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Volumn 2, Issue 2, 2001, Pages 110-119

Post-transcriptional gene silencing by double-stranded RNA

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; HARNESS;

EID: 0035261255     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/35052556     Document Type: Review
Times cited : (741)

References (80)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998). This was the first paper to describe the phenomenon of RNA interference (RNAi).
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 2
    • 0032538391 scopus 로고    scopus 로고
    • Soaking in the genome sequence
    • Tabara, H., Grishok, A. & Mello, C. Soaking in the genome sequence. Science 282, 430-431 (1998).
    • (1998) Science , vol.282 , pp. 430-431
    • Tabara, H.1    Grishok, A.2    Mello, C.3
  • 3
    • 0029024475 scopus 로고
    • par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
    • Guo, S. & Kemphues, K. J. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 81, 611-620 (1995).
    • (1995) Cell , vol.81 , pp. 611-620
    • Guo, S.1    Kemphues, K.J.2
  • 4
    • 0033230617 scopus 로고    scopus 로고
    • PKR; a sentinel kinase for cellular stress
    • Williams, B. R. PKR; a sentinel kinase for cellular stress. Oncogene 18, 6112-6120 (1999).
    • (1999) Oncogene , vol.18 , pp. 6112-6120
    • Williams, B.R.1
  • 6
    • 0032417618 scopus 로고    scopus 로고
    • RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    • Montgomery, M. K., Xu, S. & Fire, A. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 95, 15502-15507 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 15502-15507
    • Montgomery, M.K.1    Xu, S.2    Fire, A.3
  • 7
    • 0032755747 scopus 로고    scopus 로고
    • RNA interference can target pre-mRNA: Consequences for gene expression in a Caenorhabditis elegans operon
    • Bosher, J. M., Dufourcq, P., Sookhareea, S. & Labouesse, M. RNA interference can target pre-mRNA: consequences for gene expression in a Caenorhabditis elegans operon. Genetics 153, 1245-1256 (1999).
    • (1999) Genetics , vol.153 , pp. 1245-1256
    • Bosher, J.M.1    Dufourcq, P.2    Sookhareea, S.3    Labouesse, M.4
  • 8
    • 0033634682 scopus 로고    scopus 로고
    • Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference
    • Parrish, S., Fleenor, J., Xu, S., Mello, C. & Fire, A. Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference. Mol. Cell 6, 1077-1087 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 1077-1087
    • Parrish, S.1    Fleenor, J.2    Xu, S.3    Mello, C.4    Fire, A.5
  • 9
    • 0031940775 scopus 로고    scopus 로고
    • Homology-based control of gene expression patterns in transgenic petunia flowers
    • Que, Q. & Jorgensen, R. A. Homology-based control of gene expression patterns in transgenic petunia flowers. Dev. Genet. 22, 100-109 (1998).
    • (1998) Dev. Genet. , vol.22 , pp. 100-109
    • Que, Q.1    Jorgensen, R.A.2
  • 10
    • 0030220502 scopus 로고    scopus 로고
    • Chalcone synthase cosuppression phenotypes in petunia flowers: Comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences
    • Jorgensen, R. A., Cluster, P. D., English, J., Que, Q. & Napoli, C. A. Chalcone synthase cosuppression phenotypes in petunia flowers: comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences. Plant Mol. Biol. 31, 957-973 (1996).
    • (1996) Plant Mol. Biol. , vol.31 , pp. 957-973
    • Jorgensen, R.A.1    Cluster, P.D.2    English, J.3    Que, Q.4    Napoli, C.A.5
  • 11
    • 0033120047 scopus 로고    scopus 로고
    • An inverted repeat triggers cytosine methylation of identical sequences in Arabidopsis
    • Luff, B., Pawlowski, L. & Bender, J. An inverted repeat triggers cytosine methylation of identical sequences in Arabidopsis. Mol. Cell 3, 505-511 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 505-511
    • Luff, B.1    Pawlowski, L.2    Bender, J.3
  • 12
    • 0031748054 scopus 로고    scopus 로고
    • Gene silencing and homology-dependent gene silencing in Arabidopsis: Genetic modifiers and DNA methylation
    • Furner, I. J., Sheikh, M. A. & Collett, C. E. Gene silencing and homology-dependent gene silencing in Arabidopsis: genetic modifiers and DNA methylation. Genetics 149, 651-662 (1998).
