-
1
-
-
65249151919
-
Structure and function of histone methylation binding proteins
-
Adams-Cioaba MA, Min J (2009) Structure and function of histone methylation binding proteins. Biochem Cell Biol 87(1):93-105
-
(2009)
Biochem Cell Biol
, vol.87
, Issue.1
, pp. 93-105
-
-
Adams-Cioaba, M.A.1
Min, J.2
-
2
-
-
34047218122
-
HDAC inhibitors as anti-inflammatory agents
-
Adcock IM (2007) HDAC inhibitors as anti-inflammatory agents. Br J Pharmacol 150(7):829-831
-
(2007)
Br J Pharmacol
, vol.150
, Issue.7
, pp. 829-831
-
-
Adcock, I.M.1
-
3
-
-
0030743397
-
Cocaine- but not food-seeking behavior is reinstated by stress after extinction
-
Ahmed SH, Koob GF (1997) Cocaine- but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology (Berl) 132(3):289-295
-
(1997)
Psychopharmacology (Berl)
, vol.132
, Issue.3
, pp. 289-295
-
-
Ahmed, S.H.1
Koob, G.F.2
-
4
-
-
77955529815
-
Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids
-
Alexander VM, Roy M et al (2010) Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids. Int J Clin Exp Med 3(2):95-102
-
(2010)
Int J Clin Exp Med
, vol.3
, Issue.2
, pp. 95-102
-
-
Alexander, V.M.1
Roy, M.2
-
5
-
-
0032830639
-
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
-
Amir RE, Van den Veyver IB et al (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23(2):185-188
-
(1999)
Nat Genet
, vol.23
, Issue.2
, pp. 185-188
-
-
Amir, R.E.1
van den Veyver, I.B.2
-
6
-
-
24144475284
-
Reversing histone methylation
-
Bannister AJ, Kouzarides T (2005) Reversing histone methylation. Nature 436(7054):1103-1106
-
(2005)
Nature
, vol.436
, Issue.7054
, pp. 1103-1106
-
-
Bannister, A.J.1
Kouzarides, T.2
-
7
-
-
0035282458
-
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
-
Bannister AJ, Zegerman P et al (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410(6824):120-124
-
(2001)
Nature
, vol.410
, Issue.6824
, pp. 120-124
-
-
Bannister, A.J.1
Zegerman, P.2
-
8
-
-
0037143736
-
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
-
Barrot M, Olivier JD et al (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci USA 99(17):11435-11440
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.17
, pp. 11435-11440
-
-
Barrot, M.1
Olivier, J.D.2
-
9
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2):281-297
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 281-297
-
-
Bartel, D.P.1
-
10
-
-
1942435249
-
Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs
-
Bartel DP, Chen CZ (2004) Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5(5):396-400
-
(2004)
Nat Rev Genet
, vol.5
, Issue.5
, pp. 396-400
-
-
Bartel, D.P.1
Chen, C.Z.2
-
11
-
-
32444451651
-
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
-
Berton O, McClung CA et al (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311(5762):864-868
-
(2006)
Science
, vol.311
, Issue.5762
, pp. 864-868
-
-
Berton, O.1
McClung, C.A.2
-
12
-
-
78649575471
-
NF-{kappa}B as a central regulator of macrophage function in tumors
-
Biswas SK, Lewis CE (2010) NF-{kappa}B as a central regulator of macrophage function in tumors. J Leukoc Biol 88(5):877-884
-
(2010)
J Leukoc Biol
, vol.88
, Issue.5
, pp. 877-884
-
-
Biswas, S.K.1
Lewis, C.E.2
-
13
-
-
77954090605
-
Histone lysine methylation: An epigenetic modification?
-
Blackledge NP, Klose R (2010) Histone lysine methylation: an epigenetic modification? Epigenomics 2(1):151-161
-
(2010)
Epigenomics
, vol.2
, Issue.1
, pp. 151-161
-
-
Blackledge, N.P.1
Klose, R.2
-
14
-
-
57649239938
-
Decoding the epigenetic language of neuronal plasticity
-
Borrelli E, Nestler EJ et al (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60(6):961-974
-
(2008)
Neuron
, vol.60
, Issue.6
, pp. 961-974
-
-
Borrelli, E.1
Nestler, E.J.2
-
15
-
-
77249087051
-
Chemical phylogenetics of histone deacetylases
-
Bradner JE, West N et al (2009) Chemical phylogenetics of histone deacetylases. Nat Chem Biol 6(3):238-243
-
(2009)
Nat Chem Biol
, vol.6
, Issue.3
, pp. 238-243
-
-
Bradner, J.E.1
West, N.2
-
16
-
-
61349185158
-
Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse
-
Brami-Cherrier K, Roze E et al (2009) Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. J Neurochem 108(6):1323-1335
-
(2009)
J Neurochem
, vol.108
, Issue.6
, pp. 1323-1335
-
-
Brami-Cherrier, K.1
Roze, E.2
-
17
-
-
77953384502
-
Novel targeted drug therapies for the treatment of childhood acute leukemia
-
Brown P, Hunger SP et al (2009) Novel targeted drug therapies for the treatment of childhood acute leukemia. Expert Rev Hematol 2(9):145
-
(2009)
Expert Rev Hematol
, vol.2
, Issue.9
, pp. 145
-
-
Brown, P.1
Hunger, S.P.2
-
18
-
-
27144478270
-
Clinical profile of a male with Rett syndrome
-
Budden SS, Dorsey HC et al (2005) Clinical profile of a male with Rett syndrome. Brain Dev 27(Suppl 1):S69-S71
-
(2005)
Brain Dev
, vol.27
, Issue.SUPPL. 1
-
-
Budden, S.S.1
Dorsey, H.C.2
-
19
-
-
20644461933
-
Regulation of cocaine reward by CREB
-
Carlezon WA Jr, Thome J et al (1998) Regulation of cocaine reward by CREB. Science 282 (5397):2272-2275
-
(1998)
Science
, vol.282
, Issue.5397
, pp. 2272-2275
-
-
Carlezon Jr., W.A.1
Thome, J.2
-
20
-
-
0038626842
-
Identification of MeCP2 mutations in a series of females with autistic disorder
-
Carney RM, Wolpert CM et al (2003) Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr Neurol 28(3):205-211
-
(2003)
Pediatr Neurol
, vol.28
, Issue.3
, pp. 205-211
-
-
Carney, R.M.1
Wolpert, C.M.2
-
21
-
-
34247104576
-
A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy
-
Cavalleri GL, Walley NM et al (2007) A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy. Epilepsia 48(4):706-712
-
(2007)
Epilepsia
, vol.48
, Issue.4
, pp. 706-712
-
-
Cavalleri, G.L.1
Walley, N.M.2
-
22
-
-
44949262153
-
Maternal care and hippocampal plasticity: Evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
-
Champagne DL, Bagot RC et al (2008) Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J Neurosci 28(23):6037-6045
-
(2008)
J Neurosci
, vol.28
, Issue.23
, pp. 6037-6045
-
-
Champagne, D.L.1
Bagot, R.C.2
-
23
-
-
0035093830
-
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
-
