NFκB signaling regulates embryonic and adult neurogenesis

Frontiers in Biology

Volumn 7, Issue 4, 2012, Pages 277-291

  Zhang, Yonggang ^a   Hu, Wenhui ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

embryonic stem cells; neural stem cells; neurogenesis; NF B; signal transduction; transcriptional factors

Indexed keywords

EID: 84864138911     PISSN: 16747984     EISSN: 16747992     Source Type: Journal    
DOI: 10.1007/s11515-012-1233-z     Document Type: Review

References (206)

1. Alcamo E, Mizgerd J P, Horwitz B H, Bronson R, Beg A A, Scott M, Doerschuk C M, Hynes R O, Baltimore D (2001). Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruitment. J Immunol, 167(3): 1592-1600.
2. Andres-Mach M, Fike J R, Łuszczki J J (2011). Neurogenesis in the epileptic brain: a brief overview from temporal lobe epilepsy. Pharmacol Rep, 63(6): 1316-1323.
3. Andreu-Agulló C, Morante-Redolat JM, Delgado A C, Fariñas I (2009). Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci, 12(12): 1514-1523.
4. Ang H L, Tergaonkar V (2007). Notch and NFκB signaling pathways: Do they collaborate in normal vertebrate brain development and function? Bioessays, 29(10): 1039-1047.
5. Angibaud J, Louveau A, Baudouin S J, Nerrière-Daguin V, Evain S, Bonnamain V, Hulin P, Csaba Z, Dournaud P, Thinard R, Naveilhan P, Noraz N, Pellier-Monnin V, Boudin H (2011). The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis. J Neurochem, 119(4): 708-722.
6. Artegiani B, Calegari F (2012). Age-related cognitive decline: Can neural stem cells help us? Aging (Albany NY), 4(3): 176-186.
7. Ayyar S, Pistillo D, Calleja M, Brookfield A, Gittins K, Goldstone C, Simpson P (2007). NF-κB/Rel-mediated regulation of the neural fate in Drosophila. PLoS ONE, 2(11): e1178.
8. Azoitei N, Wirth T, Baumann B (2005). Activation of the IκB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem, 93(6): 1487-1501.
9. Beg A A, Sha W C, Bronson R T, Ghosh S, Baltimore D (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature, 376(6536): 167-170.
10. Ben-Hur T, Ben-Menachem O, Furer V, Einstein O, Mizrachi-Kol R, Grigoriadis N (2003). Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol Cell Neurosci, 24(3): 623-631.
11. Ben Menachem-Zidon O, Goshen I, Kreisel T, Ben Menahem Y, Reinhartz E, Ben Hur T, Yirmiya R (2008). Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology, 33(9): 2251-2262.
12. Bernardino L, Agasse F, Silva B, Ferreira R, Grade S, Malva J O (2008). Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells, 26(9): 2361-2371.
13. Boersma M C, Dresselhaus E C, De Biase L M, Mihalas A B, Bergles D E, Meffert M K (2011). A requirement for nuclear factor-κB in developmental and plasticity-associated synaptogenesis. J Neurosci, 31(14): 5414-5425.
14. Bonaguidi MA, Wheeler MA, Shapiro J S, Stadel R P, Sun G J, Ming G L, Song H (2011). In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell, 145(7): 1142-1155.
15. Bonini S A, Ferrari-Toninelli G, Uberti D, Montinaro M, Buizza L, Lanni C, Grilli M, Memo M (2011). Nuclear factor κB-dependent neurite remodeling is mediated by Notch pathway. J Neurosci, 31(32): 11697-11705.
16. Boyce B F, Yao Z, Xing L (2010). Functions of nuclear factor κB in bone. Ann N Y Acad Sci, 1192(1): 367-375.
17. Cai C, Thorne J, Grabel L (2008). Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis. Stem Cells, 26(5): 1097-1108.
18. Callan M A, Zarnescu D C (2011). Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells. Genesis, 49(6): 424-440.
19. Camandola S, Mattson M P (2007). NF-κB as a therapeutic target in neurodegenerative diseases. Expert Opin Ther Targets, 11(2): 123-132.
20. Cao Q, Kaur C, Wu C Y, Lu J, Ling E A (2011). Nuclear factor-κβ regulates notch signaling in production of proinflammatory cytokines and nitric oxide in murine BV-2 microglial cells. Neuroscience, 192: 140-154.
21. Cau E, Gradwohl G, Casarosa S, Kageyama R, Guillemot F (2000). Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development, 127(11): 2323-2332.
22. Chen G, Handel K, Roth S (2000). The maternal NF-κB/dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle. Development, 127(23): 5145-5156.
23. Chen L F, Greene WC (2004). Shaping the nuclear action of NF-κB. Nat Rev Mol Cell Biol, 5(5): 392-401.
24. Cho H H, Shin K K, Kim Y J, Song J S, Kim J M, Bae Y C, Kim C D, Jung J S (2010). NF-κB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression. J Cell Physiol, 223(1): 168-177.
25. Conti L, Cattaneo E (2010). Neural stem cell systems: physiological players or in vitro entities? Nat Rev Neurosci, 11(3): 176-187.
