메뉴 건너뛰기




Volumn 3, Issue , 2010, Pages

Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AMONAFIDE; ANTHRACYCLINE; ANTILEUKEMIC AGENT; AS 1413; AZACITIDINE; BEHENOYLARA C; BORTEZOMIB; CD135 ANTIGEN; CD33 ANTIGEN; CLOFARABINE; CORE BINDING FACTOR; CPX 351; CYTARABINE; DAUNORUBICIN; DNA METHYLTRANSFERASE INHIBITOR; ETOPOSIDE; FLUDARABINE; GEMTUZUMAB OZOGAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; HISTONE DEACETYLASE INHIBITOR; IDARUBICIN; LENALIDOMIDE; MITOXANTRONE; NUCLEOSIDE ANALOG; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SORAFENIB; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORELOXIN; VORINOSTAT; ANTINEOPLASTIC AGENT;

EID: 77951111333     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-3-17     Document Type: Review
Times cited : (53)

References (57)
  • 1
    • 0025719792 scopus 로고
    • A comparative study of two different doses of cytarabine for acute myeloid leukemia: A phase III trial of Cancer and Leukemia Group B
    • 1824249
    • A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B. RO Dillman RB Davis MR Green RB Weiss AJ Gottlieb S Caplan,, et al. Blood 1991 78 2520 2526 1824249
    • (1991) Blood , vol.78 , pp. 2520-2526
    • Dillman, R.O.1    Davis, R.B.2    Green, M.R.3    Weiss, R.B.4    Gottlieb, A.J.5    Caplan, S.6
  • 2
    • 0037352207 scopus 로고    scopus 로고
    • Is modulation of multidrug resistance a viable strategy for acute myeloid leukemia?
    • 10.1038/sj.leu.2402809. 12646935
    • Is modulation of multidrug resistance a viable strategy for acute myeloid leukemia? RA Larson, Leukemia 2003 17 488 491 10.1038/sj.leu.2402809 12646935
    • (2003) Leukemia , vol.17 , pp. 488-491
    • Larson, R.A.1
  • 3
    • 16544385074 scopus 로고    scopus 로고
    • Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with psc-833 in untreated adults with acute myeloid leukemia younger than 60 years: Final induction results of cancer and leukemia group b study 9621
    • 10.1200/JCO.2004.11.106. 15514371
    • Dose Escalation Studies of Cytarabine, Daunorubicin, and Etoposide With and Without Multidrug Resistance Modulation With PSC-833 in Untreated Adults With Acute Myeloid Leukemia Younger Than 60 Years: Final Induction Results of Cancer and Leukemia Group B Study 9621. JE Kolitz SL George RK Dodge DD Hurd BL Powell SL Allen,, et al. J Clin Oncol 2004 22 4290 4301 10.1200/JCO.2004.11.106 15514371
    • (2004) J Clin Oncol , vol.22 , pp. 4290-4301
    • Kolitz, J.E.1    George, S.L.2    Dodge, R.K.3    Hurd, D.D.4    Powell, B.L.5    Allen, S.L.6
  • 4
    • 77649202987 scopus 로고    scopus 로고
    • Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: Results of the alfa-9801 study
    • 10.1200/JCO.2009.23.2652. 20048183
    • Randomized Study of Intensified Anthracycline Doses for Induction and Recombinant Interleukin-2 for Maintenance in Patients With Acute Myeloid Leukemia Age 50 to 70 Years: Results of the ALFA-9801 Study. C Pautas F Merabet X Thomas E Raffoux C Gardin S Corm,, et al. J Clin Oncol 2010 28 808 814 10.1200/JCO.2009.23.2652 20048183
    • (2010) J Clin Oncol , vol.28 , pp. 808-814
    • Pautas, C.1    Merabet, F.2    Thomas, X.3    Raffoux, E.4    Gardin, C.5    Corm, S.6
  • 5
    • 70349467775 scopus 로고    scopus 로고
    • Anthracycline dose intensification in acute myeloid leukemia
    • 10.1056/NEJMoa0904544. 19776406
    • Anthracycline dose intensification in acute myeloid leukemia. HF Fernandez Z Sun X Yao MR Litzow SM Luger EM Paietta,, et al. N Engl J Med 2009 361 1249 1259 10.1056/NEJMoa0904544 19776406
    • (2009) N Engl J Med , vol.361 , pp. 1249-1259
    • Fernandez, H.F.1    Sun, Z.2    Yao, X.3    Litzow, M.R.4    Luger, S.M.5    Paietta, E.M.6
  • 6
    • 70349451999 scopus 로고    scopus 로고
    • High-dose daunorubicin in older patients with acute myeloid leukemia
    • 10.1056/NEJMoa0901409. 19776405
    • High-dose daunorubicin in older patients with acute myeloid leukemia. B Lowenberg GJ Ossenkoppele W van Putten HC Schouten C Graux A Ferrant,, et al. N Engl J Med 2009 361 1235 1248 10.1056/NEJMoa0901409 19776405
