-
1
-
-
33845436745
-
The myeloproliferative disorders
-
DOI 10.1056/NEJMra063728
-
Campbell PJ, Green AR. The myeloproliferative disorders. N Engl J Med. 2006;355(23):2452-2466. (Pubitemid 44903749)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.23
, pp. 2452-2466
-
-
Campbell, P.J.1
Green, A.R.2
-
2
-
-
77956578342
-
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
-
Li J, Spensberger D, Ahn JS, et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. 2010;116(9):1528-1538.
-
(2010)
Blood
, vol.116
, Issue.9
, pp. 1528-1538
-
-
Li, J.1
Spensberger, D.2
Ahn, J.S.3
-
3
-
-
77953274727
-
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
-
Mullally A, Lane SW, Ball B, et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 2010;17(6):584-596.
-
(2010)
Cancer Cell
, vol.17
, Issue.6
, pp. 584-596
-
-
Mullally, A.1
Lane, S.W.2
Ball, B.3
-
4
-
-
30844443469
-
Pathogenesis of myelofibrosis with myeloid metaplasia
-
Tefferi A. Pathogenesis of myelofibrosis with myeloid metaplasia. J Clin Oncol. 2005;23(33):8520-8530.
-
(2005)
J Clin Oncol
, vol.23
, Issue.33
, pp. 8520-8530
-
-
Tefferi, A.1
-
5
-
-
77954680141
-
CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms
-
Tyner JW, Bumm TG, Deininger J, et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood. 2010;115(25):5232-5240.
-
(2010)
Blood
, vol.115
, Issue.25
, pp. 5232-5240
-
-
Tyner, J.W.1
Bumm, T.G.2
Deininger, J.3
-
6
-
-
85047692516
-
Signalling pathways of the TNF superfamily: A double-edged sword
-
DOI 10.1038/nril184
-
Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol. 2003;3(9):745-756. (Pubitemid 41070815)
-
(2003)
Nature Reviews Immunology
, vol.3
, Issue.9
, pp. 745-756
-
-
Aggarwal, B.B.1
-
7
-
-
0035477090
-
Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation
-
DOI 10.1084/jem.194.7.941
-
Bryder D, Ramsfjell V, Dybedal I, et al. Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation. J Exp Med. 2001;194(7):941-952. (Pubitemid 32953263)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.7
, pp. 941-952
-
-
Bryder, D.1
Ramsfjell, V.2
Dybedal, I.3
Theilgaard-Monch, K.4
Hogerkorp, C.-M.5
Adolfsson, J.6
Borge, O.J.7
Jacobsen, S.E.W.8
-
8
-
-
0035885956
-
Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells
-
Dybedal I, Bryder D, Fossum A, Rusten LS, Jacobsen SE. Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells. Blood. 2001;98(6):1782-1791.
-
(2001)
Blood
, vol.98
, Issue.6
, pp. 1782-1791
-
-
Dybedal, I.1
Bryder, D.2
Fossum, A.3
Rusten, L.S.4
Jacobsen, S.E.5
-
9
-
-
6344250548
-
Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells
-
DOI 10.1038/sj.onc.1208024
-
Beyne-Rauzy O, Recher C, Dastugue N, et al. Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells. Oncogene. 2004;23(45):7507-7516. (Pubitemid 39389692)
-
(2004)
Oncogene
, vol.23
, Issue.45
, pp. 7507-7516
-
-
Beyne-Rauzy, O.1
Recher, C.2
Dastugue, N.3
Demur, C.4
Pottier, G.5
Laurent, G.6
Sabatier, L.7
Mansat-De, M.V.8
-
10
-
-
0022572130
-
The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: Synergism of tumor necrosis factor and interferon-gamma
-
Broxmeyer HE, Williams DE, Lu L, et al. The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma. J Immunol. 1986;136(12):4487-4495. (Pubitemid 16090666)
-
(1986)
Journal of Immunology
, vol.136
, Issue.12
, pp. 4487-4495
-
-
Broxmeyer, H.E.1
Williams, D.E.2
Lu, L.3
-
11
-
-
0023141312
-
Effect of recombinant human tumor necrosis factor on the colony growth of human leukemia progenitor cells and normal hematopoietic progenitor cells
-
Murase T, Hotta T, Saito H, Ohno R. Effect of recombinant human tumor necrosis factor on the colony growth of human leukemia progenitor cells and normal hematopoietic progenitor cells. Blood. 1987;69(2):467-472. (Pubitemid 17022015)
-
(1987)
Blood
, vol.69
, Issue.2
, pp. 467-472
-
-
Murase, T.1
Hotta, T.2
Saito, H.3
Ohno, R.4
-
12
-
-
34247127084
-
Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice
-
