Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 341-353

  Morén, Anita ^a   Raja, Erna ^a   Heldin, Carl Henrik ^a   Moustakas, Aristidis ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RESPONSE; BONE MORPHOGENETIC PROTEINS; DNA-BINDING DOMAIN; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR; GENE RESPONSE; NEGATIVE CONTROL; PROMOTER SEQUENCES; PROTEIN COMPLEXES; PROTEIN PHOSPHORYLATION; REGULATORY EFFECTS; SCAFFOLDING PROTEINS; SMAD SIGNALING; TUMOR SUPPRESSORS;

BONE; GROWTH KINETICS; OLIGOMERS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIGNALING; TRANSCRIPTION;

PROTEINS;

PROTEIN KINASE LKB1; PROTEIN LIP1; SCAFFOLD PROTEIN; SMAD4 PROTEIN; THREONINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EPITHELIAL MESENCHYMAL TRANSITION; GENE CONTROL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; DNA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; THREONINE; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 78650938892     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.190660     Document Type: Article

References (35)

1. Feng, X. H., and Derynck, R. (2005) Annu. Rev. Cell Dev. Biol. 21, 659-693
2. Lönn, P., Morén, A., Raja, E., Dahl, M., and Moustakas, A. (2009) Cell Res. 19, 21-35
3. Moustakas, A., and Heldin, C. H. (2009) Development 136, 3699-3714
4. Massagué, J. (2008) Cell 134, 215-230
5. Thiery, J. P., Acloque, H., Huang, R. Y., and Nieto, M. A. (2009) Cell 139, 871-890
6. Moustakas, A., and Heldin, C. H. (2007) Cancer Sci. 98, 1512-1520
7. Alessi, D. R., Sakamoto, K., and Bayascas, J. R. (2006) Annu. Rev. Biochem. 75, 137-163
8. Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R., and van Aalten, D. M. (2009) Science 326, 1707-1711
9. Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R., and van Aalten, D. M. (2009) PLoS Biol. 7, e1000126
10. Tassan, J. P., and Le Goff, X. (2004) Biol. Cell 96, 193-199
11. Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R., and Clevers, H. C. (2003) EMBO J. 22, 3062-3072
12. Smith, D. P., Rayter, S. I., Niederlander, C., Spicer, J., Jones, C. M., and Ashworth, A. (2001) Hum. Mol. Genet. 10, 2869-2877
13. Katoh, Y., Takemori, H., Horike, N., Doi, J., Muraoka, M., Min, L., and Okamoto, M. (2004) Mol. Cell. Endocrinol. 217, 109-112
14. Kowanetz, M., Lönn, P., Vanlandewijck, M., Kowanetz, K., Heldin, C. H., and Moustakas, A. (2008) J. Cell Biol. 182, 655-662
15. Katajisto, P., Vaahtomeri, K., Ekman, N., Ventelä, E., Ristimäki, A., Bardeesy, N., Feil, R., DePinho, R. A., and Mäkelä, T. P. (2008) Nat. Genet. 40, 455-459
16. Vaahtomeri, K., Ventelä, E., Laajanen, K., Katajisto, P., Wipff, P. J., Hinz, B., Vallenius, T., Tiainen, M., and Mäkelä, T. P. (2008) J. Cell Sci. 121, 3531-3540
17. Londesborough, A., Vaahtomeri, K., Tiainen, M., Katajisto, P., Ekman, N., Vallenius, T., and Mäkelä, T. P. (2008) Development 135, 2331-2338
18. Morén, A., Hellman, U., Inada, Y., Imamura, T., Heldin, C. H., and Moustakas, A. (2003) J. Biol. Chem. 278, 33571-33582
19. Kowanetz, M., Valcourt, U., Bergström, R., Heldin, C. H., and Moustakas, A. (2004) Mol. Cell. Biol. 24, 4241-4254
20. Noga, A. A., Soltys, C. L., Barr, A. J., Kovacic, S., Lopaschuk, G. D., and Dyck, J. R. (2007) Am. J. Physiol. Heart Circ. Physiol. 292, H1460-H1469
21. Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C. H., and Moustakas, A. (2001) Mol. Biol. Cell 12, 1079-1091
22. Berns, K., Hijmans, E. M., Mullenders, J., Brummelkamp, T. R., Velds, A., Heimerikx, M., Kerkhoven, R. M., Madiredjo, M., Nijkamp, W., Weigelt, B., Agami, R., Ge, W., Cavet, G., Linsley, P. S., Beijersbergen, R. L., and Bernards, R. (2004) Nature 428, 431-437
23. Jurek, A., Amagasaki, K., Gembarska, A., Heldin, C. H., and Lennartsson, J. (2009) J. Biol. Chem. 284, 4626-4634
24. Morén, A., Itoh, S., Moustakas, A., Dijke, P., and Heldin, C. H. (2000) Oncogene 19, 4396-4404
25. Wrighton, K. H., Lin, X., and Feng, X. H. (2009) Cell Res. 19, 8-20
26. Roelen, B. A., Cohen, O. S., Raychowdhury, M. K., Chadee, D. N., Zhang, Y., Kyriakis, J. M., Alessandrini, A. A., and Lin, H. Y. (2003) Am. J. Physiol. Cell Physiol. 285, C823-C830
27. Korchynskyi, O., and ten Dijke, P. (2002) J. Biol. Chem. 277, 4883-4891
28. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
29. Thuault, S., Valcourt, U., Petersen, M., Manfioletti, G., Heldin, C. H., and Moustakas, A. (2006) J. Cell Biol. 174, 175-183
30. Deckers, M., van Dinther, M., Buijs, J., Que, I., Löwik, C., van der Pluijm, G., and ten Dijke, P. (2006) Cancer Res. 66, 2202-2209
31. Shen, Z., Wu, Q., Yue, L., Li, H. C., Shen, Z. Z., and Shao, Z. M. (2005) Zhonghua Yi Xue Za Zhi 85, 15-18
32. Wicks, S. J., Lui, S., Abdel-Wahab, N., Mason, R. M., and Chantry, A. (2000) Mol. Cell. Biol. 20, 8103-8111
33. Yakymovych, I., Ten Dijke, P., Heldin, C. H., and Souchelnytskyi, S. (2001) FASEB J. 15, 553-555
34. Bardeesy, N., Sinha, M., Hezel, A. F., Signoretti, S., Hathaway, N. A., Sharpless, N. E., Loda, M., Carrasco, D. R., and DePinho, R. A. (2002) Nature 419, 162-167
35. Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H. R., Zhang, Y., and Wrana, J. L. (2005) Science 307, 1603-1609