Chen RZ, Akbarian S et al (2001) Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27(3):327-331
-
(2001)
Nat Genet
, vol.27
, Issue.3
, pp. 327-331
-
-
Chen, R.Z.1
Akbarian, S.2
-
24
-
-
0037342258
-
Glioma apoptosis induced by macrophages involves both death receptor-dependent and independent pathways
-
Chen GG, Chak EC et al (2003a) Glioma apoptosis induced by macrophages involves both death receptor-dependent and independent pathways. J Lab Clin Med 141(3):190-199
-
(2003)
J Lab Clin Med
, vol.141
, Issue.3
, pp. 190-199
-
-
Chen, G.G.1
Chak, E.C.2
-
25
-
-
0242332183
-
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
-
Chen WG, Chang Q et al (2003b) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302(5646):885-889
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 885-889
-
-
Chen, W.G.1
Chang, Q.2
-
26
-
-
8444253290
-
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice
-
Collins AL, Levenson JM et al (2004) Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet 13(21):2679-2689
-
(2004)
Hum Mol Genet
, vol.13
, Issue.21
, pp. 2679-2689
-
-
Collins, A.L.1
Levenson, J.M.2
-
27
-
-
40949148102
-
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules
-
Collins RE, Northrop JP et al (2008) The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol 15(3):245-250
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.3
, pp. 245-250
-
-
Collins, R.E.1
Northrop, J.P.2
-
28
-
-
70349085803
-
Antidepressant actions of histone deacetylase inhibitors
-
Covington HE 3rd, Maze I et al (2009) Antidepressant actions of histone deacetylase inhibitors. J Neurosci 29(37):11451-11460
-
(2009)
J Neurosci
, vol.29
, Issue.37
, pp. 11451-11460
-
-
Covington III, H.E.1
Maze, I.2
-
29
-
-
77949421463
-
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
-
Culhane JC, Wang D et al (2010) Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc 132(9):3164-3176
-
(2010)
J Am Chem Soc
, vol.132
, Issue.9
, pp. 3164-3176
-
-
Culhane, J.C.1
Wang, D.2
-
30
-
-
34548456881
-
Dietary histone deacetylase inhibitors: From cells to mice to man
-
Dashwood RH, Ho E (2007) Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol 17(5):363-369
-
(2007)
Semin Cancer Biol
, vol.17
, Issue.5
, pp. 363-369
-
-
Dashwood, R.H.1
Ho, E.2
-
31
-
-
7244221348
-
DNA methylation, cancer susceptibility, and nutrient interactions
-
Davis CD, Uthus EO (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood) 229(10):988-995
-
(2004)
Exp Biol Med (Maywood)
, vol.229
, Issue.10
, pp. 988-995
-
-
Davis, C.D.1
Uthus, E.O.2
-
32
-
-
33846062357
-
MECP2 mutant allele in a boy with Rett syndrome and his unaffected heterozygous mother
-
Dayer AG, Bottani A et al (2007) MECP2 mutant allele in a boy with Rett syndrome and his unaffected heterozygous mother. Brain Dev 29(1):47-50
-
(2007)
Brain Dev
, vol.29
, Issue.1
, pp. 47-50
-
-
Dayer, A.G.1
Bottani, A.2
-
33
-
-
0033519641
-
Structure and ligand of a histone acetyltransferase bromodomain
-
Dhalluin C, Carlson JE et al (1999) Structure and ligand of a histone acetyltransferase bromodomain. Nature 399(6735):491-496
-
(1999)
Nature
, vol.399
, Issue.6735
, pp. 491-496
-
-
Dhalluin, C.1
Carlson, J.E.2
-
34
-
-
24644518545
-
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia
-
Dong E, Agis-Balboa RC et al (2005) Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc Natl Acad Sci USA 102(35):12578-12583
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.35
, pp. 12578-12583
-
-
Dong, E.1
Agis-Balboa, R.C.2
-
35
-
-
77955909849
-
Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease
-
Dong J, Jimi E et al (2010) Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev 24(16):1709-1717
-
(2010)
Genes Dev
, vol.24
, Issue.16
, pp. 1709-1717
-
-
Dong, J.1
Jimi, E.2
-
36
-
-
67650506936
-
Open access chemical and clinical probes to support drug discovery
-
Edwards AM, Bountra C et al (2009) Open access chemical and clinical probes to support drug discovery. Nat Chem Biol 5(7):436-440
-
(2009)
Nat Chem Biol
, vol.5
, Issue.7
, pp. 436-440
-
-
Edwards, A.M.1
Bountra, C.2
-
37
-
-
0029949690
-
Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period
-
Erb S, Shaham Y et al (1996) Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology (Berl) 128(4):408-412
-
(1996)
Psychopharmacology (Berl)
, vol.128
, Issue.4
, pp. 408-412
-
-
Erb, S.1
Shaham, Y.2
-
38
-
-
70349739288
-
Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism
-
Escoubet-Lozach L, Lin IL et al (2009) Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res 69(18):7347-7356
-
(2009)
Cancer Res
, vol.69
, Issue.18
, pp. 7347-7356
-
-
Escoubet-Lozach, L.1
Lin, I.L.2
-
39
-
-
24344497413
-
Methyl-CpG binding proteins in the nervous system
-
Fan G, Hutnick L (2005) Methyl-CpG binding proteins in the nervous system. Cell Res 15 (4):255-261
-
(2005)
Cell Res
, vol.15
, Issue.4
, pp. 255-261
-
-
Fan, G.1
Hutnick, L.2
-
40
-
-
67651241751
-
Evidence for X-chromosomal schizophrenia associated with microRNA alterations
-
Feng J, Sun G et al (2009) Evidence for X-chromosomal schizophrenia associated with microRNA alterations. PLoS One 4(7):e6121
-
(2009)
PLoS One
, vol.4
, Issue.7
-
-
Feng, J.1
Sun, G.2
-
41
-
-
77953764486
-
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic
-
Ferraris DV (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J Med Chem 53(12):4561-4584
-
(2010)
J Med Chem
, vol.53
, Issue.12
, pp. 4561-4584
-
-
Ferraris, D.V.1
-
42
-
-
0035434378
-
You bet-cha: A novel family of transcriptional regulators
-
Florence B, Faller DV (2001) You bet-cha: a novel family of transcriptional regulators. Front Biosci 6:D1008-D1018
-
(2001)
Front Biosci
, vol.6
-
-
Florence, B.1
Faller, D.V.2
-
43
-
-
36549081297
-
Chromatin-modifying proteins in cancer
-
Fog CK, Jensen KT et al (2007) Chromatin-modifying proteins in cancer. APMIS 115 (10):1060-1089
-
(2007)
APMIS
, vol.115
, Issue.10
, pp. 1060-1089
-
-
Fog, C.K.1
Jensen, K.T.2
-
44
-
-
0033527727
-
Nongenomic transmission across generations of maternal behavior and stress responses in the rat
-
Francis D, Diorio J et al (1999) Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286(5442):1155-1158
-
(1999)
Science
, vol.286
, Issue.5442