    • (2009) N Engl J Med , vol.361 , pp. 1235-1248
    • Lowenberg, B.1    Ossenkoppele, G.J.2    Van Putten, W.3    Schouten, H.C.4    Graux, C.5    Ferrant, A.6
  • 7
    • 77949449142 scopus 로고    scopus 로고
    • Optimal induction and post-remission therapy for AML in first remission
    • 10.1182/asheducation-2009.1.396
    • Optimal induction and post-remission therapy for AML in first remission. JM Rowe, Hematology 2009 2009 396 405 10.1182/asheducation-2009.1.396
    • (2009) Hematology , vol.2009 , pp. 396-405
    • Rowe, J.M.1
  • 8
    • 77950806872 scopus 로고    scopus 로고
    • Phase i study of a liposomal carrier (CPX-351) containing a synergistic, fixed molar ratio of cytarabine (Ara-C) and daunorubicin (DNR) in advanced leukemias
    • abstract no. 2984. 18716130
    • Phase I Study of a Liposomal Carrier (CPX-351) Containing a Synergistic, Fixed Molar Ratio of Cytarabine (Ara-C) and Daunorubicin (DNR) in Advanced Leukemias. EJ Feldman J Lancet JE Kolitz E Ritchie AF List E Asatiani,, et al. Blood 2008 112 abstract no. 2984. 18716130
    • (2008) Blood , vol.112
    • Feldman, E.J.1    Lancet, J.2    Kolitz, J.E.3    Ritchie, E.4    List, A.F.5    Asatiani, E.6
  • 9
    • 77952921113 scopus 로고    scopus 로고
    • Phase iib randomized study of cpx-351 vs. conventional cytarabine + daunorubicin in newly diagnosed aml patients aged 60-75: Safety report
    • No1033
    • Phase IIb Randomized Study of CPX-351 Vs. Conventional Cytarabine + Daunorubicin in Newly Diagnosed AML Patients Aged 60-75: Safety Report. JE Lancet E J Feldman J E Kolitz M S Tallman D E Hogge R S Komrokji,, et al. Blood 2009 114 bstract No1033
    • (2009) Blood , vol.114
    • Lancet, J.E.1    Feldman, E.J.2    Kolitz, J.E.3    Tallman, M.S.4    Hogge, D.E.5    Komrokji, R.S.6
  • 10
    • 10744230708 scopus 로고    scopus 로고
    • A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia
    • 10.1182/blood-2003-05-1620. 12933575
    • A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. WJ Kell AK Burnett R Chopra JAL Yin RE Clark A Rohatiner,, et al. Blood 2003 102 4277 4283 10.1182/blood-2003-05-1620 12933575
    • (2003) Blood , vol.102 , pp. 4277-4283
    • Kell, W.J.1    Burnett, A.K.2    Chopra, R.3    Yin, J.A.L.4    Clark, R.E.5    Rohatiner, A.6
  • 11
    • 34249775270 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to induction chemotherapy for aml improves disease free survival without extra toxicity: Preliminary analysis of 1115 patients in the mrc aml15 trial
    • Abstract No. 13.
    • The Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy for AML Improves Disease Free Survival without Extra Toxicity: Preliminary Analysis of 1115 Patients in the MRC AML15 Trial. AK Burnett W Kell AH Goldstone, Blood 2006 108 Abstract No. 13.
    • (2006) Blood , vol.108
    • Burnett, A.K.1    Kell, W.2    Goldstone, A.H.3
  • 12
    • 77950394313 scopus 로고    scopus 로고
    • Clinical and molecular response in core binding factor acute myelogenous leukemia with fludarabine, cytarabine, g-csf and gemtuzumab ozogamicin
    • Abstract No.2056.
    • Clinical and Molecular Response in Core Binding Factor Acute Myelogenous Leukemia with Fludarabine, Cytarabine, G-CSF and Gemtuzumab Ozogamicin. G Borthakur S Faderl S Verstovsek D Jones V Gandhi Z Estrov,, et al. Blood 2009 114 Abstract No.2056.
    • (2009) Blood , vol.114
    • Borthakur, G.1    Faderl, S.2    Verstovsek, S.3    Jones, D.4    Gandhi, V.5    Estrov, Z.6
  • 13
    • 77953271333 scopus 로고    scopus 로고
    • Four Drugs Induction Therapy (fludarabine, cytarabine, idarubicin and gemtuzumab ozogamycin) for the Treatment of Elderly Acute Myeloid Leukemia Patients
    • Abstract No.1027.
    • Four Drugs Induction Therapy (fludarabine, cytarabine, idarubicin and gemtuzumab ozogamycin) for the Treatment of Elderly Acute Myeloid Leukemia Patients. S Paolini S Parisi A Candoni PP Piccaluga M Gottardi C Laterza,, et al. Blood 2009 114 Abstract No.1027.
