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Volumn 7, Issue 1, 2011, Pages 281-322

Animal models of epigenetic regulation in neuropsychiatric disorders

Author keywords

Chromatin; Epigenetics; Histone modifying enzymes; Inhibitors

Indexed keywords

ACYLTRANSFERASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HISTONE ACETYLTRANSFERASE INHIBITOR; HISTONE DEACETYLASE; HISTONE DEACETYLASE 5; HISTONE H3; HISTONE H4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHYL CPG BINDING PROTEIN 2; METHYLTRANSFERASE; MICRORNA; UNCLASSIFIED DRUG; CHROMATIN; HISTONE;

EID: 84865818829     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2010_104     Document Type: Article
Times cited : (12)

References (173)
  • 1
    • 65249151919 scopus 로고    scopus 로고
    • Structure and function of histone methylation binding proteins
    • Adams-Cioaba MA, Min J (2009) Structure and function of histone methylation binding proteins. Biochem Cell Biol 87(1):93-105
    • (2009) Biochem Cell Biol , vol.87 , Issue.1 , pp. 93-105
    • Adams-Cioaba, M.A.1    Min, J.2
  • 2
    • 34047218122 scopus 로고    scopus 로고
    • HDAC inhibitors as anti-inflammatory agents
    • Adcock IM (2007) HDAC inhibitors as anti-inflammatory agents. Br J Pharmacol 150(7):829-831
    • (2007) Br J Pharmacol , vol.150 , Issue.7 , pp. 829-831
    • Adcock, I.M.1
  • 3
    • 0030743397 scopus 로고    scopus 로고
    • Cocaine- but not food-seeking behavior is reinstated by stress after extinction
    • Ahmed SH, Koob GF (1997) Cocaine- but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology (Berl) 132(3):289-295
    • (1997) Psychopharmacology (Berl) , vol.132 , Issue.3 , pp. 289-295
    • Ahmed, S.H.1    Koob, G.F.2
  • 4
    • 77955529815 scopus 로고    scopus 로고
    • Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids
    • Alexander VM, Roy M et al (2010) Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids. Int J Clin Exp Med 3(2):95-102
    • (2010) Int J Clin Exp Med , vol.3 , Issue.2 , pp. 95-102
    • Alexander, V.M.1    Roy, M.2
  • 5
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir RE, Van den Veyver IB et al (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23(2):185-188
    • (1999) Nat Genet , vol.23 , Issue.2 , pp. 185-188
    • Amir, R.E.1    van den Veyver, I.B.2
  • 6
    • 24144475284 scopus 로고    scopus 로고
    • Reversing histone methylation
    • Bannister AJ, Kouzarides T (2005) Reversing histone methylation. Nature 436(7054):1103-1106
    • (2005) Nature , vol.436 , Issue.7054 , pp. 1103-1106
    • Bannister, A.J.1    Kouzarides, T.2
  • 7
    • 0035282458 scopus 로고    scopus 로고
    • Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    • Bannister AJ, Zegerman P et al (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410(6824):120-124
    • (2001) Nature , vol.410 , Issue.6824 , pp. 120-124
    • Bannister, A.J.1    Zegerman, P.2
  • 8
    • 0037143736 scopus 로고    scopus 로고
    • CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
    • Barrot M, Olivier JD et al (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci USA 99(17):11435-11440
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.17 , pp. 11435-11440
    • Barrot, M.1    Olivier, J.D.2
  • 9
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2):281-297
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 10
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs
    • Bartel DP, Chen CZ (2004) Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5(5):396-400
    • (2004) Nat Rev Genet , vol.5 , Issue.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.Z.2
  • 11
    • 32444451651 scopus 로고    scopus 로고
    • Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    • Berton O, McClung CA et al (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311(5762):864-868
    • (2006) Science , vol.311 , Issue.5762 , pp. 864-868
    • Berton, O.1    McClung, C.A.2
  • 12
    • 78649575471 scopus 로고    scopus 로고
    • NF-{kappa}B as a central regulator of macrophage function in tumors
    • Biswas SK, Lewis CE (2010) NF-{kappa}B as a central regulator of macrophage function in tumors. J Leukoc Biol 88(5):877-884
    • (2010) J Leukoc Biol , vol.88 , Issue.5 , pp. 877-884
    • Biswas, S.K.1    Lewis, C.E.2
  • 13
    • 77954090605 scopus 로고    scopus 로고
    • Histone lysine methylation: An epigenetic modification?
    • Blackledge NP, Klose R (2010) Histone lysine methylation: an epigenetic modification? Epigenomics 2(1):151-161
    • (2010) Epigenomics , vol.2 , Issue.1 , pp. 151-161
    • Blackledge, N.P.1    Klose, R.2
  • 14
    • 57649239938 scopus 로고    scopus 로고
    • Decoding the epigenetic language of neuronal plasticity
    • Borrelli E, Nestler EJ et al (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60(6):961-974
    • (2008) Neuron , vol.60 , Issue.6 , pp. 961-974
    • Borrelli, E.1    Nestler, E.J.2
  • 15
    • 77249087051 scopus 로고    scopus 로고
    • Chemical phylogenetics of histone deacetylases
    • Bradner JE, West N et al (2009) Chemical phylogenetics of histone deacetylases. Nat Chem Biol 6(3):238-243
    • (2009) Nat Chem Biol , vol.6 , Issue.3 , pp. 238-243
    • Bradner, J.E.1    West, N.2
  • 16
    • 61349185158 scopus 로고    scopus 로고
    • Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse
    • Brami-Cherrier K, Roze E et al (2009) Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. J Neurochem 108(6):1323-1335
    • (2009) J Neurochem , vol.108 , Issue.6 , pp. 1323-1335
    • Brami-Cherrier, K.1    Roze, E.2
  • 17
    • 77953384502 scopus 로고    scopus 로고
    • Novel targeted drug therapies for the treatment of childhood acute leukemia
    • Brown P, Hunger SP et al (2009) Novel targeted drug therapies for the treatment of childhood acute leukemia. Expert Rev Hematol 2(9):145
    • (2009) Expert Rev Hematol , vol.2 , Issue.9 , pp. 145
    • Brown, P.1    Hunger, S.P.2
  • 18
    • 27144478270 scopus 로고    scopus 로고
    • Clinical profile of a male with Rett syndrome
    • Budden SS, Dorsey HC et al (2005) Clinical profile of a male with Rett syndrome. Brain Dev 27(Suppl 1):S69-S71
    • (2005) Brain Dev , vol.27 , Issue.SUPPL. 1
    • Budden, S.S.1    Dorsey, H.C.2
  • 19