, pp. 1155-1158
-
-
Francis, D.1
Diorio, J.2
-
45
-
-
0037423186
-
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
-
Fuks F, Hurd PJ et al (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 278(6):4035-4040
-
(2003)
J Biol Chem
, vol.278
, Issue.6
, pp. 4035-4040
-
-
Fuks, F.1
Hurd, P.J.2
-
46
-
-
33846924001
-
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
-
Giacometti E, Luikenhuis S et al (2007) Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. Proc Natl Acad Sci USA 104(6):1931-1936
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.6
, pp. 1931-1936
-
-
Giacometti, E.1
Luikenhuis, S.2
-
47
-
-
15744401773
-
Eukaryotic cytosine methyltransferases
-
Goll MG, Bestor TH (2005) Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74:481-514
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 481-514
-
-
Goll, M.G.1
Bestor, T.H.2
-
48
-
-
74549200467
-
Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
-
Grayson DR, Kundakovic M et al (2008) Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol 77(2):126-135
-
(2008)
Mol Pharmacol
, vol.77
, Issue.2
, pp. 126-135
-
-
Grayson, D.R.1
Kundakovic, M.2
-
49
-
-
33748187139
-
Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli
-
Green TA, Alibhai IN et al (2006) Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci 26(32):8235-8242
-
(2006)
J Neurosci
, vol.26
, Issue.32
, pp. 8235-8242
-
-
Green, T.A.1
Alibhai, I.N.2
-
50
-
-
30644474460
-
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
-
Greiner D, Bonaldi T et al (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1(3):143-145
-
(2005)
Nat Chem Biol
, vol.1
, Issue.3
, pp. 143-145
-
-
Greiner, D.1
Bonaldi, T.2
-
51
-
-
0035914304
-
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
-
Grozinger CM, Chao ED et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276(42):38837-38843
-
(2001)
J Biol Chem
, vol.276
, Issue.42
, pp. 38837-38843
-
-
Grozinger, C.M.1
Chao, E.D.2
-
52
-
-
65549123471
-
HDAC2 negatively regulates memory formation and synaptic plasticity
-
Guan JS, Haggarty SJ et al (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459(7243):55-60
-
(2009)
Nature
, vol.459
, Issue.7243
, pp. 55-60
-
-
Guan, J.S.1
Haggarty, S.J.2
-
53
-
-
0035094767
-
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
-
Guy J, Hendrich B et al (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27(3):322-326
-
(2001)
Nat Genet
, vol.27
, Issue.3
, pp. 322-326
-
-
Guy, J.1
Hendrich, B.2
-
54
-
-
33847266846
-
Reversal of neurological defects in a mouse model of Rett syndrome
-
Guy J, Gan J et al (2007) Reversal of neurological defects in a mouse model of Rett syndrome. Science 315(5815):1143-1147
-
(2007)
Science
, vol.315
, Issue.5815
, pp. 1143-1147
-
-
Guy, J.1
Gan, J.2
-
55
-
-
39049159734
-
Histone deacetylase inhibitors: Possible implications for neurodegenerative disorders
-
Hahnen E, Hauke J et al (2008) Histone deacetylase inhibitors: possible implications for neurodegenerative disorders. Expert Opin Investig Drugs 17(2):169-184
-
(2008)
Expert Opin Investig Drugs
, vol.17
, Issue.2
, pp. 169-184
-
-
Hahnen, E.1
Hauke, J.2
-
56
-
-
0035261255
-
Post-transcriptional gene silencing by double-stranded RNA
-
Hammond SM, Caudy AA et al (2001) Post-transcriptional gene silencing by double-stranded RNA. Nat Rev Genet 2(2):110-119
-
(2001)
Nat Rev Genet
, vol.2
, Issue.2
, pp. 110-119
-
-
Hammond, S.M.1
Caudy, A.A.2
-
57
-
-
33749260519
-
Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going?
-
Hassa PO, Haenni SS et al (2006) Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev 70(3):789-829
-
(2006)
Microbiol Mol Biol Rev
, vol.70
, Issue.3
, pp. 789-829
-
-
Hassa, P.O.1
Haenni, S.S.2
-
58
-
-
60549087188
-
A novel, enigmatic histone modification: Biotinylation of histones by holocarboxylase synthetase
-
Hassan YI, Zempleni J (2008) A novel, enigmatic histone modification: biotinylation of histones by holocarboxylase synthetase. Nutr Rev 66(12):721-725
-
(2008)
Nutr Rev
, vol.66
, Issue.12
, pp. 721-725
-
-
Hassan, Y.I.1
Zempleni, J.2
-
59
-
-
59949084113
-
Nonenzymatic biotinylation of histone H2A
-
Healy S, Heightman TD et al (2009) Nonenzymatic biotinylation of histone H2A. Protein Sci 18(2):314-328
-
(2009)
Protein Sci
, vol.18
, Issue.2
, pp. 314-328
-
-
Healy, S.1
Heightman, T.D.2
-
61
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg B, Gatbonton T et al (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66(8):4368-4377
-
(2006)
Cancer Res
, vol.66
, Issue.8
, pp. 4368-4377
-
-
Heltweg, B.1
Gatbonton, T.2
-
62
-
-
77952170915
-
Histone deacetylase inhibitor MS-275 exhibits poor brain penetration: Pharmacokinetic studies of [11C]MS-275 using positron emission tomography
-
Hooker J, Kim SW et al (2010) Histone deacetylase inhibitor MS-275 exhibits poor brain penetration: pharmacokinetic studies of [11C]MS-275 using positron emission tomography. ACS Chem Neurosci 1(1):65-73
-
(2010)
ACS Chem Neurosci
, vol.1
, Issue.1
, pp. 65-73
-
-
Hooker, J.1
Kim, S.W.2
-
63
-
-
77951237809
-
Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
-
Hrzenjak A, Moinfar F et al (2010) Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer 9:49
-
(2010)
Mol Cancer
, vol.9
, pp. 49
-
-
Hrzenjak, A.1
Moinfar, F.2
-
64
-
-
61749088806
-
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
-
Huang B, Yang XD et al (2009) Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol 29(5):1375-1387
-
(2009)
Mol Cell Biol
, vol.29
, Issue.5
, pp. 1375-1387
-
-
Huang, B.1
Yang, X.D.2
-
65
-
-
77749277177
-
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing
-
Huang Y, Pastor WA et al (2010) The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One 5(1):e8888
-
(2010)
PLoS One
, vol.5
, Issue.1
-
-
Huang, Y.1
Pastor, W.A.2
-
66
-
-
33748371601
-
Neural mechanisms of addiction: The role of reward-related learning and memory
-
Hyman SE, Malenka RC et al (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565-598
-
(2006)
Annu Rev Neurosci
, vol.29
, pp. 565-598
-
-
Hyman, S.E.1
Malenka, R.C.2
-
67
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245-254
-
(2003)
Nat Genet
, vol.33
, Issue.SUPPL.
