-
1
-
-
80053321300
-
INPP4B: the new kid on the PI3K block
-
Agoulnik I.U., Hodgson M.C., Bowden W.A., Ittmann M.M. INPP4B: the new kid on the PI3K block. Oncotarget 2011, 2:321-328.
-
(2011)
Oncotarget
, vol.2
, pp. 321-328
-
-
Agoulnik, I.U.1
Hodgson, M.C.2
Bowden, W.A.3
Ittmann, M.M.4
-
2
-
-
73649100276
-
Maladaptation of critical cellular functions in asthma: bioinformatic analysis
-
Agrawal A., Sinha A., Ahmad T., Aich J., Singh P., Sharma A., et al. Maladaptation of critical cellular functions in asthma: bioinformatic analysis. Physiol Genomics 2009, 40:1-7.
-
(2009)
Physiol Genomics
, vol.40
, pp. 1-7
-
-
Agrawal, A.1
Sinha, A.2
Ahmad, T.3
Aich, J.4
Singh, P.5
Sharma, A.6
-
3
-
-
33645990004
-
Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice
-
Angelucci A., Gravina G.L., Rucci N., Millimaggi D., Festuccia C., Muzi P., et al. Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice. Endocr Relat Cancer 2006, 13:197-210.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 197-210
-
-
Angelucci, A.1
Gravina, G.L.2
Rucci, N.3
Millimaggi, D.4
Festuccia, C.5
Muzi, P.6
-
4
-
-
0029825270
-
Deletions of chromosome 20q and the pathogenesis of myeloproliferative disorders
-
Asimakopoulos F.A., Green A.R. Deletions of chromosome 20q and the pathogenesis of myeloproliferative disorders. Br J Haematol 1996, 95:219-226.
-
(1996)
Br J Haematol
, vol.95
, pp. 219-226
-
-
Asimakopoulos, F.A.1
Green, A.R.2
-
5
-
-
77956534349
-
The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole
-
Bakowski M.A., Braun V., Lam G.Y., Yeung T., Heo W.D., Meyer T., et al. The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole. Cell Host Microbe 2010, 7:453-462.
-
(2010)
Cell Host Microbe
, vol.7
, pp. 453-462
-
-
Bakowski, M.A.1
Braun, V.2
Lam, G.Y.3
Yeung, T.4
Heo, W.D.5
Meyer, T.6
-
6
-
-
35648934623
-
Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase
-
Barber M.A., Donald S., Thelen S., Anderson K.E., Thelen M., Welch H.C. Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase. J Biol Chem 2007, 282:29967-29976.
-
(2007)
J Biol Chem
, vol.282
, pp. 29967-29976
-
-
Barber, M.A.1
Donald, S.2
Thelen, S.3
Anderson, K.E.4
Thelen, M.5
Welch, H.C.6
-
7
-
-
33644775504
-
Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene
-
Barnache S., Le Scolan E., Kosmider O., Denis N., Moreau-Gachelin F. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Oncogene 2006, 25:1420-1423.
-
(2006)
Oncogene
, vol.25
, pp. 1420-1423
-
-
Barnache, S.1
Le Scolan, E.2
Kosmider, O.3
Denis, N.4
Moreau-Gachelin, F.5
-
8
-
-
51649090840
-
Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1
-
Bento J.L., Palmer N.D., Zhong M., Roh B., Lewis J.P., Wing M.R., et al. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics 2008, 92:226-234.
-
(2008)
Genomics
, vol.92
, pp. 226-234
-
-
Bento, J.L.1
Palmer, N.D.2
Zhong, M.3
Roh, B.4
Lewis, J.P.5
Wing, M.R.6
-
9
-
-
0033910573
-
Evidence for a prostate cancer-susceptibility locus on chromosome 20
-
Berry R., Schroeder J.J., French A.J., McDonnell S.K., Peterson B.J., Cunningham J.M., et al. Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am J Hum Genet 2000, 67:82-91.
-
(2000)
Am J Hum Genet
, vol.67
, pp. 82-91
-
-
Berry, R.1
Schroeder, J.J.2
French, A.J.3
McDonnell, S.K.4
Peterson, B.J.5
Cunningham, J.M.6
-
10
-
-
0034213327
-
Rho GTPases and their effector proteins
-
Bishop A.L., Hall A. Rho GTPases and their effector proteins. Biochem J 2000, 348(Pt 2):241-255.
-
(2000)
Biochem J
, vol.348
, Issue.PART 2
, pp. 241-255
-
-
Bishop, A.L.1
Hall, A.2
-
12
-
-
2342565881
-
Advances in protein kinase B signalling: AKTion on multiple fronts
-
Brazil D.P., Yang Z.Z., Hemmings B.A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 2004, 29:233-242.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 233-242
-
-
Brazil, D.P.1
Yang, Z.Z.2
Hemmings, B.A.3
-
13
-
-
34548770599
-
Brain plasticity mechanisms and memory: a party of four
-
Bruel-Jungerman E., Davis S., Laroche S. Brain plasticity mechanisms and memory: a party of four. Neuroscientist 2007, 13:492-505.
-
(2007)
Neuroscientist
, vol.13
, pp. 492-505
-
-
Bruel-Jungerman, E.1
Davis, S.2
Laroche, S.3
-
14
-
-
77149152165
-
Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis
-
Carretero-Ortega J., Walsh C.T., Hernandez-Garcia R., Reyes-Cruz G., Brown J.H., Vazquez-Prado J. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol Pharmacol 2010, 77:435-442.
