Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response

Mechanisms of Ageing and Development

Volumn 130, Issue 7, 2009, Pages 409-419

  Batsi, Christina ^a   Markopoulou, Soultana ^a   Vartholomatos, George ^b   Georgiou, Ioannis ^c   Kanavaros, Panagiotis ^d   Gorgoulis, Vassilis G ^e   Marcu, Kenneth B ^f,g,h   Kolettas, Evangelos ^a,i  

^a Clinic of Social and Family Medicine   (Greece)

^b UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^c UNIVERSITY OF IOANNINA   (Greece)

^d School of Medicine   (Greece)

^e UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^f STONY BROOK UNIVERSITY   (United States)

^g UNIVERSITY OF BOLOGNA   (Italy)

^h RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

ⁱ UNIVERSITY OF IOANNINA   (Greece)

Author keywords

DNA damage; Ha RasV12; Human fibroblasts; IKK ca; NF B; Senescence

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; ONCOPROTEIN; PROTEIN RASV12; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN P21; PROTEIN P53; TP53 PROTEIN, HUMAN;

ARTICLE; CELL AGING; CELL STRESS; CONTROLLED STUDY; CYTOLOGY; DIPLOIDY; DNA DAMAGE; FIBROBLAST; GENE ACTIVATION; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL CULTURE; CELL PROLIFERATION; GENETICS; METABOLISM;

CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FIBROBLASTS; HUMANS; NF-KAPPA B; ONCOGENE PROTEIN P21(RAS); SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67349284299     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2009.04.002     Document Type: Article

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