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
68
-
-
0032893989
-
Male Rett syndrome variant: Application of diagnostic criteria
-
Jan MM, Dooley JM et al (1999) Male Rett syndrome variant: application of diagnostic criteria. Pediatr Neurol 20(3):238-240
-
(1999)
Pediatr Neurol
, vol.20
, Issue.3
, pp. 238-240
-
-
Jan, M.M.1
Dooley, J.M.2
-
69
-
-
0035839136
-
Translating the histone code
-
Jenuwein T, Allis CD (2001) Translating the histone code. Science 293(5532):1074-1080
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
70
-
-
77954024844
-
HDAC inhibitor-mediated radiosensitization in human carcinoma cells: A general phenomenon?
-
Kim IA, Kim IH et al (2010) HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? J Radiat Res (Tokyo) 51(3):257-263
-
(2010)
J Radiat Res (Tokyo)
, vol.51
, Issue.3
, pp. 257-263
-
-
Kim, I.A.1
Kim, I.H.2
-
71
-
-
0036207456
-
A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome
-
Klauck SM, Lindsay S et al (2002) A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome. Am J Hum Genet 70(4):1034-1037
-
(2002)
Am J Hum Genet
, vol.70
, Issue.4
, pp. 1034-1037
-
-
Klauck, S.M.1
Lindsay, S.2
-
72
-
-
32344450824
-
Genomic DNA methylation: The mark and its mediators
-
Klose RJ, Bird AP (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31(2):89-97
-
(2006)
Trends Biochem Sci
, vol.31
, Issue.2
, pp. 89-97
-
-
Klose, R.J.1
Bird, A.P.2
-
73
-
-
34548060394
-
Stress, dysregulation of drug reward pathways, and the transition to drug dependence
-
Koob G, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 164(8):1149-1159
-
(2007)
Am J Psychiatry
, vol.164
, Issue.8
, pp. 1149-1159
-
-
Koob, G.1
Kreek, M.J.2
-
74
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T (2007) Chromatin modifications and their function. Cell 128(4):693-705
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 693-705
-
-
Kouzarides, T.1
-
75
-
-
35748965898
-
Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression
-
Kovacheva VP, Mellott TJ et al (2007) Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem 282(43): 31777-31788
-
(2007)
J Biol Chem
, vol.282
, Issue.43
, pp. 31777-31788
-
-
Kovacheva, V.P.1
Mellott, T.J.2
-
76
-
-
0141925713
-
DNA methylation and Rett syndrome
-
Kriaucionis S, Bird A (2003) DNA methylation and Rett syndrome. Hum Mol Genet 12 Spec No 2: R221-R227
-
(2003)
Hum Mol Genet
, vol.12
, Issue.2
-
-
Kriaucionis, S.1
Bird, A.2
-
77
-
-
66149123748
-
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
-
Kriaucionis S, Heintz N (2009) The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324(5929):929-930
-
(2009)
Science
, vol.324
, Issue.5929
, pp. 929-930
-
-
Kriaucionis, S.1
Heintz, N.2
-
78
-
-
33846783261
-
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
-
Kubicek S, O'Sullivan RJ et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25(3):473-481
-
(2007)
Mol Cell
, vol.25
, Issue.3
, pp. 473-481
-
-
Kubicek, S.1
O'Sullivan, R.J.2
-
79
-
-
26944474790
-
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
-
Kumar A, Choi KH et al (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48(2):303-314
-
(2005)
Neuron
, vol.48
, Issue.2
, pp. 303-314
-
-
Kumar, A.1
Choi, K.H.2
-
80
-
-
0035282573
-
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
-
Lachner M, O'Carroll D et al (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410(6824):116-120
-
(2001)
Nature
, vol.410
, Issue.6824
, pp. 116-120
-
-
Lachner, M.1
O'Carroll, D.2
-
81
-
-
0034540747
-
Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome
-
Lam CW, Yeung WL et al (2000) Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome. J Med Genet 37(12):E41
-
(2000)
J Med Genet
, vol.37
, Issue.12
-
-
Lam, C.W.1
Yeung, W.L.2
-
82
-
-
77957859998
-
Abrogation of NF-{kappa}B signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation
-
Langereis JD, Raaijmakers HA et al (2010) Abrogation of NF-{kappa}B signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation. J Leukoc Biol 88:655-664
-
(2010)
J Leukoc Biol
, vol.88
, pp. 655-664
-
-
Langereis, J.D.1
Raaijmakers, H.A.2
-
83
-
-
0033714888
-
HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
-
Lau OD, Kundu TK et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell 5(3):589-595
-
(2000)
Mol Cell
, vol.5
, Issue.3
, pp. 589-595
-
-
Lau, O.D.1
Kundu, T.K.2
-
84
-
-
33745187327
-
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications
-
Lee MG, Wynder C et al (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol 13(6):563-567
-
(2006)
Chem Biol
, vol.13
, Issue.6
, pp. 563-567
-
-
Lee, M.G.1
Wynder, C.2
-
85
-
-
77957091318
-
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair
-
Lee JH, Choy ML et al (2010) Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci USA 107(33):14639-14644
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.33
, pp. 14639-14644
-
-
Lee, J.H.1
Choy, M.L.2
-
86
-
-
13244276460
-
Epigenetic mechanisms in memory formation
-
Levenson JM, Sweatt JD (2005) Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6(2):108-118
-
(2005)
Nat Rev Neurosci
, vol.6
, Issue.2
, pp. 108-118
-
-
Levenson, J.M.1
Sweatt, J.D.2
-
87
-
-
79959223990
-
Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells
-
Li X, Chen BD (2009) Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells. Am J Biomed Sci 1(4):352-363
-
(2009)
Am J Biomed Sci
, vol.1
, Issue.4
, pp. 352-363
-
-
Li, X.1
Chen, B.D.2
-
88
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li E, Bestor TH et al (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69(6):915-926
-
(1992)
Cell
, vol.69
, Issue.6
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
-
89
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister R, Pelizzola M et al (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462(7271):315-322
-
(2009)
Nature
, vol.462
, Issue.7271
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
-
90
-
-
15144344289
-
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
-