-
(2010)
Mol Pharmacol
, vol.77
, pp. 435-442
-
-
Carretero-Ortega, J.1
Walsh, C.T.2
Hernandez-Garcia, R.3
Reyes-Cruz, G.4
Brown, J.H.5
Vazquez-Prado, J.6
-
15
-
-
79955975429
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
-
Carver B.S., Chapinski C., Wongvipat J., Hieronymus H., Chen Y., Chandarlapaty S., et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011, 19:575-586.
-
(2011)
Cancer Cell
, vol.19
, pp. 575-586
-
-
Carver, B.S.1
Chapinski, C.2
Wongvipat, J.3
Hieronymus, H.4
Chen, Y.5
Chandarlapaty, S.6
-
16
-
-
78751493647
-
Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells
-
Chetram M.A., Odero-Marah V., Hinton C.V. Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells. Mol Cancer Res 2011, 9:90-102.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 90-102
-
-
Chetram, M.A.1
Odero-Marah, V.2
Hinton, C.V.3
-
17
-
-
79959340773
-
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
-
Christoffersen C., Obinata H., Kumaraswamy S.B., Galvani S., Ahnstrom J., Sevvana M., et al. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A 2011, 108:9613-9618.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 9613-9618
-
-
Christoffersen, C.1
Obinata, H.2
Kumaraswamy, S.B.3
Galvani, S.4
Ahnstrom, J.5
Sevvana, M.6
-
18
-
-
9444239192
-
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
-
Darash-Yahana M., Pikarsky E., Abramovitch R., Zeira E., Pal B., Karplus R., et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004, 18:1240-1242.
-
(2004)
FASEB J
, vol.18
, pp. 1240-1242
-
-
Darash-Yahana, M.1
Pikarsky, E.2
Abramovitch, R.3
Zeira, E.4
Pal, B.5
Karplus, R.6
-
19
-
-
4143145447
-
Welch HC. P-Rex2, a new guanine-nucleotide exchange factor for Rac
-
Donald S., Hill K., Lecureuil C., Barnouin R., Krugmann S., et al. Welch HC. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett 2004, 572:172-176.
-
(2004)
FEBS Lett
, vol.572
, pp. 172-176
-
-
Donald, S.1
Hill, K.2
Lecureuil, C.3
Barnouin, R.4
Krugmann, S.5
-
20
-
-
41949120605
-
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination
-
Donald S., Humby T., Fyfe I., Segonds-Pichon A., Walker S.A., Andrews S.R., et al. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc Natl Acad Sci U S A 2008, 105:4483-4488.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 4483-4488
-
-
Donald, S.1
Humby, T.2
Fyfe, I.3
Segonds-Pichon, A.4
Walker, S.A.5
Andrews, S.R.6
-
21
-
-
27144551936
-
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils
-
Dong X., Mo Z., Bokoch G., Guo C., Li Z., Wu D. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol 2005, 15:1874-1879.
-
(2005)
Curr Biol
, vol.15
, pp. 1874-1879
-
-
Dong, X.1
Mo, Z.2
Bokoch, G.3
Guo, C.4
Li, Z.5
Wu, D.6
-
22
-
-
0942279704
-
Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes
-
Erickson J.W., Cerione R.A. Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry 2004, 43:837-842.
-
(2004)
Biochemistry
, vol.43
, pp. 837-842
-
-
Erickson, J.W.1
Cerione, R.A.2
-
23
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
24
-
-
78650818650
-
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
-
Fayard E., Xue G., Parcellier A., Bozulic L., Hemmings B.A. Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway. Curr Top Microbiol Immunol 2010, 346:31-56.
-
(2010)
Curr Top Microbiol Immunol
, vol.346
, pp. 31-56
-
-
Fayard, E.1
Xue, G.2
Parcellier, A.3
Bozulic, L.4
Hemmings, B.A.5
-
25
-
-
78650675585
-
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
-
Fedele C.G., Ooms L.M., Ho M., Vieusseux J., O'Toole S.A., Millar E.K., et al. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A 2010, 107:22231-22236.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 22231-22236
-
-
Fedele, C.G.1
Ooms, L.M.2
Ho, M.3
Vieusseux, J.4
O'Toole, S.A.5
Millar, E.K.6
-
26
-
-
33745129384
-
Characterization of the murine Inpp4b gene and identification of a novel isoform
-
Ferron M., Vacher J. Characterization of the murine Inpp4b gene and identification of a novel isoform. Gene 2006, 376:152-161.
-
(2006)
Gene
, vol.376
, pp. 152-161
-
-
Ferron, M.1
Vacher, J.2
-
27
-
-
69949170092
-
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
-
Fine B., Hodakoski C., Koujak S., Su T., Saal L.H., Maurer M., et al. Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 2009, 325:1261-1265.
-
(2009)
Science
, vol.325
, pp. 1261-1265
-
-
Fine, B.1
Hodakoski, C.2
Koujak, S.3
Su, T.4
Saal, L.H.5
Maurer, M.6
-
28
-
-
0035878325
-
A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20
-
Fossey S.C., Mychaleckyj J.C., Pendleton J.K., Snyder J.R., Bensen J.T., Hirakawa S., et al. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. Genomics 2001, 76:45-57.
-
(2001)
Genomics
, vol.76
, pp. 45-57
-
-
Fossey, S.C.1
Mychaleckyj, J.C.2
Pendleton, J.K.3
Snyder, J.R.4
Bensen, J.T.5
Hirakawa, S.6
-
29
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
Franke T.F., Kaplan D.R., Cantley L.C., Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 1997, 275:665-668.
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
30
-
-
0030991386
-
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
-
Frech M., Andjelkovic M., Ingley E., Reddy K.K., Falck J.R., Hemmings B.A. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem 1997, 272:8474-8481.