    • (2009) Blood , vol.114
    • Paolini, S.1    Parisi, S.2    Candoni, A.3    Piccaluga, P.P.4    Gottardi, M.5    Laterza, C.6
  • 14
    • 77953237520 scopus 로고    scopus 로고
    • High dose cytarabine (hidac) and mitoxantrone (mito) is an effective induction therapy for high-risk acute myeloid leukemia
    • Abstract No.1048.
    • High Dose Cytarabine (HiDAC) and Mitoxantrone (MITO) Is An Effective Induction Therapy for High-Risk Acute Myeloid Leukemia. S Larson N Campbell D Huo A Artz Y Zhang D Gajria,, et al. Blood 2009 114 Abstract No.1048.
    • (2009) Blood , vol.114
    • Larson, S.1    Campbell, N.2    Huo, D.3    Artz, A.4    Zhang, Y.5    Gajria, D.6
  • 15
    • 77953279801 scopus 로고    scopus 로고
    • Phase 2 study of FLAGM (Fludarabine+High-Dose Ara-C +G-CSF+Mitoxantrone) for relapsed or refractory acute myeloid leukemia (AML): A report from the japan adult leukemia study group (JALSG)
    • Abstract No.1058.
    • Phase 2 Study of FLAGM (Fludarabine+High-Dose Ara-C +G-CSF+Mitoxantrone) for Relapsed or Refractory Acute Myeloid Leukemia (AML): A Report From the Japan Adult Leukemia Study Group (JALSG). S Miyawaki N Hatsumi T Yamauchi, Blood 2009 114 Abstract No.1058.
    • (2009) Blood , vol.114
    • Miyawaki, S.1    Hatsumi, N.2    Yamauchi, T.3
  • 16
    • 77953249511 scopus 로고    scopus 로고
    • Adirect comparison of high dose cytarabineto combination of gemtuzumab and high dose cytarabine for acute myeloid leukemia patients in first relapse confirmed the benefit of gemtuzumab based regimens
    • Abstract No.2051.
    • A Direct comparison of high dose cytarabineto combination of gemtuzumab and high dose cytarabine for acute myeloid leukemia patients in first relapse confirmed the benefit of gemtuzumab based regimens. t prébet a charbonnier a etienne e d'incan s fürst d blaise, blood 2009 114 abstract no.2051.
    • (2009) Blood , vol.114
    • Prébet, T.1    Charbonnier, A.2    Etienne, A.3    D'Incan, E.4    Fürst, S.5    Blaise, D.6
  • 17
    • 77953258567 scopus 로고    scopus 로고
    • High Dose Cytarabine, Clofarabine and Gemtuzumab Ozogamicin (CLAC-MYL) in Relapsed or Refractory AML Patients
    • Abstract No.1060.
    • High Dose Cytarabine, Clofarabine and Gemtuzumab Ozogamicin (CLAC-MYL) in Relapsed or Refractory AML Patients. B Scappini G Gianfaldoni P Salvatore M C Susini T Izzo F Mannelli,, et al. Blood 2009 114 Abstract No.1060.
    • (2009) Blood , vol.114
    • Scappini, B.1    Gianfaldoni, G.2    Salvatore, P.3    Susini, M.C.4    Izzo, T.5    Mannelli, F.6
  • 18
    • 77950424252 scopus 로고    scopus 로고
    • Single-agent clofarabine produces durable remissions in patients with acute myelogenous leukemia (aml) who are = 70, have intermediate or unfavorable cytogenetics, antecedent hematological disorders (ahd), or 2 or more unfavorable prognostic factors
    • Abstract No.2083.
    • Single-Agent Clofarabine Produces Durable Remissions in Patients with Acute Myelogenous Leukemia (AML) Who Are = 70, Have Intermediate or Unfavorable Cytogenetics, Antecedent Hematological Disorders (AHD), or 2 or More Unfavorable Prognostic Factors. HP Erba S Faderl D F Claxton M Arellano R M Lyons T J Kovacsovics,, et al. Blood 2009 114 Abstract No.2083.
    • (2009) Blood , vol.114
    • Erba, H.P.1    Faderl, S.2    Claxton, D.F.3    Arellano, M.4    Lyons, R.M.5    Kovacsovics, T.J.6
  • 19
    • 69849103644 scopus 로고    scopus 로고
    • G-CSF priming, clofarabine and high dose cytarabine (gclac) for relapsed or refractory acute myeloid leukemia (aml)
    • Abstract No.2068. 10.1182/blood-2009-02-206730
    • G-CSF Priming, Clofarabine and High Dose Cytarabine (GCLAC) for Relapsed or Refractory Acute Myeloid Leukemia (AML). PS Becker E Estey S Petersdorf B E Storer F R Appelbaum, Blood 2009 114 Abstract No.2068. 10.1182/blood-2009-02- 206730
    • (2009) Blood , vol.114
    • Becker, P.S.1    Estey, E.2    Petersdorf, S.3    Storer, B.E.4    Appelbaum, F.R.5
  • 20
    • 77953283506 scopus 로고    scopus 로고
    • A Phase i, dose escalation study of clofarabine in combination with fractionated gemtuzumab ozogamicin in relapsed and refractory acute myeloid leukemia (aml)
    • Abstract No.2048. 19564639
    • A Phase I, Dose Escalation Study of Clofarabine in Combination with Fractionated Gemtuzumab Ozogamicin in Relapsed and Refractory Acute Myeloid Leukemia (AML). MC Foster C Amin P M Voorhees H W Van Deventer K L Richards I Anastasia,, et al. Blood 2009 114 Abstract No.2048. 19564639
    • (2009) Blood , vol.114
    • Foster, M.C.1    Amin, C.2    Voorhees, P.M.3    Van Deventer, H.W.4    Richards, K.L.5    Anastasia, I.6
  • 21
    • 77953272954 scopus 로고    scopus 로고
    • Clofarabine plus low-dose cytarabine induction followed by consolidation with clofarabine plus low-dose cytarabine alternating with decitabine as frontline therapy for patients (pts) with acute myeloid leukemia (aml) = 60 years (yrs)
    • Abstract No.2058.