26. Cox R, Chen S H, Yoo E, Segev N (2007). Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex. BMC Evol Biol, 7(1): 12.
27. Curtis MA, Low VF, Faull RL (2012). Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation. Dev Neurobiol, Online Available April 27, 2012.
28. Das S, Basu A (2008). Inflammation: a new candidate in modulating adult neurogenesis. J Neurosci Res, 86(6): 1199-1208.
29. Dave R K, Ellis T, Toumpas M C, Robson J P, Julian E, Adolphe C, Bartlett P F, Cooper H M, Reynolds B A, Wainwright B J (2011). Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS ONE, 6(2): e14680.
30. DeLotto R, DeLotto Y, Steward R, Lippincott-Schwartz J (2007). Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels during Drosophila embryogenesis. Development, 134(23): 4233-4241.
31. Denham M, Parish C L, Leaw B, Wright J, Reid C A, Petrou S, Dottori M, Thompson L H (2012). Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation. Front Cell Neurosci, 6: 11.
32. Denis-Donini S, Caprini A, Frassoni C, Grilli M (2005). Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain. Brain Res Dev Brain Res, 154(1): 81-89.
33. Denis-Donini S, Dellarole A, Crociara P, Francese M T, Bortolotto V, Quadrato G, Canonico P L, Orsetti M, Ghi P, Memo M, Bonini S A, Ferrari-Toninelli G, Grilli M (2008). Impaired adult neurogenesis associated with short-term memory defects in NF-κB p50-deficient mice. J Neurosci, 28(15): 3911-3919.
34. Dominguez I, Sanz L, Arenzana-Seisdedos F, Diaz-Meco MT, Virelizier J L, Moscat J (1993). Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-κB-like activity in Xenopus laevis oocytes. Mol Cell Biol, 13(2): 1290-1295.
35. Dong J, Liu B, Song L, Lu L, Xu H, Gu Y (2011). Neural stem cells in the ischemic and injured brain: endogenous and transplanted. Cell Tissue Bank Online Available Dec 21, 2011.
36. Encinas J M, Sierra A (2012). Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis. Behav Brain Res, 227(2): 433-439.
37. Encinas J M, Vazquez M E, Switzer R C, Chamberland D W, Nick H, Levine H G, Scarpa P J, Enikolopov G, Steindler D A (2008). Quiescent adult neural stem cells are exceptionally sensitive to cosmic radiation. Exp Neurol, 210(1): 274-279.
38. Feng Z, Porter A G (1999). NF-κB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells. J Biol Chem, 274(43): 30341-30344.
39. Fior R, Henrique D (2005). A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev Biol, 281(2): 318-333.
40. Foehr E D, Bohuslav J, Chen L F, DeNoronha C, Geleziunas R, Lin X, O'Mahony A, Greene W C (2000). The NF-κB-inducing kinase induces PC12 cell differentiation and prevents apoptosis. J Biol Chem, 275(44): 34021-34024.
41. Fridmacher V, Kaltschmidt B, Goudeau B, Ndiaye D, Rossi F M, Pfeiffer J, Kaltschmidt C, Israël A, Mémet S (2003). Forebrainspecific neuronal inhibition of nuclear factor-κB activity leads to loss of neuroprotection. J Neurosci, 23(28): 9403-9408.
42. Fujita K, Yasui S, Shinohara T, Ito K (2011). Interaction between NF-κB signaling and Notch signaling in gliogenesis of mouse mesencephalic neural crest cells. Mech Dev, 128(7-10): 496-509.
43. Gallagher D, Gutierrez H, Gavalda N, O'Keeffe G, Hay R, Davies A M (2007). Nuclear factor-κB activation via tyrosine phosphorylation of inhibitor κB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons. J Neurosci, 27(36): 9664-9669.
44. Gavaldà N, Gutierrez H, Davies A M (2009). Developmental regulation of sensory neurite growth by the tumor necrosis factor superfamily member LIGHT. J Neurosci, 29(6): 1599-1607.
45. Gavert N, Vivanti A, Hazin J, Brabletz T, Ben-Ze'ev A (2011). L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers. Mol Cancer Res, 9(1): 14-24.
46. Ghosh A, Roy A, Liu X, Kordower J H, Mufson E J, Hartley D M, Ghosh S, Mosley R L, Gendelman H E, Pahan K (2007). Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci USA, 104(47): 18754-18759.
47. Gloire G, Legrand-Poels S, Piette J (2006). NF-κB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol, 72(11): 1493-1505.
48. Gloire G, Piette J (2009). Redox regulation of nuclear post-translational modifications during NF-κB activation. Antioxid Redox Signal, 11(9): 2209-2222.
49. Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R (2008). Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry, 13(7): 717-728.
50. Goshen I, Yirmiya R (2009). Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol, 30(1): 30-45.
51. Granic I, Dolga A M, Nijholt I M, van Dijk G, Eisel U L (2009). Inflammation and NF-κB in Alzheimer's disease and diabetes. J Alzheimers Dis, 16(4): 809-821.
52. Green H F, Treacy E, Keohane A K, Sullivan A M, O'Keeffe G W, Nolan Y M (2012). A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Mol Cell Neurosci, 49(3): 311-321.
