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Volumn , Issue AUG 2012, 2012, Pages 1-29

Alcohol-Induced Plasticity in the Dynorphin/Kappa-opioid Receptor system

Author keywords

Alcohol; Amygdala; Anhedonic; Dependence; Depression; Dynorphin; Epigenetic; Ethanol; Kappa opioid receptor; Molecular mechanisms; Negative affect; Negative reinforcement; Nucleus accumbens; Operant; Oprk1; Orbitofrontal cortex; Pdyn; Prefrontal cortex; Prodynorphin; Self administration; Withdrawal

Indexed keywords

BETA ENDORPHIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DYNORPHIN; KAPPA OPIATE RECEPTOR; MESSENGER RNA; OPIATE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOSB; ALCOHOL;

EID: 84865970356     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2012.00095     Document Type: Article
Times cited : (56)

References (174)
  • 1
    • 81855161676 scopus 로고    scopus 로고
    • Molecular mechanisms of opioid receptor-dependent signaling and behavior
    • Al-Hasani, R., and Bruchas, M. R. (2011). Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology 115, 1363-1381.
    • (2011) Anesthesiology , vol.115 , pp. 1363-1381
    • Al-Hasani, R.1    Bruchas, M.R.2
  • 2
    • 0028067839 scopus 로고
    • In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]NT-3
    • Altar, C. A., Siuciak, J. A., Wright, P., Ip, N. Y., Lindsay, R. M., and Wiegand, S. J. (1994). In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]NT-3. Eur. J. Neurosci. 6, 1389-1405.
    • (1994) Eur. J. Neurosci , vol.6 , pp. 1389-1405
    • Altar, C.A.1    Siuciak, J.A.2    Wright, P.3    Ip, N.Y.4    Lindsay, R.M.5    Wiegand, S.J.6
  • 4
    • 84871750715 scopus 로고    scopus 로고
    • The endogenous opioid system in human alcoholics: Molecular adaptations in brain areas involved in cognitive control of addiction
    • doi: 10.1111/j.1369-1600.2011.00366.x
    • Bazov, I., Kononenko, O., Watanabe, H., Kuntic, V., Sarkisyan, D., Taqi, M. M., Hussain, M. Z., Nyberg, F., Yakovleva, T., and Bakalkin, G. (2011). The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Addict. Biol. doi: 10.1111/j.1369-1600.2011.00366.x
    • (2011) Addict. Biol
    • Bazov, I.1    Kononenko, O.2    Watanabe, H.3    Kuntic, V.4    Sarkisyan, D.5    Taqi, M.M.6    Hussain, M.Z.7    Nyberg, F.8    Yakovleva, T.9    Bakalkin, G.10
  • 5
    • 1642482761 scopus 로고    scopus 로고
    • Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
    • Bencherif, B., Wand, G. S., McCaul, M. E., Kim, Y. K., Ilgin, N., Dannals, R. F., and Frost, J. J. (2004). Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. Biol. Psychiatry 55, 255-262.
    • (2004) Biol. Psychiatry , vol.55 , pp. 255-262
    • Bencherif, B.1    Wand, G.S.2    McCaul, M.E.3    Kim, Y.K.4    Ilgin, N.5    Dannals, R.F.6    Frost, J.J.7
  • 6
    • 33746046737 scopus 로고    scopus 로고
    • Presynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex
    • Berger, B., Rothmaier, A. K., Wedekind, F., Zentner, J., Feuerstein, T. J., and Jackisch, R. (2006). Presynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex. Br. J. Pharmacol. 148, 795-806.
    • (2006) Br. J. Pharmacol , vol.148 , pp. 795-806
    • Berger, B.1    Rothmaier, A.K.2    Wedekind, F.3    Zentner, J.4    Feuerstein, T.J.5    Jackisch, R.6
  • 8
    • 67649426279 scopus 로고    scopus 로고
    • Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network
    • Boettiger, C. A., Kelley, E. A., Mitchell, J. M., D'Esposito, M., and Fields, H. L. (2009). Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Pharmacol. Biochem. Behav. 93, 291-299.
    • (2009) Pharmacol. Biochem. Behav , vol.93 , pp. 291-299
    • Boettiger, C.A.1    Kelley, E.A.2    Mitchell, J.M.3    D'esposito, M.4    Fields, H.L.5
  • 9
    • 0345967827 scopus 로고    scopus 로고
    • Methylphenidate treatment during pre-and periadolescence alters behavioral responses to emotional stimuli at adulthood
    • Bolanos, C. A., Barrot, M., Berton, O., Wallace-Black, D., and Nestler, E. J. (2003). Methylphenidate treatment during pre-and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol. Psychiatry 54, 1317-1329.
    • (2003) Biol. Psychiatry , vol.54 , pp. 1317-1329
    • Bolanos, C.A.1    Barrot, M.2    Berton, O.3    Wallace-Black, D.4    Nestler, E.J.5
  • 10
    • 57649239938 scopus 로고    scopus 로고
    • Decoding the epigenetic language of neuronal plasticity
    • Borrelli, E., Nestler, E. J., Allis, C. D., and Sassone-Corsi, P. (2008). Decoding the epigenetic language of neuronal plasticity. Neuron 60, 961-974.
    • (2008) Neuron , vol.60 , pp. 961-974
    • Borrelli, E.1    Nestler, E.J.2    Allis, C.D.3    Sassone-Corsi, P.4
  • 13
    • 70449658803 scopus 로고    scopus 로고
    • kappa-Opioid receptor signaling and brain reward function
    • Bruijnzeel, A. W. (2009). kappa-Opioid receptor signaling and brain reward function. Brain Res. Rev. 62, 127-146.
    • (2009) Brain Res. Rev , vol.62 , pp. 127-146
    • Bruijnzeel, A.W.1
  • 14
    • 0036062627 scopus 로고    scopus 로고
    • Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement
    • Carelli, R. M. (2002). Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. Physiol Behav. 76, 379-87.
    • (2002) Physiol Behav , vol.76 , pp. 379-387
    • Carelli, R.M.1
  • 17
    • 0346599159 scopus 로고    scopus 로고
    • Enduring behavioral effects of early exposure to methylphenidate in rats
    • Carlezon, W. A., Jr., Mague, S. D., and Andersen, S. L. (2003). Enduring behavioral effects of early exposure to methylphenidate in rats. Biol. Psychiatry 54, 1330-1337.
    • (2003) Biol. Psychiatry , vol.54 , pp. 1330-1337
    • Carlezon Jr., W.A.1    Mague, S.D.2    Andersen, S.L.3
  • 19
    • 33847292937 scopus 로고    scopus 로고
    • Chronic ethanol consumption increases dopamine uptake in the nucleus accumbens of high alcohol drinking rats
    • Carroll, M. R., Rodd, Z. A., Murphy, J. M., and Simon, J. R. (2006). Chronic ethanol consumption increases dopamine uptake in the nucleus accumbens of high alcohol drinking rats. Alcohol 40, 103-109.
    • (2006) Alcohol , vol.40 , pp. 103-109
    • Carroll, M.R.1    Rodd, Z.A.2    Murphy, J.M.3    Simon, J.R.4
  • 20
    • 0034253821 scopus 로고    scopus 로고
    • Dynorphin: Friend or foe?
    • Caudle, R. M., and Mannes, A. J. (2000). Dynorphin: friend or foe? Pain 87, 235-239.
