Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry"

Cytometry Part A

Volumn 79 A, Issue 11, 2011, Pages 897-902

  Zhao, Hong ^a   Dobrucki, Jurek ^b   Rybak, Paulina ^b   Traganos, Frank ^a   Dorota Halicka, H ^a   Darzynkiewicz, Zbigniew ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Cell cycle; DNA damage response; EdU incorporation; Hydrogen peroxide; Reactive oxygen species; Replication stress; S phase

Indexed keywords

5 ETHYNYLDEOXYURIDINE; 5-ETHYNYL-2'-DEOXYURIDINE; ATM PROTEIN; CELL CYCLE PROTEIN; DEOXYURIDINE; DNA BINDING PROTEIN; DRUG DERIVATIVE; H2AFX PROTEIN, HUMAN; HISTONE; HYDROGEN PEROXIDE; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE; CLICK CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; HUMAN; LASER SCANNING CYTOMETRY; METABOLISM; METHODOLOGY; OXIDATIVE STRESS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; STAINING; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CLICK CHEMISTRY; DEOXYURIDINE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION; HISTONES; HUMANS; HYDROGEN PEROXIDE; LASER SCANNING CYTOMETRY; MICROSCOPY, CONFOCAL; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; STAINING AND LABELING; TUMOR SUPPRESSOR PROTEINS;

EID: 80054899319     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.21137     Document Type: Article

References (45)

