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Volumn 88, Issue 5, 2010, Pages 877-884

NF-κB as a central regulator of macrophage function in tumors

Author keywords

Cancer; Cellular immunology

Indexed keywords

I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

EID: 78649575471     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0310153     Document Type: Review
Times cited : (122)

References (83)
  • 2
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumor angiogenesis
    • Murdoch, C., Muthana, M., Coffelt, S. B., Lewis, C. E. (2008) The role of myeloid cells in the promotion of tumor angiogenesis. Nat. Rev. Cancer 8, 618-631.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 3
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer
    • DOI 10.1016/j.cell.2006.02.016, PII S0092867406001917
    • Karin, M., Lawrence, T., Nizet, V. (2006) Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 124, 823-835. (Pubitemid 43261455)
    • (2006) Cell , vol.124 , Issue.4 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 4
    • 50849090319 scopus 로고    scopus 로고
    • Macrophages define the invasive microenvironment in breast cancer
    • Pollard, J. W. (2008) Macrophages define the invasive microenvironment in breast cancer. J. Leukoc. Biol. 84, 623-630.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 623-630
    • Pollard, J.W.1
  • 5
    • 42149099408 scopus 로고    scopus 로고
    • Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms
    • Biswas, S. K., Sica, A., Lewis, C. E. (2008) Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J. Immunol. 180, 2011-2017.
    • (2008) J. Immunol. , vol.180 , pp. 2011-2017
    • Biswas, S.K.1    Sica, A.2    Lewis, C.E.3
  • 6
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis, C. E., Pollard, J. W. (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66, 605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 7
    • 0347123433 scopus 로고    scopus 로고
    • Tumor-educated macrophages promote tumor progression and metastasis
    • Pollard, J. W. (2004) Tumor-educated macrophages promote tumor progression and metastasis. Nat. Rev. Cancer 4, 71-78.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 8
    • 0026500980 scopus 로고
    • Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma
    • Bottazzi, B., Walter, S., Govoni, D., Colotta, F., Mantovani, A. (1992) Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma. J. Immunol. 148, 1280-1285.
    • (1992) J. Immunol. , vol.148 , pp. 1280-1285
    • Bottazzi, B.1    Walter, S.2    Govoni, D.3    Colotta, F.4    Mantovani, A.5
  • 9
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon, B., Sozzani, S., Zhou, D., Weich, H. A., Mantovani, A., Marme, D. (1996) Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87, 3336-3343.
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marme, D.6
  • 10
    • 0033780453 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas
    • Lewis, J. S., Landers, R. J., Underwood, J. C., Harris, A. L., Lewis, C. E. (2000) Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J. Pathol. 192, 150-158.
    • (2000) J. Pathol. , vol.192 , pp. 150-158
    • Lewis, J.S.1    Landers, R.J.2    Underwood, J.C.3    Harris, A.L.4    Lewis, C.E.5
  • 12
    • 77953488665 scopus 로고    scopus 로고
    • Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis
    • Shaposhnik, Z., Wang, X., Lusis, A. J. (2010) Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis. J. Lipid Res. 51, 1962-1970.
    • (2010) J. Lipid Res. , vol.51 , pp. 1962-1970
    • Shaposhnik, Z.1    Wang, X.2    Lusis, A.J.3
  • 13
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin, E. Y., Nguyen, A. V., Russell, R. G., Pollard, J. W. (2001) Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727-740.
    • (2001) J. Exp. Med. , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 15
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • DOI 10.1158/0008-5472.CAN-06-1278
    • Lin, E. Y., Li, J. F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X. N., Pollard, J. W. (2006) Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66, 11238-11246. (Pubitemid 46009952)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.-F.2    Gnatovskiy, L.3    Deng, Y.4    Zhu, L.5    Grzesik, D.A.6    Qian, H.7    Xue, X.-N.8    Pollard, J.W.9
  • 16
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian, B., Deng, Y., Im, J. H., Muschel, R. J., Zou, Y., Li, J., Lang, R. A., Pollard, J. W. (2009) A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4, e6562.