Liu D, Diorio J et al (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277(5332):1659-1662
-
(1997)
Science
, vol.277
, Issue.5332
, pp. 1659-1662
-
-
Liu, D.1
Diorio, J.2
-
91
-
-
73249124141
-
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
-
Liu F, Chen X et al (2009) Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem 52(24):7950-7953
-
(2009)
J Med Chem
, vol.52
, Issue.24
, pp. 7950-7953
-
-
Liu, F.1
Chen, X.2
-
92
-
-
67649510355
-
Oxygenase catalyzed 5-methylcytosine hydroxylation
-
Loenarz C, Schofield CJ (2009) Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem Biol 16(6):580-583
-
(2009)
Chem Biol
, vol.16
, Issue.6
, pp. 580-583
-
-
Loenarz, C.1
Schofield, C.J.2
-
93
-
-
77952413052
-
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
-
Luthi-Carter R, Taylor DM et al (2010) SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci USA 107(17):7927-7932
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.17
, pp. 7927-7932
-
-
Luthi-Carter, R.1
Taylor, D.M.2
-
94
-
-
70349100446
-
Histone deacetylase inhibitors: Current status and overview of recent clinical trials
-
Ma X, Ezzeldin HH et al (2009) Histone deacetylase inhibitors: current status and overview of recent clinical trials. Drugs 69(14):1911-1934
-
(2009)
Drugs
, vol.69
, Issue.14
, pp. 1911-1934
-
-
Ma, X.1
Ezzeldin, H.H.2
-
95
-
-
0036818764
-
De novo MECP2 mutation in a 46, XX male patient with Rett syndrome
-
Maiwald R, Bonte A et al (2002) De novo MECP2 mutation in a 46, XX male patient with Rett syndrome. Neurogenetics 4(2):107-108
-
(2002)
Neurogenetics
, vol.4
, Issue.2
, pp. 107-108
-
-
Maiwald, R.1
Bonte, A.2
-
96
-
-
34250308083
-
Specific inhibition of p300-HAT alters global gene expression and represses HIV replication
-
Mantelingu K, Reddy BA et al (2007) Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol 14(6):645-657
-
(2007)
Chem Biol
, vol.14
, Issue.6
, pp. 645-657
-
-
Mantelingu, K.1
Reddy, B.A.2
-
97
-
-
67649379393
-
Histone acetyltransferase inhibitors and preclinical studies
-
Manzo F, Tambaro FP et al (2009) Histone acetyltransferase inhibitors and preclinical studies. Expert Opin Ther Pat 19(6):761-774
-
(2009)
Expert Opin Ther Pat
, vol.19
, Issue.6
, pp. 761-774
-
-
Manzo, F.1
Tambaro, F.P.2
-
98
-
-
23944476557
-
Classic Rett syndrome in a boy with R133C mutation of MECP2
-
Masuyama T, Matsuo M et al (2005) Classic Rett syndrome in a boy with R133C mutation of MECP2. Brain Dev 27(6):439-442
-
(2005)
Brain Dev
, vol.27
, Issue.6
, pp. 439-442
-
-
Masuyama, T.1
Matsuo, M.2
-
99
-
-
74249105659
-
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
-
Maze I, Covington HE 3rd et al (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327(5962):213-216
-
(2010)
Science
, vol.327
, Issue.5962
, pp. 213-216
-
-
Maze, I.1
Covington III, H.E.2
-
100
-
-
33845287975
-
Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome
-
McGill BE, Bundle SF et al (2006) Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 103(48):18267-18272
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.48
, pp. 18267-18272
-
-
McGill, B.E.1
Bundle, S.F.2
-
102
-
-
53349103842
-
Diet and the epigenetic (re)programming of phenotypic differences in behavior
-
McGowan PO, Meaney MJ et al (2008) Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res 1237:12-24
-
(2008)
Brain Res
, vol.1237
, pp. 12-24
-
-
McGowan, P.O.1
Meaney, M.J.2
-
103
-
-
60749105468
-
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
-
McGowan PO, Sasaki A et al (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12(3):342-348
-
(2009)
Nat Neurosci
, vol.12
, Issue.3
, pp. 342-348
-
-
McGowan, P.O.1
Sasaki, A.2
-
104
-
-
1242314197
-
Dysregulation in the suicide brain: MRNA expression of corticotrophin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region
-
Merali Z, Du L et al (2004) Dysregulation in the suicide brain: mRNA expression of corticotrophin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. J Neurosci 24(6):1478-1485
-
(2004)
J Neurosci
, vol.24
, Issue.6
, pp. 1478-1485
-
-
Merali, Z.1
Du, L.2
-
105
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger E, Wissmann M et al (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437(7057):436-439
-
(2005)
Nature
, vol.437
, Issue.7057
, pp. 436-439
-
-
Metzger, E.1
Wissmann, M.2
-
106
-
-
37749026136
-
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
-
Metzger E, Yin N et al (2008) Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol 10(1):53
-
(2008)
Nat Cell Biol
, vol.10
, Issue.1
, pp. 53
-
-
Metzger, E.1
Yin, N.2
-
107
-
-
18144425480
-
Another patient with MECP2 mutation without classic Rett syndrome phenotype
-
Milani D, Pantaleoni C et al (2005) Another patient with MECP2 mutation without classic Rett syndrome phenotype. Pediatr Neurol 32(5):355-357
-
(2005)
Pediatr Neurol
, vol.32
, Issue.5
, pp. 355-357
-
-
Milani, D.1
Pantaleoni, C.2
-
108
-
-
43149122898
-
Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells
-
Minsky N, Shema E et al (2008) Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat Cell Biol 10(4):483-488
-
(2008)
Nat Cell Biol
, vol.10
, Issue.4
, pp. 483-488
-
-
Minsky, N.1
Shema, E.2
-
109
-
-
84865827091
-
-
Note
-
Mitsubishi/Tanabe (Int. Pat. Appl. WO09/084693)
-
-
-
-
110
-
-
12744261491
-
Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
-
Moretti P, Bouwknecht JA et al (2005) Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome. Hum Mol Genet 14(2):205-220
-
(2005)
Hum Mol Genet
, vol.14
, Issue.2
, pp. 205-220
-
-
Moretti, P.1
Bouwknecht, J.A.2
-
111
-
-
61449229353
-
A genome-wide investigation of SNPs and CNVs in schizophrenia
-
Need AC, Ge D et al (2009) A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet 5(2):e1000373
-
(2009)
PLoS Genet
, vol.5
, Issue.2
-
-
Need, A.C.1
Ge, D.2
-
112
-
-
0033119780
-
DNA methylation and chromatin modification
-
Ng HH, Bird A (1999) DNA methylation and chromatin modification. Curr Opin Genet Dev 9 (2):158-163
-
(1999)
Curr Opin Genet Dev
, vol.9
, Issue.2
, pp. 158-163
-
-
Ng, H.H.1