-
(1997)
J Biol Chem
, vol.272
, pp. 8474-8481
-
-
Frech, M.1
Andjelkovic, M.2
Ingley, E.3
Reddy, K.K.4
Falck, J.R.5
Hemmings, B.A.6
-
32
-
-
33646705667
-
Regulation of the PTEN phosphatase
-
Gericke A., Munson M., Ross A.H. Regulation of the PTEN phosphatase. Gene 2006, 374:1-9.
-
(2006)
Gene
, vol.374
, pp. 1-9
-
-
Gericke, A.1
Munson, M.2
Ross, A.H.3
-
33
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
Gewinner C., Wang Z.C., Richardson A., Teruya-Feldstein J., Etemadmoghadam D., Bowtell D., et al. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009, 16:115-125.
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
Teruya-Feldstein, J.4
Etemadmoghadam, D.5
Bowtell, D.6
-
34
-
-
45149107487
-
Mechanisms of neurodegeneration in Huntington's disease
-
Gil J.M., Rego A.C. Mechanisms of neurodegeneration in Huntington's disease. Eur J Neurosci 2008, 27:2803-2820.
-
(2008)
Eur J Neurosci
, vol.27
, pp. 2803-2820
-
-
Gil, J.M.1
Rego, A.C.2
-
35
-
-
0347473801
-
Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes
-
Gillooly D.J., Raiborg C., Stenmark H. Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes. Histochem Cell Biol 2003, 120:445-453.
-
(2003)
Histochem Cell Biol
, vol.120
, pp. 445-453
-
-
Gillooly, D.J.1
Raiborg, C.2
Stenmark, H.3
-
36
-
-
0036914046
-
The molecular perspective: VEGF and angiogenesis
-
Goodsell D.S. The molecular perspective: VEGF and angiogenesis. Oncologist 2002, 7:569-570.
-
(2002)
Oncologist
, vol.7
, pp. 569-570
-
-
Goodsell, D.S.1
-
37
-
-
77952958465
-
Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways
-
Guittard G., Mortier E., Tronchere H., Firaguay G., Gerard A., Zimmermann P., et al. Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways. FEBS Lett 2010, 584:2455-2460.
-
(2010)
FEBS Lett
, vol.584
, pp. 2455-2460
-
-
Guittard, G.1
Mortier, E.2
Tronchere, H.3
Firaguay, G.4
Gerard, A.5
Zimmermann, P.6
-
38
-
-
30944454492
-
Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture
-
Harvell D.M.E., Richer J.K., Allred D.C., Sartorius C.A., Horwitz K.B. Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture. Endocrinology 2006, 147:700-713.
-
(2006)
Endocrinology
, vol.147
, pp. 700-713
-
-
Harvell, D.M.E.1
Richer, J.K.2
Allred, D.C.3
Sartorius, C.A.4
Horwitz, K.B.5
-
39
-
-
33751297031
-
Signalling through Class I PI3Ks in mammalian cells
-
Hawkins P.T., Anderson K.E., Davidson K., Stephens L.R. Signalling through Class I PI3Ks in mammalian cells. Biochem Soc Trans 2006, 34:647-662.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 647-662
-
-
Hawkins, P.T.1
Anderson, K.E.2
Davidson, K.3
Stephens, L.R.4
-
40
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N., Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004, 18:1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
41
-
-
34548151890
-
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
-
Hernandez-Negrete I., Carretero-Ortega J., Rosenfeldt H., Hernandez-Garcia R., Calderon-Salinas J.V., Reyes-Cruz G., et al. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem 2007, 282:23708-23715.
-
(2007)
J Biol Chem
, vol.282
, pp. 23708-23715
-
-
Hernandez-Negrete, I.1
Carretero-Ortega, J.2
Rosenfeldt, H.3
Hernandez-Garcia, R.4
Calderon-Salinas, J.V.5
Reyes-Cruz, G.6
-
42
-
-
14244269335
-
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits
-
Hill K., Krugmann S., Andrews S.R., Coadwell W.J., Finan P., Welch H.C., et al. Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. J Biol Chem 2005, 280:4166-4173.
-
(2005)
J Biol Chem
, vol.280
, pp. 4166-4173
-
-
Hill, K.1
Krugmann, S.2
Andrews, S.R.3
Coadwell, W.J.4
Finan, P.5
Welch, H.C.6
-
43
-
-
78751535990
-
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
-
Hodgson M.C., Shao L.J., Frolov A., Li R., Peterson L.E., Ayala G., et al. Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res 2011, 71:572-582.
-
(2011)
Cancer Res
, vol.71
, pp. 572-582
-
-
Hodgson, M.C.1
Shao, L.J.2
Frolov, A.3
Li, R.4
Peterson, L.E.5
Ayala, G.6
-
44
-
-
0037138364
-
Signaling to the Rho GTPases: networking with the DH domain
-
Hoffman G.R., Cerione R.A. Signaling to the Rho GTPases: networking with the DH domain. FEBS Lett 2002, 513:85-91.
-
(2002)
FEBS Lett
, vol.513
, pp. 85-91
-
-
Hoffman, G.R.1
Cerione, R.A.2
-
45
-
-
67349239410
-
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
-
Ivetac I., Gurung R., Hakim S., Horan K.A., Sheffield D.A., Binge L.C., et al. Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1. EMBO Rep 2009, 10:487-493.
