메뉴 건너뛰기




Volumn 105, Issue 11, 2008, Pages 4483-4488

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination

Author keywords

Ataxia; G protein coupled receptor; Guanine nucleotide exchange factor; Phosphoinositide 3 kinase; Small GTpase Rac

Indexed keywords

BRAIN PROTEIN; PROTEIN P REX1; PROTEIN P REX2; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; P REX2 PROTEIN, MOUSE; P-REX2 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

EID: 41949120605     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712324105     Document Type: Article
Times cited : (56)

References (40)
  • 1
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420:629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 2
    • 11844304062 scopus 로고    scopus 로고
    • The role of the Rho GTPases in neuronal development
    • Govek EE, Newey SE, Van Aelst L (2005) The role of the Rho GTPases in neuronal development. Genes Dev 19:1-49.
    • (2005) Genes Dev , vol.19 , pp. 1-49
    • Govek, E.E.1    Newey, S.E.2    Van Aelst, L.3
  • 3
    • 0032585635 scopus 로고    scopus 로고
    • Rac1 is required for the formation of three germ layers during gastrulation
    • Sugihara K, et al. (1998) Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17:3427-3433.
    • (1998) Oncogene , vol.17 , pp. 3427-3433
    • Sugihara, K.1
  • 4
    • 34147152711 scopus 로고    scopus 로고
    • Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons
    • Chen L, et al. (2007) Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J Neurosci 27:3884-3893.
    • (2007) J Neurosci , vol.27 , pp. 3884-3893
    • Chen, L.1
  • 5
    • 0030026182 scopus 로고    scopus 로고
    • Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
    • Luo L, et al. (1996) Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379:837-840.
    • (1996) Nature , vol.379 , pp. 837-840
    • Luo, L.1
  • 6
    • 20744460575 scopus 로고    scopus 로고
    • Generation and characterization of Rac3 knockout mice
    • Corbetta S, et al. (2005) Generation and characterization of Rac3 knockout mice. Mol Cell Biol 25:5763-5776.
    • (2005) Mol Cell Biol , vol.25 , pp. 5763-5776
    • Corbetta, S.1
  • 7
    • 34547936339 scopus 로고    scopus 로고
    • Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling
    • Iwasato T, et al. (2007) Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell 130:742-753.
    • (2007) Cell , vol.130 , pp. 742-753
    • Iwasato, T.1
  • 8
    • 0037452615 scopus 로고    scopus 로고
    • Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
    • Soderling SH, et al. (2003) Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci USA 100:1723-1728.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1723-1728
    • Soderling, S.H.1
  • 9
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman KL, Der CJ, Sondek J (2005) GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6:167-180.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 167-180
    • Rossman, K.L.1    CJ, D.2    Sondek, J.3
  • 10
    • 34249856693 scopus 로고    scopus 로고
    • The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development
    • Tolias KF, et al. (2007) The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci USA 104:7265-7270.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7265-7270
    • Tolias, K.F.1
  • 11
    • 20244369288 scopus 로고    scopus 로고
    • Vav family GEFs link activated Ephs to endocytosis and axon guidance
    • Cowan CW, et al. (2005) Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron 46:205-217.
    • (2005) Neuron , vol.46 , pp. 205-217
    • Cowan, C.W.1
  • 12
    • 0042674398 scopus 로고    scopus 로고
    • RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
    • Katoh H, Negishi M (2003) RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 424:461-464.
    • (2003) Nature , vol.424 , pp. 461-464
    • Katoh, H.1    Negishi, M.2
  • 13
    • 33748577718 scopus 로고    scopus 로고
    • The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18
    • Watabe-Uchida M, John KA, Janas JA, Newey SE, Van Aelst L (2006) The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron 51:727-739.
    • (2006) Neuron , vol.51 , pp. 727-739
    • Watabe-Uchida, M.1    John, K.A.2    Janas, J.A.3    Newey, S.E.4    Van Aelst, L.5
  • 14
    • 8544267258 scopus 로고    scopus 로고
    • GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation
    • Bryan B, et al. (2004) GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J Biol Chem 279:45824-45832.
    • (2004) J Biol Chem , vol.279 , pp. 45824-45832
    • Bryan, B.1
  • 15
    • 0037437147 scopus 로고    scopus 로고
    • Synapse formation is regulated by the signaling adaptor GIT1
    • Zhang H, Webb DJ, Asmussen H, Horwitz AF (2003) Synapse formation is regulated by the signaling adaptor GIT1. J Cell Biol 161:131-142.
    • (2003) J Cell Biol , vol.161 , pp. 131-142
    • Zhang, H.1    Webb, D.J.2    Asmussen, H.3    Horwitz, A.F.4
  • 16
    • 33745714459 scopus 로고    scopus 로고
    • Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
    • Jacquier A, et al. (2006) Alsin/Rac1 signaling controls survival and growth of spinal motoneurons. Ann Neurol 60:105-117.
    • (2006) Ann Neurol , vol.60 , pp. 105-117
    • Jacquier, A.1
  • 17
    • 14244264186 scopus 로고    scopus 로고
    • A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death
    • Kanekura K, et al. (2005) A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J Biol Chem 280:4532-4543.
    • (2005) J Biol Chem , vol.280 , pp. 4532-4543
    • Kanekura, K.1
  • 18
    • 0037155727 scopus 로고    scopus 로고
    • P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
    • Welch HC, et al. (2002) P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108:809-821.
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.1
  • 19
    • 4143145447 scopus 로고    scopus 로고
    • P-Rex2, a new guanine-nucleotide exchange factor for Rac
    • Donald S, et al. (2004) P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett 572:172-176.
    • (2004) FEBS Lett , vol.572 , pp. 172-176
    • Donald, S.1
  • 20
    • 4143060469 scopus 로고    scopus 로고
    • P-REX2, a novel PI-3-kinase sensitive Rac exchange factor
    • Rosenfeldt H, Vazquez-Prado J, Gutkind JS (2004) P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett 572:167-171.
    • (2004) FEBS Lett , vol.572 , pp. 167-171
    • Rosenfeldt, H.1    Vazquez-Prado, J.2    Gutkind, J.S.3
  • 21
    • 27144551936 scopus 로고    scopus 로고
    • P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils
    • Dong X, et al. (2005) P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol 15:1874-1879.
    • (2005) Curr Biol , vol.15 , pp. 1874-1879
    • Dong, X.1
  • 22
    • 27144440346 scopus 로고    scopus 로고
    • P-Rex1 regulates neutrophil function
    • Welch HC, et al. (2005) P-Rex1 regulates neutrophil function. Curr Biol 15:1867-1873.
    • (2005) Curr Biol , vol.15 , pp. 1867-1873
    • Welch, H.C.1
  • 23
    • 18244406265 scopus 로고    scopus 로고
    • Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
    • Yoshizawa M, et al. (2005) Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration. J Neurosci 25:4406-4419.
    • (2005) J Neurosci , vol.25 , pp. 4406-4419
    • Yoshizawa, M.1
  • 24
    • 19344368931 scopus 로고    scopus 로고
    • Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells
    • Li Z, Paik JH, Wang Z, Hla T, Wu D (2005) Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat 76:95-104.
    • (2005) Prostaglandins Other Lipid Mediat , vol.76 , pp. 95-104
    • Li, Z.1    Paik, J.H.2    Wang, Z.3    Hla, T.4    Wu, D.5
  • 25
    • 0034909402 scopus 로고    scopus 로고
    • Purification of Purkinje cells by fluorescence-activated cell sorting from transgenic mice that express green fluorescent protein
    • Tomomura M, Rice DS, Morgan JI, Yuzaki M (2001) Purification of Purkinje cells by fluorescence-activated cell sorting from transgenic mice that express green fluorescent protein. Eur J Neurosci 14:57-63.
    • (2001) Eur J Neurosci , vol.14 , pp. 57-63
    • Tomomura, M.1    Rice, D.S.2    Morgan, J.I.3    Yuzaki, M.4
  • 26
    • 0032547067 scopus 로고    scopus 로고
    • Cerebellum and learning: A complex problem
    • Hesslow G, Yeo C (1998) Cerebellum and learning: a complex problem. Science 280:1817-1819.
    • (1998) Science , vol.280 , pp. 1817-1819
    • Hesslow, G.1    Yeo, C.2
  • 27
    • 0032123560 scopus 로고    scopus 로고
    • A role for the cerebellum in learning movement coordination
    • Thach WT (1998) A role for the cerebellum in learning movement coordination. Neurobiol Learn Mem 70:177-188.
    • (1998) Neurobiol Learn Mem , vol.70 , pp. 177-188
    • Thach, W.T.1
