TGF-β-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system

International Journal of Cancer

Volumn 93, Issue 2, 2001, Pages 204-211

  Ellenrieder, Volker ^a   Hendler, Sandra F ^a   Ruhland, Claudia ^a   Boeck, Wolfgang ^a   Adler, Guido ^a   Gress, Thomas M ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Matrix metalloproteinase 2; Pancreatic cancer; TGF ; Tumor cell invasion; Urokinase plasminogen activator

Indexed keywords

GELATINASE A; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; UROKINASE;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL CULTURE; CANCER INVASION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; EPITHELIUM TUMOR; HUMAN; HUMAN CELL; METASTASIS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

ENZYME ACTIVATION; HUMANS; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PROTEASE INHIBITORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

EID: 0035879867     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1330     Document Type: Article

References (44)

1. Transforming growth factor beta and cell cycle regulation
2. Transcriptional control by the TGFbeta/Smad signalling system
3. Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase
4. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
5. TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells
6. Tumor suppressor activity of the TGF-beta pathway in human cancers
7. Transforming growth factor β in breast cancer: A working hypothesis
8. Genetic events and the role of TGF-β in epithelial tumor progression
9. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
10. TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
11. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
12. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
13. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
14. DPC4, a candidate tumor suppressor gene at human chromosome 18q,21.1
15. Tumor invasion and metastases - Role of the extracellular matrix. Rhoads memorial award lecture
16. The plasminogen-plasmin system in malignancy
17. Matrix metalloproteinases and tumor invasion: From correlation and causality to the clinic
18. Changing views of the role of matrix metalloproteinases in metastasis
19. Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
20. Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer
21. Matrix metalloproteinases and the development of cancer
22. The role of MT-MMPs and MMP-2 in the progression of pancreatic cancer
23. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain
24. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
25. In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor
26. Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro
27. Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma
28. The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients
29. New pancreas cancers cell lines that represent distinct stages of ductal differentiation
30. Use of representational difference analysis to study the effect of TGF-β on the expression profile of a pancreatic cancer cell line
31. Differential expression of heat shock proteins in pancreatic carcinoma
32. Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
33. Colon carcinoma cells switch their response to TGF-β1 with tumor progression
34. Transforming growth factor beta1 (TGF-β1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF-β1 antisense expression plasmid
35. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
36. Extracellular matrix associated transforming growth factor beta: Role in cancer cell growth and invasion
37. Transforming growth factor β1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro
38. High levels of TGF-β1 correlate with disease progression in human colon cancer
39. Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer
40. Role of transforming growth factor beta1 in invasion and metastasis in gastric carcinoma
41. Complex role of tumor cell transforming growth factor (TGF)- betas on breast carcinoma progression
42. The expression of transforming growth factor beta 1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma
43. High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression
44. Osteoblast-derived TGF-β1 modulates matrix degrading protease expression and activity in prostate cancer cells