Bird, A.2
-
113
-
-
34447133035
-
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
-
Ng SS, Kavanagh KL et al (2007) Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature 448(7149):87
-
(2007)
Nature
, vol.448
, Issue.7149
, pp. 87
-
-
Ng, S.S.1
Kavanagh, K.L.2
-
114
-
-
30744479491
-
Dietary choline deficiency alters global and genespecific DNA methylation in the developing hippocampus of mouse fetal brains
-
Niculescu MD, Craciunescu CN et al (2006) Dietary choline deficiency alters global and genespecific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J 20 (1):43-49
-
(2006)
FASEB J
, vol.20
, Issue.1
, pp. 43-49
-
-
Niculescu, M.D.1
Craciunescu, C.N.2
-
115
-
-
26444516160
-
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome
-
Nuber UA, Kriaucionis S et al (2005) Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet 14(15):2247-2256
-
(2005)
Hum Mol Genet
, vol.14
, Issue.15
, pp. 2247-2256
-
-
Nuber, U.A.1
Kriaucionis, S.2
-
116
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro TF, Kontopoulos E et al (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317(5837):516-519
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
-
117
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec M, Bleasdale JE et al (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285(11):8340-8351
-
(2010)
J Biol Chem
, vol.285
, Issue.11
, pp. 8340-8351
-
-
Pacholec, M.1
Bleasdale, J.E.2
-
118
-
-
20144372893
-
SIRT1 regulates HIV transcription via Tat deacetylation
-
Pagans S, Pedal A et al (2005) SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 3(2):e41
-
(2005)
PLoS Biol
, vol.3
, Issue.2
-
-
Pagans, S.1
Pedal, A.2
-
119
-
-
70349671463
-
Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks
-
Palmieri D, Lockman PR et al (2009) Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks. Clin Cancer Res 15 (19):6148-6157
-
(2009)
Clin Cancer Res
, vol.15
, Issue.19
, pp. 6148-6157
-
-
Palmieri, D.1
Lockman, P.R.2
-
120
-
-
41149089267
-
Histone deacetylase inhibitors: From bench to clinic
-
Paris M, Porcelloni M et al (2008) Histone deacetylase inhibitors: from bench to clinic. J Med Chem 51(6):1505
-
(2008)
J Med Chem
, vol.51
, Issue.6
, pp. 1505
-
-
Paris, M.1
Porcelloni, M.2
-
121
-
-
0015298215
-
The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
-
Penn NW, Suwalski R et al (1972) The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126(4):781-790
-
(1972)
Biochem J
, vol.126
, Issue.4
, pp. 781-790
-
-
Penn, N.W.1
Suwalski, R.2
-
122
-
-
73549094015
-
Aurora kinase inhibitors: A new class of drugs targeting the regulatory mitotic system
-
Perez Fidalgo JA, Roda D et al (2009) Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system. Clin Transl Oncol 11(12):787
-
(2009)
Clin Transl Oncol
, vol.11
, Issue.12
, pp. 787
-
-
Perez, F.J.A.1
Roda, D.2
-
123
-
-
77953469917
-
Epigenetics as a unifying principle in the aetiology of complex traits and diseases
-
Petronis A (2010) Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 465(7299):721-727
-
(2010)
Nature
, vol.465
, Issue.7299
, pp. 721-727
-
-
Petronis, A.1
-
124
-
-
30944437615
-
Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
-
Pogribny IP, Ross SA et al (2006) Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res 593(1-2):80-87
-
(2006)
Mutat Res
, vol.593
, Issue.1-2
, pp. 80-87
-
-
Pogribny, I.P.1
Ross, S.A.2
-
125
-
-
52949099506
-
GABAA receptor promoter hypermethylation in suicide brain: Implications for the involvement of epigenetic processes
-
Poulter MO, Du L et al (2008) GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biol Psychiatry 64(8):645-652
-
(2008)
Biol Psychiatry
, vol.64
, Issue.8
, pp. 645-652
-
-
Poulter, M.O.1
Du, L.2
-
126
-
-
77951161223
-
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics
-
Quinn AM, Bedford MT et al (2009) A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res 38(2):e11
-
(2009)
Nucleic Acids Res
, vol.38
, Issue.2
-
-
Quinn, A.M.1
Bedford, M.T.2
-
127
-
-
35648934049
-
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
-
Renthal W, Maze I et al (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56(3):517-529
-
(2007)
Neuron
, vol.56
, Issue.3
, pp. 517-529
-
-
Renthal, W.1
Maze, I.2
-
128
-
-
49049122082
-
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure
-
Renthal W, Carle TL et al (2008) Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci 28(29):7344-7349
-
(2008)
J Neurosci
, vol.28
, Issue.29
, pp. 7344-7349
-
-
Renthal, W.1
Carle, T.L.2
-
129
-
-
65549142573
-
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins
-
Renthal W, Kumar A et al (2009) Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62(3):335-348
-
(2009)
Neuron
, vol.62
, Issue.3
, pp. 335-348
-
-
Renthal, W.1
Kumar, A.2
-
130
-
-
4544359112
-
Structural plasticity associated with exposure to drugs of abuse
-
Robinson TE, Kolb B (2004) Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47(Suppl 1):33-46
-
(2004)
Neuropharmacology
, vol.47
, Issue.SUPPL. 1
, pp. 33-46
-
-
Robinson, T.E.1
Kolb, B.2
-
131
-
-
56749151276
-
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases
-
Rose NR, Ng SS et al (2008) Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem 51(22):7053-7056
-
(2008)
J Med Chem
, vol.51
, Issue.22
, pp. 7053-7056
-
-
Rose, N.R.1
Ng, S.S.2
-
132
-
-
77649224314
-
Selective inhibitors of the JMJD2 histone demethylases: Combined nondenaturing mass spectrometric screening and crystallographic approaches
-
Rose NR, Woon EC et al (2010) Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem 53(4):1810-1818
-
(2010)
J Med Chem
, vol.53
, Issue.4
, pp. 1810-1818
-
-
Rose, N.R.1
Woon, E.C.2
-
133
-
-
0037357210
-
Diet and DNA methylation interactions in cancer prevention
-
Ross SA (2003) Diet and DNA methylation interactions in cancer prevention. Ann N Y Acad Sci 983:197-207
-
(2003)
Ann N Y Acad Sci
, vol.983
, pp. 197-207
-
-
Ross, S.A.1
-
134
-
-
40349089627
-
Epigenetic modulation and cancer: Effect of metabolic syndrome?