1. Beckman BK, Ames BN. The free radical theory of aging matures. Phys Rev 1998; 78: 547-581.
2. Beckman KB, Ames BN. Oxidative decay of DNA. J Biol Chem 1997; 272: 13300-13305.
3. Gorbunova V, Seluanov A. Making ends meet in old age: DSB repair and aging. Mech Ageing Dev 2005; 126: 621-628.
4. Karanjawala ZE, Lieber MR. DNA damage and aging. Mech Ageing Dev 2004; 125: 405-416.
5. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003; 5: 741-747.
6. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, et al. Extension of murine life span by over expression of catalase targeted to mitochondria. Science 2005; 308: 1875-1878.
7. Vilenchik MM, Knudson AG. Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer. Proc Natl Acad Sci USA 2003; 100: 12871-12876.
8. Zhao H, Tanaka T, Halicka HD, Traganos F, Zarebski M, Dobrucki J, Darzynkiewicz Z. Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports the aging-related processes. Cytometry Part A 2007; 71A: 905-914.
9. Tanaka T, Halicka HD, Huang X, Traganos F, Darzynkiewicz Z. Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants. Cell Cycle 2006; 5: 1940-1945.
10. Tanaka T, Halicka HD, Traganos F, Darzynkiewicz Z. Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes. Cell Cycle 2006; 5: 2671-2675.
11. Shacter E, Beecham EJ, Covey JM, Kohn KW, Potter M. Activated neutrophils induce prolonged DNA damage in neighboring cells. Carcinogenesis 1988; 9: 2297-2304.
12. Chong YC, Heppner GH, Paul LA, Fulton AM. Macrophage-mediated induction of DNA strand breaks in target tumor cells. Cancer Res 1989; 49: 6652-6657.
13. Taioli E, Sram RJ, Garte BM, Kalina I, Popov TA, Farmer PB. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage (EXPAH project): Description of the population under study. Mutat Res 2007; 620: 1-6.
14. Demirbag R, Yilmaz R, Kocyigit A, Guzel S. Effect of coronary angiography on oxidative DNA damage observed in circulating lymphocytes. Angiology 2007; 58: 141-147.
15. Cadet J, Delatour T, Douki T, Gasparutto D, Pouget JP, Ravanat JL, Sauvaigo S. Hydroxyl radicals and DNA base damage. Mutat Res 1999; 424: 9-21.
16. Marnett LJ. Oxy radicals, lipid peroxidation and DNA damage. Toxicology 2002; 181-182:219-222.
17. Pastwa E, Blasiak J. Non-homologous DNA end joining. Acta Biochim Pol 2003; 50: 891-908.
18. Jeggo PA, Lobrich M. Artemis links ATM to double strand end rejoining. Cell Cycle 2005; 4: 359-362.
19. Blagosklonny MV. Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5: 2087-2102.
20. Blagosklonny MV. Paradoxes of aging. Cell Cycle 2007; 6: 2997-3003.
21. Mallette FA, Ferbeyre G. The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle 2007; 6: 1831-1836.
22. Tanaka T, Kurose A, Halicka HD, Traganos F, Darzynkiewicz Z. 2-Deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX. Cell Cycle 2006; 5: 878-882.
23. Tanaka T, Kajstura M, Halicka HD, Traganos F, Darzynkiewicz Z. Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes. Cell Prolif 2007; 40: 1-13.
24. Huang X, Tanaka T, Kurose A, Traganos F, Darzynkiewicz Z. Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species. Int J Oncol 2006; 29: 495-501.
25. Tanaka T, Halicka HD, Traganos F, Darzynkiewicz Z. Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes. Cell Cycle 2006; 5: 2671-2675.
26. Tanaka T, Kurose A, Halicka HD, Huang X, Traganos F, Darzynkiewicz Z. Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation, and apoptosis preferentially in S-phase cells; involvement of reactive oxygen species. Cell Cycle 2006; 5: 1669-1674.
27. 125IUdr-induced DNA double-strand breaks with γ-H2AX antibody. Radiat Res 2002; 158: 486-492.
28. Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci USA 2008; 105: 2415-2420.
29. Darzynkiewicz Z, Traganos F, Zhao H, Halicka HD, Li J. Cytometry of DNA replication and RNA synthesis: Historical perspective and recent advances based on "click chemistry" Cytometry Part A 2011; 79A: 328-337.
30. Diermeier-Daucher S, Clarke ST, Hill D, Vollmann-Zwerenz A, Bradford JA, Brockhoff G. Cell type specific applicability of 5-ethynyl-2-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry. Cytometry Part A 2009; 75A: 535-546.
31. Zhao H, Li J, Traganos F, Halicka HD, Zarebski M, Dobrucki J, Darzynkiewicz Z. Cell fixation in zinc salt solution (ZBF) is compatible with DNA damage response detection by phospho-specific antibodies. Cytometry Part A, 2011; 79A: 470-476.
32. Zhao, H., Traganos F, Darzynkiewicz Z. Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication. Cytometry Part A 2010; 77A: 285-293.
33. Darzynkiewicz Z, Bedner E, Gorczyca W, Melamed MR. Laser scanning cytometry. A new instrumentation with many applications. Exp Cell Res 1999; 249: 1-12.
34. Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell 2004; 118: 9-17.
35. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001; 276: 42462-42467.
36. Allen C, Ashley AK, Hromas R, Nickoloff JA. More forks on the road to replication stress recovery. J Mol Cell Biol 2011; 3: 4-12.
37. Guo Z, Kozlow S, Lavin, MF, Person MD, Paull TT. ATM activation by oxidative stress. Science 2010; 330: 517-521.
38. Guo Z, Deshpande R, Paull TT. ATM activation in the presence of oxidative stress. Cell Cycle 2010; 9: 4805-4811
39. Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J. ATM activation in normal human tissues and testicular cancer. Cell Cycle 2005; 4: 838-845.
40. Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003; 278: 12207-12213
41. Li Z, Yang J, Huang H. Oxidative stress induced H2AX phosphorylation in human spermatozoa FEBS Letters 2006; 580: 6161-6168
42. Zhang HY, Hormi-Carver K, Zhang X, Spechler SJ, Souza RF. In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks. Cancer Res 2009; 69: 9083-9089.
43. Bartkova J, Hamerlik P, Stockhausen MT, Ehrmann J, Hlobikova A, Laursen H, Kalita O, Kolar Z, Paulsen HS, Broholm H, Lukas J, Bartek J. Replication stress and oxidative DNA damage contribute to aberrant constitutive activation of DNA damage signaling in human glioma. Oncogene 2010; 29: 5095-5102
44. Braidy N, Guillemin GJ, Mansour H, Chen-Ling T, Poljak A, Grant R. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats. PLoS ONE 2011; 6: e19194.
45. 2 induced apoptosis. Cryobiology 2011; 62: 53-61.