메뉴 건너뛰기




Volumn 119, Issue 15, 2012, Pages 3539-3549

Critical requirement for Stat5 in a mouse model of polycythemia vera

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN; JANUS KINASE 2; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 84859826304     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-03-345215     Document Type: Article
Times cited : (104)

References (45)
  • 6
    • 77951759127 scopus 로고    scopus 로고
    • Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease
    • Akada H, Yan D, Zou H, Fiering S, Hutchison RE, Mohi MG. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010;115(17):3589-3597.
    • (2010) Blood , vol.115 , Issue.17 , pp. 3589-3597
    • Akada, H.1    Yan, D.2    Zou, H.3    Fiering, S.4    Hutchison, R.E.5    Mohi, M.G.6
  • 7
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • DOI 10.1182/blood-2005-12-4824
    • Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006;107(11):4274-4281. (Pubitemid 43801351)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3    Levine, R.L.4    Lee, B.H.5    Gilliland, D.G.6
  • 8
    • 33745721197 scopus 로고    scopus 로고
    • V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • DOI 10.1182/blood-2006-02-002030
    • Lacout C, Pisani DF, Tulliez M, Gachelin FM, Vainchenker W, Villeval JL. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood. 2006;108(5):1652-1660. (Pubitemid 44316134)
    • (2006) Blood , vol.108 , Issue.5 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3    Gachelin, F.M.4    Vainchenker, W.5    Villeval, J.-L.6
  • 10
    • 34447642422 scopus 로고    scopus 로고
    • Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F
    • Zaleskas VM, Krause DS, Lazarides K, et al. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS One. 2006;1: e18.
    • (2006) PLoS One , vol.1
    • Zaleskas, V.M.1    Krause, D.S.2    Lazarides, K.3
  • 11
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
    • Tiedt R, Hao-Shen H, Sobas MA, et al. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood. 2008;111(8):3931-3940.
    • (2008) Blood , vol.111 , Issue.8 , pp. 3931-3940
    • Tiedt, R.1    Hao-Shen, H.2    Sobas, M.A.3
  • 12
    • 38349035684 scopus 로고    scopus 로고
    • Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    • Shide K, Shimoda HK, Kumano T, et al. Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia. 2008;22(1): 87-95.
    • (2008) Leukemia , vol.22 , Issue.1 , pp. 87-95
    • Shide, K.1    Shimoda, H.K.2    Kumano, T.3
  • 13
    • 46749137278 scopus 로고    scopus 로고
    • Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice
    • Xing S, Wanting TH, Zhao W, et al. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008;111(10):5109-5117.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5109-5117
    • Xing, S.1    Wanting, T.H.2    Zhao, W.3
  • 14
    • 77956280929 scopus 로고    scopus 로고
    • Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knockin mice
    • Marty C, Lacout C, Martin A, et al. Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knockin mice. Blood. 2010; 116(5):783-787.
    • (2010) Blood , vol.116 , Issue.5 , pp. 783-787
    • Marty, C.1    Lacout, C.2    Martin, A.3
  • 15
    • 77953274727 scopus 로고    scopus 로고
    • Physiologic Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    • Mullally A, Lane SW, Ball B, et al. Physiologic Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 2010;17(6):584-596.
    • (2010) Cancer Cell , vol.17 , Issue.6 , pp. 584-596
    • Mullally, A.1    Lane, S.W.2    Ball, B.3
  • 16
    • 77956578342 scopus 로고    scopus 로고
    • JAK2 V617F impairs hematopoietic stem cell function in a conditional knockin mouse model of JAK2 V617Fpositive essential thrombocythemia
    • Li J, Spensberger D, Ahn JS, et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knockin mouse model of JAK2 V617Fpositive essential thrombocythemia. Blood. 2010; 116(9):1528-1538.