    • (1998) Genetics , vol.149 , pp. 651-662
    • Furner, I.J.1    Sheikh, M.A.2    Collett, C.E.3
  • 13
    • 0034636551 scopus 로고    scopus 로고
    • Disruption of the plant gene MOM releases transcriptional silencing of methylated genes
    • Amedeo, P., Habu, Y., Afsar, K., Scheid, O. M. & Paszkowski, J. Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Nature 405, 203-206 (2000).
    • (2000) Nature , vol.405 , pp. 203-206
    • Amedeo, P.1    Habu, Y.2    Afsar, K.3    Scheid, O.M.4    Paszkowski, J.5
  • 14
    • 0028020672 scopus 로고
    • Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation
    • Ingelbrechf, I., Van Houdt, H., Van Montagu, M. & Depicker, A. Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation. Proc. Natl Acad. Sci. USA 91, 10502-10506 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 10502-10506
    • Ingelbrechf, I.1    Van Houdt, H.2    Van Montagu, M.3    Depicker, A.4
  • 15
    • 0030875953 scopus 로고    scopus 로고
    • Systemic acquired silencing: Transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions
    • erratum 17, 2137 (1998)
    • Palauqui, J. C., Elmayan, T., Pollien, J. M. & Vaucheret, H. Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions. EMBO J. 16, 4738-4745 (1997); erratum 17, 2137 (1998).
    • (1997) EMBO J. , vol.16 , pp. 4738-4745
    • Palauqui, J.C.1    Elmayan, T.2    Pollien, J.M.3    Vaucheret, H.4
  • 16
    • 0030927776 scopus 로고    scopus 로고
    • Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA
    • Angell, S. M. & Baulcombe, D. C. Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA. EMBO J. 16, 3675-3684 (1997).
    • (1997) EMBO J. , vol.16 , pp. 3675-3684
    • Angell, S.M.1    Baulcombe, D.C.2
  • 17
    • 0030835456 scopus 로고    scopus 로고
    • Cosuppression in Drosophila: Gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
    • Pal-Bhadra, M., Bhadra, U. & Birchler, J. A. Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent. Cell 90, 479-490 (1997).
    • (1997) Cell , vol.90 , pp. 479-490
    • Pal-Bhadra, M.1    Bhadra, U.2    Birchler, J.A.3
  • 18
  • 19
    • 0032905930 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional silencing of rodent alpha1(I) collagen by a homologous transcriptionally self-silenced transgene
    • Bahramian, M. B. & Zarbl, H. Transcriptional and posttranscriptional silencing of rodent alpha1(I) collagen by a homologous transcriptionally self-silenced transgene. Mol. Cell. Biol. 19, 274-283 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 274-283
    • Bahramian, M.B.1    Zarbl, H.2
  • 20
    • 0029934123 scopus 로고    scopus 로고
    • Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation
    • Cogoni, C. et al. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation. EMBO J. 15, 3153-3163 (1996).
    • (1996) EMBO J. , vol.15 , pp. 3153-3163
    • Cogoni, C.1
  • 21
    • 0028286165 scopus 로고
    • Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
    • Dorer, D. R. & Henikoff, S. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77, 993-1002 (1994).
    • (1994) Cell , vol.77 , pp. 993-1002
    • Dorer, D.R.1    Henikoff, S.2
  • 22
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton, A. J. & Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286, 950-952 (1999). A potential mediator of post-transcriptional gene silencing (PTGS) was identified for the first time. This small -25-nucleotide RNA has become a hallmark of silencing processes that are mediated by double-stranded (ds) RNA molecules.
