Methyl-CpG binding proteins in the nervous system

Cell Research

Volumn 15, Issue 4, 2005, Pages 255-261

  Fan, Guoping ^a   Hutnick, Leah ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chromatin remodeling; DNA methylation; Gene silencing; Histone modification; MBD proteins; MeCP2; Neuronal differentiation

Indexed keywords

VERTEBRATA;

DNA BINDING PROTEIN; MECP2 PROTEIN, HUMAN; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; NONHISTONE PROTEIN; REPRESSOR PROTEIN;

ANIMAL; CPG ISLAND; DNA METHYLATION; GENETICS; HUMAN; METABOLISM; MUTATION; NERVOUS SYSTEM; PHYSIOLOGY; REVIEW;

ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; HUMANS; METHYL-CPG-BINDING PROTEIN 2; MUTATION; NERVOUS SYSTEM; REPRESSOR PROTEINS; RNA, MESSENGER;

EID: 24344497413     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290294     Document Type: Short Survey

References (67)

1. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33 Suppl:245-54.
2. Li E, Bestor T, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992; 69:915-26.
3. Lei H, Oh S, Okano M, et al. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 1996; 122:3195-205.
4. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999; 99:247-57.
5. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet 2000; 1:11-9.
6. Goto K, Numata M, Komura JI, et al. Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice. Differentiation 1994; 56:39-44.
7. Brooks PJ, Marietta C, Goldman D. DNA mismatch repair and DNA methylation in adult brain neurons. J Neurosci 1996; 16:939-45.
8. Feng J, Chang H, Li E, Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res 2005; 79:734-46.
9. Fan G, Beard C, Chen RZ, et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci 2001; 21:788-97.
10. Watt F, Molloy PL. Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes Dev 1998; 2:1136-43.
11. Takizawa T, Nakashima K, Namihira M, et al. DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 2001; 1:749-58.
12. Lewis JD, Meehan RR, Henzel WJ, et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 1992; 69:905-14.
13. Cross SH, Meehan RR, Nan X, Bird A. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat Genet 1997; 16:256-9.
14. Nan X, Campoy FJ, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 1997; 88:471-81,
15. Nan X, Ng HH, Johnson CA, et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998; 393:386-9.
16. Jones PL, Veenstra GJ, Wade PA, et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 1998; 19:187-91.
17. Fuks F, Hurd PJ, Wolf D, et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 2003; 278:4035-40.
18. Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol 1998; 18:6538-47.
19. Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 1999; 401:301-4.
20. Shahbazian MD, Antalffy B, Armstrong DL, Zoghbi HY. Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum Mol Genet 2002; 11:115-24.
21. Mullaney BC, Johnston MV, Blue ME. Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain. Neuroscience 2004; 123:939-49.
22. Cassel S, Revel MO, Kelche C, Zwiller J. Expression of the methyl-CpG-binding protein MeCP2 in rat brain. An ontogenetic study. Neurobiol Dis 2004; 15:206-11.
23. Nan X, Meehan RR, Bird A. Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucleic Acids Res 1993; 21:4886-92.
24. Mnatzakanian GN, Mnatzakanian GN, Lohi H, et al. A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome. Nat Genet 2004; 36:339-41.
25. Kriaucionis S, Bird A. The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res 2004; 32:1818-23.
26. Kokura K, Kaul SC, Wadhwa R, et al. The Ski protein family is required for MeCP2-mediated transcriptional repression. J Biol Chem2001; 276:34115-21.
27. Vacca M, Filippini F, Budillon A, et al. Mutation analysis of the MECP2 gene in British and Italian Rett syndrome females. J Mol Med 2001; 78:648-55.
28. Amir RE, Van den Veyver IB, Wan M, et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 1999; 23:185-8.
29. Guy J, Hendrich B, Holmes M, Martin JE, Bird A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 2001; 27:322-6.
30. Chen RZ, Akbarian S, Tudor M, Jaenisch R. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 2001; 27:327-31.
31. Shahbazian M, Young J, Yuva-Paylor L, et al. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 2002; 35:243-254.
32. Tudor M, Akbarian S, Chen RZ, Jaenisch R. Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci USA 2002; 99:15536-15541.