    • (2000) Pain , vol.87 , pp. 235-239
    • Caudle, R.M.1    Mannes, A.J.2
  • 21
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: A convergence point for many signalling pathways
    • Chao, M. V. (2003). Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309.
    • (2003) Nat. Rev. Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 22
    • 0020029345 scopus 로고
    • Dynorphin is a specific endogenous ligand of the kappa opioid receptor
    • Chavkin, C., James, I. F., and Goldstein, A. (1982). Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science 215, 413-415.
    • (1982) Science , vol.215 , pp. 413-415
    • Chavkin, C.1    James, I.F.2    Goldstein, A.3
  • 23
    • 0034028920 scopus 로고    scopus 로고
    • Effect of chronic ethanol and withdrawal on the mu-opioid receptor-and 5-Hydroxytryptamine(1A) receptor-stimulated binding of [(35)S]Guanosine-5'-O-(3thio)triphosphate in the fawn-hooded rat brain: A quantitative autoradiography study
    • Chen, F., and Lawrence, A. J. (2000). Effect of chronic ethanol and withdrawal on the mu-opioid receptor-and 5-Hydroxytryptamine(1A) receptor-stimulated binding of [(35)S]Guanosine-5'-O-(3thio)triphosphate in the fawn-hooded rat brain: A quantitative autoradiography study. J. Pharmacol. Exp. Ther. 293, 159-165.
    • (2000) J. Pharmacol. Exp. Ther , vol.293 , pp. 159-165
    • Chen, F.1    Lawrence, A.J.2
  • 24
    • 0023407002 scopus 로고
    • Responses of midbrain dorsal raphe neurons to ethanol studied in brainstem slices
    • Chu, N. S., and Keenan, L. (1987). Responses of midbrain dorsal raphe neurons to ethanol studied in brainstem slices. Alcohol 4, 373-374.
    • (1987) Alcohol , vol.4 , pp. 373-374
    • Chu, N.S.1    Keenan, L.2
  • 26
    • 10644272229 scopus 로고    scopus 로고
    • Role of GABA(B) receptor in alcohol dependence: Reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics
    • Colombo, G., Addolorato, G., Agabio, R., Carai, M. A., Pibiri, F., Serra, S., Vacca, G., and Gessa, G. L. (2004). Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox. Res. 6, 403-414.
    • (2004) Neurotox. Res , vol.6 , pp. 403-414
    • Colombo, G.1    Addolorato, G.2    Agabio, R.3    Carai, M.A.4    Pibiri, F.5    Serra, S.6    Vacca, G.7    Gessa, G.L.8
  • 29
    • 0025553738 scopus 로고
    • Opioids can evoke direct receptor-mediated excitatory as well as inhibitory effects on sensory neuron action potentials
    • Crain, S. M., and Shen, K. F. (1990). Opioids can evoke direct receptor-mediated excitatory as well as inhibitory effects on sensory neuron action potentials. NIDA Res. Monogr 105, 34-39.
    • (1990) NIDA Res. Monogr , vol.105 , pp. 34-39
    • Crain, S.M.1    Shen, K.F.2
  • 30
    • 29044435185 scopus 로고    scopus 로고
    • Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism
    • Dai, X., Thavundayil, J., and Gianoulakis, C. (2005). Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Alcohol Clin. Exp. Res. 29, 1965-1975.
    • (2005) Alcohol Clin. Exp. Res , vol.29 , pp. 1965-1975
    • Dai, X.1    Thavundayil, J.2    Gianoulakis, C.3
  • 32
    • 0343933624 scopus 로고
    • Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
    • Di, C. G., and Imperato, A. (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. U. S. A 85, 5274-5278.
    • (1988) Proc. Natl. Acad. Sci. U. S. A , vol.85 , pp. 5274-5278
    • Di, C.G.1    Imperato, A.2
  • 33
    • 0026500432 scopus 로고
    • Activity-dependent neuronal plasticity following tissue injury and inflammation
    • Dubner, R., and Ruda, M. A. (1992). Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15, 96-103.
    • (1992) Trends Neurosci , vol.15 , pp. 96-103
    • Dubner, R.1    Ruda, M.A.2
  • 35
    • 0020516360 scopus 로고
    • Dynorphin induces partially reversible paraplegia in the rat
    • Faden, A. I., and Jacobs, T. P. (1983). Dynorphin induces partially reversible paraplegia in the rat. Eur. J. Pharmacol. 91, 321-324.
    • (1983) Eur. J. Pharmacol , vol.91 , pp. 321-324
    • Faden, A.I.1    Jacobs, T.P.2
  • 36
    • 34547681422 scopus 로고    scopus 로고
    • Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement
    • Fields, H. L., Hjelmstad, G. O., Margolis, E. B., and Nicola, S. M. (2007). Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu. Rev. Neurosci. 30, 289-316.
    • (2007) Annu. Rev. Neurosci , vol.30 , pp. 289-316
    • Fields, H.L.1    Hjelmstad, G.O.2    Margolis, E.B.3    Nicola, S.M.4
  • 37
    • 0026093818 scopus 로고
    • mu-Opioid receptor-mediated inhibition of the release of radiolabelled noradrenaline and acetylcholine from rat amygdala slices
    • Frankhuijzen, A. L., Jansen, F. P., Schoffelmeer, A. N. M., and Mulder, A. H. (1991). mu-Opioid receptor-mediated inhibition of the release of radiolabelled noradrenaline and acetylcholine from rat amygdala slices. Neurochemistry International 19, 543-548.
    • (1991) Neurochemistry International , vol.19 , pp. 543-548
    • Frankhuijzen, A.L.1    Jansen, F.P.2    Schoffelmeer, A.N.M.3    Mulder, A.H.4
  • 38
    • 36448943262 scopus 로고    scopus 로고
    • Chronic ethanol exposure inhibits dopamine release via effects on the presynaptic actin cytoskeleton in PC12 cells
    • Funk, C. K., and Dohrman, D. P. (2007). Chronic ethanol exposure inhibits dopamine release via effects on the presynaptic actin cytoskeleton in PC12 cells. Brain Res. 1185, 86-94.
    • (2007) Brain Res , vol.1185 , pp. 86-94
    • Funk, C.K.1    Dohrman, D.P.2
  • 39
    • 33750931628 scopus 로고    scopus 로고
    • Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats
    • Funk, C. K., O'Dell, L. E., Crawford, E. F., and Koob, G. F. (2006). Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J. Neurosci. 26, 11324-11332.
    • (2006) J. Neurosci , vol.26 , pp. 11324-11332
    • Funk, C.K.1    O'Dell, L.E.2    Crawford, E.F.3    Koob, G.F.4
  • 40
    • 0029983167 scopus 로고    scopus 로고
    • Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism
    • Gianoulakis, C., Krishnan, B., and Thavundayil, J. (1996). Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism. Arch. Gen. Psychiatry 53, 250-257.
    • (1996) Arch. Gen. Psychiatry , vol.53 , pp. 250-257
    • Gianoulakis, C.1    Krishnan, B.2    Thavundayil, J.3
  • 41
    • 84856096611 scopus 로고    scopus 로고
    • Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence
    • Gilpin, N. W., and Roberto, M. (2012). Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. Neurosci. Biobehav. Rev. 36, 873-888.
    • (2012) Neurosci. Biobehav. Rev , vol.36 , pp. 873-888
    • Gilpin, N.W.1    Roberto, M.2
  • 42
    • 0034663345 scopus 로고    scopus 로고
    • Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior
    • Gorwood, P., Batel, P., Ades, J., Hamon, M., and Boni, C. (2000). Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol. Psychiatry 48, 259-264.
