-
1
-
-
33845436745
-
The myeloproliferative disorders
-
Campbell PJ, Green AR. The myeloproliferative disorders. N Engl J Med. 2008;355(23):2452-2466.
-
(2008)
N Engl. J. Med.
, vol.355
, Issue.23
, pp. 2452-2466
-
-
Campbell, P.J.1
Green, A.R.2
-
2
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter JE, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061.
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, J.E.1
Scott, L.M.2
Campbell, P.J.3
-
3
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
DOI 10.1038/nature03546
-
James C, Ugo V, Le Couédic J-P, et al. Aunique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148. (Pubitemid 40663494)
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.-P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
4
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
DOI 10.1056/NEJMoa051113
-
Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352(17):1779-1790. (Pubitemid 40570926)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.-S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
5
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397.
-
(2005)
Cancer Cell.
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
6
-
-
20744460045
-
Identification of an acquired JAK2 mutation in polycythemia vera
-
Zhao R, Xing S, Li Z, et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005;280(24):22788-22792.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.24
, pp. 22788-22792
-
-
Zhao, R.1
Xing, S.2
Li, Z.3
-
7
-
-
22544481483
-
Gain of function, loss of control-a molecular basis for chronic myeloproliferative disorders
-
Cazzola M, Skoda RC. Gain of function, loss of control-a molecular basis for chronic myeloproliferative disorders. Haematologica. 2005;90(7):871-874.
-
(2005)
Haematologica
, vol.90
, Issue.7
, pp. 871-874
-
-
Cazzola, M.1
Skoda, R.C.2
-
8
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
-
Pardanani AD, Levine RL, Lasho T, et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood. 2006;108(10):3472-3476.
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3472-3476
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.3
-
9
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7): e270.
-
(2006)
PLoS Med.
, vol.3
, Issue.7
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
-
10
-
-
0035811366
-
Lnk adaptor: Novel negative regulator of B cell lymphopoiesis
-
Rudd EC. Lnk adaptor: novel negative regulator of B cell lymphopoiesis. Science STKE. 2001; PE1.
-
(2001)
Science STKE
-
-
Rudd, E.C.1
-
11
-
-
48749084130
-
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
-
Bersenev A, Wu C, Balcerek J, Tong W. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J Clin Invest. 2008;118(8):2832-2844.
-
(2008)
J. Clin. Invest.
, vol.118
, Issue.8
, pp. 2832-2844
-
-
Bersenev, A.1
Wu, C.2
Balcerek, J.3
Tong, W.4
-
12
-
-
33746591727
-
Cytokines regulate postnatal hematopoietic stem cell expansion: Opposing roles of thrombopoietin and LNK
-
Buza-Vidas N, Antonchuk J, Qian H, et al. Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK. Genes Dev. 2006;20(15):2018-2023.
-
(2006)
Genes Dev.
, vol.20
, Issue.15
, pp. 2018-2023
-
-
Buza-Vidas, N.1
Antonchuk, J.2
Qian, H.3
-
13
-
-
19944400789
-
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
-
Ema H, Sudo K, Seita J, et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Develop Cell. 2005;8(6):907-914.
-
(2005)
Develop Cell.
, vol.8
, Issue.6
, pp. 907-914
-
-
Ema, H.1
Sudo, K.2
Seita, J.3
-
14
-
-
33847772982
-
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
-
Seita J, Ema H, Ooehara J, et al. Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci U S A. 2007;104(7):2349-2354.
-
(2007)
Proc. Natl. Acad. Sci. U S A
, vol.104
, Issue.7
, pp. 2349-2354
-
-
Seita, J.1
Ema, H.2
Ooehara, J.3
-
15
-
-
52449135483
-
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokineand integrin-mediated signals
-
Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S. Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokineand integrin-mediated signals. Exp Hematol. 2008;36(7):897-906.
-
(2008)
Exp. Hematol
, vol.36
, Issue.7
, pp. 897-906
-
-
Takizawa, H.1
Eto, K.2
Yoshikawa, A.3
Nakauchi, H.4
Takatsu, K.5
Takaki, S.6
-
16
-
-
4544277651
-
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
-
Tong W, Lodish FH. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med. 2004;200(5):569-580.