    • (2009) PLoS One , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.5    Li, J.6    Lang, R.A.7    Pollard, J.W.8
  • 17
    • 36549005467 scopus 로고    scopus 로고
    • Target validation using RNA interference in solid tumors
    • Aharinejad, S., Sioud, M., Lucas, T., Abraham, D. (2007) Target validation using RNA interference in solid tumors. Methods Mol. Biol. 361, 227-238.
    • (2007) Methods Mol. Biol. , vol.361 , pp. 227-238
    • Aharinejad, S.1    Sioud, M.2    Lucas, T.3    Abraham, D.4
  • 18
    • 33746926292 scopus 로고    scopus 로고
    • Clodronate-liposome-mediated depletion of tumor-associated macrophages: A new and highly effective antiangiogenic therapy approach
    • Zeisberger, S. M., Odermatt, B., Marty, C., Zehnder-Fjallman, A. H., Ballmer-Hofer, K., Schwendener, R. A. (2006) Clodronate-liposome-mediated depletion of tumor-associated macrophages: a new and highly effective antiangiogenic therapy approach. Br. J. Cancer 95, 272-281.
    • (2006) Br. J. Cancer , vol.95 , pp. 272-281
    • Zeisberger, S.M.1    Odermatt, B.2    Marty, C.3    Zehnder-Fjallman, A.H.4    Ballmer-Hofer, K.5    Schwendener, R.A.6
  • 19
    • 62549109923 scopus 로고    scopus 로고
    • High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors
    • Ojalvo, L. S., King, W., Cox, D., Pollard, J. W. (2009) High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors. Am. J. Pathol. 174, 1048-1064.
    • (2009) Am. J. Pathol. , vol.174 , pp. 1048-1064
    • Ojalvo, L.S.1    King, W.2    Cox, D.3    Pollard, J.W.4
  • 20
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumor-associated macrophages in tumor progression: Implications for new anticancer therapies
    • Bingle, L., Brown, N. J., Lewis, C. E. (2002) The role of tumor-associated macrophages in tumor progression: implications for new anticancer therapies. J. Pathol. 196, 254-265.
    • (2002) J. Pathol. , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 21
    • 0037769059 scopus 로고    scopus 로고
    • Monocyte heterogeneity and innate immunity
    • Taylor, P. R., Gordon, S. (2003) Monocyte heterogeneity and innate immunity. Immunity 19, 2-4.
    • (2003) Immunity , vol.19 , pp. 2-4
    • Taylor, P.R.1    Gordon, S.2
  • 22
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., Edwards, J. P. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 23
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., Locati, M. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677-686.
    • (2004) Trends Immunol. , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 24
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S., Taylor, P. R. (2005) Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 25
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani, A., Sozzani, S., Locati, M., Allavena, P., Sica, A. (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555.
    • (2002) Trends Immunol. , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 27
    • 0029913684 scopus 로고    scopus 로고
    • The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene
    • Dinapoli, M. R., Calderon, C. L., Lopez, D. M. (1996) The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183, 1323-1329.
    • (1996) J. Exp. Med. , vol.183 , pp. 1323-1329
    • Dinapoli, M.R.1    Calderon, C.L.2    Lopez, D.M.3
  • 28
    • 0032964813 scopus 로고    scopus 로고
    • Divergent effects of dithiocarbamates on AP-1-containing and AP-1-less NFAT sites
    • Saccani, S., Saccani, A., Varesio, L., Ghosh, P., Young, H. A., Sica, A. (1999) Divergent effects of dithiocarbamates on AP-1-containing and AP-1-less NFAT sites. Eur. J. Immunol. 29, 1194-1201.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1194-1201
    • Saccani, S.1    Saccani, A.2    Varesio, L.3    Ghosh, P.4    Young, H.A.5    Sica, A.6
  • 29
    • 28544439921 scopus 로고    scopus 로고
    • Diminished expression of transcription factors nuclear factor κB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice
    • Torroella-Kouri, M., Ma, X., Perry, G., Ivanova, M., Cejas, P. J., Owen, J. L., Iragavarapu-Charyulu, V., Lopez, D. M. (2005) Diminished expression of transcription factors nuclear factor κB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice. Cancer Res. 65, 10578-10584.