53. Grossmann M, Metcalf D, Merryfull J, Beg A, Baltimore D, Gerondakis S (1999). The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. Proc Natl Acad Sci USA, 96(21): 11848-11853.
54. Gutierrez H, Davies A M (2011). Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends Neurosci, 34(6): 316-325.
55. Häcker H, Karin M (2006). Regulation and function of IKK and IKKrelated kinases. Sci STKE, 2006(357): re13.
56. Hanson N D, Owens M J, Nemeroff C B (2011). Depression, antidepressants, and neurogenesis: a critical reappraisal. Neuropsychopharmacology, 36(13): 2589-2602.
57. Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M (2011). Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology, 36(9): 1921-1931.
58. Heanue T A, Pachnis V (2007). Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. Nat Rev Neurosci, 8(6): 466-479.
59. Hess K, Ushmorov A, Fiedler J, Brenner R E, Wirth T (2009). TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway. Bone, 45(2): 367-376.
60. Hodge R D, Hevner R F (2011). Expression and actions of transcription factors in adult hippocampal neurogenesis. Dev Neurobiol, 71(8): 680-689.
61. Hu WH, Pendergast J S, Mo X M, Brambilla R, Bracchi-Ricard V, Li F, Walters W M, Blits B, He L, Schaal S M, Bethea J R (2005). NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(κ)B activation. J Biol Chem, 280(32): 29233-29241.
62. Huehnchen P, Prozorovski T, Klaissle P, Lesemann A, Ingwersen J, Wolf S A, Kupsch A, Aktas O, Steiner B (2011). Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation. Glia, 59(1): 132-142.
63. Huillard E, Ziercher L, Blond O, Wong M, Deloulme J C, Souchelnytskyi S, Baudier J, Cochet C, Buchou T (2010). Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon. Mol Cell Biol, 30(11): 2737-2749.
64. Hyun Hwa C, Hye Joon J, Ji Sun S, Yong Chan B, Jin Sup J (2008). Crossregulation of beta-catenin/Tcf pathway by NF-κB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells. Biochim Biophys Acta, (3): 419-428.
65. Ideguchi M, Shinoyama M, Gomi M, Hayashi H, Hashimoto N, Takahashi J (2008). Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cellderived neural precursor cells. J Neurosci Res, 86(9): 1936-1943.
66. Imielski Y, Schwamborn J C, Lüningschrör P, Heimann P, Holzberg M, Werner H, Leske O, Püschel A W, Memet S, Heumann R, Israel A, Kaltschmidt C, Kaltschmidt B (2012). Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus. PLoS ONE, 7(2): e30838.
67. Inta D, Meyer-Lindenberg A, Gass P (2011). Alterations in postnatal neurogenesis and dopamine dysregulation in schizophrenia: a hypothesis. Schizophr Bull, 37(4): 674-680.
68. Islam O, Gong X, Rose-John S, Heese K (2009). Interleukin-6 and neural stem cells: more than gliogenesis. Mol Biol Cell, 20(1): 188-199.
69. Johansson S, Price J, Modo M (2008). Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells. Stem Cells, 26(9): 2444-2454.
70. Kageyama R, Ohtsuka T, Kobayashi T (2008). Roles of Hes genes in neural development. Dev Growth Differ, 50(Suppl 1): S97-S103.
71. Kajiwara K, Ogata S, Tanihara M (2005). Promotion of neurite outgrowth from fetal hippocampal cells by TNF-alpha receptor 1-derived peptide. Cell Transplant, 14(9): 665-672.
72. Kaltschmidt B, Kaltschmidt C (2009). NF-κB in the nervous system. Cold Spring Harb Perspect Biol, 1(3): a001271.
73. Kang H B, Kim Y E, Kwon H J, Sok D E, Lee Y (2007). Enhancement of NF-κB expression and activity upon differentiation of human embryonic stem cell line SNUhES3. Stem Cells Dev, 16(4): 615-624.
74. Kasperczyk H, Baumann B, Debatin K M, Fulda S (2009). Characterization of sonic hedgehog as a novel NF-κB target gene that promotes NF-κB-mediated apoptosis resistance and tumor growth in vivo. FASEB J, 23(1): 21-33.
75. Kato T Jr, Delhase M, Hoffmann A, Karin M (2003). CK2 Is a CTerminal IκB Kinase Responsible for NF-κB Activation during the UV Response. Mol Cell, 12(4): 829-839.
76. Kaul M (2008). HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis. Front Biosci, 13(13): 2484-2494.
77. Kennedy K A, Ostrakhovitch E A, Sandiford S D, Dayarathna T, Xie X, Waese E Y, Chang W Y, Feng Q, Skerjanc I S, Stanford W L, Li S S (2010). Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells. J Biol Chem, 285(23): 17974-17985.
78. Kennedy K A, Sandiford S D, Skerjanc I S, Li S S (2012). Reactive oxygen species and the neuronal fate. Cell Mol Life Sci, 69(2): 215-221.
79. Keohane A, Ryan S, Maloney E, Sullivan A M, Nolan Y M (2010). Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1. Mol Cell Neurosci, 43(1): 127-135.
