N-acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-κB in hypoxic murine embryonic fibroblasts

Journal of Biological Chemistry

Volumn 279, Issue 48, 2004, Pages 50455-50464

  Qanungo, Suparna ^a   Wang, Mi ^a   Nieminen, Anna Liisa ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CELLS; CHROMOSOMES; DNA; PROTEINS; TUMORS; VITAMINS;

APOPTOSIS; FIBROBLASTS; GENE EXPRESSION; POLYMERASE;

BIOCHEMISTRY;

ACETYLCYSTEINE; ANTIOXIDANT; CASPASE 3; CYTOCHROME C; E1A PROTEIN; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN INHIBITOR; PROTEIN P53; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; TROLOX C; VITAMIN D DERIVATIVE; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DEGRADATION; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIC CELL; INCUBATION TIME; LUNG CARCINOMA; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN SECRETION;

ACETYLCYSTEINE; ANIMALS; ANOXIA; APOPTOSIS; CELL SURVIVAL; CYTOCHROMES C; FIBROBLASTS; GLUTATHIONE; I-KAPPA B PROTEINS; MICE; NF-KAPPA B; PROTEINS; REACTIVE OXYGEN SPECIES; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

AGOUTI PACA; ANIMALIA; MURINAE;

EID: 9644270341     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406749200     Document Type: Article

References (52)