Sejas DP, Rani R, Qiu Y, et al. Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol. 2007;178(8):5277-5287. (Pubitemid 46595313)
-
(2007)
Journal of Immunology
, vol.178
, Issue.8
, pp. 5277-5287
-
-
Sejas, D.P.1
Rani, R.2
Qiu, Y.3
Zhang, X.4
Fagerlie, S.R.5
Nakano, H.6
Williams, D.A.7
Pang, Q.8
-
13
-
-
36048948219
-
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells
-
DOI 10.1172/JCI31772
-
Li J, Sejas DP, Zhang X, et al. TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells. J Clin Invest. 2007;117(11):3283-3295. (Pubitemid 350096985)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.11
, pp. 3283-3295
-
-
Li, J.1
Sejas, D.P.2
Zhang, X.3
Qiu, Y.4
Nattamai, K.J.5
Rani, R.6
Rathbun, K.R.7
Geiger, H.8
Williams, D.A.9
Bagby, G.C.10
Pang, Q.11
-
14
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
DOI 10.1016/S0140-6736(05)71142-9
-
Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061. (Pubitemid 40386783)
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Avis, T.13
Barthorpe, A.14
Bignell, G.15
Blow, M.16
Brackenbury, L.17
Buck, G.18
Clegg, S.19
Clements, J.20
Cole, J.21
Davies, H.22
Edkins, S.23
Gray, K.24
Gorton, M.25
O'Meara, S.26
Halliday, K.27
Harrison, R.28
Haynes, W.29
Hills, K.30
Hunter, C.31
Jones, D.32
Kosmidou, V.33
Laman, R.34
Lugg, R.35
Parker, A.36
Perry, J.37
Petty, R.38
Small, A.39
Solomon, H.40
Stephens, P.41
Stephens, Y.42
Stevens, C.43
Smith, R.44
Tarpey, P.45
Tofts, C.46
Varian, J.47
West, S.48
Widaa, S.49
Bamford, S.50
Butler, A.51
Dawson, E.52
Dicks, E.53
Edwards, K.54
Forbes, S.55
Greenman, C.56
Hinton, J.57
Menzies, A.58
Raine, K.59
Shepherd, R.60
Teague, J.61
Yates, A.62
Wooster, R.63
Futreal, A.64
Stratton, M.65
Green, A.R.66
more..
-
15
-
-
68749084623
-
CYT387, a selective JAK1/JAK2 inhibitor: In vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients
-
Pardanani A, Lasho T, Smith G, Burns CJ, Fantino E, Tefferi A. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia. 2009;23(8):1441-1445.
-
(2009)
Leukemia
, vol.23
, Issue.8
, pp. 1441-1445
-
-
Pardanani, A.1
Lasho, T.2
Smith, G.3
Burns, C.J.4
Fantino, E.5
Tefferi, A.6
-
16
-
-
34447627350
-
TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
-
DOI 10.1038/sj.leu.2404750, PII 2404750
-
Pardanani A, Hood J, Lasho T, et al. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia. 2007;21(8):1658-1668. (Pubitemid 47086756)
-
(2007)
Leukemia
, vol.21
, Issue.8
, pp. 1658-1668
-
-
Pardanani, A.1
Hood, J.2
Lasho, T.3
Levine, R.L.4
Martin, M.B.5
Noronha, G.6
Finke, C.7
Mak, C.C.8
Mesa, R.9
Zhu, H.10
Soll, R.11
Gilliland, D.G.12
Tefferi, A.13
-
17
-
-
33845798378
-
V617F-positive myeloproliferative disease
-
DOI 10.1158/0008-5472.CAN-06-2210
-
Bumm TG, Elsea C, Corbin AS, et al. Characterization of murine JAK2V617F-positive myeloproliferative disease. Cancer Res. 2006;66(23):11156- 11165. (Pubitemid 46009942)
-
(2006)
Cancer Research
, vol.66
, Issue.23
, pp. 11156-11165
-
-
Bumm, T.G.P.1
Elsea, C.2
Corbin, A.S.3
Loriaux, M.4
Sherbenou, D.5
Wood, L.6
Deininger, J.7
Silver, R.T.8
Druker, B.J.9
Deininger, M.W.N.10
-
18
-
-
0024151602
-
The HL60 cell line: A model system for studying human myeloid cell differentiation
-
Birnie GD. The HL60 cell line: a model system for studying human myeloid cell differentiation. Br J Cancer Suppl. 1988;9:41-45. (Pubitemid 19054738)
-
(1988)
British Journal of Cancer
, vol.58
, Issue.SUPPL. 9
, pp. 41-45
-
-
Birnie, G.D.1
-
19
-
-
0032101030
-
Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice
-
Haneline LS, Broxmeyer HE, Cooper S, et al. Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice. Blood. 1998;91(11): 4092-4098. (Pubitemid 28261970)
-
(1998)
Blood
, vol.91
, Issue.11
, pp. 4092-4098
-
-
Haneline, L.S.1
Broxmeyer, H.E.2
Cooper, S.3
Hangoc, G.4
Carreau, M.5
Buchwald, M.6
Clapp, D.W.7
-
20
-
-
77953485892
-
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
-
Oh ST, Simonds EF, Jones C, et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010;116(6):988-992.