    • (2000) Biol. Psychiatry , vol.48 , pp. 259-264
    • Gorwood, P.1    Batel, P.2    Ades, J.3    Hamon, M.4    Boni, C.5
  • 43
    • 2942522762 scopus 로고    scopus 로고
    • The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002
    • Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, S. P., Dufour, M. C., and Pickering, R. P. (2004). The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend. 74, 223-234.
    • (2004) Drug Alcohol Depend , vol.74 , pp. 223-234
    • Grant, B.F.1    Dawson, D.A.2    Stinson, F.S.3    Chou, S.P.4    Dufour, M.C.5    Pickering, R.P.6
  • 44
    • 0028806207 scopus 로고
    • Comorbidity between DSM-IV alcohol use disorders and major depression: Results of a national survey
    • Grant, B. F., and Harford, T. C. (1995). Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey. Drug Alcohol Depend. 39, 197-206.
    • (1995) Drug Alcohol Depend , vol.39 , pp. 197-206
    • Grant, B.F.1    Harford, T.C.2
  • 45
    • 69649088499 scopus 로고    scopus 로고
    • Salvinorin A exerts opposite presynaptic controls on neurotransmitter exocytosis from mouse brain nerve terminals
    • Grilli, M., Neri, E., Zappettini, S., Massa, F., Bisio, A., Romussi, G., Marchi, M., and Pittaluga, A. (2009). Salvinorin A exerts opposite presynaptic controls on neurotransmitter exocytosis from mouse brain nerve terminals. Neuropharmacology 57, 523-530.
    • (2009) Neuropharmacology , vol.57 , pp. 523-530
    • Grilli, M.1    Neri, E.2    Zappettini, S.3    Massa, F.4    Bisio, A.5    Romussi, G.6    Marchi, M.7    Pittaluga, A.8
  • 47
    • 41949114582 scopus 로고    scopus 로고
    • Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions
    • Healey, J. C., Winder, D. G., and Kash, T. L. (2008). Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions. Alcohol 42, 179-190.
    • (2008) Alcohol , vol.42 , pp. 179-190
    • Healey, J.C.1    Winder, D.G.2    Kash, T.L.3
  • 49
    • 77954189998 scopus 로고    scopus 로고
    • Extensive sequence-influenced DNA methylation polymorphism in the human genome
    • Hellman, A., and Chess, A. (2010). Extensive sequence-influenced DNA methylation polymorphism in the human genome. Epigenetics. Chromatin. 3, 11.
    • (2010) Epigenetics. Chromatin , vol.3 , pp. 11
    • Hellman, A.1    Chess, A.2
  • 50
    • 29244461748 scopus 로고    scopus 로고
    • Serotonergic modulation of the limbic system
    • Hensler, J. G. (2006). Serotonergic modulation of the limbic system. Neurosci. Biobehav. Rev. 30, 203-214.
    • (2006) Neurosci. Biobehav. Rev , vol.30 , pp. 203-214
    • Hensler, J.G.1
  • 51
    • 0035095845 scopus 로고    scopus 로고
    • Kappa opioid receptor inhibition of glutamatergic transmission in the nucleus accumbens shell
    • Hjelmstad, G. O., and Fields, H. L. (2001). Kappa opioid receptor inhibition of glutamatergic transmission in the nucleus accumbens shell. J. Neurophysiol. 85, 1153-1158.
    • (2001) J. Neurophysiol , vol.85 , pp. 1153-1158
    • Hjelmstad, G.O.1    Fields, H.L.2
  • 52
    • 0037880374 scopus 로고    scopus 로고
    • Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms
    • Hjelmstad, G. O., and Fields, H. L. (2003). Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms. J. Neurophysiol. 89, 2389-2395.
    • (2003) J. Neurophysiol , vol.89 , pp. 2389-2395
    • Hjelmstad, G.O.1    Fields, H.L.2
  • 53
    • 0027992668 scopus 로고
    • Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments
    • Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., and Nestler, E. J. (1994). Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13, 1235-1244.
    • (1994) Neuron , vol.13 , pp. 1235-1244
    • Hope, B.T.1    Nye, H.E.2    Kelz, M.B.3    Self, D.W.4    Iadarola, M.J.5    Nakabeppu, Y.6    Duman, R.S.7    Nestler, E.J.8
  • 55
    • 0035125031 scopus 로고    scopus 로고
    • Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats
    • Hyytia, P., and Kiianmaa, K. (2001). Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats. Alcohol Clin. Exp. Res. 25, 25-33.
    • (2001) Alcohol Clin. Exp. Res , vol.25 , pp. 25-33
    • Hyytia, P.1    Kiianmaa, K.2
  • 56
    • 0022638076 scopus 로고
    • Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit
    • Jackisch, R., Geppert, M., and Illes, P. (1986). Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit. J. Neurochem. 46, 1802-1810.
    • (1986) J. Neurochem , vol.46 , pp. 1802-1810
    • Jackisch, R.1    Geppert, M.2    Illes, P.3
  • 57
    • 66549117005 scopus 로고    scopus 로고
    • Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area
    • Jarjour, S., Bai, L., and Gianoulakis, C. (2009). Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area. Alcohol Clin. Exp. Res. 33, 1033-1043.
    • (2009) Alcohol Clin. Exp. Res , vol.33 , pp. 1033-1043
    • Jarjour, S.1    Bai, L.2    Gianoulakis, C.3
  • 59
    • 10844261674 scopus 로고    scopus 로고
    • Role of the serotonergic system in the neurobiology of alcoholism: Implications for treatment
    • Johnson, B. A. (2004). Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS. Drugs 18, 1105-1118.
    • (2004) CNS. Drugs , vol.18 , pp. 1105-1118
    • Johnson, B.A.1
  • 62
    • 28444442694 scopus 로고    scopus 로고
    • Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
    • Kelley, A. E., Baldo, B. A., Pratt, W. E., and Will, M. J. (2005). Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav. 86, 773-795.
    • (2005) Physiol Behav , vol.86 , pp. 773-795
    • Kelley, A.E.1    Baldo, B.A.2    Pratt, W.E.3    Will, M.J.4
  • 64
    • 0034353226 scopus 로고    scopus 로고
    • deltaFosB: A molecular switch underlying long-term neural plasticity
    • Kelz, M. B., and Nestler, E. J. (2000). deltaFosB: a molecular switch underlying long-term neural plasticity. Curr. Opin. Neurol. 13, 715-720.
    • (2000) Curr. Opin. Neurol , vol.13 , pp. 715-720
    • Kelz, M.B.1    Nestler, E.J.2
  • 66
    • 75149118146 scopus 로고    scopus 로고
    • Dynorphin, stress, and depression
    • Knoll, A. T., and Carlezon, W. A. (2010). Dynorphin, stress, and depression. Brain Res. 1314, 56-73.
    • (2010) Brain Res , vol.1314 , pp. 56-73
    • Knoll, A.T.1    Carlezon, W.A.2
  • 67
    • 0033913561 scopus 로고    scopus 로고
    • Neurobiology of addiction. Toward the development of new therapies
    • Koob, G. F. (2000). Neurobiology of addiction. Toward the development of new therapies. Ann. N. Y. Acad. Sci. 909, 170-85.
