Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo

Oncogene

Volumn 30, Issue 32, 2011, Pages 3537-3548

  Nogueira, L ^a   Ruiz Ontanon P ^a   Vazquez Barquero, A ^a   Lafarga, M ^b   Berciano, M T ^b   Aldaz, B ^c   Grande, L ^a   Casafont, I ^b   Segura, V ^c   Robles, E F ^c   Suarez, D ^a   Garcia, L F ^d   Martinez Climent, J A ^c   Fernandez Luna, J L ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

^d PHARMAMAR S A   (Spain)

Author keywords

differentiation; glioblastoma initiating cells; NF B; senescence

Indexed keywords

BAY 117083; BETA CATENIN; CYCLIN D1; DOUBLE STRANDED DNA; GLYCOSYLATED INDOLOCARBAZOL; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NESTIN; PROTEIN KINASE B; STAT3 PROTEIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; BRAIN TUMOR; CANCER CELL; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SENESCENCE; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CARBAZOLES; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIN D1; FEMALE; GENE EXPRESSION PROFILING; GLIOBLASTOMA; GLYCOSIDES; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEURAL STEM CELLS; NF-KAPPA B; NITRILES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SULFONES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 80051800349     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.74     Document Type: Article

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