NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT

Molecular Genetics and Metabolism

Volumn 104, Issue 1-2, 2011, Pages 174-179

  John, Gerrit ^a,b   Hegarty, John P ^a   Yu, Wei ^a   Berg, Arthur ^a   Pastor, Danielle M ^a   Kelly, Ashley A ^a   Wang, Yunhua ^a   Poritz, Lisa S ^a   Schreiber, Stefan ^c   Koltun, Walter A ^a   Lin, Zhenwu ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

DNA methylation; Genetic association; IBD; NFAT; NKX2 3; Transcription factor binding

Indexed keywords

BIOTIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR NKX2.3; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; B LYMPHOCYTE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA METHYLATION; ENTERITIS; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; BLOTTING, WESTERN; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HOMEODOMAIN PROTEINS; HUMANS; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NFATC TRANSCRIPTION FACTORS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 80052536374     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2011.06.023     Document Type: Article

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