    • (2000) Ann. N. Y. Acad. Sci , vol.909 , pp. 170-185
    • Koob, G.F.1
  • 68
    • 4644342311 scopus 로고    scopus 로고
    • A role for GABA mechanisms in the motivational effects of alcohol
    • Koob, G. F. (2004). A role for GABA mechanisms in the motivational effects of alcohol. Biochem. Pharmacol. 68, 1515-1525.
    • (2004) Biochem. Pharmacol , vol.68 , pp. 1515-1525
    • Koob, G.F.1
  • 69
    • 70449628050 scopus 로고    scopus 로고
    • Dynamics of neuronal circuits in addiction: Reward, antireward, and emotional memory
    • Koob, G. F. (2009). Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry 42 Suppl 1, S32-S41.
    • (2009) Pharmacopsychiatry , vol.42 , Issue.SUPPL. 1
    • Koob, G.F.1
  • 70
    • 75149143341 scopus 로고    scopus 로고
    • The role of CRF and CRF-related peptides in the dark side of addiction
    • Koob, G. F. (2010). The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res. 1314, 3-14.
    • (2010) Brain Res , vol.1314 , pp. 3-14
    • Koob, G.F.1
  • 71
    • 0023763088 scopus 로고
    • Cellular and molecular mechanisms of drug dependence
    • Koob, G. F., and Bloom, F. E. (1988). Cellular and molecular mechanisms of drug dependence. Science 242, 715-723.
    • (1988) Science , vol.242 , pp. 715-723
    • Koob, G.F.1    Bloom, F.E.2
  • 72
    • 41549113416 scopus 로고    scopus 로고
    • Addiction and the brain antireward system
    • Koob, G. F., and Le, M. M. (2008). Addiction and the brain antireward system. Annu. Rev. Psychol. 59, 29-53.
    • (2008) Annu. Rev. Psychol , vol.59 , pp. 29-53
    • Koob, G.F.1    Le, M.M.2
  • 73
    • 0026444211 scopus 로고
    • Neuropharmacology of cocaine and ethanol dependence
    • Koob, G. F., and Weiss, F. (1992). Neuropharmacology of cocaine and ethanol dependence. Recent Dev. Alcohol 10, 201-233.
    • (1992) Recent Dev. Alcohol , vol.10 , pp. 201-233
    • Koob, G.F.1    Weiss, F.2
  • 75
    • 56349120585 scopus 로고    scopus 로고
    • Effects of acute ethanol on opioid peptide release in the central amygdala: An in vivo microdialysis study
    • Lam, M. P., Marinelli, P. W., Bai, L., and Gianoulakis, C. (2008). Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis study. Psychopharmacology (Berl) 201, 261-271.
    • (2008) Psychopharmacology (Berl) , vol.201 , pp. 261-271
    • Lam, M.P.1    Marinelli, P.W.2    Bai, L.3    Gianoulakis, C.4
  • 76
    • 38349031157 scopus 로고    scopus 로고
    • The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system
    • Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., and Chavkin, C. (2008). The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J. Neurosci. 28, 407-414.
    • (2008) J. Neurosci , vol.28 , pp. 407-414
    • Land, B.B.1    Bruchas, M.R.2    Lemos, J.C.3    Xu, M.4    Melief, E.J.5    Chavkin, C.6
  • 78
    • 84859105063 scopus 로고    scopus 로고
    • Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling
    • Li, C., Pleil, K. E., Stamatakis, A. M., Busan, S., Vong, L., Lowell, B. B., Stuber, G. D., and Kash, T. L. (2012). Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biol. Psychiatry 71, 725-732.
    • (2012) Biol. Psychiatry , vol.71 , pp. 725-732
    • Li, C.1    Pleil, K.E.2    Stamatakis, A.M.3    Busan, S.4    Vong, L.5    Lowell, B.B.6    Stuber, G.D.7    Kash, T.L.8
  • 79
    • 0034537207 scopus 로고    scopus 로고
    • Repeated ethanol administration induces short-and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain
    • Lindholm, S., Ploj, K., Franck, J., and Nylander, I. (2000). Repeated ethanol administration induces short-and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain. Alcohol 22, 165-171.
    • (2000) Alcohol , vol.22 , pp. 165-171
    • Lindholm, S.1    Ploj, K.2    Franck, J.3    Nylander, I.4
  • 80
    • 34548529919 scopus 로고    scopus 로고
    • Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens
    • Lindholm, S., Rosin, A., Dahlin, I., Georgieva, J., and Franck, J. (2007). Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens. Physiol Behav. 92, 167-171.
    • (2007) Physiol Behav , vol.92 , pp. 167-171
    • Lindholm, S.1    Rosin, A.2    Dahlin, I.3    Georgieva, J.4    Franck, J.5
  • 81
    • 0035133119 scopus 로고    scopus 로고
    • The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat
    • Lindholm, S., Werme, M., Brene, S., and Franck, J. (2001). The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat. Behav. Brain Res. 120, 137-146.
    • (2001) Behav. Brain Res , vol.120 , pp. 137-146
    • Lindholm, S.1    Werme, M.2    Brene, S.3    Franck, J.4
  • 82
    • 46749093301 scopus 로고    scopus 로고
    • Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake
    • Logrip, M. L., Janak, P. H., and Ron, D. (2008). Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. FASEB J. 22, 2393-2404.
    • (2008) FASEB J , vol.22 , pp. 2393-2404
    • Logrip, M.L.1    Janak, P.H.2    Ron, D.3
  • 83
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze, B. E., and Ginty, D. D. (2002). Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623.
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 84
    • 70349678800 scopus 로고    scopus 로고
    • Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans
    • Love, T. M., Stohler, C. S., and Zubieta, J. K. (2009). Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. Arch. Gen. Psychiatry 66, 1124-1134.
    • (2009) Arch. Gen. Psychiatry , vol.66 , pp. 1124-1134
    • Love, T.M.1    Stohler, C.S.2    Zubieta, J.K.3
  • 86
    • 27744485503 scopus 로고    scopus 로고
    • Antidepressant action: To the nucleus and beyond
    • Malberg, J. E., and Blendy, J. A. (2005). Antidepressant action: to the nucleus and beyond. Trends Pharmacol. Sci. 26, 631-638.
    • (2005) Trends Pharmacol. Sci , vol.26 , pp. 631-638
    • Malberg, J.E.1    Blendy, J.A.2
  • 88
    • 0242610916 scopus 로고    scopus 로고
    • Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons
    • Margolis, E. B., Hjelmstad, G. O., Bonci, A., and Fields, H. L. (2003). Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J. Neurosci. 23, 9981-9986.
    • (2003) J. Neurosci , vol.23 , pp. 9981-9986
    • Margolis, E.B.1    Hjelmstad, G.O.2    Bonci, A.3    Fields, H.L.4
  • 90
    • 27644457033 scopus 로고    scopus 로고
    • A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration
    • Marinelli, P. W., Bai, L., Quirion, R., and Gianoulakis, C. (2005). A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration. Alcohol Clin. Exp. Res. 29, 1821-1828.
    • (2005) Alcohol Clin. Exp. Res , vol.29 , pp. 1821-1828
    • Marinelli, P.W.1    Bai, L.2    Quirion, R.3    Gianoulakis, C.4
  • 91
    • 33744724648 scopus 로고    scopus 로고
    • A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration
    • Marinelli, P. W., Lam, M., Bai, L., Quirion, R., and Gianoulakis, C. (2006). A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration. Alcohol Clin. Exp. Res. 30, 982-990.