    • Clofarabine Plus Low-Dose Cytarabine Induction Followed by Consolidation with Clofarabine Plus Low-Dose Cytarabine Alternating with Decitabine as Frontline Therapy for Patients (pts) with Acute Myeloid Leukemia (AML) = 60 Years (yrs). SA Parikh K Hagop G Garcia-Manero E Jabbour T Kadia F Ravandi,, et al. Blood 2009 114 Abstract No.2058.
    • (2009) Blood , vol.114
    • Parikh, S.A.1    Hagop, K.2    Garcia-Manero, G.3    Jabbour, E.4    Kadia, T.5    Ravandi, F.6
  • 22
    • 77953255617 scopus 로고    scopus 로고
    • A randomized phase 2 study of sapacitabine, an oral nucleoside analogue, in elderly patients with aml previously untreated or in first relapse
    • Abstract No.1061.
    • A Randomized Phase 2 Study of Sapacitabine, An Oral Nucleoside Analogue, in Elderly Patients with AML Previously Untreated or in First Relapse. HM Kantarjian G Garcia-Manero S Luger P Venugopal L J Maness M Wetzler,, et al. Blood 2009 114 Abstract No.1061.
    • (2009) Blood , vol.114
    • Kantarjian, H.M.1    Garcia-Manero, G.2    Luger, S.3    Venugopal, P.4    Maness, L.J.5    Wetzler, M.6
  • 23
    • 81255136297 scopus 로고    scopus 로고
    • APhase ii multicentre study with elacytarabine as second salvage therapyin patients with aml
    • Abstract No.1042.
    • APhase II Multicentre Study with Elacytarabine as Second Salvage Therapyin Patients with AML. S O'Brien D A Rizzieri N Vey F Ravandi U O Krug M A Sekeres,, et al. Blood 2009 114 Abstract No.1042.
    • (2009) Blood , vol.114
    • O'Brien, S.1    Rizzieri, D.A.2    Vey, N.3    Ravandi, F.4    Krug, U.O.5    Sekeres, M.A.6
  • 24
    • 73249135797 scopus 로고    scopus 로고
    • Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics
    • 10.1186/1756-8722-2-23. 19490647
    • Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics. TK Gregory D Wald Y Chen JM Vermaat Y Xiong W Tse, J Hematol Oncol 2009 2 23 10.1186/1756-8722-2-23 19490647
    • (2009) J Hematol Oncol , vol.2 , pp. 23
    • Gregory, T.K.1    Wald, D.2    Chen, Y.3    Vermaat, J.M.4    Xiong, Y.5    Tse, W.6
  • 25
    • 77953277493 scopus 로고    scopus 로고
    • Compassionate use of sorafenib in relapsed and refractory Flt3-ITD positive acute myeloid leukemia
    • Abstract No.2060.
    • Compassionate Use of Sorafenib in Relapsed and Refractory Flt3-ITD Positive Acute Myeloid Leukemia. S Metzelder S Scholl K Matthias A Reiter R G Meyer T Heinicke,, et al. Blood 2009 114 Abstract No.2060.
    • (2009) Blood , vol.114
    • Metzelder, S.1    Scholl, S.2    Matthias, K.3    Reiter, A.4    Meyer, R.G.5    Heinicke, T.6
  • 26
    • 77953235850 scopus 로고    scopus 로고
    • FLT3 Inhibitor therapy for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): Impact on survival according to FLT3 status
    • Abstract No. 1026.
    • FLT3 Inhibitor Therapy for Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML): Impact On Survival According to FLT3 Status. N Pemmaraju H M Kantarjian F Ravandi G Garcia-Manero B Gautam S A Parikh,, et al. Blood 2009 114 Abstract No. 1026.