1. Helmlinger, G., Yuan, F., Dellian, M., and Jain, R. K. (1997) Nat. Med. 3, 177-182
2. Schmaltz, C., Hardenbergh, P. H., Wells, A., and Fisher, D. E. (1998) Mol. Cell. Biol. 18, 2845-2854
3. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. (1996) Nature 379, 88-91
4. Karin, M., and Lin, A. (2002) Nat. Immunol. 3, 221-227
5. Greten, F. R., and Karin, M. (2004) Cancer Lett. 206, 193-199
6. Fan, C., Li, Q., Ross, D., and Engelhardt, J. F. (2003) J. Biol. Chem. 278, 2072-2080
7. Lin, A., and Karin, M. (2003) Semin. Cancer Biol. 13, 107-114
8. Rothwarf, D. M., and Karin, M. (1999) Sci. STKE. 1999, RE1
9. Sizemore, N., Lerner, N., Dombrowski, N., Sakurai, H., and Stark, G. R. (2002) J. Biol. Chem. 277, 3863-3869
10. Bose, S., Kar, N., Maitra, R., DiDonato, J. A., and Banerjee, A. K. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 10890-10895
11. Wang, C. Y., Guttridge, D. C., Mayo, M. W., and Baldwin, A. S., Jr. (1999) Mol. Cell. Biol. 19, 5923-5929
12. Deveraux, Q. L., Leo, E., Stennicke, H. R., Welsh, K., Salvesen, G. S., and Reed, J. C. (1999) EMBO J. 18, 5242-5251
13. Dawson, T. L., Gores, G. J., Nieminen, A. L., Herman, B., and Lemasters, J. J. (1993) Am. J. Physiol. 264, C961-C967
14. Duranteau, J., Chandel, N. S., Kulisz, A., Shao, Z., and Schumacker, P. T. (1998) J. Biol. Chem. 273, 11619-11624
15. Mansfield, K. D., Simon, M. C., and Keith, B. (2004) J. Appl. Physiol. 97, 1358-1366
16. Schreck, R., Albermann, K., and Baeuerle, P. A. (1992) Free Radic. Res. Commun. 17, 221-237
17. Cazals, V., Nabeyrat, E., Corroyer, S., de Keyzer, Y., and Clement, A. (1999) Biochim. Biophys. Acta 1448, 349-362
18. Renard, P., Zachary, M. D., Bougelet, C., Mirault, M. E., Haegeman, G., Remade, J., and Raes, M. (1997) Biochem. Pharmacol. 53, 149-160
19. Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M., and Kikugawa, K. (2003) EMBO J. 22, 3356-3366
20. Jiang, B., and Brecher, P. (2000) Hypertension 35, 914-918
21. Kamata, H., Manabe, T., Kakuta, J., Oka, S., and Hirata, H. (2002) Ann. N. Y. Acad. Sci. 973, 419-4Z2
22. Zafarullah, M., Li, W. Q., Sylvester, J., and Ahmad, M. (2003) Cell Mol. Life Sci. 60, 6-20
23. Park, S. A., Choi, K. S., Bang, J. H., Huh, K., and Kim, S. U. (2000) J. Neurochem. 75, 946-953
24. van Zandwijk, N. (1995) Chest 107, 1437-1441
25. Nieminen, A. L., Byrne, A. M., Herman, B., and Lemasters, J. J. (1997) Am. J. Physiol. 272, C1286-C1294
26. Nulton-Persson, A. C., Starke, D. W., Mieyal, J. J., and Szweda, L. I. (2003) Biochemistry 42, 4235-4242
27. Wang, G. L., Jiang, B. H., and Semenza, G. L. (1995) Biochem. Biophys. Res. Commun. 212, 550-556
28. Qanungo, S., Haldar, S., and Basu, A. (2003) Neoplasia 5, 367-374
29. Nieminen, A. L., Gores, G. J., Wray, B. E., Tanaka, Y., Herman, B., and Lemasters, J. J. (1988) Cell Calcium 9, 237-246
30. Hammond, E. M., Dorie, M. J., and Giaccia, A. J. (2003) J. Biol. Chem. 278, 12207-12213
31. Qanungo, S., Basu, A., Das, M., and Haldar, S. (2002) Oncogene 21, 4149-4157
32. Montiel-Duarte, C., Ansorena, E., Lopez-Zabalza, M. J., Cenarruzabeitia, E., and Iraburu, M. J. (2004) Biochem. Pharmacol. 67, 1025-1033
33. Bogatcheva, N. V., Dudek, S. M., Garcia, J. G., and Verin, A. D. (2003) J. Investig. Med. 51, 341-352
34. Kabore, A. F., Wang, W. J., Russo, S. J., and Beers, M. F. (2001) J. Cell Sci. 114, 293-302
35. Pardo, O.E., Lesay, A., Arcaro, A., Lopes, R., Ng, B. L., Warne, P. H., McNeish, I. A., Tetley, T. D., Lemoine, N. R., Mehmet, H., Seckl, M. J., and Downward, J. (2003) Mol. Cell. Biol. 23, 7600-7610
36. Kunz, M., and Ibrahim, S. M. (2003) Mol. Cancer 2, 23
37. Brunelle, J. K., Santore, M. T., Budinger, G. R., Tang, Y., Barrett, T. A., Zong, W. X., Kandel, E., Keith, B., Simon, M. C., Thompson, C. B., Hay, N., and Chandel, N. S. (2004) J. Biol. Chem. 279, 4305-4312
38. Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J. H., Yagita, H., Okumura, K., Doi, T., and Nakano, H. (2003) EMBO J. 22, 3898-3909
39. Michiels, C., Minet, E., Mottet, D., and Raes, M. (2002) Free Radic. Biol. Med. 33, 1231-1242
40. Porwol, T., Ehleben, W., Zierold, K., Fandrey, J., and Acker, H. (1998) Eur. J. Biochem. 256, 16-23
41. Rieber, M., and Rieber, M. S. (2003) Biochem. Pharmacol. 65, 1593-1601
42. Jones, D. P., Maellaro, E., Jiang, S., Slater, A. F., and Orrenius, S. (1995) Immunol. Lett. 45, 205-209
43. Schreck, R., Rieber, P., and Baeuerle, P. A. (1991) EMBO J. 10, 2247-2258
44. Brar, S. S., Kennedy, T. P., Whorton, A. R., Sturrock, A. B., Huecksteadt, T. P., Ghio, A. J., and Hoidal, J. R. (2001) Am. J. Physiol. Cell Physiol. 280, C659-C676
45. Obin, M., Shang, F., Gong, X., Handelman, G., Blumberg, J., and Taylor, A. (1998) FASEB J. 12, 561-569
46. Jaspers, I., Zhang, W., Fraser, A., Samet, J. M., and Reed, W. (2001) Am. J. Respir. Cell Mol. Biol. 24, 769-777
47. Seres, T., Ravichandran, V., Moriguchi, T., Rokutan, K., Thomas, J. A., and Johnston, R. B., Jr. (1996) J. Immunol. 156, 1973-1980
48. Matthews, J. R., Wakasugi, N., Virelizier, J. L., Yodoi, J., and Hay, R. T. (1992) Nucleic Acids Res. 20, 3821-3830
49. Steinbach, J. P., Wolburg, H., Klumpp, A., Probst, H., and Weller, M. (2003) Cell Death Differ. 10, 823-832
50. Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., and Green, D. R. (2004) Science 303, 1010-1014
51. Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., and Tanaka, N. (2000) Science 288, 1053-1058
52. Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W., and Vogelstein, B. (2001) Mol. Cell 7, 673-682