-
(2010)
Blood
, vol.116
, Issue.6
, pp. 988-992
-
-
Oh, S.T.1
Simonds, E.F.2
Jones, C.3
-
21
-
-
54149085320
-
JAK2 and MPL mutations in myeloproliferative neoplasms: Discovery and science
-
Kilpivaara O, Levine RL. JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science. Leukemia. 2008;22(10):1813-1817.
-
(2008)
Leukemia
, vol.22
, Issue.10
, pp. 1813-1817
-
-
Kilpivaara, O.1
Levine, R.L.2
-
22
-
-
73949118736
-
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells
-
Vanderwerf SM, Svahn J, Olson S, et al. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. Blood. 2009;114(26):5290-5298.
-
(2009)
Blood
, vol.114
, Issue.26
, pp. 5290-5298
-
-
Vanderwerf, S.M.1
Svahn, J.2
Olson, S.3
-
23
-
-
0027513715
-
Tumor necrosis factor-alpha overproduction in Fanconi's anemia
-
DOI 10.1002/ajh.2830420211
-
Schultz JC, Shahidi NT. Tumor necrosis factor-alpha overproduction in Fanconi's anemia. Am J Hematol. 1993;42(2):196-201. (Pubitemid 23062174)
-
(1993)
American Journal of Hematology
, vol.42
, Issue.2
, pp. 196-201
-
-
Schultz, J.C.1
Shahidi, N.T.2
-
24
-
-
0028123475
-
Abnormal lymphokine production: A novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor alpha
-
Rosselli F, Sanceau J, Gluckman E, Wietzerbin J, Moustacchi E. Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor alpha. Blood. 1994;83(5):1216-1225. (Pubitemid 24062844)
-
(1994)
Blood
, vol.83
, Issue.5
, pp. 1216-1225
-
-
Rosselli, F.1
Sanceau, J.2
Gluckman, E.3
Wietzerbin, J.4
Moustacchi, E.5
-
25
-
-
0141567661
-
TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro
-
DOI 10.1182/blood-2003-01-0114
-
Dufour C, Corcione A, Svahn J, et al. TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood. 2003;102(6):2053-2059. (Pubitemid 37122379)
-
(2003)
Blood
, vol.102
, Issue.6
, pp. 2053-2059
-
-
Dufour, C.1
Corcione, A.2
Svahn, J.3
Haupt, R.4
Poggi, V.5
Beka'ssy, A.N.6
Scime, R.7
Pistorio, A.8
Pistoia, V.9
-
26
-
-
79956033992
-
The stem cell fitness landscape and pathways of molecular leukemogenesis
-
Bagby GC, Fleischman AG. The stem cell fitness landscape and pathways of molecular leukemogenesis. Front Biosci (Schol Ed). 2011;3:487-500.
-
(2011)
Front Biosci (Schol Ed)
, vol.3
, pp. 487-500
-
-
Bagby, G.C.1
Fleischman, A.G.2
-
27
-
-
0032722653
-
Selective pressure as an essential force in molecular evolution of myeloid leukemic clones: A view from the window of Fanconi anemia
-
Lensch MW, Rathbun RK, Olson SB, Jones GR, Bagby GC Jr. Selective pressure as an essential force in molecular evolution of myeloid leukemic clones: a view from the window of Fanconi anemia. Leukemia. 1999;13(11):1784- 1789. (Pubitemid 29535262)
-
(1999)
Leukemia
, vol.13
, Issue.11
, pp. 1784-1789
-
-
Lensch, M.W.1
Rathbun, R.K.2
Olson, S.B.3
Jones, G.R.4
Bagby Jr., G.C.5
-
28
-
-
63449099560
-
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
-
Jones AV, Chase A, Silver RT, et al. JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms. Nat Genet. 2009;41(4):446-449.
-
(2009)
Nat Genet
, vol.41
, Issue.4
, pp. 446-449
-
-
Jones, A.V.1
Chase, A.2
Silver, R.T.3
|