    • (2009) Blood , vol.114
    • Pemmaraju, N.1    Kantarjian, H.M.2    Ravandi, F.3    Garcia-Manero, G.4    Gautam, B.5    Parikh, S.A.6
  • 27
    • 77953256894 scopus 로고    scopus 로고
    • Clinical efficacy of sorafenib in patients with acute myeloid leukemia (aml) and activating flt3-mutations
    • Abstract No.2057. 19779039
    • Clinical Efficacy of Sorafenib in Patients with Acute Myeloid Leukemia (AML) and Activating FLT3-Mutations. T Schroeder C Saure I Bruns F Zohren A G Czibere N N Safaian,, et al. Blood 2009 114 Abstract No.2057. 19779039
    • (2009) Blood , vol.114
    • Schroeder, T.1    Saure, C.2    Bruns, I.3    Zohren, F.4    Czibere, A.G.5    Safaian, N.N.6
  • 28
    • 77953271584 scopus 로고    scopus 로고
    • Patterns of molecular response to and relapse after combination of sorafenib, idarubicin, and cytarabine in patients with newly diagnosed flt3-mutant acute myeloid leukemia (aml)
    • Abstract No.2079.
    • Patterns of Molecular Response to and Relapse After Combination of Sorafenib, Idarubicin, and Cytarabine in Patients with Newly Diagnosed FLT3-Mutant Acute Myeloid Leukemia (AML). A Al-Kali D Jones J Cortes S Faderl A Xue G Garcia-Manero,, et al. Blood 2009 114 Abstract No.2079.
    • (2009) Blood , vol.114
    • Al-Kali, A.1    Jones, D.2    Cortes, J.3    Faderl, S.4    Xue, A.5    Garcia-Manero, G.6
  • 29
    • 77953050738 scopus 로고    scopus 로고
    • Effect of ras inhibition in hematopoiesis and BCR/ABL leukemogenesis
    • 18577264. 10.1186/1756-8722-1-5
    • Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis. K Baum R Ren, Journal of Hematology & Oncology 2008 1 5 18577264 10.1186/1756-8722-1-5
    • (2008) Journal of Hematology & Oncology , vol.1 , pp. 5
    • Baum, K.1    Ren, R.2
  • 30
    • 77953260941 scopus 로고    scopus 로고
    • RASGRP1/APTX ratio strongly correlates with clinical response and survival in aml patients treated with tipifarnib-bortezomib combination
    • Abstract No.1028.
    • RASGRP1/APTX Ratio Strongly Correlates with Clinical Response and Survival in AML Patients Treated with Tipifarnib-Bortezomib Combination. S Paolini E Ottaviani S Parisi F Salmi B Lama A Curti,, et al. Blood 2009 114 Abstract No.1028.
    • (2009) Blood , vol.114
    • Paolini, S.1    Ottaviani, E.2    Parisi, S.3    Salmi, F.4    Lama, B.5    Curti, A.6
  • 31
    • 84870048610 scopus 로고    scopus 로고
    • Evaluation of alternative, "low-intensity" induction regimens in elderly adults with acute myeloid leukemia (aml)
    • Abstract No.2066.
    • Evaluation of Alternative, "Low-intensity" Induction Regimens in Elderly Adults with Acute Myeloid Leukemia (AML). EJ Feldman E Ritchie U Gergis S Mayer J M Scandura P J Christos,, et al. Blood 2009 114 Abstract No.2066.
    • (2009) Blood , vol.114
    • Feldman, E.J.1    Ritchie, E.2    Gergis, U.3    Mayer, S.4    Scandura, J.M.5    Christos, P.J.6
  • 32
    • 67651153048 scopus 로고    scopus 로고
    • New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
    • 10.1186/1756-8722-2-22. 19486511
    • New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer. S Cang Y Ma D Liu, J Hematol Oncol 2009 2 22 10.1186/1756-8722-2-22 19486511
    • (2009) J Hematol Oncol , vol.2 , pp. 22
    • Cang, S.1    Ma, Y.2    Liu, D.3
  • 34
    • 77649171884 scopus 로고    scopus 로고
    • Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
    • 10.1186/1756-8722-3-5. 20132536
    • Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J Tan S Cang Y Ma RL Petrillo D Liu, J Hematol Oncol 2010 3 5 10.1186/1756-8722-3-5 20132536
    • (2010) J Hematol Oncol , vol.3 , pp. 5
    • Tan, J.1    Cang, S.2    Ma, Y.3    Petrillo, R.L.4    Liu, D.5
  • 35
    • 33747203758 scopus 로고    scopus 로고
    • Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor 2
    • 10.1182/blood-2005-09-008086. 16675713
    • Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor 2. B Sanchez-Gonzalez H Yang C Bueso-Ramos K Hoshino A Quintas-Cardama VM Richon,, et al. Blood 2006 108 1174 1182 10.1182/blood-2005-09-008086 16675713