    • (2005) Cancer Res. , vol.65 , pp. 10578-10584
    • Torroella-Kouri, M.1    Ma, X.2    Perry, G.3    Ivanova, M.4    Cejas, P.J.5    Owen, J.L.6    Iragavarapu-Charyulu, V.7    Lopez, D.M.8
  • 31
    • 33747345981 scopus 로고    scopus 로고
    • Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion
    • DOI 10.1016/j.imbio.2006.06.002, PII S0171298506000829
    • Van Ginderachter, J. A., Movahedi, K., Hassanzadeh Ghassabeh, G., Meerschaut, S., Beschin, A., Raes, G., De Baetselier, P. (2006) Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion. Immunobiology 211, 487-501. (Pubitemid 44241651)
    • (2006) Immunobiology , vol.211 , Issue.6-8 , pp. 487-501
    • Van Ginderachter, J.A.1    Movahedi, K.2    Hassanzadeh Ghassabeh, G.3    Meerschaut, S.4    Beschin, A.5    Raes, G.6    De Baetselier, P.7
  • 32
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • Lin, W. W., Karin, M. (2007) A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 117, 1175-1183.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 33
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill, F. (2004) Cancer and the chemokine network. Nat. Rev. Cancer 4, 540-550.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 35
    • 4344706372 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: Reversible adaptation to changing microenvironments
    • Stout, R. D., Suttles, J. (2004) Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J. Leukoc. Biol. 76, 509-513.
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 509-513
    • Stout, R.D.1    Suttles, J.2
  • 36
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-κB by Toll-like receptors
    • Kawai, T., Akira, S. (2007) Signaling to NF-κB by Toll-like receptors. Trends Mol. Med. 13, 460-469.
    • (2007) Trends Mol. Med. , vol.13 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 37
    • 63149160727 scopus 로고    scopus 로고
    • Regulation of macrophage function in tumors: The multifaceted role of NF-κB
    • Hagemann, T., Biswas, S. K., Lawrence, T., Sica, A., Lewis, C. E. (2009) Regulation of macrophage function in tumors: the multifaceted role of NF-κB. Blood 113, 3139-3146.
    • (2009) Blood , vol.113 , pp. 3139-3146
    • Hagemann, T.1    Biswas, S.K.2    Lawrence, T.3    Sica, A.4    Lewis, C.E.5
  • 38
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • Karin, M., Greten, F. R. (2005) NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749-759.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 39
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • Vallabhapurapu, S., Karin, M. (2009) Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 40
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-κB activation pathways and their role in innate and adaptive immunity
    • Bonizzi, G., Karin, M. (2004) The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280-288.
    • (2004) Trends Immunol. , vol.25 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 41
    • 33749265867 scopus 로고    scopus 로고
    • The alternative NF-κB pathway from biochemistry to biology: Pitfalls and promises for future drug development
    • Dejardin, E. (2006) The alternative NF-κB pathway from biochemistry to biology: pitfalls and promises for future drug development. Biochem. Pharmacol. 72, 1161-1179.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1161-1179
    • Dejardin, E.1
  • 42
    • 30044442866 scopus 로고    scopus 로고
    • How Toll-like receptors signal: What we know and what we don't know
    • O'Neill, L. A. (2006) How Toll-like receptors signal: what we know and what we don't know. Curr. Opin. Immunol. 18, 3-9.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 3-9
    • O'Neill, L.A.1
  • 43
    • 33947722603 scopus 로고    scopus 로고
    • TLR pathways and IFN-regulatory factors: To each its own
    • Colonna, M. (2007) TLR pathways and IFN-regulatory factors: to each its own. Eur. J. Immunol. 37, 306-309.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 306-309
    • Colonna, M.1
  • 44
    • 13444274668 scopus 로고    scopus 로고
    • Toll-like receptor downstream signaling
    • Kawai, T., Akira, S. (2005) Toll-like receptor downstream signaling. Arthritis Res. Ther. 7, 12-19.