    • 20644461933 scopus 로고    scopus 로고
    • Regulation of cocaine reward by CREB
    • Carlezon WA Jr, Thome J et al (1998) Regulation of cocaine reward by CREB. Science 282 (5397):2272-2275
    • (1998) Science , vol.282 , Issue.5397 , pp. 2272-2275
    • Carlezon Jr., W.A.1    Thome, J.2
  • 20
    • 0038626842 scopus 로고    scopus 로고
    • Identification of MeCP2 mutations in a series of females with autistic disorder
    • Carney RM, Wolpert CM et al (2003) Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr Neurol 28(3):205-211
    • (2003) Pediatr Neurol , vol.28 , Issue.3 , pp. 205-211
    • Carney, R.M.1    Wolpert, C.M.2
  • 21
    • 34247104576 scopus 로고    scopus 로고
    • A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy
    • Cavalleri GL, Walley NM et al (2007) A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy. Epilepsia 48(4):706-712
    • (2007) Epilepsia , vol.48 , Issue.4 , pp. 706-712
    • Cavalleri, G.L.1    Walley, N.M.2
  • 22
    • 44949262153 scopus 로고    scopus 로고
    • Maternal care and hippocampal plasticity: Evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    • Champagne DL, Bagot RC et al (2008) Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J Neurosci 28(23):6037-6045
    • (2008) J Neurosci , vol.28 , Issue.23 , pp. 6037-6045
    • Champagne, D.L.1    Bagot, R.C.2
  • 23
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    • Chen RZ, Akbarian S et al (2001) Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27(3):327-331
    • (2001) Nat Genet , vol.27 , Issue.3 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2
  • 24
    • 0037342258 scopus 로고    scopus 로고
    • Glioma apoptosis induced by macrophages involves both death receptor-dependent and independent pathways
    • Chen GG, Chak EC et al (2003a) Glioma apoptosis induced by macrophages involves both death receptor-dependent and independent pathways. J Lab Clin Med 141(3):190-199
    • (2003) J Lab Clin Med , vol.141 , Issue.3 , pp. 190-199
    • Chen, G.G.1    Chak, E.C.2
  • 25
    • 0242332183 scopus 로고    scopus 로고
    • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    • Chen WG, Chang Q et al (2003b) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302(5646):885-889
    • (2003) Science , vol.302 , Issue.5646 , pp. 885-889
    • Chen, W.G.1    Chang, Q.2
  • 26
    • 8444253290 scopus 로고    scopus 로고
    • Mild overexpression of MeCP2 causes a progressive neurological disorder in mice
    • Collins AL, Levenson JM et al (2004) Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet 13(21):2679-2689
    • (2004) Hum Mol Genet , vol.13 , Issue.21 , pp. 2679-2689
    • Collins, A.L.1    Levenson, J.M.2
  • 27
    • 40949148102 scopus 로고    scopus 로고
    • The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules
    • Collins RE, Northrop JP et al (2008) The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol 15(3):245-250
    • (2008) Nat Struct Mol Biol , vol.15 , Issue.3 , pp. 245-250
    • Collins, R.E.1    Northrop, J.P.2
  • 28
    • 70349085803 scopus 로고    scopus 로고
    • Antidepressant actions of histone deacetylase inhibitors
    • Covington HE 3rd, Maze I et al (2009) Antidepressant actions of histone deacetylase inhibitors. J Neurosci 29(37):11451-11460
    • (2009) J Neurosci , vol.29 , Issue.37 , pp. 11451-11460
    • Covington III, H.E.1    Maze, I.2
  • 29
    • 77949421463 scopus 로고    scopus 로고
    • Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
    • Culhane JC, Wang D et al (2010) Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc 132(9):3164-3176
    • (2010) J Am Chem Soc , vol.132 , Issue.9 , pp. 3164-3176
    • Culhane, J.C.1    Wang, D.2
  • 30
    • 34548456881 scopus 로고    scopus 로고
    • Dietary histone deacetylase inhibitors: From cells to mice to man
    • Dashwood RH, Ho E (2007) Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol 17(5):363-369
    • (2007) Semin Cancer Biol , vol.17 , Issue.5 , pp. 363-369
    • Dashwood, R.H.1    Ho, E.2
  • 31
    • 7244221348 scopus 로고    scopus 로고
    • DNA methylation, cancer susceptibility, and nutrient interactions
    • Davis CD, Uthus EO (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood) 229(10):988-995
    • (2004) Exp Biol Med (Maywood) , vol.229 , Issue.10 , pp. 988-995
    • Davis, C.D.1    Uthus, E.O.2
  • 32
    • 33846062357 scopus 로고    scopus 로고
    • MECP2 mutant allele in a boy with Rett syndrome and his unaffected heterozygous mother
    • Dayer AG, Bottani A et al (2007) MECP2 mutant allele in a boy with Rett syndrome and his unaffected heterozygous mother. Brain Dev 29(1):47-50
    • (2007) Brain Dev , vol.29 , Issue.1 , pp. 47-50
    • Dayer, A.G.1    Bottani, A.2
  • 33
    • 0033519641 scopus 로고    scopus 로고
    • Structure and ligand of a histone acetyltransferase bromodomain
    • Dhalluin C, Carlson JE et al (1999) Structure and ligand of a histone acetyltransferase bromodomain. Nature 399(6735):491-496
    • (1999) Nature , vol.399 , Issue.6735 , pp. 491-496
    • Dhalluin, C.1    Carlson, J.E.2
  • 34
    • 24644518545 scopus 로고    scopus 로고
    • Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia
    • Dong E, Agis-Balboa RC et al (2005) Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc Natl Acad Sci USA 102(35):12578-12583
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.35 , pp. 12578-12583
    • Dong, E.1    Agis-Balboa, R.C.2
  • 35
    • 77955909849 scopus 로고    scopus 로고
    • Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease
    • Dong J, Jimi E et al (2010) Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev 24(16):1709-1717
    • (2010) Genes Dev , vol.24 , Issue.16 , pp. 1709-1717
    • Dong, J.1    Jimi, E.2
  • 36
    • 67650506936 scopus 로고    scopus 로고
    • Open access chemical and clinical probes to support drug discovery
    • Edwards AM, Bountra C et al (2009) Open access chemical and clinical probes to support drug discovery. Nat Chem Biol 5(7):436-440
    • (2009) Nat Chem Biol , vol.5 , Issue.7 , pp. 436-440
    • Edwards, A.M.1    Bountra, C.2
  • 37
    • 0029949690 scopus 로고    scopus 로고
    • Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period