80. Kim J, Wong P K (2009). Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling. Stem Cells, 27(8): 1987-1998.
81. Kim J H, Park S H, Park S G, Choi J S, Xia Y, Sung J H (2011a). The pivotal role of reactive oxygen species generation in the hypoxiainduced stimulation of adipose-derived stem cells. Stem Cells Dev, 20(10): 1753-1761.
82. Kim J M, Song J S, Cho H H, Shin K K, Bae Y C, Lee B J, Jung J S (2011b). Effect of the modulation of leucine zipper tumor suppressor 2 expression on proliferation of various cancer cells functions as a tumor suppressor. Mol Cell Biochem, 346(1-2): 125-136.
83. Kim Y E, Kang H B, Park J A, Nam K H, Kwon H J, Lee Y (2008). Upregulation of NF-κB upon differentiation of mouse embryonic stem cells. BMB Rep, 41(10): 705-709.
84. Kishi N, Macklis J D (2010). MeCP2 functions largely cellautonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons. Exp Neurol, 222(1): 51-58.
85. Kondo T, Matsuoka A J, Shimomura A, Koehler K R, Chan R J, Miller J M, Srour E F, Hashino E (2011). Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3. Stem Cells, 29(5): 836-846.
86. Köntgen F, Grumont R J, Strasser A, Metcalf D, Li R, Tarlinton D, Gerondakis S (1995). Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev, 9(16): 1965-1977.
87. Koo J W, Duman R S (2008). IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci USA, 105(2): 751-756.
88. Koo J W, Duman R S (2009). Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Curr Opin Investig Drugs, 10(7): 664-671.
89. Koo J W, Russo S J, Ferguson D, Nestler E J, Duman R S (2010). Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci USA, 107(6): 2669-2674.
90. Kümmel D, Oeckinghaus A, Wang C, Krappmann D, Heinemann U (2008). Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells. FEBS Lett, 582(27): 3729-3733.
91. Lake B B, Ford R, Kao K R (2001). Xrel3 is required for head development in Xenopus laevis. Development, 128(2): 263-273.
92. Le Belle J E, Orozco N M, Paucar A A, Saxe J P, Mottahedeh J, Pyle A D, Wu H, Kornblum H I (2011). Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell Stem Cell, 8(1): 59-71.
93. Le Douarin N M, Calloni G W, Dupin E (2008). The stem cells of the neural crest. Cell Cycle, 7(8): 1013-1019.
94. Li Q, Estepa G, Memet S, Israel A, Verma I M (2000). Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev, 14(14): 1729-1733.
95. Li Q, Spencer N Y, Oakley F D, Buettner G R, Engelhardt J F (2009). Endosomal Nox2 facilitates redox-dependent induction of NF-κB by TNF-alpha. Antioxid Redox Signal, 11(6): 1249-1263.
96. Lilienbaum A, Sage J, Mémet S, Rassoulzadegan M, Cuzin F, Israël A (2000). NF-κB is developmentally regulated during spermatogenesis in mice. Dev Dyn, 219(3): 333-340.
97. Lin Y, Bai L, Chen W, Xu S (2010). The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets, 14(1): 45-55.
98. Lou S J, Gu P, Xu H, Xu X H, Wang M W, He C, Lu C L (2003). Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat. Sheng Li Xue Bao, 55(2): 183-186.
99. Lum M, Croze E, Wagner C, McLenachan S, Mitrovic B, Turnley A M (2008). Inhibition of neurosphere proliferation by IFNgamma but not IFNbeta is coupled to neuronal differentiation. J Neuroimmunol, 206(1-2): 32-38.
100. Lüningschrör P, Stöcker B, Kaltschmidt B, Kaltschmidt C (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4): 655-664.
101. Ma D K, Bonaguidi M A, Ming G L, Song H (2009). Adult neural stem cells in the mammalian central nervous system. Cell Res, 19(6): 672-682.
102. Mancino A, Lawrence T (2010). Nuclear factor-κB and tumor-associated macrophages. Clin Cancer Res, 16(3): 784-789.
103. Maniati E, Bossard M, Cook N, Candido J B, Emami-Shahri N, Nedospasov S A, Balkwill F R, Tuveson D A, Hagemann T (2011). Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest, 121(12): 4685-4699.
104. Marcora E, Kennedy M B (2010). The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus. Hum Mol Genet, 19(22): 4373-4384.
105. Massa P T, Aleyasin H, Park D S, Mao X, Barger S W (2006). NFκB in neurons? The uncertainty principle in neurobiology. J Neurochem, 97(3): 607-618.
106. Mattson M P, Culmsee C, Yu Z, Camandola S (2000). Roles of nuclear factor κB in neuronal survival and plasticity. J Neurochem, 74(2): 443-456.
107. Mattson M P, Meffert M K (2006). Roles for NF-κB in nerve cell survival, plasticity, and disease. Cell Death Differ, 13(5): 852-860.
108. Meneghini V, Francese MT, Carraro L, Grilli M (2010). A novel role for the receptor for advanced glycation end-products in neural progenitor cells derived from adult SubVentricular Zone. Mol Cell Neurosci, 45(2): 139-150.
