Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1

Human Molecular Genetics

Volumn 18, Issue 22, 2009, Pages 4428-4441

  Zhou, Jing ^a   Brugarolas, James ^a   Parada, Luis F ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN S6; RAPAMYCIN; TUBERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; CELL STRUCTURE; DISEASE SEVERITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE LOSS; KIDNEY CYST; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; KIDNEY TUBULES; MALE; MICE; MICE, KNOCKOUT; POLYCYSTIC KIDNEY DISEASES; PTEN PHOSPHOHYDROLASE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA; MUS;

EID: 70350688091     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp398     Document Type: Article

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