    • Erb S, Shaham Y et al (1996) Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology (Berl) 128(4):408-412
    • (1996) Psychopharmacology (Berl) , vol.128 , Issue.4 , pp. 408-412
    • Erb, S.1    Shaham, Y.2
  • 38
    • 70349739288 scopus 로고    scopus 로고
    • Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism
    • Escoubet-Lozach L, Lin IL et al (2009) Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res 69(18):7347-7356
    • (2009) Cancer Res , vol.69 , Issue.18 , pp. 7347-7356
    • Escoubet-Lozach, L.1    Lin, I.L.2
  • 39
    • 24344497413 scopus 로고    scopus 로고
    • Methyl-CpG binding proteins in the nervous system
    • Fan G, Hutnick L (2005) Methyl-CpG binding proteins in the nervous system. Cell Res 15 (4):255-261
    • (2005) Cell Res , vol.15 , Issue.4 , pp. 255-261
    • Fan, G.1    Hutnick, L.2
  • 40
    • 67651241751 scopus 로고    scopus 로고
    • Evidence for X-chromosomal schizophrenia associated with microRNA alterations
    • Feng J, Sun G et al (2009) Evidence for X-chromosomal schizophrenia associated with microRNA alterations. PLoS One 4(7):e6121
    • (2009) PLoS One , vol.4 , Issue.7
    • Feng, J.1    Sun, G.2
  • 41
    • 77953764486 scopus 로고    scopus 로고
    • Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic
    • Ferraris DV (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J Med Chem 53(12):4561-4584
    • (2010) J Med Chem , vol.53 , Issue.12 , pp. 4561-4584
    • Ferraris, D.V.1
  • 42
    • 0035434378 scopus 로고    scopus 로고
    • You bet-cha: A novel family of transcriptional regulators
    • Florence B, Faller DV (2001) You bet-cha: a novel family of transcriptional regulators. Front Biosci 6:D1008-D1018
    • (2001) Front Biosci , vol.6
    • Florence, B.1    Faller, D.V.2
  • 43
    • 36549081297 scopus 로고    scopus 로고
    • Chromatin-modifying proteins in cancer
    • Fog CK, Jensen KT et al (2007) Chromatin-modifying proteins in cancer. APMIS 115 (10):1060-1089
    • (2007) APMIS , vol.115 , Issue.10 , pp. 1060-1089
    • Fog, C.K.1    Jensen, K.T.2
  • 44
    • 0033527727 scopus 로고    scopus 로고
    • Nongenomic transmission across generations of maternal behavior and stress responses in the rat
    • Francis D, Diorio J et al (1999) Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286(5442):1155-1158
    • (1999) Science , vol.286 , Issue.5442 , pp. 1155-1158
    • Francis, D.1    Diorio, J.2
  • 45
    • 0037423186 scopus 로고    scopus 로고
    • The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
    • Fuks F, Hurd PJ et al (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 278(6):4035-4040
    • (2003) J Biol Chem , vol.278 , Issue.6 , pp. 4035-4040
    • Fuks, F.1    Hurd, P.J.2
  • 46
    • 33846924001 scopus 로고    scopus 로고
    • Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
    • Giacometti E, Luikenhuis S et al (2007) Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. Proc Natl Acad Sci USA 104(6):1931-1936
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.6 , pp. 1931-1936
    • Giacometti, E.1    Luikenhuis, S.2
  • 47
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll MG, Bestor TH (2005) Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74:481-514
    • (2005) Annu Rev Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 48
    • 74549200467 scopus 로고    scopus 로고
    • Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
    • Grayson DR, Kundakovic M et al (2008) Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol 77(2):126-135
    • (2008) Mol Pharmacol , vol.77 , Issue.2 , pp. 126-135
    • Grayson, D.R.1    Kundakovic, M.2
  • 49
    • 33748187139 scopus 로고    scopus 로고
    • Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli
    • Green TA, Alibhai IN et al (2006) Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci 26(32):8235-8242
    • (2006) J Neurosci , vol.26 , Issue.32 , pp. 8235-8242
    • Green, T.A.1    Alibhai, I.N.2
  • 50
    • 30644474460 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
    • Greiner D, Bonaldi T et al (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1(3):143-145
    • (2005) Nat Chem Biol , vol.1 , Issue.3 , pp. 143-145
    • Greiner, D.1    Bonaldi, T.2
  • 51
    • 0035914304 scopus 로고    scopus 로고
    • Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
    • Grozinger CM, Chao ED et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276(42):38837-38843
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38837-38843
    • Grozinger, C.M.1    Chao, E.D.2
  • 52
    • 65549123471 scopus 로고    scopus 로고
    • HDAC2 negatively regulates memory formation and synaptic plasticity
    • Guan JS, Haggarty SJ et al (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459(7243):55-60
    • (2009) Nature , vol.459 , Issue.7243 , pp. 55-60
    • Guan, J.S.1    Haggarty, S.J.2
  • 53
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    • Guy J, Hendrich B et al (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27(3):322-326
    • (2001) Nat Genet , vol.27 , Issue.3 , pp. 322-326
    • Guy, J.1    Hendrich, B.2
  • 54
    • 33847266846 scopus 로고    scopus 로고
    • Reversal of neurological defects in a mouse model of Rett syndrome
    • Guy J, Gan J et al (2007) Reversal of neurological defects in a mouse model of Rett syndrome. Science 315(5815):1143-1147
    • (2007) Science , vol.315 , Issue.5815 , pp. 1143-1147
    • Guy, J.1    Gan, J.2
  • 55
    • 39049159734 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Possible implications for neurodegenerative disorders
    • Hahnen E, Hauke J et al (2008) Histone deacetylase inhibitors: possible implications for neurodegenerative disorders. Expert Opin Investig Drugs 17(2):169-184
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.2 , pp. 169-184
    • Hahnen, E.1    Hauke, J.2
  • 56
    • 0035261255 scopus 로고    scopus 로고
    • Post-transcriptional gene silencing by double-stranded RNA
    • Hammond SM, Caudy AA et al (2001) Post-transcriptional gene silencing by double-stranded RNA. Nat Rev Genet 2(2):110-119
    • (2001) Nat Rev Genet , vol.2 , Issue.2 , pp. 110-119
    • Hammond, S.M.1    Caudy, A.A.2
  • 57
    • 33749260519 scopus 로고    scopus 로고
    • Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going?