-
Ross SA, Milner JA (2007) Epigenetic modulation and cancer: effect of metabolic syndrome? Am J Clin Nutr 86(3):s872-s877
-
(2007)
Am J Clin Nutr
, vol.86
, Issue.3
-
-
Ross, S.A.1
Milner, J.A.2
-
135
-
-
58049155757
-
Neurotrophic factors and structural plasticity in addiction
-
Russo SJ, Mazei-Robison MS et al (2009) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56(Suppl 1):73-82
-
(2009)
Neuropharmacology
, vol.56
, Issue.SUPPL. 1
, pp. 73-82
-
-
Russo, S.J.1
Mazei-Robison, M.S.2
-
136
-
-
30744456492
-
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
-
Sachchidanand, Resnick-Silverman L et al (2006) Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol 13 (1):81-90
-
(2006)
Chem Biol
, vol.13
, Issue.1
, pp. 81-90
-
-
Sachchidanand, R.-S.L.1
-
137
-
-
75749150081
-
A miniaturized screen for inhibitors of Jumonji histone demethylases
-
Sakurai M, Rose NR et al (2010) A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst 6(2):357-364
-
(2010)
Mol Biosyst
, vol.6
, Issue.2
, pp. 357-364
-
-
Sakurai, M.1
Rose, N.R.2
-
138
-
-
34250161829
-
Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
-
Schroeder FA, Lin CL et al (2007) Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 62(1):55-64
-
(2007)
Biol Psychiatry
, vol.62
, Issue.1
, pp. 55-64
-
-
Schroeder, F.A.1
Lin, C.L.2
-
139
-
-
0037130455
-
Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3
-
Shahbazian M, Young J et al (2002) Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 35(2):243-254
-
(2002)
Neuron
, vol.35
, Issue.2
, pp. 243-254
-
-
Shahbazian, M.1
Young, J.2
-
140
-
-
0344824404
-
Histone sumoylation is associated with transcriptional repression
-
Shiio Y, Eisenman RN (2003) Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci USA 100(23):13225
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.23
, pp. 13225
-
-
Shiio, Y.1
Eisenman, R.N.2
-
141
-
-
0037075032
-
The non-coding air RNA is required for silencing autosomal imprinted genes
-
Sleutels F, Zwart R et al (2002) The non-coding air RNA is required for silencing autosomal imprinted genes. Nature 415(6873):810-813
-
(2002)
Nature
, vol.415
, Issue.6873
, pp. 810-813
-
-
Sleutels, F.1
Zwart, R.2
-
142
-
-
0347017050
-
Protective role of L-methionine against free radical damage of rat brain synaptosomes
-
Slyshenkov VS, Shevalye AA et al (2002) Protective role of L-methionine against free radical damage of rat brain synaptosomes. Acta Biochim Pol 49(4):907-916
-
(2002)
Acta Biochim Pol
, vol.49
, Issue.4
, pp. 907-916
-
-
Slyshenkov, V.S.1
Shevalye, A.A.2
-
143
-
-
0035875049
-
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
-
Smiraglia DJ, Rush LJ et al (2001) Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum Mol Genet 10(13):1413-1419
-
(2001)
Hum Mol Genet
, vol.10
, Issue.13
, pp. 1413-1419
-
-
Smiraglia, D.J.1
Rush, L.J.2
-
144
-
-
27644473204
-
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
-
Stimson L, Rowlands MG et al (2005) Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol Cancer Ther 4(10):1521-1532
-
(2005)
Mol Cancer Ther
, vol.4
, Issue.10
, pp. 1521-1532
-
-
Stimson, L.1
Rowlands, M.G.2
-
145
-
-
45149134363
-
A phosphatase cascade by which rewarding stimuli control nucleosomal response
-
Stipanovich A, Valjent E et al (2008) A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453(7197):879-884
-
(2008)
Nature
, vol.453
, Issue.7197
, pp. 879-884
-
-
Stipanovich, A.1
Valjent, E.2
-
146
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403(6765): 41-45
-
(2000)
Nature
, vol.403
, Issue.6765
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
147
-
-
55449096356
-
Crosstalk among histone modifications
-
Suganuma T, Workman JL (2008) Crosstalk among histone modifications. Cell 135(4):604-607
-
(2008)
Cell
, vol.135
, Issue.4
, pp. 604-607
-
-
Suganuma, T.1
Workman, J.L.2
-
148
-
-
0037189502
-
A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats
-
Swinney DC, Xu YZ et al (2002) A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats. J Biol Chem 277(26):23573
-
(2002)
J Biol Chem
, vol.277
, Issue.26
, pp. 23573
-
-
Swinney, D.C.1
Xu, Y.Z.2
-
149
-
-
65249157050
-
Epigenetics, DNA methylation, and chromatin modifying drugs
-
Szyf M (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49:243-263
-
(2009)
Annu Rev Pharmacol Toxicol
, vol.49
, pp. 243-263
-
-
Szyf, M.1
-
150
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, Koh KP et al (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324(5929):930-935
-
(2009)
Science
, vol.324
, Issue.5929
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
-
151
-
-
79951847599
-
Histone deacetylase inhibitor therapy in epithelial ovarian cancer
-
Takai N, Narahara H (2010) Histone deacetylase inhibitor therapy in epithelial ovarian cancer. J Oncol 2010:458431
-
(2010)
J Oncol
, vol.2010
, pp. 458431
-
-
Takai, N.1
Narahara, H.2
-
152
-
-
77649171884
-
Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
-
Tan J, Cang S et al (2010) Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J Hematol Oncol 3:5
-
(2010)
J Hematol Oncol
, vol.3
, pp. 5
-
-
Tan, J.1
Cang, S.2
-
153
-
-
35848961668
-
How chromatin-binding modules interpret histone modifications: Lessons from professional pocket pickers
-
Taverna SD, Li H et al (2007) How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol 14(11):1025-1040
-
(2007)
Nat Struct Mol Biol