-
(2009)
EMBO Rep
, vol.10
, pp. 487-493
-
-
Ivetac, I.1
Gurung, R.2
Hakim, S.3
Horan, K.A.4
Sheffield, D.A.5
Binge, L.C.6
-
46
-
-
20944450964
-
The type I alpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
-
Ivetac I., Munday A.D., Kisseleva M.V., Zhang X.M., Luff S., Tiganis T., et al. The type I alpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell 2005, 16:2218-2233.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 2218-2233
-
-
Ivetac, I.1
Munday, A.D.2
Kisseleva, M.V.3
Zhang, X.M.4
Luff, S.5
Tiganis, T.6
-
47
-
-
77957777637
-
Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase
-
Jackson C., Welch H.C., Bellamy T.C. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 2010, 5:e11962.
-
(2010)
PLoS One
, vol.5
-
-
Jackson, C.1
Welch, H.C.2
Bellamy, T.C.3
-
48
-
-
0029993517
-
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
-
James S.R., Downes C.P., Gigg R., Grove S.J., Holmes A.B., Alessi D.R. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem J 1996, 315(Pt 3):709-713.
-
(1996)
Biochem J
, vol.315
, Issue.PART 3
, pp. 709-713
-
-
James, S.R.1
Downes, C.P.2
Gigg, R.3
Grove, S.J.4
Holmes, A.B.5
Alessi, D.R.6
-
49
-
-
79959847002
-
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
-
Kim E.K., Yun S.J., Ha J.M., Kim Y.W., Jin I.H., Yun J., et al. Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. Oncogene 2011.
-
(2011)
Oncogene
-
-
Kim, E.K.1
Yun, S.J.2
Ha, J.M.3
Kim, Y.W.4
Jin, I.H.5
Yun, J.6
-
50
-
-
51749090593
-
Sphingosine-1-phosphate regulation of mammalian development
-
Kono M., Allende M.L., Proia R.L. Sphingosine-1-phosphate regulation of mammalian development. Biochim Biophys Acta 2008, 1781:435-441.
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 435-441
-
-
Kono, M.1
Allende, M.L.2
Proia, R.L.3
-
51
-
-
66149161804
-
Genetics of asthma: a molecular biologist perspective
-
Kumar A., Ghosh B. Genetics of asthma: a molecular biologist perspective. Clin Mol Allergy 2009, 7:7.
-
(2009)
Clin Mol Allergy
, vol.7
, pp. 7
-
-
Kumar, A.1
Ghosh, B.2
-
52
-
-
0344308248
-
BopB is a type III secreted protein in Bordetella bronchiseptica and is required for cytotoxicity against cultured mammalian cells
-
Kuwae A., Ohishi M., Watanabe M., Nagai M., Abe A. BopB is a type III secreted protein in Bordetella bronchiseptica and is required for cytotoxicity against cultured mammalian cells. Cell Microbiol 2003, 5:973-983.
-
(2003)
Cell Microbiol
, vol.5
, pp. 973-983
-
-
Kuwae, A.1
Ohishi, M.2
Watanabe, M.3
Nagai, M.4
Abe, A.5
-
53
-
-
0034120979
-
Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines
-
Larramendy M.L., Lushnikova T., Bjorkqvist A.M., Wistuba I.I., Virmani A.K., Shivapurkar N., et al. Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines. Cancer Genet Cytogenet 2000, 119:132-138.
-
(2000)
Cancer Genet Cytogenet
, vol.119
, pp. 132-138
-
-
Larramendy, M.L.1
Lushnikova, T.2
Bjorkqvist, A.M.3
Wistuba, I.I.4
Virmani, A.K.5
Shivapurkar, N.6
-
54
-
-
0037041023
-
Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1
-
Lawe D.C., Chawla A., Merithew E., Dumas J., Carrington W., Fogarty K., et al. Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem 2002, 277:8611-8617.
-
(2002)
J Biol Chem
, vol.277
, pp. 8611-8617
-
-
Lawe, D.C.1
Chawla, A.2
Merithew, E.3
Dumas, J.4
Carrington, W.5
Fogarty, K.6
-
55
-
-
74749085362
-
Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor
-
Ledezma-Sanchez B.A., Garcia-Regalado A., Guzman-Hernandez M.L., Vazquez-Prado J. Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor. Biochem Biophys Res Commun 2010, 391:1647-1652.
-
(2010)
Biochem Biophys Res Commun
, vol.391
, pp. 1647-1652
-
-
Ledezma-Sanchez, B.A.1
Garcia-Regalado, A.2
Guzman-Hernandez, M.L.3
Vazquez-Prado, J.4
-
56
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
-
Lee J.O., Yang H., Georgescu M.M., Di Cristofano A., Maehama T., Shi Y., et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999, 99:323-334.
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
-
57
-
-
77956879227
-
Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans
-
Lewis J.P., Palmer N.D., Ellington J.B., Divers J., Ng M.C., Lu L., et al. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics 2010, 96:211-219.
-
(2010)
Genomics
, vol.96
, pp. 211-219
-
-
Lewis, J.P.1
Palmer, N.D.2
Ellington, J.B.3
Divers, J.4
Ng, M.C.5
Lu, L.6
-
58
-
-
0028786852
-
Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5
-
Li G., D'Souza-Schorey C., Barbieri M.A., Roberts R.L., Klippel A., Williams L.T., et al. Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci U S A 1995, 92:10207-10211.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10207-10211
-
-
Li, G.1
D'Souza-Schorey, C.2
Barbieri, M.A.3
Roberts, R.L.4
Klippel, A.5
Williams, L.T.6
-
59
-
-
19344368931
-
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells
-
Li Z., Paik J.H., Wang Z., Hla T., Wu D. Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat 2005, 76:95-104.