    • (2006) Blood , vol.108 , pp. 1174-1182
    • Sanchez-Gonzalez, B.1    Yang, H.2    Bueso-Ramos, C.3    Hoshino, K.4    Quintas-Cardama, A.5    Richon, V.M.6
  • 36
    • 63449114868 scopus 로고    scopus 로고
    • Preclinical studies of vorinostat (suberoylanilide hydroxamic acid) combined with cytosine arabinoside and etoposide for treatment of acute leukemias 1
    • 10.1158/1078-0432.CCR-08-1587. 19223502
    • Preclinical studies of vorinostat (suberoylanilide hydroxamic acid) combined with cytosine arabinoside and etoposide for treatment of acute leukemias 1. K Shiozawa T Nakanishi M Tan HB Fang WC Wang MJ Edelman,, et al. Clin Cancer Res 2009 15 1698 1707 10.1158/1078-0432.CCR-08-1587 19223502
    • (2009) Clin Cancer Res , vol.15 , pp. 1698-1707
    • Shiozawa, K.1    Nakanishi, T.2    Tan, M.3    Fang, H.B.4    Wang, W.C.5    Edelman, M.J.6
  • 37
    • 77953272953 scopus 로고    scopus 로고
    • Phase II study of vorinostat in combination with idarubicin (Ida) and cytarabine (ara-C) as Front Line therapy in acute myelogenous leukemia (AML) or higher risk myelodysplastic syndrome (MDS)
    • Abstract No.1055. 19420352
    • Phase II Study of Vorinostat in Combination with Idarubicin (Ida) and Cytarabine (ara-C) as Front Line Therapy in Acute Myelogenous Leukemia (AML) or Higher Risk Myelodysplastic Syndrome (MDS). G Garcia-Manero F P Tambaro N B Bekele E Jabbour F Ravandi H Yang,, et al. Blood 2009 114 Abstract No.1055. 19420352
    • (2009) Blood , vol.114
    • Garcia-Manero, G.1    Tambaro, F.P.2    Bekele, N.B.3    Jabbour, E.4    Ravandi, F.5    Yang, H.6
  • 38
    • 77953269795 scopus 로고    scopus 로고
    • Vorinostat in combination with decitabine for the treatment of relapsed or newly diagnosed acute myelogenous leukemia (aml) or myelodysplastic syndrome (mds): A phase i, dose-escalation study
    • Abstract No.2089.
    • Vorinostat in Combination with Decitabine for the Treatment of Relapsed or Newly Diagnosed Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS): A Phase I, Dose-Escalation Study. M Kirschbaum G Ivana S L Goldberg L Kujawski E Atallah P Marks,, et al. Blood 2009 114 Abstract No.2089.
    • (2009) Blood , vol.114
    • Kirschbaum, M.1    Ivana, G.2    Goldberg, S.L.3    Kujawski, L.4    Atallah, E.5    Marks, P.6
  • 39
    • 77950389106 scopus 로고    scopus 로고
    • Phase 2 study of decitabine and gemtuzumab ozogamicin in acute myelogenous leukemia and high-risk myelodysplastic syndrome-outcome in previously untreated patients
    • Abstract No.1053.
    • Phase 2 Study of Decitabine and Gemtuzumab Ozogamicin in Acute Myelogenous Leukemia and High-Risk Myelodysplastic Syndrome-Outcome in Previously Untreated Patients. G Borthakur G Garcia-Manero Z Estrov M Konopleva J A Burger De A Thomas,, et al. Blood 2009 114 Abstract No.1053.
    • (2009) Blood , vol.114
    • Borthakur, G.1    Garcia-Manero, G.2    Estrov, Z.3    Konopleva, M.4    Burger, J.A.5    Thomas, D.A.6
  • 41
    • 77953234036 scopus 로고    scopus 로고
    • Azacytidine in refractory or relapsed aml after intensive chemotherapy (ic): Results of the french atu program
    • Abstract No.1054.
    • Azacytidine in Refractory or Relapsed AML After Intensive Chemotherapy (IC): Results of the French ATU Program. R Itzykson S Thepo C Reche J Delaunay B Quesnel, Blood 2009 114 Abstract No.1054.
    • (2009) Blood , vol.114
    • Itzykson, R.1    Thepo, S.2    Reche, C.3    Delaunay, J.4    Quesnel, B.5
  • 42
    • 79959782002 scopus 로고    scopus 로고
    • Azacitadine and low-dose gemtuzumab ozogamicin for the treatment of poor-risk acute myeloid leukemia (aml) and myelodysplastic syndromes (mds), including relapsed, refractory disease
    • Abstract No.1034.
    • Azacitadine and Low-Dose Gemtuzumab Ozogamicin for the Treatment of Poor-Risk Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Relapsed, Refractory Disease. LC Michaelis D Shafer K Barton T Rodriguez S Smith P Stiff,, et al. Blood 2009 114 Abstract No.1034.
