H2O2-induced AP-1 activation and its effect on p21WAF1/CIP1-mediated G2/M arrest in a p53-deficient human lung cancer cell

Biochemical and Biophysical Research Communications

Volumn 293, Issue 4, 2002, Pages 1248-1253

  Wook Chung, Youn ^a   Jeong, Dae won ^a   Yun Won, Joo ^a   Choi, Eui Ju ^a   Hyun Choi, Yung ^b   Young Kim, Ick ^a  

^a Korea University   (South Korea)

^b Dong Eui University   (South Korea)

Author keywords

Activator protein 1; Extracellular signal regulated kinase; Oxidative stress; p21WAF1 CIP1; Reactive oxygen species; Redox

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DNA; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; ASSAY; BINDING SITE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MITOSIS INHIBITION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; CELL CYCLE; CELL NUCLEUS; CELL SEPARATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME INHIBITORS; FLAVONOIDS; FLOW CYTOMETRY; G2 PHASE; GENES, P53; HUMANS; HYDROGEN PEROXIDE; LUCIFERASES; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0036079812     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00360-1     Document Type: Article

References (38)

1. Low levels of reactive oxygen species as modulators of cell function
2. Protein oxidation in aging, disease, and oxidative stress
3. 2: Senescence-like growth arrest or apoptosis?
4. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases
5. Antioxidant and redox regulation of gene transcription
6. Mechanism of c-fos induction by active oxygen
7. Oxidant carcinogenesis and antioxidant defense
8. Rapid and preferential activation of the c-jun gene during the mammalian UV response
9. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
10. Ultraviolet-A induces activation of AP-1 in cultured human keratinocytes
11. Induction of fos RNA by DNA-damaging agents
12. Cell and tissue responses to oxidative damage
13. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
14. Control of cell cycle progression by c-Jun is p53 dependent
15. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
16. Repair defect in p21 WAF1/CIP1 -/- human cancer cells
17. Cell-cycle arrest versus cell death in cancer therapy
18. Inhibitors of mammalian G1 cyclin-dependent kinases
19. 2. Role in cell survival following oxidant injury
20. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway
21. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress
22. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
23. Involvement of p85 in p53-dependent apoptotic response to oxidative stress
24. Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression
25. Nuclear accumulation of p21Cip1 at the onset of mitosis: A role at the G2/M-phase transition
26. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
27. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
28. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase
29. Principles of CDK regulation
30. Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells
31. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1
32. Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor
33. Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase
34. Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species
35. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
36. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin
37. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
38. The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)