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 23
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond, S. M., Bernstein, E., Beach, D. & Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296 (2000). The authors identify a dsRNA-inducible nuclease activity that targets mRNAs for degradation. They also show that this enzyme is associated with -22-nucleotide RNA fragments (guide RNAs) that might determine target specificity.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 24
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore, P. D., Tuschl, T., Sharp, P. A. & Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000). By developing their earlier work on an in vitro RNAi system, these authors show that -22-nucleotide guide RNAs can be produced directly from longer dsRNAs in vitro and that target mRNAs are cleaved in response to dsRNAs at -22-nucleotide intervals.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 25
    • 0034609759 scopus 로고    scopus 로고
    • Evidence that processed small dsRNAs may mediate sequence specific mRNA degradation during RNAi in Drosophila embryos
    • Yang, D., Lu, H. & Erickson, J. W. Evidence that processed small dsRNAs may mediate sequence specific mRNA degradation during RNAi in Drosophila embryos. Curr. Biol. 10, 1191-1200 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 1191-1200
    • Yang, D.1    Lu, H.2    Erickson, J.W.3
  • 26
    • 0034596989 scopus 로고    scopus 로고
    • Transcriptional silencing and promoter methylation triggered by double-stranded RNA
    • Mette, M. F., Aufsatz, W., van der Winden, J., Matzke, M. A. & Matzke, A. J. M. Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J. 19, 5194-5201 (2000).
    • (2000) EMBO J. , vol.19 , pp. 5194-5201
    • Mette, M.F.1    Aufsatz, W.2    Van Der Winden, J.3    Matzke, M.A.4    Matzke, A.J.M.5
  • 27
    • 0034634360 scopus 로고    scopus 로고
    • Transgene and transposon silencing in chlamydomonas reinhardtii by a DEAH-Box RNA helicase
    • Wu-Scharf, D., Jeong, B., Zhang, C. & Cerutti, H. Transgene and transposon silencing in chlamydomonas reinhardtii by a DEAH-Box RNA helicase. Science 290, 1159-1163 (2000).
    • (2000) Science , vol.290 , pp. 1159-1163
    • Wu-Scharf, D.1    Jeong, B.2    Zhang, C.3    Cerutti, H.4
  • 29
    • 0034633770 scopus 로고    scopus 로고
    • AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals
    • Fagard, M., Boutet, S., Morel, J. B., Bellini, C. & Vaucheret, H. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. Proc. Natl Acad. Sci. USA 97, 11650-11654 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11650-11654
    • Fagard, M.1    Boutet, S.2    Morel, J.B.3    Bellini, C.4    Vaucheret, H.5
  • 30
    • 0032472373 scopus 로고    scopus 로고
    • AGO1 defines a novel locus of Arabidopsis controlling leaf development
    • Bohmert, K. et al. AGO1 defines a novel locus of Arabidopsis controlling leaf development. EMBO J. 17, 170-180 (1998).
    • (1998) EMBO J. , vol.17 , pp. 170-180
    • Bohmert, K.1
  • 31
    • 0030755562 scopus 로고    scopus 로고
    • A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
    • Lin, H. & Spradling, A. C. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 124, 2463-2476 (1997).
    • (1997) Development , vol.124 , pp. 2463-2476
    • Lin, H.1    Spradling, A.C.2
  • 32
    • 0032510774 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a rabbit elF2C protein
    • Zou, C., Zhang, Z., Wu, S. & Osterman, J. C. Molecular cloning and characterization of a rabbit elF2C protein. Gene 211, 187-194 (1998).
    • (1998) Gene , vol.211 , pp. 187-194
    • Zou, C.1    Zhang, Z.2    Wu, S.3    Osterman, J.C.4
  • 33
    • 0032879978 scopus 로고    scopus 로고
    • GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation
    • Cikaluk, D. E. et al. GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation. Mol. Biol. Cell 10, 3357-3372 (1999).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3357-3372
    • Cikaluk, D.E.1
  • 34
    • 0034737747 scopus 로고    scopus 로고
    • Genetic requirements for inheritance of RNAi in C. elegans
    • Grishok, A., Tabara, H. & Mello, C. C. Genetic requirements for inheritance of RNAi in C. elegans. Science 287, 2494-2497 (2000).