109. Metzger M (2010). Neurogenesis in the enteric nervous system. Arch Ital Biol, 148(2): 73-83.
110. Ming G L, Song H (2011). Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron, 70(4): 687-702.
111. Mir A, Kaufman L, Noor A, Motazacker M M, Jamil T, Azam M, Kahrizi K, Rafiq M A, Weksberg R, Nasr T, Naeem F, Tzschach A, Kuss A W, Ishak G E, Doherty D, Ropers H H, Barkovich A J, Najmabadi H, Ayub M, Vincent J B (2009). Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-betabinding protein, in nonsyndromic autosomal-recessive mental retardation. Am J Hum Genet, 85(6): 909-915.
112. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S (2003). The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell, 113(5): 631-642.
113. Mochida G H, Mahajnah M, Hill A D, Basel-Vanagaite L, Gleason D, Hill R S, Bodell A, Crosier M, Straussberg R, Walsh C A (2009). A truncating mutation of TRAPPC9 is associated with autosomalrecessive intellectual disability and postnatal microcephaly. Am J Hum Genet, 85(6): 897-902.
114. Montano-Almendras C P, Essaghir A, Schoemans H, Varis I, Noel LA, Velghe AI, Latinne D, Knoops L, Demoulin J B (2012). ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor proliferation and differentiation into eosinophils: role of NF-κB. Haematologica, Online Available Jan 22, 2012.
115. Morgan M J, Liu Z G (2011). Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res, 21(1): 103-115.
116. Mu Y, Gage F H (2011). Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener, 6(1): 85.
117. Mu Y, Lee SW, Gage F H (2010). Signaling in adult neurogenesis. Curr Opin Neurobiol, 20(4): 416-423.
118. Mukaino M, Nakamura M, Okada S, Toyama Y, Liu M, Okano H (2008). [Role of IL-6 in regulation of inflammation and stem cell differentiation in CNS trauma]. Nihon Rinsho Meneki Gakkai Kaishi, 31(2): 93-98 (Role of IL-6 in regulation of inflammation and stem cell differentiation in CNS trauma).
119. Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H (2007). Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur J Neurosci, 25(3): 649-658.
120. Nishikimi A, Mukai J, Yamada M (1999). Nuclear translocation of nuclear factor κB in early 1-cell mouse embryos. Biol Reprod, 60(6): 1536-1541.
121. Nogueira L, Ruiz-Ontañon P, Vazquez-Barquero A, Lafarga M, Berciano M T, Aldaz B, Grande L, Casafont I, Segura V, Robles E F, Suarez D, Garcia L F, Martinez-Climent J A, Fernandez-Luna J L (2011). Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo. Oncogene, 30(32): 3537-3548.
122. Noor A, Windpassinger C, Patel M, Stachowiak B, Mikhailov A, Azam M, Irfan M, Siddiqui Z K, Naeem F, Paterson A D, Lutfullah M, Vincent J B, Ayub M (2008). CC2D2A, encoding a coiled-coil and C2 domain protein, causes autosomal-recessive mental retardation with retinitis pigmentosa. Am J Hum Genet, 82(4): 1011-1018.
123. Okamoto S, Kang Y J, Brechtel C W, Siviglia E, Russo R, Clemente A, Harrop A, McKercher S, Kaul M, Lipton S A (2007). HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. Cell Stem Cell, 1(2): 230-236.
124. Okano H (2006). Adult neural stem cells and central nervous system repair. Ernst Schering Res Found Workshop, 60: 215-228.
125. Osakada F, Takahashi M (2011). Neural induction and patterning in Mammalian pluripotent stem cells. CNS Neurol Disord Drug Targets, 10(4): 419-432.
126. Paciolla M, Boni R, Fusco F, Pescatore A, Poeta L, Ursini M V, Lioi M B, Miano M G (2011). Nuclear factor-κ-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-κB/p65 activation during in vitro oocyte maturation and early embryogenesis. Hum Reprod, 26(5): 1191-1201.
127. Pan J X, Ding K, Wang C Y (2012). Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chin J Cancer, Online Available Jan 9, 2012.
128. Pardal R, Ortega-Sáenz P, Durán R, Platero-Luengo A, López-Barneo J (2010). The carotid body, a neurogenic niche in the adult peripheral nervous system. Arch Ital Biol, 148(2): 95-105.
129. Pathania M, Yan L D, Bordey A (2010). A symphony of signals conducts early and late stages of adult neurogenesis. Neuropharmacology, 58(6): 865-876.
130. Pei Y, Brun S N, Markant S L, Lento W, Gibson P, Taketo M M, Giovannini M, Gilbertson R J, Wechsler-Reya R J (2012). WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development, 139(10): 1724-1733.
131. Peng H, Whitney N, Wu Y, Tian C, Dou H, Zhou Y, Zheng J (2008). HIV-1-infected and/or immune-activated macrophage-secreted TNFalpha affects human fetal cortical neural progenitor cell proliferation and differentiation. Glia, 56(8): 903-916.