33. Luikenhuis S, Giacometti E, Beard CF, Jaenisch R. Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci USA 2004; 101:6033-8.
34. Collins AL, Levenson JM, Vilaythong AP, et al. Mild over-expression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet 2004; 13:2679-89.
35. Martinowich K, Hattori D, Wu H, et al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 2003; 302:890-893.
36. Chen WG, Chang Q, Lin Y, et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003; 302:885-889.
37. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 1998; 20:709-26.
38. Shieh PB, Hu SC, Bobb K, Timmusk T, Ghosh A. Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 1998; 20:727-40.
39. Lunyak W, Burgess R, Prefontaine GG, et al. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 2002; 298:1747-52.
40. Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet 2005; 37:31-40.
41. Wade PA, Jones PL, Vermaak D, et al. Histone deacetylase directs the dominant silencing of transcription in chromatin: association with MeCP2 and the Mi-2 chromodomain SWI/SNF ATPase. Cold Spring Harb Symp Quant Biol 1998; 63:435-45.
42. Harikrishnan KN, Chow MZ, Baker EK, et al. Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nat Genet 2005; 37:254-64.
43. von Kries JP, Buhrmester H, Stratling WH. A matrix/scaffold attachment region binding protein: identification, purification, and mode of binding. Cell 1991; 64:123-35.
44. Weitzel JM, Buhrmester H, Stratling WH. Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2. Mol Cell Biol 1997; 17:5656-66.
45. Georgel PT, Horowitz-Scherer RA, Adkins N, et al. Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem 2003; 278:32181-8.
46. Bowen NJ, Palmer MB, Wade PA. Chromosomal regulation by MeCP2: structural and enzymatic considerations. Cell Mol Life Sci 2004; 61:2163-7.
47. Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR. A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos. Mol Cell 2003; 12:425-35.
48. Kishi N, Macklis JD. MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol Cell Neurosci 2004; 27:306-21.
49. Cohen DR, Matarazzo V, Palmer AM, et al. Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis. Mol Cell Neurosci 2003; 22:417-29.
50. Matarazzo V, Cohen D, Palmer AM, et al. The transcriptional repressor Mecp2 regulates terminal neuronal differentiation. Mol Cell Neurosci 2004; 27:44-58.
51. Ng HH, Jeppesen P, Bird A. Active repression of methylated genes by the chromosomal protein MBD1. Mol Cell Biol 2000; 20:1394-406.
52. Jorgensen HF, Ben-Porath I, Bird AP. Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol Cell Biol 2004; 24:3387-95.
53. Sarraf SA, Stancheva I. Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol Cell 2004; 15:595-605.
54. Zhao X, Ueba T, Christie BR, et al. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci USA 2003; 100:6777-82.
55. Zhang Y, Ng HH, Erdjument-Bromage H, et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 1999; 13:1924-35.
56. Ng HH, Zhang Y, Hendrich B, et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet 1999; 23:58-61.
57. Wade PA, Gegonne A, Jones PL, et al. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nature Genet 1999; 23:62-66.
58. Feng Q, Zhang Y. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev 2001; 15:827-32.
59. Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 1999; 397:568-9.
60. Fujita H, Fujii R, Aratani S, et al. Antithetic effects of MBD2a on gene regulation. Mol Cell Biol 2003; 23:2645-57.
61. Jung BP, Zhang G, Nitsch R, et al. Differential expression of methyl CpG-binding domain containing factor MBD3 in the developing and adult rat brain. J Neurobiol 2003; 55:220-32.
62. Francis J, Jung B, Zhang G, et al. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Neuroscience 2002; 113:79-87.
63. Jung BP, Zhang G, Ho W, Francis J, Eubanks JH. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Neuroscience 2002; 115:515-24.
64. Hendrich B, Guy J, Ramsahoye B, Wilson VA, Bird A. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev 2001; 15:710-23.
65. Prokhortchouk A, Hendrich B, Jorgensen H, et al. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev 2001; 15:1613-8.
66. Ruzov A, Dunican DS, Prokhortchouk A, et al. Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. Development 2004; 131:6185-94.
67. Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell 2003; 12:723-34.