, vol.14
, Issue.11
, pp. 1025-1040
-
-
Taverna, S.D.1
Li, H.2
-
154
-
-
0037168650
-
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
-
Tremolizzo L, Carboni G et al (2002) An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA 99(26): 17095-17100
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.26
, pp. 17095-17100
-
-
Tremolizzo, L.1
Carboni, G.2
-
155
-
-
17444379438
-
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
-
Tremolizzo L, Doueiri MS et al (2005) Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry 57(5):500-509
-
(2005)
Biol Psychiatry
, vol.57
, Issue.5
, pp. 500-509
-
-
Tremolizzo, L.1
Doueiri, M.S.2
-
156
-
-
33645357786
-
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
-
Tsankova NM, Berton O et al (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9(4):519-525
-
(2006)
Nat Neurosci
, vol.9
, Issue.4
, pp. 519-525
-
-
Tsankova, N.M.1
Berton, O.2
-
157
-
-
34247509796
-
Epigenetic regulation in psychiatric disorders
-
Tsankova N, Renthal W et al (2007) Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 8(5):355-367
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.5
, pp. 355-367
-
-
Tsankova, N.1
Renthal, W.2
-
158
-
-
33845233581
-
Reelin down-regulation in mice and psychosis endophenotypes
-
Tueting P, Doueiri MS et al (2006) Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev 30(8):1065-1077
-
(2006)
Neurosci Biobehav Rev
, vol.30
, Issue.8
, pp. 1065-1077
-
-
Tueting, P.1
Doueiri, M.S.2
-
159
-
-
0036403334
-
Genetic effects of methylation diets
-
Van den Veyver IB (2002) Genetic effects of methylation diets. Annu Rev Nutr 22:255-282
-
(2002)
Annu Rev Nutr
, vol.22
, pp. 255-282
-
-
van den Veyver, I.B.1
-
160
-
-
68049120458
-
Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes
-
Voso MT, Santini V et al (2009) Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. Clin Cancer Res 15(15): 5002-5007
-
(2009)
Clin Cancer Res
, vol.15
, Issue.15
, pp. 5002-5007
-
-
Voso, M.T.1
Santini, V.2
-
162
-
-
71449109387
-
New patented histone deacetylase inhibitors
-
Wang H, Dymock BW (2009) New patented histone deacetylase inhibitors. Expert Opin Ther Pat 19(12):1727-1757
-
(2009)
Expert Opin Ther Pat
, vol.19
, Issue.12
, pp. 1727-1757
-
-
Wang, H.1
Dymock, B.W.2
-
163
-
-
0035054930
-
Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein
-
Watson P, Black G et al (2001) Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein. J Med Genet 38(4):224-228
-
(2001)
J Med Genet
, vol.38
, Issue.4
, pp. 224-228
-
-
Watson, P.1
Black, G.2
-
164
-
-
3342989681
-
Epigenetic programming by maternal behavior
-
Weaver IC, Cervoni N et al (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7(8):847-854
-
(2004)
Nat Neurosci
, vol.7
, Issue.8
, pp. 847-854
-
-
Weaver, I.C.1
Cervoni, N.2
-
165
-
-
28044436691
-
Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life
-
Weaver IC, Champagne FA et al (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25(47):11045-11054
-
(2005)
J Neurosci
, vol.25
, Issue.47
, pp. 11045-11054
-
-
Weaver, I.C.1
Champagne, F.A.2
-
166
-
-
33644763991
-
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
-
Weaver IC, Meaney MJ et al (2006) Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci USA 103(9):3480-3485
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.9
, pp. 3480-3485
-
-
Weaver, I.C.1
Meaney, M.J.2
-
167
-
-
85044706427
-
Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: An AlphaScreen-based assay for antagonists of methyl-lysine binding proteins
-
Wigle TJ, Herold JM et al (2010) Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins. J Biomol Screen 15(1):62-71
-
(2010)
J Biomol Screen
, vol.15
, Issue.1
, pp. 62-71
-
-
Wigle, T.J.1
Herold, J.M.2
-
168
-
-
0012218196
-
Biochemical and sleep studies of schizophrenia: A review of the literature - 1960-1970
-
Wyatt A, Benedict RG, Davis J (1971) Biochemical and sleep studies of schizophrenia: a review of the literature - 1960-1970. Schizophr Bull 4:10-44
-
(1971)
Schizophr Bull
, vol.4
, pp. 10-44
-
-
Wyatt, A.1
Benedict, R.G.2
Davis, J.3
-
169
-
-
34447338875
-
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine
-
Yang M, Culhane JC et al (2007) Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry 46(27): 8058-8065
-
(2007)
Biochemistry
, vol.46
, Issue.27
, pp. 8058-8065
-
-
Yang, M.1
Culhane, J.C.2
-
170
-
-
0024996768
-
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
-
Yoshida M, Kijima M et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28):17174-17179
-
(1990)
J Biol Chem
, vol.265
, Issue.28
, pp. 17174-17179
-
-
Yoshida, M.1
Kijima, M.2
-
171
-
-
33749590330
-
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
-
Zhou Z, Hong EJ et al (2006) Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52(2):255-269
-
(2006)
Neuron
, vol.52
, Issue.2
, pp. 255-269
-
-
Zhou, Z.1
Hong, E.J.2
-
172
-
-
77951111333
-
Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights
-
Zhu X, Ma Y et al (2010) Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights. J Hematol Oncol 3:17
-
(2010)
J Hematol Oncol
, vol.3
, pp. 17
-
-
Zhu, X.1
Ma, Y.2
-
173
-
-
70149112313
-
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation
-
Zippo A, Serafini R et al (2009) Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell 138(6):1122
-
(2009)
Cell
, vol.138
, Issue.6
, pp. 1122
-
-
Zippo, A.1
Serafini, R.2
|