    • (2005) Arthritis Res. Ther. , vol.7 , pp. 12-19
    • Kawai, T.1    Akira, S.2
  • 45
    • 0036779446 scopus 로고    scopus 로고
    • Toll-like receptor signaling and regulation of cytokine gene expression in the immune system
    • 70, 72
    • Ozato, K., Tsujimura, H., Tamura, T. (2002) Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques (Suppl.), 66-68, 70, 72.
    • (2002) Biotechniques , Issue.SUPPL. , pp. 66-68
    • Ozato, K.1    Tsujimura, H.2    Tamura, T.3
  • 46
    • 0035067108 scopus 로고    scopus 로고
    • Requirement for STAT1 in LPS-induced gene expression in macrophages
    • Ohmori, Y., Hamilton, T. A. (2001) Requirement for STAT1 in LPS-induced gene expression in macrophages. J. Leukoc. Biol. 69, 598-604.
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 598-604
    • Ohmori, Y.1    Hamilton, T.A.2
  • 47
    • 38849126223 scopus 로고    scopus 로고
    • Coordinate NF-κB and STAT1 activation promotes development of myeloid type 1 dendritic cells
    • Vakkila, J., Demarco, R. A., Lotze, M. T. (2008) Coordinate NF-κB and STAT1 activation promotes development of myeloid type 1 dendritic cells. Scand. J. Immunol. 67, 260-269.
    • (2008) Scand. J. Immunol. , vol.67 , pp. 260-269
    • Vakkila, J.1    Demarco, R.A.2    Lotze, M.T.3
  • 48
    • 0035061538 scopus 로고    scopus 로고
    • IRF family of transcription factors as regulators of host defense
    • Taniguchi, T., Ogasawara, K., Takaoka, A., Tanaka, N. (2001) IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623-655.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 623-655
    • Taniguchi, T.1    Ogasawara, K.2    Takaoka, A.3    Tanaka, N.4
  • 50
    • 0032779561 scopus 로고    scopus 로고
    • The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    • Donnelly, R. P., Dickensheets, H., Finbloom, D. S. (1999) The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J. Interferon Cytokine Res. 19, 563-573.
    • (1999) J. Interferon Cytokine Res , vol.19 , pp. 563-573
    • Donnelly, R.P.1    Dickensheets, H.2    Finbloom, D.S.3
  • 51
    • 3543141120 scopus 로고    scopus 로고
    • A new modality for immunosuppression: Targeting the JAK/STAT pathway
    • O'Shea, J. J., Pesu, M., Borie, D. C., Changelian, P. S. (2004) A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat. Rev. Drug Discov. 3, 555-564.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 555-564
    • O'Shea, J.J.1    Pesu, M.2    Borie, D.C.3    Changelian, P.S.4
  • 52
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica, A., Bronte, V. (2007) Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117, 1155-1166.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 53
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z. W., Egan, L. J., Kagnoff, M. F., Karin, M. (2004) IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 55
    • 21244472975 scopus 로고    scopus 로고
    • IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda, S., Kamata, H., Luo, J. L., Leffert, H., Karin, M. (2005) IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 57
    • 34447328059 scopus 로고    scopus 로고
    • Cancer. Sex, cytokines, and cancer
    • Lawrence, T., Hageman, T., Balkwill, F. (2007) Cancer. Sex, cytokines, and cancer. Science 317, 51-52.
    • (2007) Science , vol.317 , pp. 51-52
    • Lawrence, T.1    Hageman, T.2    Balkwill, F.3
  • 58
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill, F., Charles, K. A., Mantovani, A. (2005) Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7, 211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 59
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., Karin, M. (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 60
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum, S., Medzhitov, R. (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127.
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 63
    • 70350529527 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: In situ reprogramming of tumor-associated macrophages
    • Stout, R. D., Watkins, S. K., Suttles, J. (2009) Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J. Leukoc. Biol. 86, 1105-1109.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1105-1109
    • Stout, R.D.1    Watkins, S.K.2    Suttles, J.3
  • 64
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of IL-10 mediates defective IL-12 production and NF-κ B activation in tumor-associated macrophages
    • Sica, A., Saccani, A., Bottazzi, B., Polentarutti, N., Vecchi, A., van Damme, J., Mantovani, A. (2000) Autocrine production of IL-10 mediates defective IL-12 production and NF-κ B activation in tumor-associated macrophages. J. Immunol. 164, 762-767.