    • Hassa PO, Haenni SS et al (2006) Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev 70(3):789-829
    • (2006) Microbiol Mol Biol Rev , vol.70 , Issue.3 , pp. 789-829
    • Hassa, P.O.1    Haenni, S.S.2
  • 58
    • 60549087188 scopus 로고    scopus 로고
    • A novel, enigmatic histone modification: Biotinylation of histones by holocarboxylase synthetase
    • Hassan YI, Zempleni J (2008) A novel, enigmatic histone modification: biotinylation of histones by holocarboxylase synthetase. Nutr Rev 66(12):721-725
    • (2008) Nutr Rev , vol.66 , Issue.12 , pp. 721-725
    • Hassan, Y.I.1    Zempleni, J.2
  • 59
    • 59949084113 scopus 로고    scopus 로고
    • Nonenzymatic biotinylation of histone H2A
    • Healy S, Heightman TD et al (2009) Nonenzymatic biotinylation of histone H2A. Protein Sci 18(2):314-328
    • (2009) Protein Sci , vol.18 , Issue.2 , pp. 314-328
    • Healy, S.1    Heightman, T.D.2
  • 61
    • 33646254136 scopus 로고    scopus 로고
    • Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    • Heltweg B, Gatbonton T et al (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66(8):4368-4377
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4368-4377
    • Heltweg, B.1    Gatbonton, T.2
  • 62
    • 77952170915 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor MS-275 exhibits poor brain penetration: Pharmacokinetic studies of [11C]MS-275 using positron emission tomography
    • Hooker J, Kim SW et al (2010) Histone deacetylase inhibitor MS-275 exhibits poor brain penetration: pharmacokinetic studies of [11C]MS-275 using positron emission tomography. ACS Chem Neurosci 1(1):65-73
    • (2010) ACS Chem Neurosci , vol.1 , Issue.1 , pp. 65-73
    • Hooker, J.1    Kim, S.W.2
  • 63
    • 77951237809 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
    • Hrzenjak A, Moinfar F et al (2010) Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer 9:49
    • (2010) Mol Cancer , vol.9 , pp. 49
    • Hrzenjak, A.1    Moinfar, F.2
  • 64
    • 61749088806 scopus 로고    scopus 로고
    • Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
    • Huang B, Yang XD et al (2009) Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol 29(5):1375-1387
    • (2009) Mol Cell Biol , vol.29 , Issue.5 , pp. 1375-1387
    • Huang, B.1    Yang, X.D.2
  • 65
    • 77749277177 scopus 로고    scopus 로고
    • The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing
    • Huang Y, Pastor WA et al (2010) The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One 5(1):e8888
    • (2010) PLoS One , vol.5 , Issue.1
    • Huang, Y.1    Pastor, W.A.2
  • 66
    • 33748371601 scopus 로고    scopus 로고
    • Neural mechanisms of addiction: The role of reward-related learning and memory
    • Hyman SE, Malenka RC et al (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565-598
    • (2006) Annu Rev Neurosci , vol.29 , pp. 565-598
    • Hyman, S.E.1    Malenka, R.C.2
  • 67
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245-254
    • (2003) Nat Genet , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 68
    • 0032893989 scopus 로고    scopus 로고
    • Male Rett syndrome variant: Application of diagnostic criteria
    • Jan MM, Dooley JM et al (1999) Male Rett syndrome variant: application of diagnostic criteria. Pediatr Neurol 20(3):238-240
    • (1999) Pediatr Neurol , vol.20 , Issue.3 , pp. 238-240
    • Jan, M.M.1    Dooley, J.M.2
  • 69
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD (2001) Translating the histone code. Science 293(5532):1074-1080
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 70
    • 77954024844 scopus 로고    scopus 로고
    • HDAC inhibitor-mediated radiosensitization in human carcinoma cells: A general phenomenon?
    • Kim IA, Kim IH et al (2010) HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? J Radiat Res (Tokyo) 51(3):257-263
    • (2010) J Radiat Res (Tokyo) , vol.51 , Issue.3 , pp. 257-263
    • Kim, I.A.1    Kim, I.H.2
  • 71
    • 0036207456 scopus 로고    scopus 로고
    • A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome
    • Klauck SM, Lindsay S et al (2002) A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome. Am J Hum Genet 70(4):1034-1037
    • (2002) Am J Hum Genet , vol.70 , Issue.4 , pp. 1034-1037
    • Klauck, S.M.1    Lindsay, S.2
  • 72
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose RJ, Bird AP (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31(2):89-97
    • (2006) Trends Biochem Sci , vol.31 , Issue.2 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 73
    • 34548060394 scopus 로고    scopus 로고
    • Stress, dysregulation of drug reward pathways, and the transition to drug dependence
    • Koob G, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 164(8):1149-1159
    • (2007) Am J Psychiatry , vol.164 , Issue.8 , pp. 1149-1159
    • Koob, G.1    Kreek, M.J.2
  • 74
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T (2007) Chromatin modifications and their function. Cell 128(4):693-705
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 75
    • 35748965898 scopus 로고    scopus 로고
    • Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression
    • Kovacheva VP, Mellott TJ et al (2007) Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem 282(43): 31777-31788
    • (2007) J Biol Chem , vol.282 , Issue.43 , pp. 31777-31788
    • Kovacheva, V.P.1    Mellott, T.J.2
  • 76
    • 0141925713 scopus 로고    scopus 로고
    • DNA methylation and Rett syndrome
    • Kriaucionis S, Bird A (2003) DNA methylation and Rett syndrome. Hum Mol Genet 12 Spec No 2: R221-R227
    • (2003) Hum Mol Genet , vol.12 , Issue.2
    • Kriaucionis, S.1    Bird, A.2
  • 77
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S, Heintz N (2009) The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324(5929):929-930
    • (2009) Science , vol.324 , Issue.5929 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 78
    • 33846783261 scopus 로고    scopus 로고
    • Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
    • Kubicek S, O'Sullivan RJ et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25(3):473-481
    • (2007) Mol Cell , vol.25 , Issue.3 , pp. 473-481
    • Kubicek, S.1    O'Sullivan, R.J.2
  • 79
    • 26944474790 scopus 로고    scopus 로고
    • Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    • Kumar A, Choi KH et al (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48(2):303-314
    • (2005) Neuron , vol.48 , Issue.2 , pp. 303-314
    • Kumar, A.1    Choi, K.H.2
  • 80
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner M, O'Carroll D et al (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410(6824):116-120
    • (2001) Nature , vol.410 , Issue.6824 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2
  • 81
    • 0034540747 scopus 로고    scopus 로고
    • Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome
    • Lam CW, Yeung WL et al (2000) Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome. J Med Genet 37(12):E41
    • (2000) J Med Genet , vol.37 , Issue.12
    • Lam, C.W.1    Yeung, W.L.2
  • 82
    • 77957859998 scopus 로고    scopus 로고
    • Abrogation of NF-{kappa}B signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation
    • Langereis JD, Raaijmakers HA et al (2010) Abrogation of NF-{kappa}B signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation. J Leukoc Biol 88:655-664
    • (2010) J Leukoc Biol , vol.88 , pp. 655-664
    • Langereis, J.D.1    Raaijmakers, H.A.2
  • 83
    • 0033714888 scopus 로고    scopus 로고
    • HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
    • Lau OD, Kundu TK et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell 5(3):589-595
    • (2000) Mol Cell , vol.5 , Issue.3 , pp. 589-595
    • Lau, O.D.1    Kundu, T.K.2
  • 84
    • 33745187327 scopus 로고    scopus 로고
    • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications
    • Lee MG, Wynder C et al (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol 13(6):563-567
    • (2006) Chem Biol , vol.13 , Issue.6 , pp. 563-567
    • Lee, M.G.1    Wynder, C.2
  • 85
    • 77957091318 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair
    • Lee JH, Choy ML et al (2010) Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci USA 107(33):14639-14644
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.33 , pp. 14639-14644
    • Lee, J.H.1    Choy, M.L.2
  • 86
    • 13244276460 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory formation
    • Levenson JM, Sweatt JD (2005) Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6(2):108-118
    • (2005) Nat Rev Neurosci , vol.6 , Issue.2 , pp. 108-118
    • Levenson, J.M.1    Sweatt, J.D.2
  • 87
    • 79959223990 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells
    • Li X, Chen BD (2009) Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells. Am J Biomed Sci 1(4):352-363
    • (2009) Am J Biomed Sci , vol.1 , Issue.4 , pp. 352-363
    • Li, X.1    Chen, B.D.2
  • 88
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH et al (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69(6):915-926
    • (1992) Cell , vol.69 , Issue.6 , pp. 915-926
    • Li, E.1    Bestor, T.H.2
  • 89
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister R, Pelizzola M et al (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462(7271):315-322
    • (2009) Nature , vol.462 , Issue.7271 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2
  • 90
    • 15144344289 scopus 로고    scopus 로고
    • Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
    • Liu D, Diorio J et al (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277(5332):1659-1662
    • (1997) Science , vol.277 , Issue.5332 , pp. 1659-1662
    • Liu, D.1    Diorio, J.2
  • 91
    • 73249124141 scopus 로고    scopus 로고
    • Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
    • Liu F, Chen X et al (2009) Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem 52(24):7950-7953
    • (2009) J Med Chem , vol.52 , Issue.24 , pp. 7950-7953
    • Liu, F.1    Chen, X.2
  • 92
    • 67649510355 scopus 로고    scopus 로고
    • Oxygenase catalyzed 5-methylcytosine hydroxylation
    • Loenarz C, Schofield CJ (2009) Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem Biol 16(6):580-583
    • (2009) Chem Biol , vol.16 , Issue.6 , pp. 580-583
    • Loenarz, C.1    Schofield, C.J.2
  • 93
    • 77952413052 scopus 로고    scopus 로고
    • SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
    • Luthi-Carter R, Taylor DM et al (2010) SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci USA 107(17):7927-7932
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.17 , pp. 7927-7932
    • Luthi-Carter, R.1    Taylor, D.M.2
  • 94
    • 70349100446 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Current status and overview of recent clinical trials
    • Ma X, Ezzeldin HH et al (2009) Histone deacetylase inhibitors: current status and overview of recent clinical trials. Drugs 69(14):1911-1934
    • (2009) Drugs , vol.69 , Issue.14 , pp. 1911-1934
    • Ma, X.1    Ezzeldin, H.H.2
  • 95
    • 0036818764 scopus 로고    scopus 로고
    • De novo MECP2 mutation in a 46, XX male patient with Rett syndrome
    • Maiwald R, Bonte A et al (2002) De novo MECP2 mutation in a 46, XX male patient with Rett syndrome. Neurogenetics 4(2):107-108
    • (2002) Neurogenetics , vol.4 , Issue.2 , pp. 107-108
    • Maiwald, R.1    Bonte, A.2
  • 96
    • 34250308083 scopus 로고    scopus 로고
    • Specific inhibition of p300-HAT alters global gene expression and represses HIV replication
    • Mantelingu K, Reddy BA et al (2007) Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol 14(6):645-657
    • (2007) Chem Biol , vol.14 , Issue.6 , pp. 645-657
    • Mantelingu, K.1    Reddy, B.A.2
  • 97
    • 67649379393 scopus 로고    scopus 로고
    • Histone acetyltransferase inhibitors and preclinical studies
    • Manzo F, Tambaro FP et al (2009) Histone acetyltransferase inhibitors and preclinical studies. Expert Opin Ther Pat 19(6):761-774
    • (2009) Expert Opin Ther Pat , vol.19 , Issue.6 , pp. 761-774
    • Manzo, F.1    Tambaro, F.P.2
  • 98
    • 23944476557 scopus 로고    scopus 로고
    • Classic Rett syndrome in a boy with R133C mutation of MECP2
    • Masuyama T, Matsuo M et al (2005) Classic Rett syndrome in a boy with R133C mutation of MECP2. Brain Dev 27(6):439-442
    • (2005) Brain Dev , vol.27 , Issue.6 , pp. 439-442
    • Masuyama, T.1    Matsuo, M.2
  • 99
    • 74249105659 scopus 로고    scopus 로고
    • Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    • Maze I, Covington HE 3rd et al (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327(5962):213-216
    • (2010) Science , vol.327 , Issue.5962 , pp. 213-216
    • Maze, I.1    Covington III, H.E.2
  • 100
    • 33845287975 scopus 로고    scopus 로고
    • Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome
    • McGill BE, Bundle SF et al (2006) Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 103(48):18267-18272
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.48 , pp. 18267-18272
    • McGill, B.E.1    Bundle, S.F.2
  • 102
    • 53349103842 scopus 로고    scopus 로고
    • Diet and the epigenetic (re)programming of phenotypic differences in behavior
    • McGowan PO, Meaney MJ et al (2008) Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res 1237:12-24
    • (2008) Brain Res , vol.1237 , pp. 12-24
    • McGowan, P.O.1    Meaney, M.J.2
  • 103
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • McGowan PO, Sasaki A et al (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12(3):342-348
    • (2009) Nat Neurosci , vol.12 , Issue.3 , pp. 342-348
    • McGowan, P.O.1    Sasaki, A.2
  • 104
    • 1242314197 scopus 로고    scopus 로고
    • Dysregulation in the suicide brain: MRNA expression of corticotrophin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region
    • Merali Z, Du L et al (2004) Dysregulation in the suicide brain: mRNA expression of corticotrophin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. J Neurosci 24(6):1478-1485
    • (2004) J Neurosci , vol.24 , Issue.6 , pp. 1478-1485
    • Merali, Z.1    Du, L.2
  • 105
    • 24144462170 scopus 로고    scopus 로고
    • LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
    • Metzger E, Wissmann M et al (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437(7057):436-439
    • (2005) Nature , vol.437 , Issue.7057 , pp. 436-439
    • Metzger, E.1    Wissmann, M.2
  • 106
    • 37749026136 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
    • Metzger E, Yin N et al (2008) Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol 10(1):53
    • (2008) Nat Cell Biol , vol.10 , Issue.1 , pp. 53
    • Metzger, E.1    Yin, N.2
  • 107
    • 18144425480 scopus 로고    scopus 로고
    • Another patient with MECP2 mutation without classic Rett syndrome phenotype
    • Milani D, Pantaleoni C et al (2005) Another patient with MECP2 mutation without classic Rett syndrome phenotype. Pediatr Neurol 32(5):355-357
    • (2005) Pediatr Neurol , vol.32 , Issue.5 , pp. 355-357
    • Milani, D.1    Pantaleoni, C.2
  • 108
    • 43149122898 scopus 로고    scopus 로고
    • Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells
    • Minsky N, Shema E et al (2008) Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat Cell Biol 10(4):483-488
    • (2008) Nat Cell Biol , vol.10 , Issue.4 , pp. 483-488
    • Minsky, N.1    Shema, E.2
  • 109
    • 84865827091 scopus 로고    scopus 로고
    • Note
    • Mitsubishi/Tanabe (Int. Pat. Appl. WO09/084693)
  • 110
    • 12744261491 scopus 로고    scopus 로고
    • Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
    • Moretti P, Bouwknecht JA et al (2005) Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome. Hum Mol Genet 14(2):205-220
    • (2005) Hum Mol Genet , vol.14 , Issue.2 , pp. 205-220
    • Moretti, P.1    Bouwknecht, J.A.2
  • 111
    • 61449229353 scopus 로고    scopus 로고
    • A genome-wide investigation of SNPs and CNVs in schizophrenia
    • Need AC, Ge D et al (2009) A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet 5(2):e1000373
    • (2009) PLoS Genet , vol.5 , Issue.2
    • Need, A.C.1    Ge, D.2
  • 112
    • 0033119780 scopus 로고    scopus 로고
    • DNA methylation and chromatin modification
    • Ng HH, Bird A (1999) DNA methylation and chromatin modification. Curr Opin Genet Dev 9 (2):158-163
    • (1999) Curr Opin Genet Dev , vol.9 , Issue.2 , pp. 158-163
    • Ng, H.H.1    Bird, A.2
  • 113
    • 34447133035 scopus 로고    scopus 로고
    • Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
    • Ng SS, Kavanagh KL et al (2007) Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature 448(7149):87
    • (2007) Nature , vol.448 , Issue.7149 , pp. 87
    • Ng, S.S.1    Kavanagh, K.L.2
  • 114
    • 30744479491 scopus 로고    scopus 로고
    • Dietary choline deficiency alters global and genespecific DNA methylation in the developing hippocampus of mouse fetal brains
    • Niculescu MD, Craciunescu CN et al (2006) Dietary choline deficiency alters global and genespecific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J 20 (1):43-49
    • (2006) FASEB J , vol.20 , Issue.1 , pp. 43-49
    • Niculescu, M.D.1    Craciunescu, C.N.2
  • 115
    • 26444516160 scopus 로고    scopus 로고
    • Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome
    • Nuber UA, Kriaucionis S et al (2005) Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet 14(15):2247-2256
    • (2005) Hum Mol Genet , vol.14 , Issue.15 , pp. 2247-2256
    • Nuber, U.A.1    Kriaucionis, S.2
  • 116
    • 34547599329 scopus 로고    scopus 로고
    • Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    • Outeiro TF, Kontopoulos E et al (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317(5837):516-519
    • (2007) Science , vol.317 , Issue.5837 , pp. 516-519
    • Outeiro, T.F.1    Kontopoulos, E.2
  • 117
    • 77950246109 scopus 로고    scopus 로고
    • SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    • Pacholec M, Bleasdale JE et al (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285(11):8340-8351
    • (2010) J Biol Chem , vol.285 , Issue.11 , pp. 8340-8351
    • Pacholec, M.1    Bleasdale, J.E.2
  • 118
    • 20144372893 scopus 로고    scopus 로고
    • SIRT1 regulates HIV transcription via Tat deacetylation
    • Pagans S, Pedal A et al (2005) SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 3(2):e41
    • (2005) PLoS Biol , vol.3 , Issue.2
    • Pagans, S.1    Pedal, A.2
  • 119
    • 70349671463 scopus 로고    scopus 로고
    • Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks
    • Palmieri D, Lockman PR et al (2009) Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks. Clin Cancer Res 15 (19):6148-6157
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6148-6157
    • Palmieri, D.1    Lockman, P.R.2
  • 120
    • 41149089267 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: From bench to clinic
    • Paris M, Porcelloni M et al (2008) Histone deacetylase inhibitors: from bench to clinic. J Med Chem 51(6):1505
    • (2008) J Med Chem , vol.51 , Issue.6 , pp. 1505
    • Paris, M.1    Porcelloni, M.2
  • 121
    • 0015298215 scopus 로고
    • The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
    • Penn NW, Suwalski R et al (1972) The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126(4):781-790
    • (1972) Biochem J , vol.126 , Issue.4 , pp. 781-790
    • Penn, N.W.1    Suwalski, R.2
  • 122
    • 73549094015 scopus 로고    scopus 로고
    • Aurora kinase inhibitors: A new class of drugs targeting the regulatory mitotic system
    • Perez Fidalgo JA, Roda D et al (2009) Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system. Clin Transl Oncol 11(12):787
    • (2009) Clin Transl Oncol , vol.11 , Issue.12 , pp. 787
    • Perez, F.J.A.1    Roda, D.2
  • 123
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • Petronis A (2010) Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 465(7299):721-727
    • (2010) Nature , vol.465 , Issue.7299 , pp. 721-727
    • Petronis, A.1
  • 124
    • 30944437615 scopus 로고    scopus 로고
    • Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
    • Pogribny IP, Ross SA et al (2006) Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res 593(1-2):80-87
    • (2006) Mutat Res , vol.593 , Issue.1-2 , pp. 80-87
    • Pogribny, I.P.1    Ross, S.A.2
  • 125
    • 52949099506 scopus 로고    scopus 로고
    • GABAA receptor promoter hypermethylation in suicide brain: Implications for the involvement of epigenetic processes
    • Poulter MO, Du L et al (2008) GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biol Psychiatry 64(8):645-652
    • (2008) Biol Psychiatry , vol.64 , Issue.8 , pp. 645-652
    • Poulter, M.O.1    Du, L.2
  • 126
    • 77951161223 scopus 로고    scopus 로고
    • A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics
    • Quinn AM, Bedford MT et al (2009) A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res 38(2):e11
    • (2009) Nucleic Acids Res , vol.38 , Issue.2
    • Quinn, A.M.1    Bedford, M.T.2
  • 127
    • 35648934049 scopus 로고    scopus 로고
    • Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
    • Renthal W, Maze I et al (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56(3):517-529
    • (2007) Neuron , vol.56 , Issue.3 , pp. 517-529
    • Renthal, W.1    Maze, I.2
  • 128
    • 49049122082 scopus 로고    scopus 로고
    • Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure
    • Renthal W, Carle TL et al (2008) Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci 28(29):7344-7349
    • (2008) J Neurosci , vol.28 , Issue.29 , pp. 7344-7349
    • Renthal, W.1    Carle, T.L.2
  • 129
    • 65549142573 scopus 로고    scopus 로고
    • Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins
    • Renthal W, Kumar A et al (2009) Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62(3):335-348
    • (2009) Neuron , vol.62 , Issue.3 , pp. 335-348
    • Renthal, W.1    Kumar, A.2
  • 130
    • 4544359112 scopus 로고    scopus 로고
    • Structural plasticity associated with exposure to drugs of abuse
    • Robinson TE, Kolb B (2004) Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47(Suppl 1):33-46
    • (2004) Neuropharmacology , vol.47 , Issue.SUPPL. 1 , pp. 33-46
    • Robinson, T.E.1    Kolb, B.2
  • 131
    • 56749151276 scopus 로고    scopus 로고
    • Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases
    • Rose NR, Ng SS et al (2008) Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem 51(22):7053-7056
    • (2008) J Med Chem , vol.51 , Issue.22 , pp. 7053-7056
    • Rose, N.R.1    Ng, S.S.2
  • 132
    • 77649224314 scopus 로고    scopus 로고
    • Selective inhibitors of the JMJD2 histone demethylases: Combined nondenaturing mass spectrometric screening and crystallographic approaches
    • Rose NR, Woon EC et al (2010) Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem 53(4):1810-1818
    • (2010) J Med Chem , vol.53 , Issue.4 , pp. 1810-1818
    • Rose, N.R.1    Woon, E.C.2
  • 133
    • 0037357210 scopus 로고    scopus 로고
    • Diet and DNA methylation interactions in cancer prevention
    • Ross SA (2003) Diet and DNA methylation interactions in cancer prevention. Ann N Y Acad Sci 983:197-207
    • (2003) Ann N Y Acad Sci , vol.983 , pp. 197-207
    • Ross, S.A.1
  • 134
    • 40349089627 scopus 로고    scopus 로고
    • Epigenetic modulation and cancer: Effect of metabolic syndrome?