  • 28
    • 3543031667 scopus 로고    scopus 로고
    • Pathways to motor incoordination: The inherited ataxias
    • Taroni F, DiDonato S (2004) Pathways to motor incoordination: the inherited ataxias. Nat Rev Neurosci 5:641-655.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 641-655
    • Taroni, F.1    DiDonato, S.2
  • 29
    • 0033560924 scopus 로고    scopus 로고
    • Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
    • Carter RJ, et al. (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci 19:3248-3257.
    • (1999) J Neurosci , vol.19 , pp. 3248-3257
    • Carter, R.J.1
  • 30
    • 33750911761 scopus 로고    scopus 로고
    • Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease
    • Colebrooke RE, et al. (2006) Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. Eur J Neurosci 24:2622-2630.
    • (2006) Eur J Neurosci , vol.24 , pp. 2622-2630
    • Colebrooke, R.E.1
  • 31
    • 26644440895 scopus 로고    scopus 로고
    • Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice
    • Brunskill EW, et al. (2005) Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur J Neurosci 22:1265-1276.
    • (2005) Eur J Neurosci , vol.22 , pp. 1265-1276
    • Brunskill, E.W.1
  • 32
    • 0034927844 scopus 로고    scopus 로고
    • Neural circuit regulation of prepulse inhibition of startle in the rat: Current knowledge and future challenges
    • Swerdlow NR, Geyer MA, Braff DL (2001) Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) 156:194-215.
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 194-215
    • Swerdlow, N.R.1    Geyer, M.A.2    Braff, D.L.3
  • 33
    • 23344441592 scopus 로고    scopus 로고
    • Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination
    • Beglopoulos V, et al. (2005) Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol 25:7278-7288.
    • (2005) Mol Cell Biol , vol.25 , pp. 7278-7288
    • Beglopoulos, V.1
  • 34
    • 0034906626 scopus 로고    scopus 로고
    • Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex
    • Takeuchi T, et al. (2001) Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur J Neurosci 14:153-160.
    • (2001) Eur J Neurosci , vol.14 , pp. 153-160
    • Takeuchi, T.1
  • 35
    • 16244411099 scopus 로고    scopus 로고
    • Imprinted Nesp55 influences behavioral reactivity to novel environments
    • Plagge A, et al. (2005) Imprinted Nesp55 influences behavioral reactivity to novel environments. Mol Cell Biol 25:3019-3026.
    • (2005) Mol Cell Biol , vol.25 , pp. 3019-3026
    • Plagge, A.1
  • 36
    • 12344251554 scopus 로고    scopus 로고
    • Sexual dimorphism in cerebellar structure, function, and response to environmental perturbations
    • Nguon K, Ladd B, Baxter MG, Sajdel-Sulkowska EM (2005) Sexual dimorphism in cerebellar structure, function, and response to environmental perturbations. Prog Brain Res 148:341-351.
    • (2005) Prog Brain Res , vol.148 , pp. 341-351
    • Nguon, K.1    Ladd, B.2    Baxter, M.G.3    Sajdel-Sulkowska, E.M.4
  • 37
    • 33845386437 scopus 로고    scopus 로고
    • It is not all hormones: Alternative explanations for sexual differentiation of the brain
    • Davies W, Wilkinson LS (2006) It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Res 1126:36-45.
    • (2006) Brain Res , vol.1126 , pp. 36-45
    • Davies, W.1    Wilkinson, L.S.2
  • 38
    • 0035155962 scopus 로고    scopus 로고
    • Mutant mice as a model for cerebellar ataxia
    • Grusser-Cornehls U, Baurle J (2001) Mutant mice as a model for cerebellar ataxia. Prog Neurobiol 63:489-540.
    • (2001) Prog Neurobiol , vol.63 , pp. 489-540
    • Grusser-Cornehls, U.1    Baurle, J.2
  • 39
    • 33646687963 scopus 로고    scopus 로고
    • A protein-protein interaction network for human in herited ataxias and disorders of Purkinje cell degeneration
    • Lim HT, et al. (2006) A protein-protein interaction network for human in herited ataxias and disorders of Purkinje cell degeneration. Cell 125:801-814.
    • (2006) Cell , vol.125 , pp. 801-814
    • Lim, H.T.1
  • 40
    • 0034788432 scopus 로고    scopus 로고
    • Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)
    • Giese KP, et al. (2001) Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1) Neuropharmacology 41:791-800.
    • (2001) Neuropharmacology , vol.41 , pp. 791-800
    • Giese, K.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.