-
(2005)
Prostaglandins Other Lipid Mediat
, vol.76
, pp. 95-104
-
-
Li, Z.1
Paik, J.H.2
Wang, Z.3
Hla, T.4
Wu, D.5
-
60
-
-
65949092291
-
PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches
-
Ligresti G., Militello L., Steelman L.S., Cavallaro A., Basile F., Nicoletti F., et al. PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches. Cell Cycle 2009, 8:1352-1358.
-
(2009)
Cell Cycle
, vol.8
, pp. 1352-1358
-
-
Ligresti, G.1
Militello, L.2
Steelman, L.S.3
Cavallaro, A.4
Basile, F.5
Nicoletti, F.6
-
61
-
-
57749106585
-
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells
-
Lin H.-J.L., Zuo T., Lin C.-H., Kuo C.T., Liyanarachchi S., Sun S., et al. Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Res 2008, 68:10257-10266.
-
(2008)
Cancer Res
, vol.68
, pp. 10257-10266
-
-
Lin, H.-J.L.1
Zuo, T.2
Lin, C.-H.3
Kuo, C.T.4
Liyanarachchi, S.5
Sun, S.6
-
62
-
-
39149097499
-
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity
-
Ma K., Cheung S.M., Marshall A.J., Duronio V. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cell Signal 2008, 20:684-694.
-
(2008)
Cell Signal
, vol.20
, pp. 684-694
-
-
Ma, K.1
Cheung, S.M.2
Marshall, A.J.3
Duronio, V.4
-
63
-
-
84865636842
-
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma
-
Abstract nr 1041
-
Magnussen A., Karlsson C., Soderkvist P., Karlsson M.G., Thunell L.K. Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma. Abstract Cancer Res 2011, 71. Abstract nr 1041.
-
(2011)
Abstract Cancer Res
, vol.71
-
-
Magnussen, A.1
Karlsson, C.2
Soderkvist, P.3
Karlsson, M.G.4
Thunell, L.K.5
-
64
-
-
0345687489
-
The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo
-
Martemyanov K.A., Lishko P.V., Calero N., Keresztes G., Sokolov M., Strissel K.J., et al. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J Neurosci 2003, 23:10175-10181.
-
(2003)
J Neurosci
, vol.23
, pp. 10175-10181
-
-
Martemyanov, K.A.1
Lishko, P.V.2
Calero, N.3
Keresztes, G.4
Sokolov, M.5
Strissel, K.J.6
-
65
-
-
33644855674
-
Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity
-
Mayeenuddin L.H., Garrison J.C. Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. J Biol Chem 2006, 281:1921-1928.
-
(2006)
J Biol Chem
, vol.281
, pp. 1921-1928
-
-
Mayeenuddin, L.H.1
Garrison, J.C.2
-
66
-
-
33644867116
-
Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers
-
Mayeenuddin L.H., McIntire W.E., Garrison J.C. Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers. J Biol Chem 2006, 281:1913-1920.
-
(2006)
J Biol Chem
, vol.281
, pp. 1913-1920
-
-
Mayeenuddin, L.H.1
McIntire, W.E.2
Garrison, J.C.3
-
67
-
-
79952281692
-
P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer
-
Montero J.C., Seoane S., Ocana A., Pandiella A. P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer. Oncogene 2010, 30:1059-1071.
-
(2010)
Oncogene
, vol.30
, pp. 1059-1071
-
-
Montero, J.C.1
Seoane, S.2
Ocana, A.3
Pandiella, A.4
-
68
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
Mora A., Komander D., van Aalten D.M., Alessi D.R. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 2004, 15:161-170.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
van Aalten, D.M.3
Alessi, D.R.4
-
69
-
-
79958764107
-
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
-
Mulholland D.J., Tran L.M., Li Y., Cai H., Morim A., Wang S., et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 2011, 19:792-804.
-
(2011)
Cancer Cell
, vol.19
, pp. 792-804
-
-
Mulholland, D.J.1
Tran, L.M.2
Li, Y.3
Cai, H.4
Morim, A.5
Wang, S.6
-
70
-
-
0033616619
-
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
-
Munday A.D., Norris F.A., Caldwell K.K., Brown S., Majerus P.W., Mitchell C.A. The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. Proc Natl Acad Sci U S A 1999, 96:3640-3645.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3640-3645
-
-
Munday, A.D.1
Norris, F.A.2
Caldwell, K.K.3
Brown, S.4
Majerus, P.W.5
Mitchell, C.A.6
-
71
-
-
0036161583
-
Electrostatic control of the membrane targeting of C2 domains
-
Murray D., Honig B. Electrostatic control of the membrane targeting of C2 domains. Mol Cell 2002, 9:145-154.
-
(2002)
Mol Cell
, vol.9
, pp. 145-154
-
-
Murray, D.1
Honig, B.2
-
72
-
-
34447650761
-
High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization
-
Naylor T.L., Greshock J., Wang Y., Colligon T., Yu Q.C., Clemmer V., et al. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res 2005, 7:R1186-R1198.
-
(2005)
Breast Cancer Res
, vol.7
-
-
Naylor, T.L.1
Greshock, J.2
Wang, Y.3
Colligon, T.4
Yu, Q.C.5
Clemmer, V.6
-
73
-
-
77951935528
-
Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells
-
Nie B., Cheng N., Dinauer M.C., Ye R.D. Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. Cell Signal 2010, 22:770-782.
-
(2010)
Cell Signal
, vol.22
, pp. 770-782
-
-
Nie, B.1
Cheng, N.2
Dinauer, M.C.3
Ye, R.D.4
-
74
-
-
18644379244
-
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology
-
Niebuhr K., Giuriato S., Pedron T., Philpott D.J., Gaits F., Sable J., et al. Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology. EMBO J 2002, 21:5069-5078.