    • (2006) Alcohol Clin. Exp. Res , vol.30 , pp. 982-990
    • Marinelli, P.W.1    Lam, M.2    Bai, L.3    Quirion, R.4    Gianoulakis, C.5
  • 92
    • 0041874899 scopus 로고    scopus 로고
    • A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administration
    • Marinelli, P. W., Quirion, R., and Gianoulakis, C. (2003). A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administration. Psychopharmacology (Berl) 169, 60-67.
    • (2003) Psychopharmacology (Berl) , vol.169 , pp. 60-67
    • Marinelli, P.W.1    Quirion, R.2    Gianoulakis, C.3
  • 93
    • 3342943177 scopus 로고    scopus 로고
    • An in vivo profile of beta-endorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol
    • Marinelli, P. W., Quirion, R., and Gianoulakis, C. (2004). An in vivo profile of beta-endorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol. Neuroscience 127, 777-784.
    • (2004) Neuroscience , vol.127 , pp. 777-784
    • Marinelli, P.W.1    Quirion, R.2    Gianoulakis, C.3
  • 95
    • 34548336779 scopus 로고    scopus 로고
    • New insights into BDNF function in depression and anxiety
    • Martinowich, K., Manji, H., and Lu, B. (2007). New insights into BDNF function in depression and anxiety. Nat. Neurosci. 10, 1089-1093.
    • (2007) Nat. Neurosci , vol.10 , pp. 1089-1093
    • Martinowich, K.1    Manji, H.2    Lu, B.3
  • 97
    • 0032466081 scopus 로고    scopus 로고
    • Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents
    • McBride, W. J., and Li, T. K. (1998). Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev. Neurobiol. 12, 339-369.
    • (1998) Crit Rev. Neurobiol , vol.12 , pp. 339-369
    • McBride, W.J.1    Li, T.K.2
  • 98
    • 36549064711 scopus 로고    scopus 로고
    • Neuroplasticity mediated by altered gene expression
    • McClung, C. A., and Nestler, E. J. (2008). Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33, 3-17.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 3-17
    • McClung, C.A.1    Nestler, E.J.2
  • 100
    • 33745218286 scopus 로고    scopus 로고
    • The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: A role in alcohol drinking but not in anxiety-like behaviors in rats
    • Misra, K., and Pandey, S. C. (2006). The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats. Neuropsychopharmacology 31, 1406-1419.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1406-1419
    • Misra, K.1    Pandey, S.C.2
  • 101
    • 0035930494 scopus 로고    scopus 로고
    • Effects of voluntary ethanol intake on the expression of Ca(2+) /calmodulin-dependent protein kinase IV and on CREB expression and phosphorylation in the rat nucleus accumbens
    • Misra, K., Roy, A., and Pandey, S. C. (2001). Effects of voluntary ethanol intake on the expression of Ca(2+) /calmodulin-dependent protein kinase IV and on CREB expression and phosphorylation in the rat nucleus accumbens. Neuroreport 12, 4133-7413.
    • (2001) Neuroreport , vol.12 , pp. 4133-4137
    • Misra, K.1    Roy, A.2    Pandey, S.C.3
  • 102
    • 0030200394 scopus 로고    scopus 로고
    • Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal
    • Moratalla, R., Elibol, B., Vallejo, M., and Graybiel, A. M. (1996). Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron 17, 147-156.
    • (1996) Neuron , vol.17 , pp. 147-156
    • Moratalla, R.1    Elibol, B.2    Vallejo, M.3    Graybiel, A.M.4
  • 103
    • 0021876216 scopus 로고
    • Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
    • Mucha, R. F., and Herz, A. (1985). Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl) 86, 274-280.
    • (1985) Psychopharmacology (Berl) , vol.86 , pp. 274-280
    • Mucha, R.F.1    Herz, A.2
  • 104
    • 0021262915 scopus 로고
    • Kappa-and delta-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release
    • Mulder, A. H., Wardeh, G., Hogenboom, F., and Frankhuyzen, A. L. (1984). Kappa-and delta-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release. Nature 308, 278-280.
    • (1984) Nature , vol.308 , pp. 278-280
    • Mulder, A.H.1    Wardeh, G.2    Hogenboom, F.3    Frankhuyzen, A.L.4
  • 105
    • 33748791795 scopus 로고    scopus 로고
    • Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood?
    • Nair, A., and Vaidya, V. A. (2006). Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? J. Biosci. 31, 423-434.
    • (2006) J. Biosci , vol.31 , pp. 423-434
    • Nair, A.1    Vaidya, V.A.2
  • 106
    • 79957848671 scopus 로고    scopus 로고
    • kappa-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats
    • Nealey, K. A., Smith, A. W., Davis, S. M., Smith, D. G., and Walker, B. M. (2011). kappa-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats. Neuropharmacology 61, 35-42.
    • (2011) Neuropharmacology , vol.61 , pp. 35-42
    • Nealey, K.A.1    Smith, A.W.2    Davis, S.M.3    Smith, D.G.4    Walker, B.M.5
  • 107
    • 51449118642 scopus 로고    scopus 로고
    • Review. Transcriptional mechanisms of addiction: Role of DeltaFosB
    • Nestler, E. J. (2008). Review. Transcriptional mechanisms of addiction: role of DeltaFosB. Philos. Trans. R. Soc. Lond B Biol. Sci. 363, 3245-3255.
    • (2008) Philos. Trans. R. Soc. Lond B Biol. Sci , vol.363 , pp. 3245-3255
    • Nestler, E.J.1
  • 108
    • 0035949351 scopus 로고    scopus 로고
    • DeltaFosB: A sustained molecular switch for addiction
    • Nestler, E. J., Barrot, M., and Self, D. W. (2001). DeltaFosB: a sustained molecular switch for addiction. Proc. Natl. Acad. Sci. U. S. A 98, 11042-11046.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 11042-11046
    • Nestler, E.J.1    Barrot, M.2    Self, D.W.3
  • 109
    • 33746900423 scopus 로고    scopus 로고
    • The mesolimbic dopamine reward circuit in depression
    • Nestler, E. J., and Carlezon, W. A., Jr. (2006). The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 59, 1151-1159.
    • (2006) Biol. Psychiatry , vol.59 , pp. 1151-1159
    • Nestler, E.J.1    Carlezon Jr., W.A.2
  • 110
    • 0037115028 scopus 로고    scopus 로고
    • Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
    • Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., and Duman, R. S. (2002). Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J. Neurosci. 22, 10883-10890.
    • (2002) J. Neurosci , vol.22 , pp. 10883-10890
    • Newton, S.S.1    Thome, J.2    Wallace, T.L.3    Shirayama, Y.4    Schlesinger, L.5    Sakai, N.6    Chen, J.7    Neve, R.8    Nestler, E.J.9    Duman, R.S.10
  • 111
    • 0029960788 scopus 로고    scopus 로고
    • Induction of chronic Fos-related antigens in rat brain by chronic morphine administration
    • Nye, H. E., and Nestler, E. J. (1996). Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Mol. Pharmacol. 49, 636-645.
    • (1996) Mol. Pharmacol , vol.49 , pp. 636-645
    • Nye, H.E.1    Nestler, E.J.2
  • 112
    • 9244259156 scopus 로고    scopus 로고
    • Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure
    • O'Dell, L. E., Roberts, A. J., Smith, R. T., and Koob, G. F. (2004). Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol Clin. Exp. Res. 28, 1676-1682.
