PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Nature Structural and Molecular Biology

Volumn 16, Issue 3, 2009, Pages 304-311

  Zhao, Quan ^a,b   Rank, Gerhard ^a   Tan, Yuen T ^a   Li, Haitao ^c   Moritz, Robert L ^d   Simpson, Richard J ^d   Cerruti, Loretta ^a   Curtis, David J ^a   Patel, Dinshaw J ^c   Allis, C David ^e   Cunningham, John M ^f   Jane, Stephen M ^a,g  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b NANJING UNIVERSITY   (China)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e ROCKEFELLER UNIVERSITY   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BETA GLOBIN; DNA METHYLTRANSFERASE 3A; HISTONE H4; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BONE MARROW; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; ERYTHROID PRECURSOR CELL; GENE ACTIVATION; GENE LOCUS; GENE SILENCING; GENE TARGETING; GLOBIN GENE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF;

ARGININE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ERYTHROID PRECURSOR CELLS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HISTONES; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN METHYLTRANSFERASES;

MAMMALIA;

EID: 62049086288     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1568     Document Type: Article

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