    • (2000) Science , vol.287 , pp. 2494-2497
    • Grishok, A.1    Tabara, H.2    Mello, C.C.3
  • 35
    • 0032717319 scopus 로고    scopus 로고
    • The rde-1 gene, RNA interference, and transposon silencing in C. elegans
    • Tabara, H. et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99, 123-132 (1999). With reference 26, this is one of the first reports of the genetic analysis of RNAi in C. elegans. This paper establishes a link between RNAI and transposon silencing and links the ARGONAUTE family of proteins to the silencing process.
    • (1999) Cell , vol.99 , pp. 123-132
    • Tabara, H.1
  • 36
    • 0032739015 scopus 로고    scopus 로고
    • Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
    • Ketting, R. F., Haverkamp, T. H., van Luenen, H. G. & Plasterk, R. H. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell 99, 133-141 (1999). Establishes a link between RNAi and transposon silencing and identifies a putative nuclease as an effector of silencing.
    • (1999) Cell , vol.99 , pp. 133-141
    • Ketting, R.F.1    Haverkamp, T.H.2    Van Luenen, H.G.3    Plasterk, R.H.4
  • 37
    • 0033151822 scopus 로고    scopus 로고
    • Werner syndrome helicase contains a 5′→3′ exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding
    • Suzuki, N., Shiratori, M., Goto, M. & Furuichi, Y. Werner syndrome helicase contains a 5′→3′ exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding. Nucleic Acids Res. 27, 2361-2368 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2361-2368
    • Suzuki, N.1    Shiratori, M.2    Goto, M.3    Furuichi, Y.4
  • 38
    • 0032545423 scopus 로고    scopus 로고
    • Werner syndrome protein. II. Characterization of the integral 3′→5′ DNA exonuclease
    • Kamath-Loeb, A. S., Shen, J. C., Loeb, L. A. & Fry, M. Werner syndrome protein. II. Characterization of the integral 3′→5′ DNA exonuclease. J. Biol. Chem. 273, 34145-34150 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 34145-34150
    • Kamath-Loeb, A.S.1    Shen, J.C.2    Loeb, L.A.3    Fry, M.4
  • 39
    • 0032545515 scopus 로고    scopus 로고
    • Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide
    • Shen, J. C. et al. Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide. J. Biol. Chem. 273, 34139-34144 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 34139-34144
    • Shen, J.C.1
  • 40
    • 0031686571 scopus 로고    scopus 로고
    • The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease
    • Huang, S. et al. The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nature Genet. 20, 114-116 (1998).
    • (1998) Nature Genet. , vol.20 , pp. 114-116
    • Huang, S.1
  • 41
    • 0028321487 scopus 로고
    • The Tc5 family of transposable elements in Caenorhabditis elegans
    • Collins, J. J. & Anderson, P. The Tc5 family of transposable elements in Caenorhabditis elegans. Genetics 137, 771-781 (1994).
    • (1994) Genetics , vol.137 , pp. 771-781
    • Collins, J.J.1    Anderson, P.2
  • 42
    • 0034665818 scopus 로고    scopus 로고
    • A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans
    • Domeier, M. E. et al. A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science 289, 1928-1931 (2000).
    • (2000) Science , vol.289 , pp. 1928-1931
    • Domeier, M.E.1
  • 43
    • 0032771414 scopus 로고    scopus 로고
    • SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
    • Page, M. F., Carr, B., Anders, K. R., Grimson, A. & Anderson, P. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol. Cell. Biol. 19, 5943-5951 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5943-5951
    • Page, M.F.1    Carr, B.2    Anders, K.R.3    Grimson, A.4    Anderson, P.5
  • 44
    • 0033579344 scopus 로고    scopus 로고
    • Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase
    • Cogoni, C. & Macino, G. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase. Science 286, 2342-2344 (1999).
    • (1999) Science , vol.286 , pp. 2342-2344
    • Cogoni, C.1    Macino, G.2
  • 45
    • 0029116861 scopus 로고
    • Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development
    • Qiao, L. et al. Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development. Genetics 141, 551-569 (1995).
