Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

Oncogene

Volumn 30, Issue 26, 2011, Pages 2954-2963

  Kim, E K ^a   Yun, S J ^a   Ha, J M ^a   Kim, Y W ^a   Jin, I H ^a   Yun, J ^b   Shin, H K ^c   Song, S H ^a   Kim, J H ^a   Lee, J S ^a   Kim, C D ^a   Bae, S S ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Dong A University   (South Korea)

^c Pusan National University   (South Korea)

Author keywords

Akt; invasion; metastasis; mTOR; P Rex1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE DEPENDENT RAC EXCHANGER 1; PROTEIN AKT1; PROTEIN KINASE B; PROTEIN KINASE B BETA; RAPAMYCIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INVASION; CELL MIGRATION; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CELL MOVEMENT; CELLS, CULTURED; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS;

MAMMALIA; RAPTORES;

EID: 79959847002     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.22     Document Type: Article

References (31)

1. Alessi DR, Cohen P. (1998). Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8: 55-62. (Pubitemid 28122141)
2. Bae SS, Cho H, Mu J, Birnbaum MJ. (2003). Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem 278: 49530-49536.
3. Barber MA, Welch HC. (2006). PI3K and RAC signalling in leukocyte and cancer cell migration. Bull Cancer 93: E44-E52.
4. Brazil DP, Yang ZZ, Hemmings BA. (2004). Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29: 233-242. (Pubitemid 38591317)
5. Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A et al. (2008). Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 118: 3065-3074.
6. Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw III EB et al. (2001a). Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBb). Science 292: 1728-1731. (Pubitemid 32506248)
7. Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. (2001b). Akt1/PKBa is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276: 38349-38352.
8. Chung CY, Lee S, Briscoe C, Ellsworth C, Firtel RA. (2000). Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc Natl Acad Sci USA 97: 5225-5230. (Pubitemid 30313700)
9. Datta SR, Brunet A, Greenberg ME. (1999). Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
10. Dunn SE, Ehrlich M, Sharp NJ, Reiss K, Solomon G, Hawkins R et al. (1998). A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res 58: 3353-3361. (Pubitemid 28371076)
11. Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K et al. (2005). Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 9: 389-402. (Pubitemid 41235808)
12. Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W et al. (2003). The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63: 2172-2178. (Pubitemid 36538623)
13. Hernandez-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernandez-Garcia R, Calderon-Salinas JV, Reyes-Cruz G et al. (2007). P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem 282: 23708-23715. (Pubitemid 47311970)
14. Higuchi M, Masuyama N, Fukui Y, Suzuki A, Gotoh Y. (2001). Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr Biol 11: 1958-1962. (Pubitemid 33146422)
15. Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A et al. (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-1128. (Pubitemid 39468014)
16. Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S et al. (2007). Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci USA 104: 7438-7443. (Pubitemid 47185924)
17. Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS et al. (2001). Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. Faseb J 15: 1953-1962. (Pubitemid 32848799)
18. Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H et al. (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163-175. (Pubitemid 34876545)
19. Kim EK, Tucker DF, Yun SJ, Do KH, Kim MS, Kim JH et al. (2008a). Linker region of Akt1/protein kinase Ba mediates platelet-derived growth factor-induced translocation and cell migration. Cell Signal 20: 2030-2037.
20. Kim EK, Yun SJ, Do KH, Kim MS, Cho M, Suh DS et al. (2008b). Lysophosphatidic acid induces cell migration through the selective activation of Akt1. Exp Mol Med 40: 445-452.
21. LeRoith D, Werner H, Beitner-Johnson D, Roberts Jr CT. (1995). Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16: 143-163.
22. O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D et al. (2006). mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66: 1500-1508. (Pubitemid 43259931)
23. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H et al. (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor- independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302. (Pubitemid 38991819)
24. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101. (Pubitemid 40262113)
25. Sheng S, Qiao M, Pardee AB. (2009). Metastasis and AKT activation. J Cell Physiol 218: 451-454.
26. van Golen CM, Schwab TS, Kim B, Soules ME, Su Oh S, Fung K et al. (2006). Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone. Cancer Res 66: 6570-6578. (Pubitemid 44085612)
27. Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D. (2002). Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62: 1030-1035. (Pubitemid 34160283)
28. Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM et al. (2009). Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. FEBS Lett 583: 685-690.
29. Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL et al. (2007). PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest 117: 730-738. (Pubitemid 46348531)
30. Zhang J, Gao Z, Yin J, Quon MJ, Ye J. (2008). S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(a) signaling through IKK2. J Biol Chem 283: 35375-35382.
31. Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J. (2006). Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem 281: 36443-36453. (Pubitemid 46041378)