Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 674, Issue 1-2, 2009, Pages 131-136

  Nowsheen, Somaira ^a   Wukovich, Rebecca L ^a   Aziz, Khaled ^a   Kalogerinis, Peter T ^a   Richardson, Christopher C ^a   Panayiotidis, Mihalis I ^b   Bonner, William M ^c   Sedelnikova, Olga A ^c   Georgakilas, Alexandros G ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF NEVADA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer biomarkers; Clustered DNA damage; Human tumors; Oxidative stress

Indexed keywords

AMINOPEPTIDASE; APE1 ENZYME; DEOXYRIBONUCLEASE; DNA; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; HISTONE H2AX; NTH1 ENZYME; OGG1 ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA ISOLATION; DNA REPAIR; GENE CLUSTER; HUMAN; HUMAN TISSUE; KIDNEY CANCER; LIVER CANCER; OVARY CANCER; OXIDATIVE STRESS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ADOLESCENT; AGED; AGED, 80 AND OVER; CELL TRANSFORMATION, NEOPLASTIC; CHILD; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; MULTIGENE FAMILY; NEOPLASMS; OXIDATIVE STRESS; YOUNG ADULT;

ESCHERICHIA COLI;

EID: 61649086403     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.09.010     Document Type: Article

References (49)

1. Nilsen H., and Krokan H.E. Base excision repair in a network of defense and tolerance. Carcinogenesis 22 (2001) 987-998
2. Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
3. Hussain S.P., Hofseth L.J., and Harris C.C. Radical causes of cancer. Nat. Rev. Cancer 3 (2003) 276-285
4. Loft S., and Moller P. Oxidative DNA damage and human cancer: need for cohort studies. Antioxid. Redox Signal. 8 (2006) 1021-1031
5. Joseph T., Kusumakumary P., Chacko P., Abraham A., and Pillai M.R. DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia. Cancer Lett. 217 (2005) 17-24
6. Cooke M.S., Evans M.D., Dizdaroglu M., and Lunec J. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17 (2003) 1195-1214
7. De Bont R., and van Larebeke N. Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis 19 (2004) 169-185
8. Fan R., Kumaravel T.S., Jalali F., Marrano P., Squire J.A., and Bristow R.G. Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Cancer Res. 64 (2001) 8526-8533
9. Hannah M.A., Siddiqui Y., Rostom A., Al-Ahdal M.N., Chaudhary M.A., and Kunhi M. Evidence of DNA repair/processing defects in cultured skin fibroblasts from breast cancer patients. Cancer Res. 61 (2001) 3627-3631
10. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
11. Lindahl T., and Wood R.D. Quality control of DNA repair. Science 286 (1999) 1897-1905
12. Ward J.F. The complexity of DNA damage: relevance to biological consequences. Int. J. Radiat. Biol. 66 (1994) 427-432
13. Ward J.F. Some biochemical consequences of the spatial distribution of ionizing radiation produced free radicals. Radiat. Res. 86 (1981) 185-195
14. Georgakilas A.G. Processing of DNA damage clusters in human cells: current status of knowledge. Mol. Biosyst. 4 (2008) 30-35
15. Georgakilas A.G., Bennett P.V., Wilson III D.M., and Sutherland B.M. Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. Nucleic Acids Res. 32 (2004) 5609-5620
16. Malyarchuk S., Brame K.L., Youngblood R., Shi R., and Harrison L. Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli. Nucleic Acids Res. 32 (2004) 5721-5731
17. Pearson C.G., Shikazono N., Thacker J., and O'Neill P. Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site. Nucleic Acids Res. 32 (2004) 263-270
18. Sutherland B., Bennett P.V., Sidorkina O., and Laval J. DNA damage clusters induced by ionizing radiation in isolated DNA and in human cells. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 103-108
19. Singleton B.K., Griffin C.S., and Thacker J. Clustered DNA damage leads to complex genetic changes in irradiated human cells. Cancer Res. 62 (2002) 6263-6269
20. Weinfeld M., Rasouli-Nia A., Chaudhry M.A., and Britten R.A. Response of base excision repair enzymes to complex DNA lesions. Radiat. Res. 156 (2001) 584-589
21. Sutherland B.M., Bennett P.V., Cintron N.S., Guida P., and Laval J. Low levels of endogenous oxidative damage cluster levels in unirradiated viral and human DNAs. Free Radic. Biol. Med. 35 (2003) 495-503
22. Gollapalle E., Wong R., Adetolu R., Tsao D., Francisco D., Sigounas G., and Georgakilas A.G. Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells. Radiat. Res. 167 (2007) 207-216