-
(2002)
EMBO J
, vol.21
, pp. 5069-5078
-
-
Niebuhr, K.1
Giuriato, S.2
Pedron, T.3
Philpott, D.J.4
Gaits, F.5
Sable, J.6
-
75
-
-
0030863996
-
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family
-
Norris F.A., Atkins R.C., Majerus P.W. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem 1997, 272:23859-23864.
-
(1997)
J Biol Chem
, vol.272
, pp. 23859-23864
-
-
Norris, F.A.1
Atkins, R.C.2
Majerus, P.W.3
-
76
-
-
0030890880
-
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
-
Norris F.A., Atkins R.C., Majerus P.W. Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets. J Biol Chem 1997, 272:10987-10989.
-
(1997)
J Biol Chem
, vol.272
, pp. 10987-10989
-
-
Norris, F.A.1
Atkins, R.C.2
Majerus, P.W.3
-
77
-
-
0028289708
-
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography
-
Norris F.A., Majerus P.W. Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem 1994, 269:8716-8720.
-
(1994)
J Biol Chem
, vol.269
, pp. 8716-8720
-
-
Norris, F.A.1
Majerus, P.W.2
-
78
-
-
0032564446
-
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase
-
Norris F.A., Wilson M.P., Wallis T.S., Galyov E.E., Majerus P.W. SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci U S A 1998, 95:14057-14059.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14057-14059
-
-
Norris, F.A.1
Wilson, M.P.2
Wallis, T.S.3
Galyov, E.E.4
Majerus, P.W.5
-
79
-
-
0035950222
-
A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice
-
Nystuen A., Legare M.E., Shultz L.D., Frankel W.N. A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron 2001, 32:203-212.
-
(2001)
Neuron
, vol.32
, pp. 203-212
-
-
Nystuen, A.1
Legare, M.E.2
Shultz, L.D.3
Frankel, W.N.4
-
80
-
-
59849084796
-
Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays
-
Ooms L.M., Dyson J.M., Kong A.M., Mitchell C.A. Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays. Methods Mol Biol 2009, 462:223-239.
-
(2009)
Methods Mol Biol
, vol.462
, pp. 223-239
-
-
Ooms, L.M.1
Dyson, J.M.2
Kong, A.M.3
Mitchell, C.A.4
-
81
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
-
(2005)
Cell
, vol.121
, pp. 335-348
-
-
Orimo, A.1
Gupta, P.B.2
Sgroi, D.C.3
Arenzana-Seisdedos, F.4
Delaunay, T.5
Naeem, R.6
-
82
-
-
0028318783
-
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
-
Ottaviano Y.L., Issa J.P., Parl F.F., Smith H.S., Baylin S.B., Davidson N.E. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res 1994, 54:2552-2555.
-
(1994)
Cancer Res
, vol.54
, pp. 2552-2555
-
-
Ottaviano, Y.L.1
Issa, J.P.2
Parl, F.F.3
Smith, H.S.4
Baylin, S.B.5
Davidson, N.E.6
-
83
-
-
33644850315
-
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection
-
Pendaries C., Tronchere H., Arbibe L., Mounier J., Gozani O., Cantley L., et al. PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J 2006, 25:1024-1034.
-
(2006)
EMBO J
, vol.25
, pp. 1024-1034
-
-
Pendaries, C.1
Tronchere, H.2
Arbibe, L.3
Mounier, J.4
Gozani, O.5
Cantley, L.6
-
84
-
-
77953966511
-
Sphingosine 1-phosphate and cancer
-
Pyne N.J., Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010, 10:489-503.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 489-503
-
-
Pyne, N.J.1
Pyne, S.2
-
85
-
-
67349167687
-
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
-
Qin J., Xie Y., Wang B., Hoshino M., Wolff D.W., Zhao J., et al. Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene 2009, 28:1853-1863.
-
(2009)
Oncogene
, vol.28
, pp. 1853-1863
-
-
Qin, J.1
Xie, Y.2
Wang, B.3
Hoshino, M.4
Wolff, D.W.5
Zhao, J.6
-
86
-
-
0030200110
-
PEST sequences and regulation by proteolysis
-
Rechsteiner M., Rogers S.W. PEST sequences and regulation by proteolysis. Trends Biochem Sci 1996, 21:267-271.
-
(1996)
Trends Biochem Sci
, vol.21
, pp. 267-271
-
-
Rechsteiner, M.1
Rogers, S.W.2
-
87
-
-
0043073128
-
Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm
-
Rosen H., Liao J. Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Curr Opin Chem Biol 2003, 7:461-468.
-
(2003)
Curr Opin Chem Biol
, vol.7
, pp. 461-468
-
-
Rosen, H.1
Liao, J.2
-
88
-
-
4143060469
-
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor
-
Rosenfeldt H., Vazquez-Prado J., Gutkind J.S. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett 2004, 572:167-171.
-
(2004)
FEBS Lett
, vol.572
, pp. 167-171
-
-
Rosenfeldt, H.1
Vazquez-Prado, J.2
Gutkind, J.S.3
-
89
-
-
77949538154
-
Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4
-
Sachs A.J., David S.A., Haider N.B., Nystuen A.M. Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. PLoS One 2009, 4:e8270.
-
(2009)
PLoS One
, vol.4
-
-
Sachs, A.J.1
David, S.A.2
Haider, N.B.3
Nystuen, A.M.4
-
91
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
92
-
-
77953027360
-
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death
-
Sasaki J., Kofuji S., Itoh R., Momiyama T., Takayama K., Murakami H., et al. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature 2010, 465:497-501.