    • (2010) Blood , vol.116 , Issue.9 , pp. 1528-1538
    • Li, J.1    Spensberger, D.2    Ahn, J.S.3
  • 17
    • 77949535491 scopus 로고    scopus 로고
    • Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis
    • Santos FP, Kantarjian HM, Jain N, et al. Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis. Blood. 2010;115(6):1131-1136.
    • (2010) Blood , vol.115 , Issue.6 , pp. 1131-1136
    • Santos, F.P.1    Kantarjian, H.M.2    Jain, N.3
  • 18
    • 79952333359 scopus 로고    scopus 로고
    • Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis
    • Pardanani A, Gotlib JR, Jamieson C, et al. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol. 2011;29(7): 789-796.
    • (2011) J Clin Oncol , vol.29 , Issue.7 , pp. 789-796
    • Pardanani, A.1    Gotlib, J.R.2    Jamieson, C.3
  • 19
    • 77949331464 scopus 로고    scopus 로고
    • STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant
    • Funakoshi-Tago M, Tago K, Abe M, Sonoda Y, Kasahara T. STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant. J Biol Chem. 2010;285(8):5296-5307.
    • (2010) J Biol Chem , vol.285 , Issue.8 , pp. 5296-5307
    • Funakoshi-Tago, M.1    Tago, K.2    Abe, M.3    Sonoda, Y.4    Kasahara, T.5
  • 20
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • DOI 10.1128/MCB.24.18.8037-8047.2004
    • Cui Y, Riedlinger G, Miyoshi K, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004;24(18):8037-8047. (Pubitemid 39167454)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5    Deng, C.-X.6    Robinson, G.W.7    Hennighausen, L.8
  • 21
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kühn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269(5229): 1427-1429.
    • (1995) Science , vol.269 , Issue.5229 , pp. 1427-1429
    • Kühn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 24
    • 0016391236 scopus 로고
    • Letter: Bone-marrow responses in polycythemia vera
    • Prchal JF, Axelrad AA. Letter: Bone-marrow responses in polycythemia vera. N Engl J Med. 1974;290(24):1382.
    • (1974) N Engl J Med , vol.290 , Issue.24 , pp. 1382
    • Prchal, J.F.1    Axelrad, A.A.2
  • 25
    • 52649091181 scopus 로고    scopus 로고
    • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    • Zhu BM, McLaughlin SK, Na R, et al. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008;112(5):2071-2080.
    • (2008) Blood , vol.112 , Issue.5 , pp. 2071-2080
    • Zhu, B.M.1    McLaughlin, S.K.2    Na, R.3
  • 26
    • 55249095625 scopus 로고    scopus 로고
    • Myeloproliferative disorders
    • Levine RL, Gilliland DG. Myeloproliferative disorders. Blood. 2008;112(6):2190-2198.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2190-2198
    • Levine, R.L.1    Gilliland, D.G.2
  • 27
    • 58149398623 scopus 로고    scopus 로고
    • Translation of the Philadelphia chromosome into therapy for CML
    • Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood. 2008; 112(13):4808-4817.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4808-4817
    • Druker, B.J.1
  • 28
    • 42249090881 scopus 로고    scopus 로고
    • Targeting ras in myeloid leukemias
    • DOI 10.1158/1078-0432.CCR-07-1005
    • Braun BS, Shannon K. Targeting Ras in myeloid leukemias. Clin Cancer Res. 2008;14(8):2249-2252. (Pubitemid 351551055)
    • (2008) Clinical Cancer Research , vol.14 , Issue.8 , pp. 2249-2252
    • Braun, B.S.1    Shannon, K.2
  • 29
    • 0033519238 scopus 로고    scopus 로고
    • The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
    • DOI 10.1084/jem.189.9.1399
    • Li S, Ilaria RLJr,Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med. 1999;189(9): 1399-1412. (Pubitemid 29227526)
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.9 , pp. 1399-1412
    • Li, S.1    Ilaria Jr., R.L.2    Million, R.P.3    Daley, G.Q.4    Van Etten, R.A.5
  • 33
    • 79953247371 scopus 로고    scopus 로고
    • Differential biologic activity of disease-associated JAK2 mutants
    • Zou H, Yan D, Mohi G. Differential biologic activity of disease-associated JAK2 mutants. FEBS Lett. 2011;585(7):1007-1013.