    • (2004) Alcohol Clin. Exp. Res , vol.28 , pp. 1676-1682
    • O'Dell, L.E.1    Roberts, A.J.2    Smith, R.T.3    Koob, G.F.4
  • 113
    • 0036181179 scopus 로고    scopus 로고
    • Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamopituitary-adrenocortical axis
    • O'Malley, S. S., Krishnan-Sarin, S., Farren, C., Sinha, R., and Kreek, M. J. (2002). Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamopituitary-adrenocortical axis. Psychopharmacology (Berl) 160, 19-29.
    • (2002) Psychopharmacology (Berl) , vol.160 , pp. 19-29
    • O'Malley, S.S.1    Krishnan-Sarin, S.2    Farren, C.3    Sinha, R.4    Kreek, M.J.5
  • 114
    • 26444506279 scopus 로고    scopus 로고
    • Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
    • Pandey, S. C., Zhang, H., Roy, A., and Xu, T. (2005). Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J. Clin. Invest 115, 2762-2773.
    • (2005) J. Clin. Invest , vol.115 , pp. 2762-2773
    • Pandey, S.C.1    Zhang, H.2    Roy, A.3    Xu, T.4
  • 116
    • 0022494591 scopus 로고
    • Psychotomimesis mediated by kappa opiate receptors
    • Pfeiffer, A., Brantl, V., Herz, A., and Emrich, H. M. (1986). Psychotomimesis mediated by kappa opiate receptors. Science 233, 774-776.
    • (1986) Science , vol.233 , pp. 774-776
    • Pfeiffer, A.1    Brantl, V.2    Herz, A.3    Emrich, H.M.4
  • 117
    • 0031010157 scopus 로고    scopus 로고
    • Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: Electrophysiological studies
    • Pistis, M., Muntoni, A. L., Gessa, G., and Diana, M. (1997). Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies. Neuroscience 79, 171-176.
    • (1997) Neuroscience , vol.79 , pp. 171-176
    • Pistis, M.1    Muntoni, A.L.2    Gessa, G.3    Diana, M.4
  • 118
    • 0035884949 scopus 로고    scopus 로고
    • Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens
    • Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., and Carlezon, W. A., Jr. (2001). Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J. Neurosci. 21, 7397-7403.
    • (2001) J. Neurosci , vol.21 , pp. 7397-7403
    • Pliakas, A.M.1    Carlson, R.R.2    Neve, R.L.3    Konradi, C.4    Nestler, E.J.5    Carlezon Jr., W.A.6
  • 119
    • 19244369081 scopus 로고    scopus 로고
    • Ethanol withdrawal enhances the prodynorphin system activity in the rat nucleus accumbens
    • Przewlocka, B., Turchan, J., Lason, W., and Przewlocki, R. (1997). Ethanol withdrawal enhances the prodynorphin system activity in the rat nucleus accumbens. Neurosci. Lett. 238, 13-16.
    • (1997) Neurosci. Lett , vol.238 , pp. 13-16
    • Przewlocka, B.1    Turchan, J.2    Lason, W.3    Przewlocki, R.4
  • 120
    • 0032840525 scopus 로고    scopus 로고
    • Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes
    • Rawls, S. M., McGinty, J. F., and Terrian, D. M. (1999). Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes. J. Neurochem. 73, 1058-1065.
    • (1999) J. Neurochem , vol.73 , pp. 1058-1065
    • Rawls, S.M.1    McGinty, J.F.2    Terrian, D.M.3
  • 121
    • 0025226205 scopus 로고
    • Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study
    • Regier, D. A., Farmer, M. E., Rae, D. S., Locke, B. Z., Keith, S. J., Judd, L. L., and Goodwin, F. K. (1990). Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264, 2511-2518.
    • (1990) JAMA , vol.264 , pp. 2511-2518
    • Regier, D.A.1    Farmer, M.E.2    Rae, D.S.3    Locke, B.Z.4    Keith, S.J.5    Judd, L.L.6    Goodwin, F.K.7
  • 122
    • 48149096013 scopus 로고    scopus 로고
    • Epigenetic mechanisms in drug addiction
    • Renthal, W., and Nestler, E. J. (2008). Epigenetic mechanisms in drug addiction. Trends Mol. Med. 14, 341-350.
    • (2008) Trends Mol. Med , vol.14 , pp. 341-350
    • Renthal, W.1    Nestler, E.J.2
  • 123
    • 59149092643 scopus 로고    scopus 로고
    • Subcellular targeting of kappa-opioid receptors in the rat nucleus locus coeruleus
    • Reyes, B. A., Chavkin, C., and van Bockstaele, E. J. (2009). Subcellular targeting of kappa-opioid receptors in the rat nucleus locus coeruleus. J. Comp Neurol. 512, 419-431.
    • (2009) J. Comp Neurol , vol.512 , pp. 419-431
    • Reyes, B.A.1    Chavkin, C.2    van Bockstaele, E.J.3
  • 124
    • 80051693596 scopus 로고    scopus 로고
    • Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    • Reynard, L. N., Bui, C., Canty-Laird, E. G., Young, D. A., and Loughlin, J. (2011). Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Hum. Mol. Genet. 20, 3450-3460.
    • (2011) Hum. Mol. Genet , vol.20 , pp. 3450-3460
    • Reynard, L.N.1    Bui, C.2    Canty-Laird, E.G.3    Young, D.A.4    Loughlin, J.5
  • 125
    • 0034008709 scopus 로고    scopus 로고
    • Excessive ethanol drinking following a history of dependence: Animal model of allostasis
    • Roberts, A. J., Heyser, C. J., Cole, M., Griffin, P., and Koob, G. F. (2000). Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology 22, 581-594.
    • (2000) Neuropsychopharmacology , vol.22 , pp. 581-594
    • Roberts, A.J.1    Heyser, C.J.2    Cole, M.3    Griffin, P.4    Koob, G.F.5
  • 126
    • 80054827869 scopus 로고    scopus 로고
    • Transcriptional and epigenetic mechanisms of addiction
    • Robison, A. J., and Nestler, E. J. (2011). Transcriptional and epigenetic mechanisms of addiction. Nat. Rev. Neurosci. 12, 623-637.
    • (2011) Nat. Rev. Neurosci , vol.12 , pp. 623-637
    • Robison, A.J.1    Nestler, E.J.2
  • 127
    • 0032870007 scopus 로고    scopus 로고
    • Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens
    • Rosin, A., Lindholm, S., Franck, J., and Georgieva, J. (1999). Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neurosci. Lett. 275, 1-4.
    • (1999) Neurosci. Lett , vol.275 , pp. 1-4
    • Rosin, A.1    Lindholm, S.2    Franck, J.3    Georgieva, J.4
  • 128
    • 68649088591 scopus 로고    scopus 로고
    • Regulation of chromatin structure in memory formation
    • Roth, T. L., and Sweatt, J. D. (2009). Regulation of chromatin structure in memory formation. Curr. Opin. Neurobiol. 19, 336-342.
    • (2009) Curr. Opin. Neurobiol , vol.19 , pp. 336-342
    • Roth, T.L.1    Sweatt, J.D.2
  • 130
    • 0030611663 scopus 로고    scopus 로고
    • Kappa1-and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum
    • Schoffelmeer, A. N., Hogenboom, F., and Mulder, A. H. (1997). Kappa1-and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. Br. J. Pharmacol. 122, 520-524.