    • (1995) Genetics , vol.141 , pp. 551-569
    • Qiao, L.1
  • 46
    • 0034708215 scopus 로고    scopus 로고
    • EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
    • erratum in 10, R393-R394 (2000)
    • Smardon, A. et al. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr. Biol. 10, 169-178 (2000); erratum in 10, R393-R394 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 169-178
    • Smardon, A.1
  • 47
    • 0033551328 scopus 로고    scopus 로고
    • Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
    • Cogoni, C. & Macino, G. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature 399, 166-169 (1999).
    • (1999) Nature , vol.399 , pp. 166-169
    • Cogoni, C.1    Macino, G.2
  • 48
    • 0034716924 scopus 로고    scopus 로고
    • An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
    • Dalmay, T., Hamilton, A., Rudd, S., Angell, S. & Baulcombe, D. C. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell 101, 543-553 (2000).
    • (2000) Cell , vol.101 , pp. 543-553
    • Dalmay, T.1    Hamilton, A.2    Rudd, S.3    Angell, S.4    Baulcombe, D.C.5
  • 49
    • 0034716907 scopus 로고    scopus 로고
    • Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
    • Mourrain, P. et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell 101, 533-542 (2000).
    • (2000) Cell , vol.101 , pp. 533-542
    • Mourrain, P.1
  • 50
    • 0033572660 scopus 로고    scopus 로고
    • Targeted mRNA degradation by double-stranded RNA in vitro
    • Tuschl, T., Zamore, P. D., Lehmann, R., Bartel, D. P. & Sharp, P. A. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev. 13, 3191-3197 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 3191-3197
    • Tuschl, T.1    Zamore, P.D.2    Lehmann, R.3    Bartel, D.P.4    Sharp, P.A.5
  • 51
    • 0034724519 scopus 로고    scopus 로고
    • Double-stranded RNA as a template for gene silencing
    • Bass, B. L. Double-stranded RNA as a template for gene silencing. Cell 101, 235-238 (2000).
    • (2000) Cell , vol.101 , pp. 235-238
    • Bass, B.L.1
  • 52
    • 0034306266 scopus 로고    scopus 로고
    • Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the piwi domain
    • Cerutti, L., Mian, N. & Bateman, A. Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the piwi domain. Trends Biochem. Sci. 10, 481-482 (2000).
    • (2000) Trends Biochem. Sci. , vol.10 , pp. 481-482
    • Cerutti, L.1    Mian, N.2    Bateman, A.3
  • 53
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A. C., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.C.2    Hammond, S.M.3    Hannon, G.J.4
  • 54
    • 0034176335 scopus 로고    scopus 로고
    • Initiation of genetic recombination and recombination-dependent replication
    • Kowalczykowski, S. C. Initiation of genetic recombination and recombination-dependent replication. Trends Biochem. Sci. 25, 156-165 (2000).
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 156-165
    • Kowalczykowski, S.C.1
  • 55
    • 0033968037 scopus 로고    scopus 로고
    • Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes
    • Tavernarakis, N., Wang, S. L., Dorovkov, M., Ryazanov, A. & Driscoll, M. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nature Genet. 24, 180-183 (2000).
    • (2000) Nature Genet. , vol.24 , pp. 180-183
    • Tavernarakis, N.1    Wang, S.L.2    Dorovkov, M.3    Ryazanov, A.4    Driscoll, M.5
  • 56
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • Fraser, A. G. et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330 (2000).
    • (2000) Nature , vol.408 , pp. 325-330
    • Fraser, A.G.1
  • 57
    • 0034676448 scopus 로고    scopus 로고
    • Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
    • Gonczy, P. et al. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408, 331-336 (2000).
    • (2000) Nature , vol.408 , pp. 331-336
    • Gonczy, P.1
  • 58
    • 0033883114 scopus 로고    scopus 로고
    • Heritable gene silencing in Drosophila using double stranded RNA
    • Kennerdell, J. R. & Carthew, R. W. Heritable gene silencing in Drosophila using double stranded RNA. Nature Biotechnol. 17, 896-898 (2000).
    • (2000) Nature Biotechnol. , vol.17 , pp. 896-898
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 59
    • 0034612276 scopus 로고    scopus 로고
    • Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
    • Clemens, J. C. et al. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl Acad. Sci. USA 97, 6499-6503 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 6499-6503
    • Clemens, J.C.1
  • 60
    • 0034674713 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in Drosophila
    • Rong, Y. S. & Golic, K. G. Gene targeting by homologous recombination in Drosophila. Science 288, 2013-2018 (2000).