    • Ross SA, Milner JA (2007) Epigenetic modulation and cancer: effect of metabolic syndrome? Am J Clin Nutr 86(3):s872-s877
    • (2007) Am J Clin Nutr , vol.86 , Issue.3
    • Ross, S.A.1    Milner, J.A.2
  • 135
    • 58049155757 scopus 로고    scopus 로고
    • Neurotrophic factors and structural plasticity in addiction
    • Russo SJ, Mazei-Robison MS et al (2009) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56(Suppl 1):73-82
    • (2009) Neuropharmacology , vol.56 , Issue.SUPPL. 1 , pp. 73-82
    • Russo, S.J.1    Mazei-Robison, M.S.2
  • 136
    • 30744456492 scopus 로고    scopus 로고
    • Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
    • Sachchidanand, Resnick-Silverman L et al (2006) Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol 13 (1):81-90
    • (2006) Chem Biol , vol.13 , Issue.1 , pp. 81-90
    • Sachchidanand, R.-S.L.1
  • 137
    • 75749150081 scopus 로고    scopus 로고
    • A miniaturized screen for inhibitors of Jumonji histone demethylases
    • Sakurai M, Rose NR et al (2010) A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst 6(2):357-364
    • (2010) Mol Biosyst , vol.6 , Issue.2 , pp. 357-364
    • Sakurai, M.1    Rose, N.R.2
  • 138
    • 34250161829 scopus 로고    scopus 로고
    • Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
    • Schroeder FA, Lin CL et al (2007) Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 62(1):55-64
    • (2007) Biol Psychiatry , vol.62 , Issue.1 , pp. 55-64
    • Schroeder, F.A.1    Lin, C.L.2
  • 139
    • 0037130455 scopus 로고    scopus 로고
    • Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3
    • Shahbazian M, Young J et al (2002) Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 35(2):243-254
    • (2002) Neuron , vol.35 , Issue.2 , pp. 243-254
    • Shahbazian, M.1    Young, J.2
  • 140
    • 0344824404 scopus 로고    scopus 로고
    • Histone sumoylation is associated with transcriptional repression
    • Shiio Y, Eisenman RN (2003) Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci USA 100(23):13225
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.23 , pp. 13225
    • Shiio, Y.1    Eisenman, R.N.2
  • 141
    • 0037075032 scopus 로고    scopus 로고
    • The non-coding air RNA is required for silencing autosomal imprinted genes
    • Sleutels F, Zwart R et al (2002) The non-coding air RNA is required for silencing autosomal imprinted genes. Nature 415(6873):810-813
    • (2002) Nature , vol.415 , Issue.6873 , pp. 810-813
    • Sleutels, F.1    Zwart, R.2
  • 142
    • 0347017050 scopus 로고    scopus 로고
    • Protective role of L-methionine against free radical damage of rat brain synaptosomes
    • Slyshenkov VS, Shevalye AA et al (2002) Protective role of L-methionine against free radical damage of rat brain synaptosomes. Acta Biochim Pol 49(4):907-916
    • (2002) Acta Biochim Pol , vol.49 , Issue.4 , pp. 907-916
    • Slyshenkov, V.S.1    Shevalye, A.A.2
  • 143
    • 0035875049 scopus 로고    scopus 로고
    • Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
    • Smiraglia DJ, Rush LJ et al (2001) Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum Mol Genet 10(13):1413-1419
    • (2001) Hum Mol Genet , vol.10 , Issue.13 , pp. 1413-1419
    • Smiraglia, D.J.1    Rush, L.J.2
  • 144
    • 27644473204 scopus 로고    scopus 로고
    • Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
    • Stimson L, Rowlands MG et al (2005) Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol Cancer Ther 4(10):1521-1532
    • (2005) Mol Cancer Ther , vol.4 , Issue.10 , pp. 1521-1532
    • Stimson, L.1    Rowlands, M.G.2
  • 145
    • 45149134363 scopus 로고    scopus 로고
    • A phosphatase cascade by which rewarding stimuli control nucleosomal response
    • Stipanovich A, Valjent E et al (2008) A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453(7197):879-884
    • (2008) Nature , vol.453 , Issue.7197 , pp. 879-884
    • Stipanovich, A.1    Valjent, E.2
  • 146
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403(6765): 41-45
    • (2000) Nature , vol.403 , Issue.6765 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 147
    • 55449096356 scopus 로고    scopus 로고
    • Crosstalk among histone modifications
    • Suganuma T, Workman JL (2008) Crosstalk among histone modifications. Cell 135(4):604-607
    • (2008) Cell , vol.135 , Issue.4 , pp. 604-607
    • Suganuma, T.1    Workman, J.L.2
  • 148
    • 0037189502 scopus 로고    scopus 로고
    • A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats
    • Swinney DC, Xu YZ et al (2002) A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats. J Biol Chem 277(26):23573
    • (2002) J Biol Chem , vol.277 , Issue.26 , pp. 23573
    • Swinney, D.C.1    Xu, Y.Z.2
  • 149
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin modifying drugs
    • Szyf M (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49:243-263
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 150
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP et al (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324(5929):930-935
    • (2009) Science , vol.324 , Issue.5929 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2
  • 151
    • 79951847599 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor therapy in epithelial ovarian cancer
    • Takai N, Narahara H (2010) Histone deacetylase inhibitor therapy in epithelial ovarian cancer. J Oncol 2010:458431
    • (2010) J Oncol , vol.2010 , pp. 458431
    • Takai, N.1    Narahara, H.2
  • 152
    • 77649171884 scopus 로고    scopus 로고
    • Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
    • Tan J, Cang S et al (2010) Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J Hematol Oncol 3:5
    • (2010) J Hematol Oncol , vol.3 , pp. 5
    • Tan, J.1    Cang, S.2
  • 153
    • 35848961668 scopus 로고    scopus 로고
    • How chromatin-binding modules interpret histone modifications: Lessons from professional pocket pickers
    • Taverna SD, Li H et al (2007) How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol 14(11):1025-1040
    • (2007) Nat Struct Mol Biol , vol.14 , Issue.11 , pp. 1025-1040
    • Taverna, S.D.1    Li, H.2
