The selective κ-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat

Behavioural Brain Research

Volumn 120, Issue 2, 2001, Pages 137-146

  Lindholm, Sara ^a,b   Werme, Martin ^a   Brené, Stefan ^a   Franck, Johan ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Dynorphin; Ethanol intake; Kappa; Lewis rat; Nor binaltorphimine; Opioid receptor; U50,488H

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; KAPPA OPIATE RECEPTOR; OPIATE AGONIST; OPIATE ANTAGONIST; SODIUM CHLORIDE;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FLUID INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ALCOHOL DRINKING; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DEPRESSION, CHEMICAL; DRINKING; ETHANOL; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; RATS; RATS, INBRED LEW; RECEPTORS, OPIOID, KAPPA;

EID: 0035133119     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(00)00368-5     Document Type: Article

References (49)

1. Blockade of δ-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release
2. Ascending noradrenaline neurons from the pons and the medulla oblongata
3. The κ-opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats
4. Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats
5. Evidence for the existence of monoamine neurons in the central nervous system. I. Demonstration of monoamine-containing neurons in the cell bodies of brainstem neurons
6. Differential involvement of ventral tegmental μ, δ and κ opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies
7. Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats
8. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
9. Opposite effects of μ and κ opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats
10. Nor-binaltorphimine: a potent and selective κ-opioid receptor antagonist with long-lasting activity in vivo
11. Modulation of volitional ethanol intake in the rat by central δ-opioid receptors
12. Importance of δ opioid receptors in maintaining high alcohol drinking
13. κ Opioid inhibition of morphine and cocaine self-administration in rats
14. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens
15. Endogenous opioid systems and alcohol addiction
16. The κ agonists PD117302 and U50488 produce a biphasic effect on 24 h food intake in the rat
17. Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test
18. Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats
19. Responding for oral ethanol after naloxone treatment by alcohol-preferring AA rats
20. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol
21. Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions
22. The δ 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference
23. Effect of μ opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking
24. κ-Opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice
25. Properties of a selective kappa agonist: U-50,488H
26. U50,488, a κ opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats
27. A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence
28. Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by κ-opioid receptor activation in mice
29. Bremazocine reduces unrestricted free-choice ethanol self-administration in rats without affecting sucrose preference
30. Naltrexone in the treatment of alcoholism: a clinical review
31. Opioid antagonists in the treatment of alcohol dependence: clinical efficacy and prevention of relapse
32. Binaltorphimine and nor-binaltorphimine, potent and selective κ-opioid receptor antagonists
33. Oral ethanol self-administration in the rat: effect of naloxone
34. U69593, a κ-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking
35. κ-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine
36. Drugs to decrease alcohol drinking
37. The limited access paradigm: description of one method
38. Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes
39. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
40. Cellular sites for dynorphin activation of κ-opioid receptors in the rat nucleus accumbens shell
41. Stereotaxic mapping of the monoamine pathways in the rat brain
42. Naltrexone in the treatment of alcohol dependence
43. Naltrexone blocks the post-shock increase of ethanol consumption
44. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants
45. Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide
46. Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay
47. Oral ethanol-reinforced responding in rhesus monkeys: effects of opioid antagonists selective for the μ-, κ-, or δ-receptor
48. Dopamine release in the nucleus accumbens during heroin self-administration is modulated by κ opioid receptors: an in vivo fast-cyclic voltammetry study