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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
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The first determination of the receptor mechanism of action of FTY720-P and formal evidence for inhibition of lymphocyte egress from lymph node into lymph by the non-hydrolyzable FTY-phosphonate.
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Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C.et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 296:2002;346-349 The first determination of the receptor mechanism of action of FTY720-P and formal evidence for inhibition of lymphocyte egress from lymph node into lymph by the non-hydrolyzable FTY-phosphonate.
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Confirmation of the S1P receptor basis of FTY720 action.
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FTY720: Targeting G-protein-coupled receptors for S1P in transplantation and autoimmunity
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Brinkmann V., Lynch K. FTY720: targeting G-protein-coupled receptors for S1P in transplantation and autoimmunity. Curr Opin Immunol. 14:2002;569-575.
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Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells
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Demonstration of the importance of preformed stores of S1P in platelets.
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Yatomi Y., Ohmori T., Rile G., Kazama F., Okamoto H., Sano T., Satoh K., Kume S., Tigyi G., Igarashi Y., Ozaki Y. Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells. Blood. 96:2000;3431-3438 Demonstration of the importance of preformed stores of S1P in platelets.
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Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors
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Takuwa Y. Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. Biochimica Biophysica Acta. 1582:2002;112-120.
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Takuwa, Y.1
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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
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A role for S1P receptors in the maintenance of endothelial barriers that might be of therapeutic import.
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Garcia J.G.N., Liu F., Verin A.D., Birukova A., Dechert M.A., Gerthoffer W.T., Bamberg J.R., English D. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest. 108:2001;689-701 A role for S1P receptors in the maintenance of endothelial barriers that might be of therapeutic import.
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Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
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The importance of multiple coupling pathways for transduction by the S1P system.
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Sugimoto N., Takuwa N., Okamoto H., Sakurada S., Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol. 23:2003;1534-1545 The importance of multiple coupling pathways for transduction by the S1P system.
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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
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Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., Milstien S., Spiegel S. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science. 291:2001;1800-1803.
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Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions
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Bound versus free ligand is a truism that is sometimes neglected.
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Murata N., Sato K., Kon J., Tomura H., Yanagita M., Kuwabara A., Ui M., Okajima F. Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem J. 352:2000;809-815 Bound versus free ligand is a truism that is sometimes neglected.
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0034608826
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Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
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Mandala S.M., Thornton R., Galve-Roperh I., Poulton S., Peterson C., Olivera A., Bergstrom J., Kurtz M.B., Spiegel S. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Proc Natl Acad Sci USA. 97:2000;7859-7864.
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0035310611
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Sphingosylyphosphocholine is a naturally occurring lipid mediator in blood plasma: A possible role in regulating cardiac function via sphingolipid receptors
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Effects on cardiac function always matter.
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Liliom K., Sun G., Bunemann M., Virag T., Nusser N., Baker D.L., Wang D.A., Fabian M.J., Brandts B., Bender K.et al. Sphingosylyphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. Biochem J. 355:2001;189-197 Effects on cardiac function always matter.
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21
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0036239322
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Cell type-specific localization of human cardiac S1P receptors
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Effects on cardiac function always matter.
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Mazurais D., Robert P., Gout B., Berrebi-Bertrand I., Laville M.P., Calmels T. Cell type-specific localization of human cardiac S1P receptors. J Histochem Cytochem. 50:2002;661-669 Effects on cardiac function always matter.
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Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors
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Mayer zu Heringdorf D., Lass H., Kuchar I., Lipinski M., Alemany R., Rumenapp U., Jakobs K.H. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. Eur J Pharmacol. 414:2001;145-154.
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Sphingosine 1-phosphate and control of vascular tone
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This paper defines the role of S1P in regulation of vascular tone.
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Dantas A.P.V., Igarashi J., Michel T. Sphingosine 1-phosphate and control of vascular tone. Am J Physiol Heart Circ Physiol. 284:2003;H2045-H2052 This paper defines the role of S1P in regulation of vascular tone.
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Dantas, A.P.V.1
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Rosen H, Sanna M, Alfonso C: Egress: a receptor-regulated step in lymphocyte trafficking. Immunol Rev 2003, in press.
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FTY720: Targetting G-protein coupled receptors for spingosine 1-phosphate in transplantation and autoimmunity
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Brinkmann V., Lynch K. FTY720: targetting G-protein coupled receptors for spingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol. 14:2002;569-575.
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0034671505
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Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate
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A useful binding model for S1P.
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Parrill A.L., Wang D., Bautista D.L., Van Brocklyn J.R., Lorincz Z., Fischer D.J., Baker D.L., Liliom K., Spiegel S., Tigyi G. Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. J Biol Chem. 275:2000;39379-39384 A useful binding model for S1P.
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Parrill, A.L.1
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Molecular basis for the lysophosphatidic acid receptor agonist selectivity
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A useful binding model for lysophosphatidic acid.
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Uhlenbrock K., Gassenhuber H., Kostenis E.U. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell Signal. 14:2002;941-953.
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The lysophosphatidylcholine receptor G2A plays a role in the long term suppression of autoimmunity, and presumably the maintenance of tolerance.
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The lysophosphatidylcholine receptor G2A plays a role in the long term suppression of autoimmunity, and presumably the maintenance of tolerance.
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Le L.Q., Kabarowski J.H., Weng Z., Satterthwaite A.B., Harvill E.T., Jensen E.R., Miller J.F., Witte O.N. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 14: 2001;561-571 The lysophosphatidylcholine receptor G2A plays a role in the long term suppression of autoimmunity, and presumably the maintenance of tolerance.
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Le, L.Q.1
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Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart
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Coronary artery vasospasm can be mediated by S1P - a potential adverse effect or therapeutic opportunity for antagonists?
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Sugiyama A., Yatomi Y., Ozaki Y., Hashimoto K. Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. Cardiovasc Res. 46:2000;119-125 Coronary artery vasospasm can be mediated by S1P - a potential adverse effect or therapeutic opportunity for antagonists?
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A classic paper elucidating the role of Edg-1 in vascular maturation.
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Liu Y., Wada R., Yamashita T., Mi Y., Deng C.X., Hobson J.P., Rosenfeldt H.M., Nava V.E., Chae S.S., Lee M.J.et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 106:2000;951-961 A classic paper elucidating the role of Edg-1 in vascular maturation.
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Liu, Y.1
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Yagi H., Kamba R., Chiba K., Soga H., Yaguchi K., Nakamura M., Itoh T. Immunosuppressant FTY720 inhibits thymocyte emigration. Eur J Immunol. 30:2000;1435-1444.
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