    • (2000) Science , vol.288 , pp. 2013-2018
    • Rong, Y.S.1    Golic, K.G.2
  • 61
    • 0032410928 scopus 로고    scopus 로고
    • Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
    • Ngo, H., Tschudi, C., Gull, K. & Ullu, E. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl Acad. Sci. USA 95, 14687-14692 (1998)
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 14687-14692
    • Ngo, H.1    Tschudi, C.2    Gull, K.3    Ullu, E.4
  • 62
    • 0033608994 scopus 로고    scopus 로고
    • Double stranded RNA specifically disrupts gene expression during planarian regeneration
    • Alvarado, A. S. & Newmark, P. A. Double stranded RNA specifically disrupts gene expression during planarian regeneration. Proc. Natl Acad. Sci. USA 96, 5049-5054 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5049-5054
    • Alvarado, A.S.1    Newmark, P.A.2
  • 63
    • 0033766888 scopus 로고    scopus 로고
    • Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference
    • Svoboda, P., Stein, P., Hayashi, H. & Schultz, R. M. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development 127, 4147-4156 (2000).
    • (2000) Development , vol.127 , pp. 4147-4156
    • Svoboda, P.1    Stein, P.2    Hayashi, H.3    Schultz, R.M.4
  • 64
    • 0033789992 scopus 로고    scopus 로고
    • Specific interference with gene function by double-stranded RNA in early mouse development
    • Wianny, F. & Zemicka-Goetz, M. Specific interference with gene function by double-stranded RNA in early mouse development. Nature Cell Biol. 2, 70-75 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 70-75
    • Wianny, F.1    Zemicka-Goetz, M.2
  • 65
    • 0034683099 scopus 로고    scopus 로고
    • Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target
    • Ui-Tei, K., Zenno, S., Miyata, Y. & Saigo, K. Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target. FEBS Lett. 479, 79-82 (2000).
    • (2000) FEBS Lett. , vol.479 , pp. 79-82
    • Ui-Tei, K.1    Zenno, S.2    Miyata, Y.3    Saigo, K.4
  • 66
    • 0032757554 scopus 로고    scopus 로고
    • Cosuppression of I transposon activity in Drosophila by I-containing sense and antisense transgenes
    • Jensen, S., Gassama, M. P. & Heidmann, T. Cosuppression of I transposon activity in Drosophila by I-containing sense and antisense transgenes. Genetics 153, 1767-1774 (1999).
    • (1999) Genetics , vol.153 , pp. 1767-1774
    • Jensen, S.1    Gassama, M.P.2    Heidmann, T.3
  • 67
    • 0033756232 scopus 로고    scopus 로고
    • New insights on pomology-dependent silencing of I factor activity by transgenes containing ORF1 in Drosophila melanogaster
    • Malinsky, S., Bucheton, A. & Busseau, I. New insights on pomology-dependent silencing of I factor activity by transgenes containing ORF1 in Drosophila melanogaster. Genetics 156, 1147-1155 (2000).
    • (2000) Genetics , vol.156 , pp. 1147-1155
    • Malinsky, S.1    Bucheton, A.2    Busseau, I.3
  • 68
    • 0032538794 scopus 로고    scopus 로고
    • Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana
    • Brigneti, G. et al. Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana. EMBO J. 17, 6739-6746 (1998).
    • (1998) EMBO J. , vol.17 , pp. 6739-6746
    • Brigneti, G.1
  • 69
    • 0033598840 scopus 로고    scopus 로고
    • Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants
    • Voinnet, O., Pinto, Y. M. & Baulcombe, D. C. Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants. Proc. Natl Acad. Sci. USA 96, 14147-14152 (1999). This is one of several papers that establishes a second biological function for RNAi by linking dsRNA-induced silencing to virus resistance in plants.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14147-14152
    • Voinnet, O.1    Pinto, Y.M.2    Baulcombe, D.C.3
  • 71
    • 0033928734 scopus 로고    scopus 로고
    • Genetic interference in Trypanosoma brucei by heritable and indicible double-stranded RNA
    • Shi, H. et al. Genetic interference in Trypanosoma brucei by heritable and indicible double-stranded RNA. RNA 6, 1069-1076 (2000).