    • (1997) Br. J. Pharmacol , vol.122 , pp. 520-524
    • Schoffelmeer, A.N.1    Hogenboom, F.2    Mulder, A.H.3
  • 131
    • 67849101645 scopus 로고    scopus 로고
    • 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases
    • Schwarzer
    • Schwarzer, C. (2009). 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases. Pharmacol. Ther. 123, 353-370.
    • (2009) Pharmacol. Ther , vol.123 , pp. 353-370
    • Schwarzer, C.1
  • 132
    • 78349279582 scopus 로고    scopus 로고
    • Expression of serotonin transporter in mice with ethanol physical dependency
    • Shibasaki, M., Inoue, M., Kurokawa, K., Ogou, S., and Ohkuma, S. (2010). Expression of serotonin transporter in mice with ethanol physical dependency. J. Pharmacol. Sci. 114, 234-237.
    • (2010) J. Pharmacol. Sci , vol.114 , pp. 234-237
    • Shibasaki, M.1    Inoue, M.2    Kurokawa, K.3    Ogou, S.4    Ohkuma, S.5
  • 133
    • 0023489245 scopus 로고
    • Motivational properties of opioids: Evidence that an activation of delta-receptors mediates reinforcement processes
    • Shippenberg, T. S., Bals-Kubik, R., and Herz, A. (1987). Motivational properties of opioids: evidence that an activation of delta-receptors mediates reinforcement processes. Brain Res. 436, 234-239.
    • (1987) Brain Res , vol.436 , pp. 234-239
    • Shippenberg, T.S.1    Bals-Kubik, R.2    Herz, A.3
  • 134
    • 0030740849 scopus 로고    scopus 로고
    • Sensitization to the behavioral effects of cocaine: Modulation by dynorphin and kappa-opioid receptor agonists
    • Shippenberg, T. S., and Rea, W. (1997). Sensitization to the behavioral effects of cocaine: modulation by dynorphin and kappa-opioid receptor agonists. Pharmacol. Biochem. Behav. 57, 449-455.
    • (1997) Pharmacol. Biochem. Behav , vol.57 , pp. 449-455
    • Shippenberg, T.S.1    Rea, W.2
  • 135
    • 34648832260 scopus 로고    scopus 로고
    • Dynorphin and the pathophysiology of drug addiction
    • Shippenberg, T. S., Zapata, A., and Chefer, V. I. (2007). Dynorphin and the pathophysiology of drug addiction. Pharmacol. Ther. 116, 306-321.
    • (2007) Pharmacol. Ther , vol.116 , pp. 306-321
    • Shippenberg, T.S.1    Zapata, A.2    Chefer, V.I.3
  • 136
    • 77954238686 scopus 로고    scopus 로고
    • Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome
    • Shoemaker, R., Deng, J., Wang, W., and Zhang, K. (2010). Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res. 20, 883-889.
    • (2010) Genome Res , vol.20 , pp. 883-889
    • Shoemaker, R.1    Deng, J.2    Wang, W.3    Zhang, K.4
  • 138
    • 10744229214 scopus 로고    scopus 로고
    • Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation
    • Singh, I. N., Goody, R. J., Goebel, S. M., Martin, K. M., Knapp, P. E., Marinova, Z., Hirschberg, D., Yakovleva, T., Bergman, T., Bakalkin, G., and Hauser, K. F. (2003). Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation. Neuroscience 122, 1013-1023.
    • (2003) Neuroscience , vol.122 , pp. 1013-1023
    • Singh, I.N.1    Goody, R.J.2    Goebel, S.M.3    Martin, K.M.4    Knapp, P.E.5    Marinova, Z.6    Hirschberg, D.7    Yakovleva, T.8    Bergman, T.9    Bakalkin, G.10    Hauser, K.F.11
  • 139
    • 0016045280 scopus 로고
    • An opponent-process theory of motivation. I. Temporal dynamics of affect
    • Solomon, R. L., and Corbit, J. D. (1974). An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol. Rev. 81, 119-145.
    • (1974) Psychol. Rev , vol.81 , pp. 119-145
    • Solomon, R.L.1    Corbit, J.D.2
  • 140
    • 67649985942 scopus 로고    scopus 로고
    • Alcoholism: A systems approach from molecular physiology to addictive behavior
    • Spanagel, R. (2009). Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev. 89, 649-705.
    • (2009) Physiol Rev , vol.89 , pp. 649-705
    • Spanagel, R.1
  • 141
    • 0026559951 scopus 로고
    • Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
    • Spanagel, R., Herz, A., and Shippenberg, T. S. (1992). Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc. Natl. Acad. Sci. U. S. A 89, 2046-2050.
    • (1992) Proc. Natl. Acad. Sci. U. S. A , vol.89 , pp. 2046-2050
    • Spanagel, R.1    Herz, A.2    Shippenberg, T.S.3
  • 142
    • 77953288431 scopus 로고    scopus 로고
    • Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration
    • Sperling, R. E., Gomes, S. M., Sypek, E. I., Carey, A. N., and McLaughlin, J. P. (2010). Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration. Psychopharmacology (Berl) 210, 199-209.
    • (2010) Psychopharmacology (Berl) , vol.210 , pp. 199-209
    • Sperling, R.E.1    Gomes, S.M.2    Sypek, E.I.3    Carey, A.N.4    McLaughlin, J.P.5
  • 143
    • 0031949311 scopus 로고    scopus 로고
    • A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat
    • Stromberg, M. F., Casale, M., Volpicelli, L., Volpicelli, J. R., and O'Brien, C. P. (1998). A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. Alcohol 15, 281-289.
    • (1998) Alcohol , vol.15 , pp. 281-289
    • Stromberg, M.F.1    Casale, M.2    Volpicelli, L.3    Volpicelli, J.R.4    O'Brien, C.P.5
  • 146
    • 20444507161 scopus 로고    scopus 로고
    • mu-Opioids disinhibit and kappa-opioids inhibit serotonin efflux in the dorsal raphe nucleus
    • Tao, R., and Auerbach, S. B. (2005). mu-Opioids disinhibit and kappa-opioids inhibit serotonin efflux in the dorsal raphe nucleus. Brain Res. 1049, 70-79.
    • (2005) Brain Res , vol.1049 , pp. 70-79
    • Tao, R.1    Auerbach, S.B.2
  • 147
    • 79953173198 scopus 로고    scopus 로고
    • Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain
    • Taqi, M. M., Bazov, I., Watanabe, H., Nyberg, F., Yakovleva, T., and Bakalkin, G. (2011a). Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. Brain Res. 1385, 18-25.
    • (2011) Brain Res , vol.1385 , pp. 18-25
    • Taqi, M.M.1    Bazov, I.2    Watanabe, H.3    Nyberg, F.4    Yakovleva, T.5    Bakalkin, G.6
  • 149
    • 84857657943 scopus 로고    scopus 로고
    • The dynorphin/kappa-opioid receptor system and its role in psychiatric disorders
    • Tejeda, H. A., Shippenberg, T. S., and Henriksson, R. (2012). The dynorphin/kappa-opioid receptor system and its role in psychiatric disorders. Cell Mol. Life Sci. 69, 857-896.