    • (2000) J. Immunol. , vol.164 , pp. 762-767
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3    Polentarutti, N.4    Vecchi, A.5    Van Damme, J.6    Mantovani, A.7
  • 65
  • 66
    • 27144558287 scopus 로고    scopus 로고
    • Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion
    • Colombo, M. P., Mantovani, A. (2005) Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion. Cancer Res. 65, 9113-9116.
    • (2005) Cancer Res. , vol.65 , pp. 9113-9116
    • Colombo, M.P.1    Mantovani, A.2
  • 67
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci, C., Vicari, A. P., Sangaletti, S., Trinchieri, G., Colombo, M. P. (2005) Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res. 65, 3437-3446.
    • (2005) Cancer Res. , vol.65 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 68
    • 76049128364 scopus 로고    scopus 로고
    • Nuclear factor-κB and tumor-associated macrophages
    • Mancino, A., Lawrence, T. (2010) Nuclear factor-κB and tumor-associated macrophages. Clin. Cancer Res. 16, 784-789.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 784-789
    • Mancino, A.1    Lawrence, T.2
  • 69
    • 17844386319 scopus 로고    scopus 로고
    • IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
    • Lawrence, T., Bebien, M., Liu, G. Y., Nizet, V., Karin, M. (2005) IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation. Nature 434, 1138-1143.
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 70
  • 75
    • 85046913982 scopus 로고    scopus 로고
    • Constitutive non-canonical NFκB signaling in pancreatic cancer cells
    • Wharry, C. E., Haines, K. M., Carroll, R. G., May, M. J. (2009) Constitutive non-canonical NFκB signaling in pancreatic cancer cells. Cancer Biol. Ther. 8, 1567-1576.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1567-1576
    • Wharry, C.E.1    Haines, K.M.2    Carroll, R.G.3    May, M.J.4
  • 77
    • 0033709813 scopus 로고    scopus 로고
    • Critical role of C/EBPδ and C/EBPβ factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1β in articular chondrocytes
    • Thomas, B., Berenbaum, F., Humbert, L., Bian, H., Bereziat, G., Crofford, L., Olivier, J. L. (2000) Critical role of C/EBPδ and C/EBPβ factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1β in articular chondrocytes. Eur. J. Biochem. 267, 6798-6809.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 6798-6809
    • Thomas, B.1    Berenbaum, F.2    Humbert, L.3    Bian, H.4    Bereziat, G.5    Crofford, L.6    Olivier, J.L.7
  • 78
    • 0034008927 scopus 로고    scopus 로고
    • Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages
    • Wadleigh, D. J., Reddy, S. T., Kopp, E., Ghosh, S., Herschman, H. R. (2000) Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J. Biol. Chem. 275, 6259-6266.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6259-6266
    • Wadleigh, D.J.1    Reddy, S.T.2    Kopp, E.3    Ghosh, S.4    Herschman, H.R.5
  • 79
    • 0035476888 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages
    • Klimp, A. H., Hollema, H., Kempinga, C., van der Zee, A. G., de Vries, E. G., Daemen, T. (2001) Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages. Cancer Res. 61, 7305-7309.
    • (2001) Cancer Res. , vol.61 , pp. 7305-7309
    • Klimp, A.H.1    Hollema, H.2    Kempinga, C.3    Van Der Zee, A.G.4    De Vries, E.G.5    Daemen, T.6
  • 80
    • 33644761875 scopus 로고    scopus 로고
    • Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells
    • Banerjee, A., Gugasyan, R., McMahon, M., Gerondakis, S. (2006) Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc. Natl. Acad. Sci. USA 103, 3274-3279.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 3274-3279
    • Banerjee, A.1    Gugasyan, R.2    McMahon, M.3    Gerondakis, S.4
  • 81
  • 83
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-κB in inflammation
    • Ghosh, S., Hayden, M. S. (2008) New regulators of NF-κB in inflammation. Nat. Rev. Immunol. 8, 837-848.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2


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