132. Perkins N D (2007). Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol, 8(1): 49-62.
133. Philippe O, Rio M, Carioux A, Plaza J M, Guigue P, Molinari F, Boddaert N, Bole-Feysot C, Nitschke P, Smahi A, Munnich A, Colleaux L (2009). Combination of linkage mapping and microarrayexpression analysis identifies NF-κB signaling defect as a cause of autosomal-recessive mental retardation. Am J Hum Genet, 85(6): 903-908.
134. Piao Y J, Seo Y H, Hong F, Kim J H, Kim Y J, Kang MH, Kim B S, Jo S A, Jo I, Jue D M, Kang I, Ha J, Kim S S (2005). Nox 2 stimulates muscle differentiation via NF-κB/iNOS pathway. Free Radic Biol Med, 38(8): 989-1001.
135. Politi C, Del Turco D, Sie JM, Golinski P A, Tegeder I, Deller T, Schultz C (2008). Accumulation of phosphorylated IκB alpha and activated IKK in nodes of Ranvier. Neuropathol Appl Neurobiol, 34(3): 357-365.
136. Qin L, Crews F T (2012). NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration. J Neuroinflammation, 9(1): 5.
137. Quirling M, Page S, Jilg N, Plenagl K, Peus D, Grubmüller C, Weingärtner M, Fischer C, Neumeier D, Brand K (2004). Detection of IKKbeta-IKKgamma subcomplexes in monocytic cells and characterization of associated signaling. J Biol Chem, 279(36): 37452-37460.
138. Razani B, Reichardt A D, Cheng G (2011). Non-canonical NF-κB signaling activation and regulation: principles and perspectives. Immunol Rev, 244(1): 44-54.
139. Reeves G T, Stathopoulos A (2009). Graded dorsal and differential gene regulation in the Drosophila embryo. Cold Spring Harb Perspect Biol, 1(4): a000836.
140. Reikvam H, Olsnes A M, Gjertsen B T, Ersvar E, Bruserud O (2009). Nuclear factor-κB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia. Crit Rev Oncog, 15(1-2): 1-41.
141. Ricci-Vitiani L, Casalbore P, Petrucci G, Lauretti L, Montano N, Larocca L M, Falchetti M L, Lombardi D G, Gerevini V D, Cenciarelli C, D'Alessandris Q G, Fernandez E, De Maria R, Maira G, Peschle C, Parati E, Pallini R (2006). Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord. Neurol Res, 28(5): 488-492.
142. Richards G R, Smith A J, Cuddon P, Ma Q P, Leveridge M, Kerby J, Roderick H L, Bootman M D, Simpson P B (2006). The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells. J Neurochem, 97(1): 201-210.
143. Richardson J C, Garcia Estrabot A M, Woodland H R (1994). XrelA, a Xenopus maternal and zygotic homologue of the p65 subunit of NF-κ B. Characterisation of transcriptional properties in the developing embryo and identification of a negative interference mutant. Mech Dev, 45(2): 173-189.
144. Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M (2007). Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol, 9(9): 1081-1088.
145. Rubio-Araiz A, Arévalo-Martín A, Gómez-Torres O, Navarro-Galve B, García-Ovejero D, Suetterlin P, Sánchez-Heras E, Molina-Holgado E, Molina-Holgado F (2008). The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation. Mol Cell Neurosci, 38(3): 374-380.
146. Saldanha-Araujo F, Haddad R, Malmegrim de Farias K C, Alves Souza AD, Palma P V, Araujo A G, Orellana M D, Voltarelli J C, Covas D T, Zago M A, Panepucci R A (2011). Mesenchymal stem cells promote the sustained expression of CD69 on activated Tlymphocytes: roles of canonical and non-canonical NF-κB signaling. J Cell Mol Med, Online Available July 21, 2011.
147. Sanchez-Ponce D, Tapia M, Muñoz A, Garrido J J (2008). New role of IKK alpha/beta phosphorylated I κB alpha in axon outgrowth and axon initial segment development. Mol Cell Neurosci, 37(4): 832-844.
148. Sauvageot C M, Stiles C D (2002). Molecular mechanisms controlling cortical gliogenesis. Curr Opin Neurobiol, 12(3): 244-249.
149. Schäfer K H, Micci M A, Pasricha P J (2009). Neural stem cell transplantation in the enteric nervous system: roadmaps and roadblocks. Neurogastroenterol Motil, 21(2): 103-112.
150. Schmidt-Ullrich R, Mémet S, Lilienbaum A, Feuillard J, Raphaël M, Israel A (1996). NF-κB activity in transgenic mice: developmental regulation and tissue specificity. Development, 122(7): 2117-2128.
151. Schölzke M N, Röttinger A, Murikinati S, Gehrig N, Leib C, Schwaninger M (2011). TWEAK regulates proliferation and differentiation of adult neural progenitor cells. Mol Cell Neurosci, 46(1): 325-332.
152. Schölzke M N, Schwaninger M (2007). Transcriptional regulation of neurogenesis: potential mechanisms in cerebral ischemia. J Mol Med (Berl), 85(6): 577-588.
153. Schultz C, König H G, Del Turco D, Politi C, Eckert G P, Ghebremedhin E, Prehn J H, Kögel D, Deller T (2006). Coincident enrichment of phosphorylated IκBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci, 33(1): 68-80.