    • (2000) RNA , vol.6 , pp. 1069-1076
    • Shi, H.1
  • 72
    • 0033883114 scopus 로고    scopus 로고
    • Heritable gene silencing in Drosophila using double-stranded RNA
    • Kennerdell, J. R. & Carthew, R. W. Heritable gene silencing in Drosophila using double-stranded RNA. Nature Biotechnol. 18, 896-898 (2000).
    • (2000) Nature Biotechnol. , vol.18 , pp. 896-898
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 73
    • 0034650510 scopus 로고    scopus 로고
    • Double-stranded RNA injection produces null phenotypes in zebrafish
    • erratum 220, 432 (2000)
    • Li, Y. X., Farrell, M. J., Liu, R., Mohanty, N. & Kirby, M. L. Double-stranded RNA injection produces null phenotypes in zebrafish. Dev. Biol. 217, 394-405 (2000); erratum 220, 432 (2000).
    • (2000) Dev. Biol. , vol.217 , pp. 394-405
    • Li, Y.X.1    Farrell, M.J.2    Liu, R.3    Mohanty, N.4    Kirby, M.L.5
  • 74
    • 0033575910 scopus 로고    scopus 로고
    • Double-stranded RNA induces specific developmental defects in zebrafish embryos
    • Wargelius, A., Ellingsen, S. & Fjose, A. Double-stranded RNA induces specific developmental defects in zebrafish embryos. Biochem. Biophys. Res. Commun. 263, 156-161 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 156-161
    • Wargelius, A.1    Ellingsen, S.2    Fjose, A.3
  • 75
    • 0034254815 scopus 로고    scopus 로고
    • Too much interference: Injection of double-stranded RNA has nonspecific effects in the zebrafish embryo
    • Oates, A. C., Bruce, A. E. & Ho, R. K. Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo. Dev. Biol. 224, 20-28 (2000).
    • (2000) Dev. Biol. , vol.224 , pp. 20-28
    • Oates, A.C.1    Bruce, A.E.2    Ho, R.K.3
  • 76
    • 0033602489 scopus 로고    scopus 로고
    • Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
    • Fraser, A. G., James, C., Evan, G. I. & Hengartner, M. O. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr. Biol. 9, 292-301 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 292-301
    • Fraser, A.G.1    James, C.2    Evan, G.I.3    Hengartner, M.O.4
  • 77
    • 0033968037 scopus 로고    scopus 로고
    • Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes
    • Tavernarakis, N., Wang, S. L., Dorovkov, M., Ryazanov, A. & Driscoll, M. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nature Genet. 24, 180-183 (2000).
    • (2000) Nature Genet. , vol.24 , pp. 180-183
    • Tavernarakis, N.1    Wang, S.L.2    Dorovkov, M.3    Ryazanov, A.4    Driscoll, M.5
  • 78
    • 0033928734 scopus 로고    scopus 로고
    • Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA
    • Shi, H. et al. Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA. RNA 6, 1069-1076 (2000).
    • (2000) RNA , vol.6 , pp. 1069-1076
    • Shi, H.1
  • 79
    • 0034712919 scopus 로고    scopus 로고
    • Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana
    • Chuang, C. F. & Meyerowitz, E. M. Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana. Proc. Natl Acad. Sci. USA 97, 4985-4990 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4985-4990
    • Chuang, C.F.1    Meyerowitz, E.M.2
  • 80
    • 0034704084 scopus 로고    scopus 로고
    • Interference of Trypanosoma brucei gene expression by RNA Interference using an integratable vector with opposing T7 promoters
    • Wang, Z., Morris, J. C., Drew, M. E. & England, P. T. Interference of Trypanosoma brucei gene expression by RNA Interference using an integratable vector with opposing T7 promoters. J. Biol. Chem. 275, 40174-40179 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40174-40179
    • Wang, Z.1    Morris, J.C.2    Drew, M.E.3    England, P.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.