Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death

Free Radical Biology and Medicine

Volumn 36, Issue 1, 2004, Pages 53-64

  De Haan, Judy B ^a,d   Bladier, Cecile ^a   Lotfi Miri, Mehrnoush ^a   Taylor, Juliet ^a   Hutchinson, Paul ^b   Crack, Peter J ^a   Hertzog, Paul ^a   Kola, Ismail ^c  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c MERCK RESEARCH LABORATORIES   (United States)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Antioxidant; Apoptosis; Free radicals; Glutathione peroxidase 1; Necrosis; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; DNA; EPIDERMAL GROWTH FACTOR; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; FIBROBLAST; KNOCKOUT MOUSE; MALE; MORPHOLOGY; MOUSE; MUTANT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SENESCENCE; SERUM;

EID: 0346687676     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2003.10.020     Document Type: Article

References (34)

1. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11:1956;298-300.
2. Brawn K., Fridovich I. DNA strand scission by enzymically generated oxygen radicals. Arch. Biochem. Biophys. 206:1981;414-419.
3. Sies H., de Groot H. Role of reactive oxygen species in cell toxicology. Toxicol. Lett. 64-65:1992;547-551.
4. Gutteridge J.M., Halliwell B. Free radicals and antioxidants in the year 2000: a historical look to the future. Ann. NY Acad. Sci. 899:2000;136-147.
5. Harman D. Free radical involvement in aging: pathophysiology and therapeutic implications. Drugs Aging. 3:1993;60-80.
6. Pappolla M.A., Chyan Y.J., Omar R.A., Hsiao K., Perry G., Smith M.A., Bozner P. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am. J. Pathol. 152:1998;871-877.
7. Ceballos I., Lafron M., Javoy-Agid F., Hirsch E., Sinet P.M., Agid Y. Superoxide dismutase and Parkinson's disease. Lancet. 335:1990;1035-1036.
8. Groner Y., Elroy-Stein O., Avraham K.B., Yarom R., Schickler M., Knobler H., Rotman G. Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human Cu/Zn-superoxide dismutase gene. J. Physiol. Paris. 84:1990;53-77.
9. de Haan J.B., Newman J.D., Kola I. Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains. Mol. Brain Res. 13:1992;179-186.
10. 2. Hum. Mol. Genet. 5:1996;283-292.
11. Chen Q., Ames B.N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci USA. 91:1994;4130-4134.
12. Imlay J.A., Chin S.M., Linn S. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science. 240:1988;640-642.
13. Avraham K.B., Sugarman H., Rotshenker S., Groner Y. Down's syndrome: morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice. J. Neurocytol. 20:1991;208-215.
14. Nabarra B., Casanova M., Paris D., Nicole A., Toyama K., Sinet P.M., Ceballos I., London J. Transgenic mice overexpressing the human Cu/Zn-SOD gene: ultrastructural studies of a premature thymic involution model of Down's syndrome (trisomy 21). Lab. Invest. 74:1996;617-626.
15. Beckman J.S., Chen J., Crow J.P., Ye Y.Z. Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. Prog. Brain Res. 103:1994;371-380.
16. de Haan J.B., Bladier C., Griffiths P., Kelner M., O'Shea R.D., Cheung N.S., Bronson R.T., Silvestro M.J., Wild S., Zheng S.S., Beart P.M., Hertzog P.J., Kola I. Mice with a homozygous null mutation for the most abundant glutathione peroxidase Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J. Biol. Chem. 273:1998;22528-22536.
17. Esposito L.A., Kokoszka J.E., Waymire K.G., Cottrell B., MacGregor G.R., Wallace D.C. Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic. Biol. Med. 28:2000;754-766.
18. Phaneuf S., Leeuwenburgh C. Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am. J. Physiol. Regul. Integrative Comp. Physiol. 282:2002;R423-R430.
19. Sneider E.L., Epstein C.J. Replication rate and lifespan of cultured fibroblasts in Down's syndrome. Proc. Soc. Exp. Biol. Med. 142:1972;1092-1094.
20. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
21. Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M.A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry. 13:1992;795-808.
22. Iannello R.C., Mar J.H., Ordahl C.P. Characterization of a promoter element required for transcription in myocardial cells. J. Biol. Chem. 266:1991;3309-3316.
23. Kumazaki T., Robetorye R.S., Robetorye S.C., Smith J.R. Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area. Exp. Cell Res. 195:1991;13-19.
24. Berube N.G., Smith J.R., Periera-Smith O.M. Insights from model systems: the genetics of cellular senescence. Am. J. Hum. Genet. 62:1998;1015-1019.
25. Seitz C.S., Lin Q., Deng H., Khavari P.A. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB. Proc. Natl. Acad. Sci. USA. 95:1998;2307-2312.
26. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12:1993;2005-2015.
27. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
28. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry. 27:1997;1-20.
29. van Engeland M., Nieland L.J.W., Ramaekers F.C.S., Schutte B., Reutelingsperger C.P.M. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry. 31:1998;1-9.
30. Yarom R., Sapoznikov D., Havivi Y., Avraham K.B., Schickler M., Groner Y. Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: a model for tongue pathology in Down's syndrome. J. Neurol. Sci. 88:1988;41-53.
31. Kelner M.J., Bagnell R. Alteration of growth rate and fibronectin by imbalances in superoxide dismutase and glutathione peroxidase activity. Biol. Reactive Intermediates. IV:1990;305-309.
32. Fahim M.A., Robins N. Ultrastructural studies of young and old mouse-neuromuscular junctions. J. Neurocytol. 11:1982;641-656.
33. Wiese A.G., Pacifici R.E., Davies K.J.A. Transient adaptation to oxidative stress in mammalian cells. Arch. Biochem. Biophys. 318:1995;231-240.
34. Davies K.J.A. The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life. 48:1999;41-47.