    • (2009) Blood , vol.114
    • Michaelis, L.C.1    Shafer, D.2    Barton, K.3    Rodriguez, T.4    Smith, S.5    Stiff, P.6
  • 43
    • 77953269566 scopus 로고    scopus 로고
    • Epigenetic targeting via transcriptional inhibition of dna methyltransferase: A phase i study of bortezomib in combination with 5-azacytidine in adults with relapsed or refractory acute myeloid leukemia (aml)
    • Abstract No.2065. 19553637
    • Epigenetic targeting via transcriptional inhibition of dna methyltransferase: a phase i study of bortezomib in combination with 5-azacytidine in adults with relapsed or refractory acute myeloid leukemia (aml). w blum r b klisovic a walker r garzon s liu l j schaaf,, et al. blood 2009 114 abstract no.2065. 19553637
    • (2009) Blood , vol.114
    • Blum, W.1    Klisovic, R.B.2    Walker, A.3    Garzon, R.4    Liu, S.5    Schaaf, L.J.6
  • 44
    • 70449473591 scopus 로고    scopus 로고
    • A phase i trial of the epigenetic modulators vorinostat, in combination with azacitidine (azac) in patients with the myelodysplastic syndrome (mds) and acute myeloid leukemia (aml): A study of the new york cancer consortium
    • A phase i trial of the epigenetic modulators vorinostat, in combination with azacitidine (azac) in patients with the myelodysplastic syndrome (mds) and acute myeloid leukemia (aml): a study of the new york cancer consortium. lr silverman a verma r odchimar-reissig a leblanc v najfeld j gabrilove,, et al. ash annual meeting abstracts 2008 112 3656
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 3656
    • Silverman, L.R.1    Verma, A.2    Odchimar-Reissig, R.3    Leblanc, A.4    Najfeld, V.5    Gabrilove, J.6
  • 45
    • 77953256893 scopus 로고    scopus 로고
    • A Phase 2 Dose Regimen Optimization Study of Three Schedules of Voreloxin as Single Agent Therapy for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia
    • Abstract No.1037.
    • A Phase 2 Dose Regimen Optimization Study of Three Schedules of Voreloxin as Single Agent Therapy for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia. F Ravandi H M Kantarjian L D Cripe M Maris M Cooper S R Dakhil,, et al. Blood 2009 114 Abstract No.1037.
    • (2009) Blood , vol.114
    • Ravandi, F.1    Kantarjian, H.M.2    Cripe, L.D.3    Maris, M.4    Cooper, M.5    Dakhil, S.R.6
  • 46
    • 77953283741 scopus 로고    scopus 로고
    • Amonafide l-malate (as1413) in combination with cytarabine is equally effective in older and younger patients with secondary acute myeloid leukemia (aml); Final data from a phase ii study
    • Abstract No.1047.
    • Amonafide L-Malate (AS1413) in Combination with Cytarabine Is Equally Effective in Older and Younger Patients with Secondary Acute Myeloid Leukemia (AML); Final Data From a Phase II Study. HP Erba M O'Donnell S L Allen M R Baer B L Powell R M Stone,, et al. Blood 2009 114 Abstract No.1047.
    • (2009) Blood , vol.114
    • Erba, H.P.1    O'Donnell, M.2    Allen, S.L.3    Baer, M.R.4    Powell, B.L.5    Stone, R.M.6
  • 47
    • 77953268451 scopus 로고    scopus 로고
    • High remission rates and long-term survival in a high percentage of patients achieved by intensive chemotherapy for aml and further improvement of supportive care
    • Abstract No.1052.
    • High Remission Rates and Long-Term Survival in a High Percentage of Patients Achieved by Intensive Chemotherapy for AML and Further Improvement of Supportive Care. T Kyo A Kimura K Kyo N Yoshida H Asaoku K Iwato,, et al. Blood 2009 114 Abstract No.1052.
    • (2009) Blood , vol.114
    • Kyo, T.1    Kimura, A.2    Kyo, K.3    Yoshida, N.4    Asaoku, H.5    Iwato, K.6
  • 48
    • 67651167047 scopus 로고    scopus 로고
    • Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome
    • 10.1186/1756-8722-2-20. 19439093
    • Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome. A Raza N Galili N Callander L Ochoa L Piro P Emanuel,, et al. J Hematol Oncol 2009 2 20 10.1186/1756-8722-2- 20 19439093
    • (2009) J Hematol Oncol , vol.2 , pp. 20
    • Raza, A.1    Galili, N.2    Callander, N.3    Ochoa, L.4    Piro, L.5    Emanuel, P.6
  • 49
    • 69949096727 scopus 로고    scopus 로고
    • Mechanism of action of lenalidomide in hematological malignancies
    • 10.1186/1756-8722-2-36. 19674465
    • Mechanism of action of lenalidomide in hematological malignancies. V Kotla S Goel S Nischal C Heuck K Vivek B Das,, et al. J Hematol Oncol 2009 2 36 10.1186/1756-8722-2-36 19674465
    • (2009) J Hematol Oncol , vol.2 , pp. 36
    • Kotla, V.1    Goel, S.2    Nischal, S.3    Heuck, C.4    Vivek, K.5    Das, B.6
  • 50
    • 77953267930 scopus 로고    scopus 로고
    • Lenalidomide (len) combined to intensive chemotherapy (ic) in aml and higher risk mds with del 5q. interim results of a phase i/ii study
    • Abstract No.1049.
