Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

Biochemistry

Volumn 46, Issue 27, 2007, Pages 8058-8065

  Yang, Maojun ^a   Culhane, Jeffrey C ^b   Szewczuk, Lawrence M ^b   Jalili, Pegah ^a   Ball, Haydn L ^a   Machius, Mischa ^a   Cole, Philip A ^a   Yu, Hongtao ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIGENETIC MARKS; HISTONE LYSINE DEMETHYLASE; THERAPEUTIC POTENTIAL;

ACETYLATION; CHEMICAL MODIFICATION; ENZYME INHIBITION; METHYLATION; NUCLEOTIDES; TRANSCRIPTION;

AMINES;

AMINE OXIDASE (FLAVIN CONTAINING); ANTIDEPRESSANT AGENT; FLAVINE ADENINE NUCLEOTIDE; HISTONE; HISTONE DEMETHYLASE; HISTONE H3; LYSINE SPECIFIC DEMETHYLASE 1; METHYLTRANSFERASE; MONOAMINE OXIDASE INHIBITOR; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CANCER GROWTH; CATALYSIS; CHEMICAL MODIFICATION; CHROMATIN; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; EPIGENETICS; GENETIC TRANSCRIPTION; MASS SPECTROMETRY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANTIDEPRESSIVE AGENTS; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; OXIDOREDUCTASES, N-DEMETHYLATING; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TRANYLCYPROMINE;

GYMNOMYZA;

EID: 34447338875     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700664y     Document Type: Article

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