
-
-
0033536637
-
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
-
Joazeiro C.A., Wing S.S., Huang H., et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 1999, 286:309-312.
-
(1999)
Science
, vol.286
, pp. 309-312
-
-
Joazeiro, C.A.1
Wing, S.S.2
Huang, H.3
-
66
-
-
0033392493
-
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
-
Levkowitz G., Waterman H., Ettenberg S.A., et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 1999, 4:1029-1040.
-
(1999)
Mol Cell
, vol.4
, pp. 1029-1040
-
-
Levkowitz, G.1
Waterman, H.2
Ettenberg, S.A.3
-
67
-
-
0033615732
-
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
-
Yokouchi M., Kondo T., Houghton A., et al. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem 1999, 274:31707-31712.
-
(1999)
J Biol Chem
, vol.274
, pp. 31707-31712
-
-
Yokouchi, M.1
Kondo, T.2
Houghton, A.3
-
68
-
-
77949525475
-
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
-
Saur S.J., Sangkhae V., Geddis A.E., et al. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. Blood 2010, 115:1254-1263.
-
(2010)
Blood
, vol.115
, pp. 1254-1263
-
-
Saur, S.J.1
Sangkhae, V.2
Geddis, A.E.3
-
69
-
-
67650401377
-
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
-
Grand F.H., Hidalgo-Curtis C.E., Ernst T., et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood 2009, 113:6182-6192.
-
(2009)
Blood
, vol.113
, pp. 6182-6192
-
-
Grand, F.H.1
Hidalgo-Curtis, C.E.2
Ernst, T.3
-
70
-
-
84864773907
-
CBL mutations in myeloproliferative neoplasms are also found in its proline-rich domain and in patients with the V617FJAK2
-
Aranaz P., Hurtado C., Erquiaga I., et al. CBL mutations in myeloproliferative neoplasms are also found in its proline-rich domain and in patients with the V617FJAK2. Haematologica 2012, 97(8):1234-1241.
-
(2012)
Haematologica
, vol.97
, Issue.8
, pp. 1234-1241
-
-
Aranaz, P.1
Hurtado, C.2
Erquiaga, I.3
-
71
-
-
49249132865
-
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins
-
Dimitriou I.D., Clemenza L., Scotter A.J., et al. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol Rev 2008, 224:265-283.
-
(2008)
Immunol Rev
, vol.224
, pp. 265-283
-
-
Dimitriou, I.D.1
Clemenza, L.2
Scotter, A.J.3
-
72
-
-
70350455110
-
A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses
-
Suessmuth Y., Elliott J., Percy M.J., et al. A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses. Br J Haematol 2009, 147:450-458.
-
(2009)
Br J Haematol
, vol.147
, pp. 450-458
-
-
Suessmuth, Y.1
Elliott, J.2
Percy, M.J.3
-
73
-
-
33847223121
-
Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
-
Jost E., do O.N., Dahl E., et al. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. Leukemia 2007, 21:505-510.
-
(2007)
Leukemia
, vol.21
, pp. 505-510
-
-
Jost, E.1
do, O.N.2
Dahl, E.3
-
74
-
-
50549085051
-
Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases
-
Teofili L., Martini M., Cenci T., et al. Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases. Int J Cancer 2008, 123:1586-1592.
-
(2008)
Int J Cancer
, vol.123
, pp. 1586-1592
-
-
Teofili, L.1
Martini, M.2
Cenci, T.3
-
75
-
-
42249115029
-
Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders
-
Capello D., Deambrogi C., Rossi D., et al. Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders. Br J Haematol 2008, 141:504-511.
-
(2008)
Br J Haematol
, vol.141
, pp. 504-511
-
-
Capello, D.1
Deambrogi, C.2
Rossi, D.3
-
76
-
-
67349263024
-
SOCS3 inhibits TPO-stimulated, but not spontaneous, megakaryocytic growth in primary myelofibrosis
-
Chaligne R., Tonetti C., Besancenot R., et al. SOCS3 inhibits TPO-stimulated, but not spontaneous, megakaryocytic growth in primary myelofibrosis. Leukemia 2009, 23:1186-1190.
-
(2009)
Leukemia
, vol.23
, pp. 1186-1190
-
-
Chaligne, R.1
Tonetti, C.2
Besancenot, R.3
-
77
-
-
66349113501
-
SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases
-
Elliott J., Suessmuth Y., Scott L.M., et al. SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases. Haematologica 2009, 94:576-580.
-
(2009)
Haematologica
, vol.94
, pp. 576-580
-
-
Elliott, J.1
Suessmuth, Y.2
Scott, L.M.3
-
78
-
-
34249728880
-
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
-
Hookham M.B., Elliott J., Suessmuth Y., et al. The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood 2007, 109:4924-4929.
-
(2007)
Blood
, vol.109
, pp. 4924-4929
-
-
Hookham, M.B.1
Elliott, J.2
Suessmuth, Y.3
-
79
-
-
69449087032
-
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling
-
Haan S., Wuller S., Kaczor J., et al. SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling. Oncogene 2009, 28:3069-3080.
