Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor

Biochemical and Biophysical Research Communications

Volumn 391, Issue 4, 2010, Pages 1647-1652

  Ledezma Sánchez, Benjamín Alejandro ^a   García Regalado, Alejandro ^a   Guzmán Hernández, María Luisa ^a   Vázquez Prado, José ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Cell migration; P Rex1; PDZ domain; S1P1; Sphingosine 1 phosphate

Indexed keywords

DIMER; MONOMER; P REX 1 PROTEIN; REX PROTEIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CELL LINE; CELL MEMBRANE; CELL MOVEMENT; ENDOTHELIAL CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; PDZ DOMAINS; PROTEIN MULTIMERIZATION; RECEPTORS, LYSOSPHINGOLIPID;

EID: 74749085362     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.108     Document Type: Article

References (29)

1. Kono M., Allende M.L., and Proia R.L. Sphingosine-1-phosphate regulation of mammalian development. Biochim. Biophys. Acta 1781 (2008) 435-441
2. Spiegel S., and Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell. Biol. 4 (2003) 397-407
3. Rosen H., and Goetzl E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 5 (2005) 560-570
4. Donati C., and Bruni P. Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. Biochim. Biophys. Acta 1758 (2006) 2037-2048
5. Rosen H., Gonzalez-Cabrera P.J., Sanna M.G., and Brown S. Sphingosine 1-phosphate receptor signaling. Annu. Rev. Biochem. 78 (2009) 743-768
6. Lee M.J., Thangada S., Paik J.H., Sapkota G.P., Ancellin N., Chae S.S., Wu M., Morales-Ruiz M., Sessa W.C., Alessi D.R., and Hla T. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol. Cell 8 (2001) 693-704
7. Morales-Ruiz M., Lee M.J., Zollner S., Gratton J.P., Scotland R., Shiojima I., Walsh K., Hla T., and Sessa W.C. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J. Biol. Chem. 276 (2001) 19672-19677
8. Lee M.J., Thangada S., Claffey K.P., Ancellin N., Liu C.H., Kluk M., Volpi M., Sha'afi R.I., and Hla T. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99 (1999) 301-312
9. Igarashi J., Erwin P.A., Dantas A.P., Chen H., and Michel T. VEGF induces S1P1 receptors in endothelial cells: implications for cross-talk between sphingolipid and growth factor receptors. Proc. Natl. Acad. Sci. USA 100 (2003) 10664-10669
10. LaMontagne K., Littlewood-Evans A., Schnell C., O'Reilly T., Wyder L., Sanchez T., Probst B., Butler J., Wood A., Liau G., Billy E., Theuer A., Hla T., and Wood J. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 66 (2006) 221-231
11. Rosen H., Gonzalez-Cabrera P., Marsolais D., Cahalan S., Don A.S., and Sanna M.G. Modulating tone: the overture of S1P receptor immunotherapeutics. Immunol. Rev. 223 (2008) 221-235
12. Watterson K.R., Johnston E., Chalmers C., Pronin A., Cook S.J., Benovic J.L., and Palmer T.M. Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. J. Biol. Chem. 277 (2002) 5767-5777
13. Liu C.H., Thangada S., Lee M.J., Van Brocklyn J.R., Spiegel S., and Hla T. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol. Biol. Cell 10 (1999) 1179-1190
14. Bockaert J., Dumuis A., Fagni L., and Marin P. GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?. Curr. Opin. Drug Discov. Dev. 7 (2004) 649-657
15. Becamel C., Alonso G., Galeotti N., Demey E., Jouin P., Ullmer C., Dumuis A., Bockaert J., and Marin P. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. EMBO J. 21 (2002) 2332-2342
16. Welch H.C., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., and Stephens L.R. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108 (2002) 809-821
17. Welch H.C., Condliffe A.M., Milne L.J., Ferguson G.J., Hill K., Webb L.M., Okkenhaug K., Coadwell W.J., Andrews S.R., Thelen M., Jones G.E., Hawkins P.T., and Stephens L.R. P-Rex1 regulates neutrophil function. Curr. Biol. 15 (2005) 1867-1873
18. Dong X., Mo Z., Bokoch G., Guo C., Li Z., and Wu D. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr. Biol. 15 (2005) 1874-1879
19. Yoshizawa M., Kawauchi T., Sone M., Nishimura Y.V., Terao M., Chihama K., Nabeshima Y., and Hoshino M. Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration. J. Neurosci. 25 (2005) 4406-4419
20. Rosenfeldt H., Vazquez-Prado J., and Gutkind J.S. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett. 572 (2004) 167-171
21. Donald S., Hill K., Lecureuil C., Barnouin R., Krugmann S., John Coadwell W., Andrews S.R., Walker S.A., Hawkins P.T., Stephens L.R., and Welch H.C. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 572 (2004) 172-176
22. Li Z., Paik J.H., Wang Z., Hla T., and Wu D. Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat. 76 (2005) 95-104
23. Hill K., Krugmann S., Andrews S.R., Coadwell W.J., Finan P., Welch H.C., Hawkins P.T., and Stephens L.R. Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. J. Biol. Chem. 280 (2005) 4166-4173
24. Hernandez-Negrete I., Carretero-Ortega J., Rosenfeldt H., Hernandez-Garcia R., Calderon-Salinas J.V., Reyes-Cruz G., Gutkind J.S., and Vazquez-Prado J. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J. Biol. Chem. 282 (2007) 23708-23715
25. Van Brocklyn J.R., Behbahani B., and Lee N.H. Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors. Biochim. Biophys. Acta 1582 (2002) 89-93
26. Vazquez-Prado J., Basile J., and Gutkind J.S. Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. Methods Enzymol. 390 (2004) 259-285
27. Oo M.L., Thangada S., Wu M.T., Liu C.H., Macdonald T.L., Lynch K.R., Lin C.Y., and Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J. Biol. Chem. 282 (2007) 9082-9089
28. Perrot V., Vazquez-Prado J., and Gutkind J.S. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J. Biol. Chem. 277 (2002) 43115-43120
29. Taya S., Inagaki N., Sengiku H., Makino H., Iwamatsu A., Urakawa I., Nagao K., Kataoka S., and Kaibuchi K. Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J. Cell Biol. 155 (2001) 809-820