154. Schwarz T J, Ebert B, Lie D C (2012). Stem cell maintenance in the adult mammalian hippocampus: A matter of signal integration? Dev Neurobiol, Online Available April 5, 2012.
155. Senftleben U, Cao Y, Xiao G, Greten F R, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun S C, Karin M (2001). Activation by IKKalpha of a second, evolutionary conserved, NF-κ B signaling pathway. Science, 293(5534): 1495-1499.
156. Sha D, Chin L S, Li L (2010). Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-κB signaling. Hum Mol Genet, 19(2): 352-363.
157. Sha W C, Liou H C, Tuomanen E I, Baltimore D (1995). Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell, 80(2): 321-330.
158. Shi Y, Sun G, Zhao C, Stewart R (2008). Neural stem cell self-renewal. Crit Rev Oncol Hematol, 65(1): 43-53.
159. Shingo T, Sorokan S T, Shimazaki T, Weiss S (2001). Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci, 21(24): 9733-9743.
160. Siebzehnrubl F A, Vedam-Mai V, Azari H, Reynolds B A, Deleyrolle L P (2011). Isolation and characterization of adult neural stem cells. Methods Mol Biol, 750: 61-77.
161. Song X Q, Lv L X, Li W Q, Hao Y H, Zhao J P (2009). The interaction of nuclear factor-κB and cytokines is associated with schizophrenia. Biol Psychiatry, 65(6): 481-488.
162. Sun S C (2012). The noncanonical NF-κB pathway. Immunol Rev, 246(1): 125-140.
163. Taupin P (2008). Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells. Int J Med Sci, 5(3): 127-132.
164. Teng F Y, Tang B L (2010). NF-κB signaling in neurite growth and neuronal survival. Rev Neurosci, 21(4): 299-314.
165. Tepavčević V, Lazarini F, Alfaro-Cervello C, Kerninon C, Yoshikawa K, Garcia-Verdugo J M, Lledo P M, Nait-Oumesmar B, Baron-van Evercooren A (2011). Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis. J Clin Invest, 121(12): 4722-4734.
166. Torchinsky A, Toder V (2004). To die or not to die: the function of the transcription factor NF-κB in embryos exposed to stress. Am J Reprod Immunol, 51(2): 138-143.
167. Torres J, Watt F M (2008). Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFκB and cooperating with Stat3. Nat Cell Biol, 10(2): 194-201.
168. Vaillend C, Poirier R, Laroche S (2008). Genes, plasticity and mental retardation. Behav Brain Res, 192(1): 88-105.
169. Vaira S, Johnson T, Hirbe A C, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher K N, Faccio R, Novack D V (2008). RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci USA, 105(10): 3897-3902.
170. van den Berge S A, van Strien M E, Korecka J A, Dijkstra A A, Sluijs J A, Kooijman L, Eggers R, De Filippis L, Vescovi A L, Verhaagen J, van de Berg W D, Hol E M (2011). The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain. Brain, 134(Pt 11): 3249-3263.
171. Viatour P, Merville M P, Bours V, Chariot A (2005). Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends Biochem Sci, 30(1): 43-52.
172. Vieira H L, Alves P M, Vercelli A (2011). Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species. Prog Neurobiol, 93(3): 444-455.
173. Vilas-Boas F, Henrique D (2010). HES6-1 and HES6-2 function through different mechanisms during neuronal differentiation. PLoS ONE, 5(12): e15459.
174. Villeda S A, Luo J, Mosher K I, Zou B, Britschgi M, Bieri G, Stan T M, Fainberg N, Ding Z, Eggel A, Lucin K M, Czirr E, Park J S, Couillard-Després S, Aigner L, Li G, Peskind E R, Kaye J A, Quinn J F, Galasko D R, Xie X S, Rando T A, Wyss-Coray T (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 477(7362): 90-94.
175. Wang D D, Bordey A (2008). The astrocyte odyssey. Prog Neurobiol, 86(4): 342-367.
176. -/-doubleknockout mice. J Exp Med, 185(7): 1359-1370.
177. Westlake C J, Baye L M, Nachury M V, Wright K J, Ervin K E, Phu L, Chalouni C, Beck J S, Kirkpatrick D S, Slusarski D C, Sheffield V C, Scheller R H, Jackson P K (2011). Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci USA, 108(7): 2759-2764.
178. Whitney N P, Eidem T M, Peng H, Huang Y, Zheng J C (2009). Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J Neurochem, 108(6): 1343-1359.
179. Widera D, Kaus A, Kaltschmidt C, Kaltschmidt B (2008). Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? J Cell Mol Med, 12(2): 459-470.
180. Widera D, Mikenberg I, Elvers M, Kaltschmidt C, Kaltschmidt B (2006a). Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-κB signaling. BMC Neurosci, 7(1): 64.
181. Widera D, Mikenberg I, Kaltschmidt B, Kaltschmidt C (2006b). Potential role of NF-κB in adult neural stem cells: the underrated steersman? Int J Dev Neurosci, 24(2-3): 91-102.