-
(2004)
J. Exp. Med.
, vol.200
, Issue.5
, pp. 569-580
-
-
Tong, W.1
Lodish, F.H.2
-
17
-
-
20444426803
-
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
-
Tong W, Lodish FH. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood. 2005;105(12):4604-4612.
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4604-4612
-
-
Tong, W.1
Lodish, F.H.2
-
18
-
-
36148995898
-
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
-
Gery S, Gueller S, Chumakova K, Kawamata N, Liu L, Koeffler HP. Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders. Blood. 2007;110(9):3360-3364.
-
(2007)
Blood
, vol.110
, Issue.9
, pp. 3360-3364
-
-
Gery, S.1
Gueller, S.2
Chumakova, K.3
Kawamata, N.4
Liu, L.5
Koeffler, H.P.6
-
19
-
-
67149083222
-
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
-
Gery S, Qi C, Gueller S, Hongtao X, Tefferi A, Koeffler HP. Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F. J Leuk Biol. 2009;85(6):957-965.
-
(2009)
J. Leuk Biol.
, vol.85
, Issue.6
, pp. 957-965
-
-
Gery, S.1
Qi, C.2
Gueller, S.3
Hongtao, X.4
Tefferi, A.5
Koeffler, H.P.6
-
20
-
-
0037148516
-
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
-
Takaki S, MoritaH, Tezuka Y, Takatsu K. Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J Exp Med. 2002;195(2):151-160.
-
(2002)
J. Exp. Med.
, vol.195
, Issue.2
, pp. 151-160
-
-
Takaki, S.1
MoritaH2
Tezuka, Y.3
Takatsu, K.4
-
21
-
-
0037124306
-
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
-
Velazquez L, Cheng MA, Fleming EH, et al. Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med. 2002;195(12):1599-1611.
-
(2002)
J. Exp. Med.
, vol.195
, Issue.12
, pp. 1599-1611
-
-
Velazquez, L.1
Cheng, M.A.2
Fleming, E.H.3
-
22
-
-
33746059048
-
High molecular response rate of polycythemia vera patients treated with pegylated interferon α-2a
-
Kiladjian JJ, Cassinat B, Turlure P, et al. High molecular response rate of polycythemia vera patients treated with pegylated interferon α-2a. Blood. 2006;108(6):2037-2040.
-
(2006)
Blood
, vol.108
, Issue.6
, pp. 2037-2040
-
-
Kiladjian, J.J.1
Cassinat, B.2
Turlure, P.3
-
23
-
-
36348999273
-
Evidence for MPLW515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
-
Chaligne R, James C, Tonetti C, et al. Evidence for MPLW515L/K mutations in hematopoietic stem cells in primitive myelofibrosis. Blood. 2007;110(10):3735-3743.
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3735-3743
-
-
Chaligne, R.1
James, C.2
Tonetti, C.3
-
24
-
-
58149147644
-
Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells
-
Simon C, Dondi E, Chaix A, et al. Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood. 2008;112(10):4039-4047.
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 4039-4047
-
-
Simon, C.1
Dondi, E.2
Chaix, A.3
-
25
-
-
77953485892
-
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
-
Oh ST, Simonds EF, Jones C, et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010;116(6):988-992.
-
(2010)
Blood
, vol.116
, Issue.6
, pp. 988-992
-
-
Oh, S.T.1
Simonds, E.F.2
Jones, C.3
-
26
-
-
0036179224
-
Elevation of serum thrombopoietin precedes thrombocytosis in acute infections
-
Ishiguro A, Suzuki Y, Mito M, et al. Elevation of serum thrombopoietin precedes thrombocytosis in acute infections. Br J Haematol. 2002;116(3):612-618.
-
(2002)
Br. J. Haematol
, vol.116
, Issue.3
, pp. 612-618
-
-
Ishiguro, A.1
Suzuki, Y.2
Mito, M.3
-
27
-
-
31044439372
-
The molecular mechanisms that control thrombopoiesis
-
Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest. 2005;115(12):3339-3347.
