Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 18962-18967

  Lu, Xiaohui ^a   Levine, Ross ^b   Tong, Wei ^a   Wernig, Gerlinde ^b   Pikman, Yana ^b   Zarnegar, Sara ^a   Gilliland, D Gary ^b,c   Lodish, Harvey ^a,d  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NONE   (United States)

Author keywords

Erythropoietin receptor; Myeloproliferative diseases; STAT5 activation

Indexed keywords

CYTOKINE RECEPTOR; ERYTHROPOIETIN RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; GROWTH FACTOR; JANUS KINASE; JANUS KINASE 2; STAT PROTEIN; STAT5 PROTEIN; THROMBOPOIETIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL TRANSFORMATION; CHRONIC MYELOMONOCYTIC LEUKEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LYMPHOID CELL; MOUSE; MYELOFIBROSIS; MYELOID METAPLASIA; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PLEIOTROPY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOMATIC MUTATION; THROMBOCYTHEMIA;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL LINEAGE; CYTOKINES; DIMERIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPRECIPITATION; JANUS KINASE 2; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYELOPROLIFERATIVE DISORDERS; ONCOGENE PROTEINS; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, CYTOKINE; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, THROMBOPOIETIN; RETROVIRIDAE; SIGNAL TRANSDUCTION; TIME FACTORS;

ANIMALIA;

EID: 30044437118     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509714102     Document Type: Article

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