182. Widera D, Mikenberg I, Kaus A, Kaltschmidt C, Kaltschmidt B (2006c). Nuclear factor-κB controls the reaggregation of 3D neurosphere cultures in vitro. Eur Cell Mater, 11: 76-84, discussion 85.
183. Winner B, Kohl Z, Gage F H (2011). Neurodegenerative disease and adult neurogenesis. Eur J Neurosci, 33(6): 1139-1151.
184. Wong E T, Tergaonkar V (2009). Roles of NF-κB in health and disease: mechanisms and therapeutic potential. Clin Sci (Lond), 116(6): 451-465.
185. Wong G, Goldshmit Y, Turnley A M (2004). Interferon-gamma but not TNF alpha promotes neuronal differentiation and neurite outgrowth of murine adult neural stem cells. Exp Neurol, 187(1): 171-177.
186. Wooten M W, Seibenhener M L, Neidigh K B, Vandenplas M L (2000). Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells. Mol Cell Biol, 20(13): 4494-4504.
187. Woronicz J D, Gao X, Cao Z, Rothe M, Goeddel D V (1997). IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-alpha and NIK. Science, 278(5339): 866-869.
188. Wu J P, Kuo J S, Liu Y L, Tzeng S F (2000). Tumor necrosis factor-alpha modulates the proliferation of neural progenitors in the subventricular/ ventricular zone of adult rat brain. Neurosci Lett, 292(3): 203-206.
189. Xiao M, Inal C E, Parekh V I, Li X H, Whitnall M H (2009). Role of NF-κB in hematopoietic niche function of osteoblasts after radiation injury. Exp Hematol, 37(1): 52-64.
190. Yaddanapudi K, De Miranda J, Hornig M, Lipkin W I (2011). Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway. PLoS ONE, 6(10): e26766.
191. Yang C, Atkinson S P, Vilella F, Lloret M, Armstrong L, Mann D A, Lako M (2010). Opposing putative roles for canonical and noncanonical NFκB signaling on the survival, proliferation, and differentiation potential of human embryonic stem cells. Stem Cells, 28(11): 1970-1980.
192. Yang L, Tao L Y, Chen X P (2007). Roles of NF-κB in central nervous system damage and repair. Neurosci Bull, 23(5): 307-313.
193. Yeo J E, Kang S K 2007. Selenium effectively inhibits ROS-mediated apoptotic neural precursor cell death in vitro and in vivo in traumatic brain injury. Biochim Biophys Acta, (11-12): 1199-1210.
194. Yirmiya R, Goshen I (2011). Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun, 25(2): 181-213.
195. Yoneyama M, Kawada K, Gotoh Y, Shiba T, Ogita K (2010). Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells. Neurochem Int, 56(6-7): 740-746.
196. Young K M, Bartlett P F, Coulson E J (2006). Neural progenitor number is regulated by nuclear factor-κB p65 and p50 subunit-dependent proliferation rather than cell survival. J Neurosci Res, 83(1): 39-49.
197. Zhang C, Wu H, Zhu X, Wang Y, Guo J (2011). Role of transcription factors in neurogenesis after cerebral ischemia. Rev Neurosci, 22(4): 457-465.
198. Zhang Q, Wang C, Liu Z, Liu X, Han C, Cao X, Li N (2012a). Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation. J Biol Chem, 287(9): 6208-6217.
199. Zhang Y, Liu J, Yao S, Li F, Xin L, Lai M, Bracchi-Ricard V, Xu H, Yen W, Meng W, Liu S, Yang L, Karmally S, Liu J, Zhu H, Gordon J, Khalili K, Srinivasan S, Bethea J R, Mo X, Hu W (2012b). Nuclear factor κB signaling initiates early differentiation of neural stem cells. Stem Cells, 30(3): 510-524.
200. Zhao C, Deng W, Gage F H (2008). Mechanisms and functional implications of adult neurogenesis. Cell, 132(4): 645-660.
201. Zhao C, Xiu Y, Ashton J, Xing L, Morita Y, Jordan C T, Boyce B F (2012). Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions. Stem Cells, 30(4): 709-718.
202. Zhao M, Li X D, Chen Z (2010). CC2D1A, a DM14 and C2 domain protein, activates NF-κB through the canonical pathway. J Biol Chem, 285(32): 24372-24380.
203. Zhu C, Liu Z, Gui L, Yao W, Qian W, Zhang C (2008). Mutated IκBalpha represses proliferation of immortalized neural progenitor cells and prevents their apoptosis after oxygen-glucose deprivation. Brain Res, 1244: 24-31.
204. Ziercher L, Filhol O, Laudet B, Prudent R, Cochet C, Buchou T (2011). Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell. Mol Cell Biochem, 356(1-2): 75-81.
205. Zong M, Satoh A, Yu M K, Siu K Y, Ng W Y, Chan H C, Tanner J A, Yu S (2012). TRAPPC9 mediates the interaction between p150 and COPII vesicles at the target membrane. PLoS ONE, 7(1): e29995.
206. Zong M, Wu X G, Chan C W, Choi M Y, Chan H C, Tanner J A, Yu S (2011). The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability. PLoS ONE, 6(8): e23350.