Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions

Stem Cells

Volumn 30, Issue 4, 2012, Pages 709-718

  Zhao, Chen ^a   Xiu, Yan ^a   Ashton, John ^a   Xing, Lianping ^a   Morita, Yoshikazu ^a,b   Jordan, Craig T ^a   Boyce, Brendan F ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

Author keywords

Hematopoietic stem cell; Niche; Noncanonical NF B; Osteoblast; RelB

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL COUNT; CELL CYCLE; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; HEMATOPOIETIC STEM CELL; MICROENVIRONMENT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SIZE; CELLULAR MICROENVIRONMENT; CYTOKINES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INFLAMMATION MEDIATORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; OSTEOBLASTS; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSCRIPTION FACTOR RELB;

MUS;

EID: 84859503920     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1050     Document Type: Article

References (48)

1. Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 2006;6:93-106. (Pubitemid 43361585)
2. Orkin SH, Zon LI. Hematopoiesis: An evolving paradigm for stem cell biology. Cell 2008;132:631-644. (Pubitemid 351260057)
3. Morrison SJ, Spradling AC. Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life. Cell 2008;132: 598-611. (Pubitemid 351253690)
4. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat Immunol 2006;7:333-337.
5. Kiel MJ, Morrison SJ. Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 2008;8:290-301. (Pubitemid 351432804)
6. Zon LI. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 2008;453:306-313. (Pubitemid 351693136)
7. Mendez-Ferrer S, Michurina TV, Ferraro F et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829-834.
8. Kiel MJ, Yilmaz OH, Iwashita T et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005;121:1109-1121. (Pubitemid 40884400)
9. Arai F, Hirao A, Ohmura M et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004;118:149-161. (Pubitemid 38962572)
10. Calvi LM, Adams GB, Weibrecht KW et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-846. (Pubitemid 37351468)
11. Zhang J, Niu C, Ye L et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-841. (Pubitemid 37351467)
12. Chitteti BR, Cheng YH, Poteat B et al. Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function. Blood 2010;115:3239-3248.
13. Raaijmakers MH, Mukherjee S, Guo S et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010; 464:852-857.
14. Kobayashi H, Butler JM, O'Donnell R et al. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol 2010;12:1046-1056.
15. Wilson A, Laurenti E, Trumpp A. Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev 2009;19: 461-468.
16. Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science 2010;327:542-545.
17. Zhao C, Chen A, Jamieson CH et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009;458:776-779.
18. Zhao C, Blum J, Chen A et al. Loss of β-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 2007;12:528-541. (Pubitemid 350199070)
19. Vallabhapurapu S, Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annu Rev Immunol 2009;27: 693-733.
20. Boyce BF, Yao Z, Xing L. Functions of nuclear factor κB in bone. Ann N Y Acad Sci 2010;1192:367-375.
21. Ghosh S, Hayden MS. New regulators of NF-κB in inflammation. Nat Rev Immunol 2008;8:837-848.
22. Beg AA, Sha WC, Bronson RT et al. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376:167-170.
23. Burkly L, Hession C, Ogata L et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 1995; 373:531-536.
24. Weih F, Carrasco D, Durham SK et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 1995;80:331-340.
25. Franzoso G, Carlson L, Xing L et al. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev 1997;11:3482-3496. (Pubitemid 28023969)
26. Horwitz BH, Scott ML, Cherry SR et al. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells. Immunity 1997;6:765-772. (Pubitemid 27305738)
27. Iotsova V, Caamano J, Loy J et al. Osteopetrosis in mice lacking NF-κB1 and NF-κB2. Nat Med 1997;3:1285-1289. (Pubitemid 27508833)
28. Grossmann M, Metcalf D, Merryfull J et al. The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. Proc Natl Acad Sci USA 1999;96:11848-11853. (Pubitemid 29502821)
29. Mold JE, Venkatasubrahmanyam S, Burt TD et al. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science 2010;330:1695-1699.
30. Satyanarayana A, Gudmundsson KO, Chen X et al. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood 2010;116:2921-2931.
31. Morikawa S, Mabuchi Y, Kubota Y et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 2009;206:2483-2496.
32. Panepucci RA, Oliveira LH, Zanette DL et al. Increased levels of NOTCH1, NF-κB, and other interconnected transcription factors characterize primitive sets of hematopoietic stem cells. Stem Cells Dev 2010;19:321-332.
33. Soysa NS, Alles N, Weih D et al. The pivotal role of the alternative NF-κB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res 2010;25:809-818.
34. Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells. Proc Natl Acad Sci USA 2001;98:14541-14546. (Pubitemid 33121428)
35. Osawa M, Hanada K, Hamada H et al. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996;273:242-245. (Pubitemid 26285891)
36. Cashen AF, Lazarus HM, Devine SM. Mobilizing stem cells from normal donors: Is it possible to improve upon G-CSF? Bone Marrow Transplant 2007;39:577-588. (Pubitemid 46729051)
37. Sugiyama T, Kohara H, Noda M et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-988. (Pubitemid 44894948)
38. Qian H, Buza-Vidas N, Hyland CD et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007;1:671-684. (Pubitemid 350215331)
39. Yoshihara H, Arai F, Hosokawa K et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007;1:685-697. (Pubitemid 350215333)
40. Stier S, Ko Y, Forkert R et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med 2005;201:1781-1791. (Pubitemid 41002897)
41. Nilsson SK, Johnston HM, Whitty GA et al. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 2005;106:1232-1239. (Pubitemid 41129584)
42. Hannum C, Culpepper J, Campbell D et al. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 1994;368:643-648. (Pubitemid 24153389)
43. Rupec RA, Jundt F, Rebholz B et al. Stroma-mediated dysregulation of myelopoiesis in mice lacking IjBa. Immunity 2005;22:479-491. (Pubitemid 40545113)
44. Baldridge MT, King KY, Boles NC et al. Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection. Nature 2010;465:793-797.
45. Singh P, Yao Y, Weliver A et al. Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow. Stem Cells 2008;26:1009-1016.
46. Murray PJ, Young RA, Daley GQ. Hematopoietic remodeling in interferon- gamma-deficient mice infected with mycobacteria. Blood 1998; 91:2914-2924. (Pubitemid 28227542)
47. Feng CG, Weksberg DC, Taylor GA et al. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2008;2:83-89.
48. dos Santos NR, Williame M, Gachet S et al. RelB-dependent stromal cells promote T-cell leukemogenesis. PLoS One 2008;3:e2555.