-
(2005)
J. Clin. Invest.
, vol.115
, Issue.12
, pp. 3339-3347
-
-
Kaushansky, K.1
-
28
-
-
33747748126
-
Binding of SH2-B family members within a potential regulatory region maintains JAK2 in an active state
-
Kurzer JH, Saharinen P, Silvennoinen O, Carter-Su C. Binding of SH2-B family members within a potential regulatory region maintains JAK2 in an active state. Mol Cell Biol. 2006;26(17):6381-6394.
-
(2006)
Mol. Cell. Biol.
, vol.26
, Issue.17
, pp. 6381-6394
-
-
Kurzer, J.H.1
Saharinen, P.2
Silvennoinen, O.3
Carter-Su, C.4
-
29
-
-
33845663497
-
SH2B1 (SH2-B) and JAK2: A multifunctional adaptor protein and kinase made for each other
-
Maures TJ, Kurzer JH, Carter-Su C. SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other. Trends Endocrinol Metab. 2006;18(1):38-45.
-
(2006)
Trends Endocrinol Metab.
, vol.18
, Issue.1
, pp. 38-45
-
-
Maures, T.J.1
Kurzer, J.H.2
Carter-Su, C.3
-
30
-
-
64249098439
-
Expression of the adaptor protein Lnk in leukemia cells
-
Gery S, Gueller S, Nowak V, Sohn J, Hofman WK, Koeffler HP. Expression of the adaptor protein Lnk in leukemia cells. Exp Hematol. 2009;37(5):585-592.
-
(2009)
Exp. Hematol
, vol.37
, Issue.5
, pp. 585-592
-
-
Gery, S.1
Gueller, S.2
Nowak, V.3
Sohn, J.4
Hofman, W.K.5
Koeffler, H.P.6
-
31
-
-
50949108208
-
Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells
-
Kent DG, Dykstra BJ, Cheyne J, Ma E, Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood. 2008;112(3):560-567.
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 560-567
-
-
Kent, D.G.1
Dykstra, B.J.2
Cheyne, J.3
Ma, E.4
Eaves, C.J.5
-
33
-
-
57949086449
-
SOCS2: Inhibitor of JAK2V617F-mediated signal transduction
-
Quentmeier H, Geffers R, Jost E, et al. SOCS2: inhibitor of JAK2V617F-mediated signal transduction. Leukemia. 2008;22(12):2169-2175.
-
(2008)
Leukemia
, vol.22
, Issue.12
, pp. 2169-2175
-
-
Quentmeier, H.1
Geffers, R.2
Jost, E.3
-
34
-
-
34249728880
-
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
-
Hookham MB, Elliott J, Suessmuth Y, et al. The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood. 2007;109(11):4924-4929.
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4924-4929
-
-
Hookham, M.B.1
Elliott, J.2
Suessmuth, Y.3
-
35
-
-
0034004130
-
Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-Bbeta
-
Rui L, Gunter DR, Herrington J, Carter-Su C. Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-Bbeta. Mol Cell Biol. 2000;20(9):3168-3177.
-
(2000)
Mol. Cell. Biol.
, vol.20
, Issue.9
, pp. 3168-3177
-
-
Rui, L.1
Gunter, D.R.2
Herrington, J.3
Carter-Su, C.4
-
36
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F, DuPont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
-
(2009)
N Engl. J. Med.
, vol.360
, Issue.22
, pp. 2289-2301
-
-
Delhommeau, F.1
DuPont, S.2
Valle, V.D.3
-
37
-
-
33846007215
-
Evidence that the JAK2 G1849T (V617) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis
-
Delhommeau F, DuPont S, Tonetti C, et al. Evidence that the JAK2 G1849T (V617) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis. Blood. 2007;109(1):71-77.
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 71-77
-
-
Delhommeau, F.1
DuPont, S.2
Tonetti, C.3
-
38
-
-
77953193307
-
Lnk constrains myeloproliferative diseases in mice
-
Bersenev A, Wu C, Balcerek J, et al. Lnk constrains myeloproliferative diseases in mice. J Clin Invest. 2010;120(6):2058-22069.
-
(2010)
J. Clin. Invest.
, vol.120
, Issue.6
, pp. 2058-22069
-
-
Bersenev, A.1
Wu, C.2
Balcerek, J.3
|