Essential role of the histone methyltransferase G9a in cocaine-induced plasticity

Science

Volumn 327, Issue 5962, 2010, Pages 213-216

  Maze, Ian ^a   Covingtoni III, Herbert E ^a   Dietz, David M ^a   Laplant, Quincey ^a,b   Renthal, William ^b   Russo, Scott J ^a   Mechanic, Max ^b   Mouzon, Ezekiell ^a   Neve, Rachael L ^c   Haggarty, Stephen J ^c,d   Ren, Yanhua ^a   Sampath, Srihari C ^e   Hurd, Yasmin L ^a   Greengard, Paul ^e   Tarakhovsky, Alexander ^e   Schaefer, Anne ^e   Nestler, Eric J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE PHOSPHORIBOSYLTRANSFERASE; COCAINE; DOXYCYCLINE; HISTONE H3; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE G9A; LYSINE; TRANSCRIPTION FACTOR FOSB; UNCLASSIFIED DRUG;

BEHAVIORAL RESPONSE; ENZYME ACTIVITY; GENE TRANSFER; GENETIC ANALYSIS; LEAF; METHYLATION; MORPHOLOGY;

ARTICLE; BRAIN REGION; CHROMATIN IMMUNOPRECIPITATION; DENDRITIC SPINE; DOWN REGULATION; GENE TRANSFER; METHYLATION; MUTAGENESIS; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ANIMALS; BEHAVIOR, ANIMAL; COCAINE; COCAINE-RELATED DISORDERS; DENDRITIC SPINES; DOWN-REGULATION; ENZYME REPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; MALE; METHYLATION; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; NEURONS; NUCLEUS ACCUMBENS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-FOS; REWARD; SELF ADMINISTRATION; TRANSCRIPTION, GENETIC;

MUS;

EID: 74249105659     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1179438     Document Type: Article

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28. This work was supported by grants from the National Institute on Drug Abuse: P01 DA08227 and R0l DA07359 (E.J.N.) and P0110044 (P.G.). E.J.N, certifies that none of the materials included in the manuscript have been previously published or are under consideration elsewhere, including on the Internet. All work involving the use of animals was conducted in accordance with institutional and Institutional Animal Care and Use Committee guidelines at both the University of Texas Southwestern Medical Center and Mount Sinai School of Medicine.