-
(2009)
Oncogene
, vol.28
, pp. 3069-3080
-
-
Haan, S.1
Wuller, S.2
Kaczor, J.3
-
80
-
-
79953247371
-
Differential biological activity of disease-associated JAK2 mutants
-
Zou H., Yan D., Mohi G. Differential biological activity of disease-associated JAK2 mutants. FEBS Lett 2011, 585:1007-1013.
-
(2011)
FEBS Lett
, vol.585
, pp. 1007-1013
-
-
Zou, H.1
Yan, D.2
Mohi, G.3
-
81
-
-
33845798378
-
Characterization of murine JAK2V617F-positive myeloproliferative disease
-
Bumm T.G., Elsea C., Corbin A.S., et al. Characterization of murine JAK2V617F-positive myeloproliferative disease. Cancer Res 2006, 66:11156-11165.
-
(2006)
Cancer Res
, vol.66
, pp. 11156-11165
-
-
Bumm, T.G.1
Elsea, C.2
Corbin, A.S.3
-
82
-
-
33745721197
-
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
-
Lacout C., Pisani D.F., Tulliez M., et al. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 2006, 108:1652-1660.
-
(2006)
Blood
, vol.108
, pp. 1652-1660
-
-
Lacout, C.1
Pisani, D.F.2
Tulliez, M.3
-
83
-
-
33744490974
-
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
-
Wernig G., Mercher T., Okabe R., et al. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 2006, 107:4274-4281.
-
(2006)
Blood
, vol.107
, pp. 4274-4281
-
-
Wernig, G.1
Mercher, T.2
Okabe, R.3
-
84
-
-
34447642422
-
Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F
-
Zaleskas V.M., Krause D.S., Lazarides K., et al. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS One 2006, 1:e18.
-
(2006)
PLoS One
, vol.1
-
-
Zaleskas, V.M.1
Krause, D.S.2
Lazarides, K.3
-
85
-
-
77951031498
-
Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis
-
Koppikar P., Abdel-Wahab O., Hedvat C., et al. Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood 2010, 115:2919-2927.
-
(2010)
Blood
, vol.115
, pp. 2919-2927
-
-
Koppikar, P.1
Abdel-Wahab, O.2
Hedvat, C.3
-
86
-
-
77951759127
-
Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease
-
Akada H., Yan D., Zou H., et al. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood 2010, 115:3589-3597.
-
(2010)
Blood
, vol.115
, pp. 3589-3597
-
-
Akada, H.1
Yan, D.2
Zou, H.3
-
87
-
-
77956578342
-
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
-
Li J., Spensberger D., Ahn J.S., et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood 2010, 116:1528-1538.
-
(2010)
Blood
, vol.116
, pp. 1528-1538
-
-
Li, J.1
Spensberger, D.2
Ahn, J.S.3
-
88
-
-
77956280929
-
Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice
-
Marty C., Lacout C., Martin A., et al. Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice. Blood 2010, 116:783-787.
-
(2010)
Blood
, vol.116
, pp. 783-787
-
-
Marty, C.1
Lacout, C.2
Martin, A.3
-
89
-
-
77953274727
-
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
-
Mullally A., Lane S.W., Ball B., et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 2010, 17:584-596.
-
(2010)
Cancer Cell
, vol.17
, pp. 584-596
-
-
Mullally, A.1
Lane, S.W.2
Ball, B.3
-
90
-
-
79956096380
-
Mouse models of myeloproliferative neoplasms: JAK of all grades
-
Li J., Kent D.G., Chen E., et al. Mouse models of myeloproliferative neoplasms: JAK of all grades. Dis Model Mech 2011, 4:311-317.
-
(2011)
Dis Model Mech
, vol.4
, pp. 311-317
-
-
Li, J.1
Kent, D.G.2
Chen, E.3
-
91
-
-
84859826304
-
Critical requirement for Stat5 in a mouse model of polycythemia vera
-
Yan D., Hutchison R.E., Mohi G. Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood 2012, 119(15):3539-3549.
-
(2012)
Blood
, vol.119
, Issue.15
, pp. 3539-3549
-
-
Yan, D.1
Hutchison, R.E.2
Mohi, G.3
-
92
-
-
84859865097
-
Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and Jak2V617F in mice
-
Walz C., Ahmed W., Lazarides K., et al. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and Jak2V617F in mice. Blood 2012, 119(15):3550-3560.
-
(2012)
Blood
, vol.119
, Issue.15
, pp. 3550-3560
-
-
Walz, C.1
Ahmed, W.2
Lazarides, K.3
-
93
-
-
79953109597
-
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
-
Nelson E.A., Walker S.R., Weisberg E., et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood 2011, 117:3421-3429.
-
(2011)
Blood
, vol.117
, pp. 3421-3429
-
-
Nelson, E.A.1
Walker, S.R.2
Weisberg, E.3
-
94
-
-
84859822414
-
Advancing the STATus of MPN pathogenesis
-
Shah N.P., Shannon K. Advancing the STATus of MPN pathogenesis. Blood 2012, 119:3374-3376.