  • 154
    • 0037168650 scopus 로고    scopus 로고
    • An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
    • Tremolizzo L, Carboni G et al (2002) An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA 99(26): 17095-17100
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.26 , pp. 17095-17100
    • Tremolizzo, L.1    Carboni, G.2
  • 155
    • 17444379438 scopus 로고    scopus 로고
    • Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
    • Tremolizzo L, Doueiri MS et al (2005) Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry 57(5):500-509
    • (2005) Biol Psychiatry , vol.57 , Issue.5 , pp. 500-509
    • Tremolizzo, L.1    Doueiri, M.S.2
  • 156
    • 33645357786 scopus 로고    scopus 로고
    • Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    • Tsankova NM, Berton O et al (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9(4):519-525
    • (2006) Nat Neurosci , vol.9 , Issue.4 , pp. 519-525
    • Tsankova, N.M.1    Berton, O.2
  • 157
    • 34247509796 scopus 로고    scopus 로고
    • Epigenetic regulation in psychiatric disorders
    • Tsankova N, Renthal W et al (2007) Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 8(5):355-367
    • (2007) Nat Rev Neurosci , vol.8 , Issue.5 , pp. 355-367
    • Tsankova, N.1    Renthal, W.2
  • 158
    • 33845233581 scopus 로고    scopus 로고
    • Reelin down-regulation in mice and psychosis endophenotypes
    • Tueting P, Doueiri MS et al (2006) Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev 30(8):1065-1077
    • (2006) Neurosci Biobehav Rev , vol.30 , Issue.8 , pp. 1065-1077
    • Tueting, P.1    Doueiri, M.S.2
  • 159
    • 0036403334 scopus 로고    scopus 로고
    • Genetic effects of methylation diets
    • Van den Veyver IB (2002) Genetic effects of methylation diets. Annu Rev Nutr 22:255-282
    • (2002) Annu Rev Nutr , vol.22 , pp. 255-282
    • van den Veyver, I.B.1
  • 160
    • 68049120458 scopus 로고    scopus 로고
    • Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes
    • Voso MT, Santini V et al (2009) Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. Clin Cancer Res 15(15): 5002-5007
    • (2009) Clin Cancer Res , vol.15 , Issue.15 , pp. 5002-5007
    • Voso, M.T.1    Santini, V.2
  • 162
    • 71449109387 scopus 로고    scopus 로고
    • New patented histone deacetylase inhibitors
    • Wang H, Dymock BW (2009) New patented histone deacetylase inhibitors. Expert Opin Ther Pat 19(12):1727-1757
    • (2009) Expert Opin Ther Pat , vol.19 , Issue.12 , pp. 1727-1757
    • Wang, H.1    Dymock, B.W.2
  • 163
    • 0035054930 scopus 로고    scopus 로고
    • Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein
    • Watson P, Black G et al (2001) Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein. J Med Genet 38(4):224-228
    • (2001) J Med Genet , vol.38 , Issue.4 , pp. 224-228
    • Watson, P.1    Black, G.2
  • 164
    • 3342989681 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior
    • Weaver IC, Cervoni N et al (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7(8):847-854
    • (2004) Nat Neurosci , vol.7 , Issue.8 , pp. 847-854
    • Weaver, I.C.1    Cervoni, N.2
  • 165
    • 28044436691 scopus 로고    scopus 로고
    • Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life
    • Weaver IC, Champagne FA et al (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25(47):11045-11054
    • (2005) J Neurosci , vol.25 , Issue.47 , pp. 11045-11054
    • Weaver, I.C.1    Champagne, F.A.2
  • 166
    • 33644763991 scopus 로고    scopus 로고
    • Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    • Weaver IC, Meaney MJ et al (2006) Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci USA 103(9):3480-3485
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.9 , pp. 3480-3485
    • Weaver, I.C.1    Meaney, M.J.2
  • 167
    • 85044706427 scopus 로고    scopus 로고
    • Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: An AlphaScreen-based assay for antagonists of methyl-lysine binding proteins
    • Wigle TJ, Herold JM et al (2010) Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins. J Biomol Screen 15(1):62-71
    • (2010) J Biomol Screen , vol.15 , Issue.1 , pp. 62-71
    • Wigle, T.J.1    Herold, J.M.2
  • 168
    • 0012218196 scopus 로고
    • Biochemical and sleep studies of schizophrenia: A review of the literature - 1960-1970
    • Wyatt A, Benedict RG, Davis J (1971) Biochemical and sleep studies of schizophrenia: a review of the literature - 1960-1970. Schizophr Bull 4:10-44
    • (1971) Schizophr Bull , vol.4 , pp. 10-44
    • Wyatt, A.1    Benedict, R.G.2    Davis, J.3
  • 169
    • 34447338875 scopus 로고    scopus 로고
    • Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine
    • Yang M, Culhane JC et al (2007) Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry 46(27): 8058-8065
    • (2007) Biochemistry , vol.46 , Issue.27 , pp. 8058-8065
    • Yang, M.1    Culhane, J.C.2
  • 170
    • 0024996768 scopus 로고
    • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
    • Yoshida M, Kijima M et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28):17174-17179
    • (1990) J Biol Chem , vol.265 , Issue.28 , pp. 17174-17179
    • Yoshida, M.1    Kijima, M.2
  • 171
    • 33749590330 scopus 로고    scopus 로고
    • Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
    • Zhou Z, Hong EJ et al (2006) Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52(2):255-269
    • (2006) Neuron , vol.52 , Issue.2 , pp. 255-269
    • Zhou, Z.1    Hong, E.J.2
  • 172
    • 77951111333 scopus 로고    scopus 로고
    • Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights
    • Zhu X, Ma Y et al (2010) Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights. J Hematol Oncol 3:17
    • (2010) J Hematol Oncol , vol.3 , pp. 17
    • Zhu, X.1    Ma, Y.2
  • 173
    • 70149112313 scopus 로고    scopus 로고
    • Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation
    • Zippo A, Serafini R et al (2009) Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell 138(6):1122
    • (2009) Cell , vol.138 , Issue.6 , pp. 1122
    • Zippo, A.1    Serafini, R.2


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