    • (2011) FEBS Lett , vol.585 , Issue.7 , pp. 1007-1013
    • Zou, H.1    Yan, D.2    Mohi, G.3
  • 34
    • 0032481383 scopus 로고    scopus 로고
    • IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways
    • DOI 10.1093/emboj/17.4.1006
    • O'Farrell AM, Liu Y, Moore KW, Mui AL. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 1998;17(4):1006-1018. (Pubitemid 28077655)
    • (1998) EMBO Journal , vol.17 , Issue.4 , pp. 1006-1018
    • O'Farrell, A.-M.1    Liu, Y.2    Moore, K.W.3    Mui, A.L.-F.4
  • 35
    • 0037130481 scopus 로고    scopus 로고
    • Overexpression of a dominant negative form, of STAT3 selectively impairs hematopoietic stem cell activity
    • DOI 10.1038/sj.onc.1205592
    • Oh IH, Eaves CJ. Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene. 2002; 21(31):4778-4787. (Pubitemid 34879453)
    • (2002) Oncogene , vol.21 , Issue.31 , pp. 4778-4787
    • Oh, I.-H.1    Eaves, C.J.2
  • 36
    • 80052161065 scopus 로고    scopus 로고
    • SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis
    • Zhang L, Friedman AD. SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis. Blood. 2011;118(8):2266-2274.
    • (2011) Blood , vol.118 , Issue.8 , pp. 2266-2274
    • Zhang, L.1    Friedman, A.D.2
  • 37
    • 0037332003 scopus 로고    scopus 로고
    • Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    • de Boer J, Williams A, Skavdis G, et al. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol. 2003; 33(2):314-325.
    • (2003) Eur J Immunol , vol.33 , Issue.2 , pp. 314-325
    • De Boer, J.1    Williams, A.2    Skavdis, G.3
  • 40
    • 0033597715 scopus 로고    scopus 로고
    • Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b/- mice: A direct role for Stat5 in Bcl-X(L) induction
    • Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999; 98(2):181-191.
    • (1999) Cell , vol.98 , Issue.2 , pp. 181-191
    • Socolovsky, M.1    Fallon, A.E.2    Wang, S.3    Brugnara, C.4    Lodish, H.F.5
  • 41
    • 77953667590 scopus 로고    scopus 로고
    • Stat5 is indispensable for the maintenance of bcr/ablpositive leukaemia
    • Hoelbl A, Schuster C, Kovacic B, et al. Stat5 is indispensable for the maintenance of bcr/ablpositive leukaemia. EMBO Mol Med. 2010;2(3): 98-110.
    • (2010) EMBO Mol Med , vol.2 , Issue.3 , pp. 98-110
    • Hoelbl, A.1    Schuster, C.2    Kovacic, B.3
  • 42
    • 66549086623 scopus 로고    scopus 로고
    • Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement
    • Wang Z, Li G, Tse W, Bunting KD. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood. 2009;113(20):4856-4865.
    • (2009) Blood , vol.113 , Issue.20 , pp. 4856-4865
    • Wang, Z.1    Li, G.2    Tse, W.3    Bunting, K.D.4
  • 43
    • 33745057158 scopus 로고    scopus 로고
    • STAT5 signaling is required for the efficient induction and maintenance of CMLin mice
    • DOI 10.1182/blood-2005-10-4110
    • Ye D, Wolff N, Li L, Zhang S, Ilaria RL Jr. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Blood. 2006; 107(12):4917-4925. (Pubitemid 43882645)
    • (2006) Blood , vol.107 , Issue.12 , pp. 4917-4925
    • Ye, D.1    Wolff, N.2    Li, L.3    Zhang, S.4    Ilaria Jr., R.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.