Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Tanwar, Pradeep S ^a,b   Kaneko Tarui, Tomoko ^a   Zhang, LiHua ^a   Tanaka, Yoshihiro ^a   Crum, Christopher P ^c   Teixeira, Jose M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; HISTONE H3; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; RAPAMYCIN; STROMAL LIVER KINASE B1; TUBERIN; UNCLASSIFIED DRUG;

ADENOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL EXPANSION; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIUM CANCER; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; GENE; GENE DELETION; GENE LOSS; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; MOUSE; MOUSE MUTANT; NONHUMAN; ONCOGENE; PHENOTYPE; PROTEIN PHOSPHORYLATION; PTEN GENE; SIGNAL TRANSDUCTION; STROMAL LIVER KINASE B1 GENE; TUBEROUS SCLEROSIS 1 GENE; TUBEROUS SCLEROSIS 2 GENE; UTERINE CERVIX CANCER; UTERINE TUBE TUMOR; VAGINA CANCER;

ADENOMA; ANIMALS; CERVIX UTERI; DISEASE MODELS, ANIMAL; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; OVARY; OVIDUCTS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SIROLIMUS; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA; MUS;

EID: 84866147755     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002906     Document Type: Article

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