-
(2012)
Blood
, vol.119
, pp. 3374-3376
-
-
Shah, N.P.1
Shannon, K.2
-
95
-
-
33750077275
-
Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia
-
Mesa R.A., Tefferi A., Lasho T.S., et al. Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia. Leukemia 2006, 20:1800-1808.
-
(2006)
Leukemia
, vol.20
, pp. 1800-1808
-
-
Mesa, R.A.1
Tefferi, A.2
Lasho, T.S.3
-
96
-
-
35448929374
-
JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling
-
Schwemmers S., Will B., Waller C.F., et al. JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling. Exp Hematol 2007, 35:1695-1703.
-
(2007)
Exp Hematol
, vol.35
, pp. 1695-1703
-
-
Schwemmers, S.1
Will, B.2
Waller, C.F.3
-
97
-
-
34347385613
-
Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation
-
Teofili L., Martini M., Cenci T., et al. Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. Blood 2007, 110:354-359.
-
(2007)
Blood
, vol.110
, pp. 354-359
-
-
Teofili, L.1
Martini, M.2
Cenci, T.3
-
98
-
-
70350446987
-
Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms
-
Grimwade L.F., Happerfield L., Tristram C., et al. Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms. Br J Haematol 2009, 147:495-506.
-
(2009)
Br J Haematol
, vol.147
, pp. 495-506
-
-
Grimwade, L.F.1
Happerfield, L.2
Tristram, C.3
-
99
-
-
80051651725
-
Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms
-
Anand S., Stedham F., Gudgin E., et al. Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms. Blood 2011, 118:1610-1621.
-
(2011)
Blood
, vol.118
, pp. 1610-1621
-
-
Anand, S.1
Stedham, F.2
Gudgin, E.3
-
100
-
-
78249256979
-
Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling
-
Chen E., Beer P.A., Godfrey A.L., et al. Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling. Cancer Cell 2010, 18:524-535.
-
(2010)
Cancer Cell
, vol.18
, pp. 524-535
-
-
Chen, E.1
Beer, P.A.2
Godfrey, A.L.3
-
101
-
-
33748308794
-
JAK signaling globally counteracts heterochromatic gene silencing
-
Shi S., Calhoun H.C., Xia F., et al. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet 2006, 38:1071-1076.
-
(2006)
Nat Genet
, vol.38
, pp. 1071-1076
-
-
Shi, S.1
Calhoun, H.C.2
Xia, F.3
-
102
-
-
70349975711
-
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
-
Dawson M.A., Bannister A.J., Gottgens B., et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 2009, 461:819-822.
-
(2009)
Nature
, vol.461
, pp. 819-822
-
-
Dawson, M.A.1
Bannister, A.J.2
Gottgens, B.3
-
103
-
-
34547751335
-
HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation
-
Panteleeva I., Boutillier S., See V., et al. HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J 2007, 26:3616-3628.
-
(2007)
EMBO J
, vol.26
, pp. 3616-3628
-
-
Panteleeva, I.1
Boutillier, S.2
See, V.3
-
104
-
-
79751486147
-
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation
-
Liu F., Zhao X., Perna F., et al. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell 2011, 19:283-294.
-
(2011)
Cancer Cell
, vol.19
, pp. 283-294
-
-
Liu, F.1
Zhao, X.2
Perna, F.3
-
105
-
-
62049086288
-
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
-
Zhao Q., Rank G., Tan Y.T., et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol 2009, 16:304-311.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 304-311
-
-
Zhao, Q.1
Rank, G.2
Tan, Y.T.3
-
106
-
-
30844443469
-
Pathogenesis of myelofibrosis with myeloid metaplasia
-
Tefferi A. Pathogenesis of myelofibrosis with myeloid metaplasia. J Clin Oncol 2005, 23:8520-8530.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8520-8530
-
-
Tefferi, A.1
-
107
-
-
83455201579
-
TNFalpha facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms
-
Fleischman A.G., Aichberger K.J., Luty S.B., et al. TNFalpha facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood 2011, 118:6392-6398.
-
(2011)
Blood
, vol.118
, pp. 6392-6398
-
-
Fleischman, A.G.1
Aichberger, K.J.2
Luty, S.B.3
-
108
-
-
84856515296
-
Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms
-
Hoermann G., Cerny-Reiterer S., Herrmann H., et al. Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms. FASEB J 2012, 26:894-906.
-
(2012)
FASEB J
, vol.26
, pp. 894-906
-
-
Hoermann, G.1
Cerny-Reiterer, S.2
Herrmann, H.3
-
109
-
-
79957923046
-
Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor
-
Manshouri T., Estrov Z., Quintas-Cardama A., et al. Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res 2011, 71:3831-3840.
-
(2011)
Cancer Res
, vol.71
, pp. 3831-3840
-
-
Manshouri, T.1
Estrov, Z.2
Quintas-Cardama, A.3
|