ΔFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction

Journal of Neuroscience

Volumn 27, Issue 39, 2007, Pages 10497-10507

  Winstanley, Catharine A ^a,c   LaPlant, Quincey ^a   Theobald, David E H ^a   Green, Thomas A ^a   Bachtell, Ryan K ^a   Perrotti, Linda I ^a   DiLeone, Ralph J ^a,d   Russo, Scott J ^a   Garth, William J ^b   Self, David W ^a   Nestler, Eric J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Delay discounting; Five choice serial reaction time task; Gene microarray; Impulsivity; Orbitofrontal cortex

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; COCAINE; METABOTROPIC RECEPTOR 5; SUBSTANCE P; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR JUND; CENTRAL STIMULANT AGENT; FOSB PROTEIN, RAT; PROTEIN C FOS; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENTION; BEHAVIOR CHANGE; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DECISION MAKING; DNA MICROARRAY; GENE TRANSFER; MALE; NONHUMAN; ORBITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; COCAINE DEPENDENCE; DISEASE MODEL; DRUG EFFECT; DRUG TOLERANCE; FRONTAL LOBE; GENE EXPRESSION PROFILING; LONG EVANS RAT; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; COCAINE-RELATED DISORDERS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DRUG TOLERANCE; FRONTAL LOBE; GENE EXPRESSION PROFILING; GENE TRANSFER TECHNIQUES; MALE; NEUROPSYCHOLOGICAL TESTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY;

EID: 34848851967     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2566-07.2007     Document Type: Article

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