    • Lenalidomide (LEN) Combined to Intensive Chemotherapy (IC) in AML and Higher Risk MDS with Del 5q. Interim Results of a Phase I/II Study. L Ades A Stamatoullas E Raffoux T Prebet P Lenain R Guieze,, et al. Blood 2009 114 Abstract No.1049.
    • (2009) Blood , vol.114
    • Ades, L.1    Stamatoullas, A.2    Raffoux, E.3    Prebet, T.4    Lenain, P.5    Guieze, R.6
  • 51
    • 67651089847 scopus 로고    scopus 로고
    • Targeting the oncogene eIF4E with ribavirin: A novel therapeutic avenue in acute myeloid leukemia
    • Abstract No.2085. 10.1182/blood-2009-02-205153
    • Targeting the Oncogene eIF4E with Ribavirin: A Novel Therapeutic Avenue in Acute Myeloid Leukemia. SE Assouline E Cocolakis C Rousseau B Culjkovic N Beslu A Amri,, et al. Blood 2009 114 Abstract No.2085. 10.1182/blood-2009-02- 205153
    • (2009) Blood , vol.114
    • Assouline, S.E.1    Cocolakis, E.2    Rousseau, C.3    Culjkovic, B.4    Beslu, N.5    Amri, A.6
  • 52
    • 77953253523 scopus 로고    scopus 로고
    • A phase 1 dose-escalation study of the novel KSP inhibitor ARRY-520 in advanced leukemias
    • Abstract No.2047. 19420352
    • A Phase 1 Dose-Escalation Study of the Novel KSP Inhibitor ARRY-520 in Advanced Leukemias. G Garcia-Manero J H Khoury G Borthakur F Ravandi T Kadia Z Estrov,, et al. Blood 2009 114 Abstract No.2047. 19420352
    • (2009) Blood , vol.114
    • Garcia-Manero, G.1    Khoury, J.H.2    Borthakur, G.3    Ravandi, F.4    Kadia, T.5    Estrov, Z.6
  • 53
    • 77953272952 scopus 로고
    • Phase I/II study to assess the safety and efficacy of the aurora B kinase inhibitor, AZD in patients with advanced acute myeloid leukemia
    • Abstract No.2080.
    • Phase I/II Study to Assess the Safety and Efficacy of the Aurora B Kinase Inhibitor, AZD in Patients with Advanced Acute Myeloid Leukemia. B Lowenberg P Rousselot G Martinelli A Goudie P Stockman H Kantarjian, Blood 1152 114 Abstract No.2080.
    • (1152) Blood , vol.114
    • Lowenberg, B.1    Rousselot, P.2    Martinelli, G.3    Goudie, A.4    Stockman, P.5    Kantarjian, H.6
  • 54
    • 77949464718 scopus 로고    scopus 로고
    • From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
    • 20149254. 10.1186/1756-8722-3-8
    • From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. C Fremin S Meloche, Journal of Hematology & Oncology 2010 3 8 20149254 10.1186/1756-8722-3-8
    • (2010) Journal of Hematology & Oncology , vol.3 , pp. 8
    • Fremin, C.1    Meloche, S.2
  • 55
    • 77953269277 scopus 로고    scopus 로고
    • Targeting MEK1/2 signaling cascade by AS70 a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo
    • Targeting MEK1/2 signaling cascade by AS70 a novel selective MEK1/2 Inhibitor, induces pleiotropic anti-myeloma activity in vitro and In Vivo. YT Tai K kim XF Li M fulciniti W Song S nahar,, et al. ASH annual Meeting Abstracts 2009 114 3848
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 3848
    • Tai, Y.T.1    Kim, K.2    Li, X.F.3    Fulciniti, M.4    Song, W.5    Nahar, S.6
  • 56
    • 77953237268 scopus 로고    scopus 로고
    • Phase ii study of the oral mek inhibitor azd6244 in advanced acute myeloid leukemia (aml)
    • Abstract No.2081.
    • Phase II Study of the Oral MEK Inhibitor AZD6244 in Advanced Acute Myeloid Leukemia (AML). O Odenike E Curran N Iyengar L Popplewell M Kirschbaum H P Erba,, et al. Blood 2009 114 Abstract No.2081.
    • (2009) Blood , vol.114
    • Odenike, O.1    Curran, E.2    Iyengar, N.3    Popplewell, L.4    Kirschbaum, M.5    Erba, H.P.6
  • 57
    • 77953279799 scopus 로고    scopus 로고
    • Phase i study of the novel survivin and cdc2/cdk1 inhibitor terameprocol in patients with advanced leukemias
    • Abstract No.1039.
    • Phase I Study of the Novel Survivin and cdc2/CDK1 Inhibitor Terameprocol in Patients with Advanced Leukemias. R Tibes K T McDonagh L Lekakis N Frazer S Mohrland B Dawn,, et al. Blood 2009 114 Abstract No.1039.
    • (2009) Blood , vol.114
    • Tibes, R.1    McDonagh, K.T.2    Lekakis, L.3    Frazer, N.4    Mohrland, S.5    Dawn, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.