23. Bennett P.V., Cuomo N.L., Paul S., Tafrov S.T., and Sutherland B.M. Endogenous DNA damage clusters in human skin, 3-D model and cultured skin cells. Free Radic. Biol. Med. 39 (2005) 832-839
24. Bennett P.V., Cintron N.S., Gros L., Laval J., and Sutherland B.M. Are endogenous clustered DNA damages induced in human cells?. Free Radic. Biol. Med. 37 (2004) 488-499
25. El-Bayoumy K. The protective role of selenium on genetic damage and on cancer. Mutat. Res. 475 (2001) 123-139
26. Sedelnikova O.A., and Bonner W.M. GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence. Cell Cycle 5 (2006) 231-240
27. Hada M., and Georgakilas A.G. Formation of clustered DNA damage after high-LET irradiation: a review. J. Radiat. Res. 49 (2008) 203-210
28. Liu X., and Roy R. Truncation of amino-terminal tail stimulates activity of human Endonuclease III (hNTH1). J. Mol. Biol. 321 (2002) 265-276
29. Sutherland B.M., Georgakilas A.G., Bennett P.V., Laval J., and Sutherland J.C. Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis. Mutat. Res. (Review) 531 (2003) 93-107
30. Marenstein D.R., Chan M.K., Altaminaro A., Basu A.K., Boorstein R.J., Cunningham R.P., and Teebor G.W. Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. J. Biol. Chem. 278 (2003) 9005-9012
31. Toyokuni S., Okamoto K., Yodoi J., and Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 358 (1995) 1-3
32. Nakamura J., and Swenberg A.J. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Res. 59 (1999) 2522-2526
33. Klungland A., Rosewell I., Hollenbach S., Larsen E., Daly G., Epe B., Seeberg E., Lindahl T., and Barnes D.E. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 13300-13305
34. Atamna H., Cheung I., and Ames B.N. A method of detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 686-691
35. Chastain II P.D., Nakamura J., Swenberg J., and Kaufman D. Nonrandom AP site distribution in highly proliferative cells. FASEB J. 20 (2006) 2612-2614
36. Francisco D.C., Peddi P., Hair J.M., Flood B.A., Cecil A.M., Kalogerinis P.T., Sigounas G., and Georgakilas A.G. Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and non-malignant MCF-10A cells. Free Radic. Biol. Med. 44 (2008) 558-569
37. Calaf G., and Russo J. Transformation of human breast epithelial cells by chemical carcinogens. Carcinogenesis 14 (1993) 483-492
38. Futreal P.A., Liu Q., Shattuck-Eidens D., Cochran C., Harshman K., Tavtigian S., Bennett L.M., Haugen-Strano A., Swensen J., Miki Y., Eddington K., McClure M., Frye C., Weaver-Feldhaus J., Ding W., Gholami Z., Soderkvist P., Terry L., Jhanwar S., Berchuck A., Inglehart J.D., Marks J., Ballinger D.G., Barrett J.C., Skolnick M.H., Kamb A., and Wiseman R. BRCA1 mutations in primary breast and ovarian carcinomas. Science 266 (1994) 120-122
39. Helzlsouer K., Harris E., Parshad R., Perry H.R., Price F.M., and Sanford K.K. DNA repair proficiency: potential susceptibility factor for breast cancer. J. Natl. Cancer Inst. 88 (1996) 754-755
40. Li D., Zhang W., Zhu J., Chang P., Sahin A., Singletary E., Bondy M., Hazra T., Mitra S., Lau S.S., Shen J., and DiGiovanni J. Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer. Mol. Carcinog. 31 (2001) 214-223
41. Peltomaki P. Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum. Mol. Genet. 10 (2001) 735-740
42. Barciszewska A.-M., Murawa D., Gawronska I., Murawa P., Nowak S., and Barciszewska M.Z. Analysis of 5-methylcytosine in DNA of breast and colon cancer tissues. IUBMB Life 59 (2007) 765-770
43. Hankinson S., Colditz G., and Willett W. Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res. 6 (2004) 213-218
44. Bolton J.L., and Thatcher G.R.J. Potential mechanisms of estrogen quinone carcinogenesis. Chem. Res. Toxicol. 21 (2008) 93-101
45. Akbari M., and Krokan H. Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging. Mech. Ageing Dev. 129 (2008) 353-365
46. Szatrowski T.P., and Nathan C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51 (1991) 794-798
47. Sokolov M.V., Dickey J.S., Bonner W.M., and Sedelnikova O.A. γ-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication. Cell Cycle 6 (2007) 2210-2212
48. Bartkova J., Horejsi Z., Koed K., Kramer A., Tort F., Zieger K., Guldberg P., Sehested M., Nesland J.M., Lukas C., Orntoft T., Lukas J., and Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434 (2005) 864-870
49. Sutherland B.M., Bennett P.V., Sidorkina O., and Laval J. Clustered damages and total lesions induced in DNA by ionizing radiation: oxidized bases and strand breaks. Biochemistry 39 (2000) 8026-8031