    • (2012) Cell Mol. Life Sci , vol.69 , pp. 857-896
    • Tejeda, H.A.1    Shippenberg, T.S.2    Henriksson, R.3
  • 150
    • 0034656653 scopus 로고    scopus 로고
    • High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice
    • Thiele, T. E., Willis, B., Stadler, J., Reynolds, J. G., Bernstein, I. L., and McKnight, G. S. (2000). High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice. J. Neurosci. 20, RC75.
    • (2000) J. Neurosci , vol.20
    • Thiele, T.E.1    Willis, B.2    Stadler, J.3    Reynolds, J.G.4    Bernstein, I.L.5    McKnight, G.S.6
  • 151
    • 0037459252 scopus 로고    scopus 로고
    • Sequence context at human single nucleotide polymorphisms: Overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands
    • Tomso, D. J., and Bell, D. A. (2003). Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands. J. Mol. Biol. 327, 303-308.
    • (2003) J. Mol. Biol , vol.327 , pp. 303-308
    • Tomso, D.J.1    Bell, D.A.2
  • 152
    • 0032913423 scopus 로고    scopus 로고
    • The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat
    • Turchan, J., Przewlocka, B., Toth, G., Lason, W., Borsodi, A., and Przewlocki, R. (1999). The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience 91, 971-977.
    • (1999) Neuroscience , vol.91 , pp. 971-977
    • Turchan, J.1    Przewlocka, B.2    Toth, G.3    Lason, W.4    Borsodi, A.5    Przewlocki, R.6
  • 153
    • 0035209299 scopus 로고    scopus 로고
    • Polysubstance abuse-vulnerability genes: Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms
    • Uhl, G. R., Liu, Q. R., Walther, D., Hess, J., and Naiman, D. (2001). Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am. J. Hum. Genet. 69, 1290-1300.
    • (2001) Am. J. Hum. Genet , vol.69 , pp. 1290-1300
    • Uhl, G.R.1    Liu, Q.R.2    Walther, D.3    Hess, J.4    Naiman, D.5
  • 155
    • 37749042738 scopus 로고    scopus 로고
    • Serotonergic anti-depressants and ethanol withdrawal syndrome: A review
    • Uzbay, I. T. (2008). Serotonergic anti-depressants and ethanol withdrawal syndrome: a review. Alcohol Alcohol 43, 15-24.
    • (2008) Alcohol Alcohol , vol.43 , pp. 15-24
    • Uzbay, I.T.1
  • 156
    • 0036798776 scopus 로고    scopus 로고
    • Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor
    • Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., and Koob, G. F. (2002). Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin. Exp. Res. 26, 1494-1501.
    • (2002) Alcohol Clin. Exp. Res , vol.26 , pp. 1494-1501
    • Valdez, G.R.1    Roberts, A.J.2    Chan, K.3    Davis, H.4    Brennan, M.5    Zorrilla, E.P.6    Koob, G.F.7
  • 158
    • 84861199710 scopus 로고    scopus 로고
    • Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process
    • DOI:10.1016/j.alcohol.2012.01.001
    • Walker, B. M. (2012). Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process. Alcohol DOI:10.1016/j.alcohol.2012.01.001.
    • (2012) Alcohol
    • Walker, B.M.1
  • 159
    • 34249683744 scopus 로고    scopus 로고
    • Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats
    • Walker, B. M., and Ettenberg, A. (2007). Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats. Behav. Neurosci. 121, 401-410.
    • (2007) Behav. Neurosci , vol.121 , pp. 401-410
    • Walker, B.M.1    Ettenberg, A.2
  • 160
    • 38149072294 scopus 로고    scopus 로고
    • Pharmacological Evidence for a Motivational Role of kappa-Opioid Systems in Ethanol Dependence
    • Walker, B. M., and Koob, G. F. (2008a). Pharmacological Evidence for a Motivational Role of kappa-Opioid Systems in Ethanol Dependence. Neuropsychopharmacology 33, 643-652.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 643-652
    • Walker, B.M.1    Koob, G.F.2
  • 161
    • 38149072294 scopus 로고    scopus 로고
    • Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence
    • Walker, B. M., and Koob, G. F. (2008b). Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology 33, 643-652.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 643-652
    • Walker, B.M.1    Koob, G.F.2
  • 162
    • 84861188841 scopus 로고    scopus 로고
    • Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence
    • DOI: 10.1016/j.alcohol.2011.10.006
    • Walker, B. M., Valdez, G. R., McLaughlin, J. P., and Bakalkin, G. (2012). Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence. Alcohol DOI: 10.1016/j.alcohol.2011.10.006.
    • (2012) Alcohol
    • Walker, B.M.1    Valdez, G.R.2    McLaughlin, J.P.3    Bakalkin, G.4
  • 163
    • 78649910013 scopus 로고    scopus 로고
    • Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    • Walker, B. M., Zorrilla, E. P., and Koob, G. F. (2011). Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addict. Biol. 16, 116-119.
    • (2011) Addict. Biol , vol.16 , pp. 116-119
    • Walker, B.M.1    Zorrilla, E.P.2    Koob, G.F.3
  • 164
    • 35548990188 scopus 로고    scopus 로고
    • We gather together: Insulators and genome organization
    • Wallace, J. A., and Felsenfeld, G. (2007). We gather together: insulators and genome organization. Curr. Opin. Genet. Dev. 17, 400-407.
    • (2007) Curr. Opin. Genet. Dev , vol.17 , pp. 400-407
    • Wallace, J.A.1    Felsenfeld, G.2
  • 166
    • 77953290684 scopus 로고    scopus 로고
    • The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
    • Wee, S., and Koob, G. F. (2010). The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl) 210, 121-135.
    • (2010) Psychopharmacology (Berl) , vol.210 , pp. 121-135
    • Wee, S.1    Koob, G.F.2
  • 167
    • 0023678336 scopus 로고
    • Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs
    • Werling, L. L., Frattali, A., Portoghese, P. S., Takemori, A. E., and Cox, B. M. (1988). Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs. J. Pharmacol. Exp. Ther. 246, 282-286.
    • (1988) J. Pharmacol. Exp. Ther , vol.246 , pp. 282-286
    • Werling, L.L.1    Frattali, A.2    Portoghese, P.S.3    Takemori, A.E.4    Cox, B.M.5
  • 168
    • 0025071211 scopus 로고
    • Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization
    • Wetmore, C., Ernfors, P., Persson, H., and Olson, L. (1990). Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp. Neurol. 109, 141-152.
    • (1990) Exp. Neurol , vol.109 , pp. 141-152
    • Wetmore, C.1    Ernfors, P.2    Persson, H.3    Olson, L.4
  • 169
    • 58049150787 scopus 로고    scopus 로고
    • Dissecting motivational circuitry to understand substance abuse
    • Wheeler, R. A., and Carelli, R. M. (2009). Dissecting motivational circuitry to understand substance abuse. Neuropharmacology 56 Suppl 1, 149-159.
    • (2009) Neuropharmacology , vol.56 , Issue.SUPPL. 1 , pp. 149-159
    • Wheeler, R.A.1    Carelli, R.M.2
  • 170
  • 172
    • 64549109310 scopus 로고    scopus 로고
    • SNP-based prediction of the human germ cell methylation landscape
    • Xie, H., Wang, M., Bischof, J., Bonaldo, M. F., and Soares, M. B. (2009). SNP-based prediction of the human germ cell methylation landscape. Genomics 93, 434-540.
    • (2009) Genomics , vol.93 , pp. 434-440
    • Xie, H.1    Wang, M.2    Bischof, J.3    Bonaldo, M.F.4    Soares, M.B.5


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