-
(2010)
Nature
, vol.465
, pp. 497-501
-
-
Sasaki, J.1
Kofuji, S.2
Itoh, R.3
Momiyama, T.4
Takayama, K.5
Murakami, H.6
-
93
-
-
41749102195
-
A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma
-
Sharma M., Batra J., Mabalirajan U., Sharma S., Nagarkatti R., Aich J., et al. A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma. Am J Respir Crit Care Med 2008, 177:712-719.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 712-719
-
-
Sharma, M.1
Batra, J.2
Mabalirajan, U.3
Sharma, S.4
Nagarkatti, R.5
Aich, J.6
-
94
-
-
33947141370
-
Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain
-
Shearn C.T., Norris F.A. Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain. Biochem Biophys Res Commun 2007, 356:255-259.
-
(2007)
Biochem Biophys Res Commun
, vol.356
, pp. 255-259
-
-
Shearn, C.T.1
Norris, F.A.2
-
95
-
-
0034804631
-
Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene
-
Shearn C.T., Walker J., Norris F.A. Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. Biochem Biophys Res Commun 2001, 286:119-125.
-
(2001)
Biochem Biophys Res Commun
, vol.286
, pp. 119-125
-
-
Shearn, C.T.1
Walker, J.2
Norris, F.A.3
-
96
-
-
23944437499
-
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
-
Shin H.W., Hayashi M., Christoforidis S., Lacas-Gervais S., Hoepfner S., Wenk M.R., et al. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol 2005, 170:607-618.
-
(2005)
J Cell Biol
, vol.170
, pp. 607-618
-
-
Shin, H.W.1
Hayashi, M.2
Christoforidis, S.3
Lacas-Gervais, S.4
Hoepfner, S.5
Wenk, M.R.6
-
97
-
-
0033981633
-
Rab GTPases coordinate endocytosis
-
Somsel Rodman J., Wandinger-Ness A. Rab GTPases coordinate endocytosis. J Cell Sci 2000, 113(Pt 2):183-192.
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 2
, pp. 183-192
-
-
Somsel Rodman, J.1
Wandinger-Ness, A.2
-
98
-
-
78650235523
-
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer
-
Sosa M.S., Lopez-Haber C., Yang C., Wang H., Lemmon M.A., Busillo J.M., et al. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 2010, 40:877-892.
-
(2010)
Mol Cell
, vol.40
, pp. 877-892
-
-
Sosa, M.S.1
Lopez-Haber, C.2
Yang, C.3
Wang, H.4
Lemmon, M.A.5
Busillo, J.M.6
-
99
-
-
0038218405
-
Sphingosine-1-phosphate: an enigmatic signalling lipid
-
Spiegel S., Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003, 4:397-407.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, S.2
-
100
-
-
0029933270
-
Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro
-
Spiro D.J., Boll W., Kirchhausen T., Wessling-Resnick M. Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol Biol Cell 1996, 7:355-367.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 355-367
-
-
Spiro, D.J.1
Boll, W.2
Kirchhausen, T.3
Wessling-Resnick, M.4
-
101
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V., Suzuki A., de la Pompa J.L., Brothers G.M., Mirtsos C., Sasaki T., et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998, 95:29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
de la Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
-
102
-
-
0033853351
-
Chromosomal alterations in human pancreatic endocrine tumors
-
Stumpf E., Aalto Y., Hoog A., Kjellman M., Otonkoski T., Knuutila S., et al. Chromosomal alterations in human pancreatic endocrine tumors. Genes Chromosomes Cancer 2000, 29:83-87.
-
(2000)
Genes Chromosomes Cancer
, vol.29
, pp. 83-87
-
-
Stumpf, E.1
Aalto, Y.2
Hoog, A.3
Kjellman, M.4
Otonkoski, T.5
Knuutila, S.6
-
103
-
-
77954255681
-
Integrative genomic profiling of human prostate cancer
-
Taylor B.S., Schultz N., Hieronymus H., Gopalan A., Xiao Y., Carver B.S., et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010, 18:11-22.
-
(2010)
Cancer Cell
, vol.18
, pp. 11-22
-
-
Taylor, B.S.1
Schultz, N.2
Hieronymus, H.3
Gopalan, A.4
Xiao, Y.5
Carver, B.S.6
-
104
-
-
0036800454
-
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella
-
Terebiznik M.R., Vieira O.V., Marcus S.L., Slade A., Yip C.M., Trimble W.S., et al. Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol 2002, 4:766-773.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 766-773
-
-
Terebiznik, M.R.1
Vieira, O.V.2
Marcus, S.L.3
Slade, A.4
Yip, C.M.5
Trimble, W.S.6
-
105
-
-
77749279906
-
Expression map of the human exome in CD34+ cells and blood cells: increased alternative splicing in cell motility and immune response genes
-
Tondeur S., Pangault C., Le Carrour T., Lannay Y., Benmahdi R., Cubizolle A., et al. Expression map of the human exome in CD34+ cells and blood cells: increased alternative splicing in cell motility and immune response genes. PLoS One 2010, 5:e8990.
-
(2010)
PLoS One
, vol.5
-
-
Tondeur, S.1
Pangault, C.2
Le Carrour, T.3
Lannay, Y.4
Benmahdi, R.5
Cubizolle, A.6
-
106
-
-
30044446496
-
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases
-
Ungewickell A., Hugge C., Kisseleva M., Chang S.C., Zou J., Feng Y., et al. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A 2005, 102:18854-18859.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18854-18859
-
-
Ungewickell, A.1
Hugge, C.2
Kisseleva, M.3
Chang, S.C.4
Zou, J.5
Feng, Y.6
-
107
-
-
45449098229
-
Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA
-
Urano D., Nakata A., Mizuno N., Tago K., Itoh H. Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA. Cell Signal 2008, 20:1545-1554.
-
(2008)
Cell Signal
, vol.20
, pp. 1545-1554
-
-
Urano, D.1
Nakata, A.2
Mizuno, N.3
Tago, K.4
Itoh, H.5
-
108
-
-
0037503653
-
PDZ domains-glue and guide
-
van Ham M., Hendriks W. PDZ domains-glue and guide. Mol Biol Rep 2003, 30:69-82.
-
(2003)
Mol Biol Rep
, vol.30
, pp. 69-82
-
-
van Ham, M.1
Hendriks, W.2
-
109
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
Vanhaesebroeck B., Guillermet-Guibert J., Graupera M., Bilanges B. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol 2010, 11:329-341.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 329-341
-
-
Vanhaesebroeck, B.1
Guillermet-Guibert, J.2
Graupera, M.3
Bilanges, B.4
-
110
-
-
0034610340
-
Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1
-
Vyas P., Norris F.A., Joseph R., Majerus P.W., Orkin S.H. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A 2000, 97:13696-13701.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 13696-13701
-
-
Vyas, P.1
Norris, F.A.2
Joseph, R.3
Majerus, P.W.4
Orkin, S.H.5
-
111
-
-
55549090682
-
Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis
-
Wang Z., Dong X., Li Z., Smith J.D., Wu D. Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis. Prostaglandins Other Lipid Mediat 2008, 87:9-13.
-
(2008)
Prostaglandins Other Lipid Mediat
, vol.87
, pp. 9-13
-
-
Wang, Z.1
Dong, X.2
Li, Z.3
Smith, J.D.4
Wu, D.5
-
112
-
-
53349151719
-
P-Rex1-a multidomain protein that regulates neurite differentiation
-
Waters J.E., Astle M.V., Ooms L.M., Balamatsias D., Gurung R., Mitchell C.A. P-Rex1-a multidomain protein that regulates neurite differentiation. J Cell Sci 2008, 121:2892-2903.
-
(2008)
J Cell Sci
, vol.121
, pp. 2892-2903
-
-
Waters, J.E.1
Astle, M.V.2
Ooms, L.M.3
Balamatsias, D.4
Gurung, R.5
Mitchell, C.A.6
-
113
-
-
0037155727
-
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
-
Welch H.C., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., et al. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 2002, 108:809-821.
-
(2002)
Cell
, vol.108
, pp. 809-821
-
-
Welch, H.C.1
Coadwell, W.J.2
Ellson, C.D.3
Ferguson, G.J.4
Andrews, S.R.5
Erdjument-Bromage, H.6
-
114
-
-
27144440346
-
P-Rex1 regulates neutrophil function
-
Welch H.C., Condliffe A.M., Milne L.J., Ferguson G.J., Hill K., Webb L.M., et al. P-Rex1 regulates neutrophil function. Curr Biol 2005, 15:1867-1873.
-
(2005)
Curr Biol
, vol.15
, pp. 1867-1873
-
-
Welch, H.C.1
Condliffe, A.M.2
Milne, L.J.3
Ferguson, G.J.4
Hill, K.5
Webb, L.M.6
-
115
-
-
20444376939
-
A genetic screen for candidate tumor suppressors identifies REST
-
Westbrook T.F., Martin E.S., Schlabach M.R., Leng Y., Liang A.C., Feng B., et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 2005, 121:837-848.
-
(2005)
Cell
, vol.121
, pp. 837-848
-
-
Westbrook, T.F.1
Martin, E.S.2
Schlabach, M.R.3
Leng, Y.4
Liang, A.C.5
Feng, B.6
-
116
-
-
79960384694
-
Epigenetic regulation of phosphatidylinositol 3,4,5-Triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells
-
Wong C.Y., Wuriyanghan H., Xie Y., Lin M.F., Abel P.W., Tu Y. Epigenetic regulation of phosphatidylinositol 3,4,5-Triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. J Biol Chem 2011, 286:25813-25822.
-
(2011)
J Biol Chem
, vol.286
, pp. 25813-25822
-
-
Wong, C.Y.1
Wuriyanghan, H.2
Xie, Y.3
Lin, M.F.4
Abel, P.W.5
Tu, Y.6
-
117
-
-
0032431032
-
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
-
Wu X., Senechal K., Neshat M.S., Whang Y.E., Sawyers C.L. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1998, 95:15587-15591.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15587-15591
-
-
Wu, X.1
Senechal, K.2
Neshat, M.S.3
Whang, Y.E.4
Sawyers, C.L.5
-
118
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
119
-
-
18244406265
-
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
-
Yoshizawa M., Kawauchi T., Sone M., Nishimura Y.V., Terao M., Chihama K., et al. Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration. J Neurosci 2005, 25:4406-4419.
-
(2005)
J Neurosci
, vol.25
, pp. 4406-4419
-
-
Yoshizawa, M.1
Kawauchi, T.2
Sone, M.3
Nishimura, Y.V.4
Terao, M.5
Chihama, K.6
-
120
-
-
36749043176
-
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
-
Zou J., Marjanovic J., Kisseleva M.V., Wilson M., Majerus P.W. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci U S A 2007, 104:16834-16839.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16834-16839
-
-
Zou, J.1
Marjanovic, J.2
Kisseleva, M.V.3
Wilson, M.4
Majerus, P.W.5
|