NF-κB activity in transgenic mice: Developmental regulation and tissue specificity

Development

Volumn 122, Issue 7, 1996, Pages 2117-2128

  Schmidt Ullrich, Ruth ^a,c   Mémet, Sylvie ^a   Lilienbaum, Alain ^a   Feuillard, Jean ^b   Raphaël, Martine ^b   Israë, Alain ^a  

^a INSTITUT PASTEUR   (France)

^b AVICENNE HOSPITAL   (France)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Central nervous system; Mouse; Tissue specificity; Transcription factor NF B Rel; Transgenics

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; BETA GALACTOSIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; BRAIN CORTEX; BRAIN DEVELOPMENT; CEREBELLUM; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GASTRULATION; GENE CONTROL; GENE EXPRESSION; LYMPH NODE; MOUSE; NIDATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RHOMBENCEPHALON; SPINAL CORD; SPLEEN; THYMUS; TRANSGENE; ANIMAL; ANTIBODY SPECIFICITY; BRAIN LEVEL; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CHEMISTRY; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; LACTOSE OPERON; LYMPHOID TISSUE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BETA-GALACTOSIDASE; BRAIN CHEMISTRY; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; EMBRYO; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; LAC OPERON; LYMPHOID TISSUE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NF-KAPPA B; ORGAN SPECIFICITY; PREGNANCY; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0029666306     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Baeuerle, P. A. and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
2. Bakalkin, G. Y., Yakovleva, T. and L. Terenius (1993). NF-κB-like factors in the murine brain. Developmentally-regulated and tissue-specific expression. Mol. Brain Res. 20, 137-146.
3. Beg, A. A. and Baldwin, A. S. (1993). The I-κB proteins : multifunctional regulators of rel/NF-κB transcription factors. Genes Dev. 7, 2064-2070
4. Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S. and Baltimore, D. (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376, 167-170.
5. Blank, V., Kourilsky, P. and Israël, A. (1992). NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem Sci. 17, 135-140.
6. Carrasco, D., Ryseck, R.-P and Bravo, R. (1993). Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. Development 118, 1221-1231.
7. Carrasco, D., Weih, F. and Bravo, R. (1994). Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development 120, 2991-3004.
8. Church, G. M. and Gilbert, W. (1984). Genomic sequencing. Proc. Natl. Acad. Sci. USA 81, 1991-1995.
9. Cogswell, P. C., Scheinman, R. I., Baldwin, A. S. (1993). Promoter of the human NF-κB p50/p105 gene : regulation by NF-κB subunits and by c-Rel. J. Immunol. 150, 2794-2804
10. Cressman, D. E., Greenbaum, L. E., Haber, B. A. and Taub, R. (1994). Rapid activation of post-hepatectomy factor/nuclear factor κB in hepatocytes, a primary response in the regenerating liver. J Biol. Chem. 269, 30429-30435.
11. Grilli, M., Chiu, J. J. S. and Lenardo, M. (1993). NF-κB and rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143, 1-62.
12. Guerrini, L., Blasi, F. and Denis-Donini, S. (1995). Synaptic activation of NF-κB by glutamate in cerebellar granule neurons in vitro. Proc. Natl. Acad. Sci. USA 92, 9077-9081.
13. Hanley, T. and Merlie, J. P. (1991). Transgene detection in unpurified mouse tail DNA by polymerase chain reaction. BioTechniques 10, 56.
14. Hogan, B., Beddington, R., Constantini, F. and Lacy, E. (1994). Manipulating the Mouse Embryo. A Laboratory Manual. New York: Cold Spring Harbour Laboratory Press.
15. Iademarco, M. F., McQuillan, J. J., Rosen, G. D. and Dean, D. C. (1992). Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 267, 16323-16329.
16. Kaltschmidt, C., Kaltschmidt, B. and Baeuerle P. (1993). Brain synapses contain inducible forms of the transcription factor NF-κB. Mech. Dev. 43, 135-147.
17. Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H. and Baeuerle P. (1994). Constitutive NF-κB activity in neurons. Mol. Cell. Biol. 14, 3981-3992.
18. Kaszubska, W., Hooft van Huijsduijnen, R., Ghersa, P., DeRaemy-Schenk, A.-M., Chen, B. P. C., Hai, T., DeLamarter, J. F. and Whelan, J. (1993). Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selectin promoter response to cytokines. Mol. Cell. Biol. 13, 7180-7190.
19. Köntgen, F., Grumont, R. J., Strasser, A., Metcalf, D., Li, R., Tarlinton, D. and Gerondakis, S. (1995). Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression. Genes Dev. 9, 1965-1977.
20. Korner, M., Rattner, A., Mauxion, F., Sen., R. and Citri, Y. (1989). A brain-specific transcription activator. Neuron 3, 563-572.
21. Kuhar, S. G., Feng, L., Vidan, S., Ross, M. E., Hatten, M. E. and Heintz, N. (1993). Changing patterns of gene expression define 4 stages of cerebellar granule neuron differentiation. Development 117, 97-104.
22. Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R. and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293.
23. Lernbecher, T., Müller, U. and Wirth, T. (1993). Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature 365, 767-770.
24. Liou, H. C., Sha, W. C., Scott, M. L. and Baltimore, D. (1994). Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol Cell Biol 14, 5349-5359.
25. Mercurio, F., Didonato, J. A., Rosette, C. and Karin, M. (1993). p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction. Genes Dev 7, 705-718.
26. Nolan, G. P. and Baltimore, D. (1992). The inhibitory ankyrin and activator Rel proteins. Curr. Opin. Genet. Dev. 2, 211-220.
27. Paxinos, G. (1985). In The Rat Nervous System. (ed. G. Paxinos). New York: Academic Press Inc.
28. Rattner, A., Korner, M., Walker, M. D. and Citri, Y. (1993). NF-κB activates the HIV promoter in neurons. EMBO J. 12, 4261-4267.
29. Rice, N. R., Mackichan, M. L. and Israel, A. (1992). The precursor of NF-κB p50 has IκB-like functions. Cell 71, 243-253.
30. Sha, W. C., Liou, H.-C., Tuomanen, E. I. and Baltimore, D. (1995). Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80, 321-330.
31. Shu, H. B., Agranoff, A. B., Nabel, E. G., Leung, K., Duckett, C. S., Neish, A. S., Collins, T. and Nabel, G. J. (1993). Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-κB subunits in endothelial and epithelial cells. Mol. Cell. Biol. 13, 6283-6289.
32. Siebenlist, U., Franzoso, G. and Brown, K. (1994). Structure, regulation, and function of NF-κB. Annu. Rev. Cell Biol. 10, 405-455.
33. Smith, R. L., Geller, A. I., Escudero, K. W. and Wilcox, C. L. (1995). Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector. J. Virol. 69, 4593-4599.
34. Steward, R. (1987). Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene c-rel. Science 238, 692-694.
35. St. Johnston, D. and Nüsslein-Volhard, C. (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68, 209-219.
36. Ten, R. M., Paya, C. V., Israël, N., Le Bail, O., Mattai, M.-G., Virelizier, J.-L., Kourilsky, P. and Israél, A. (1992). The characterization of the promoter of the gene encoding the p50 subunit of NF-κB indicates that it participates in its own regulation. EMBO J. 11, 195-203.
37. Tewari, M., Dobrzansky, P., Mohn, K. L., Cressman, D. E., Hsu, J. C., Bravo, R. and Taub, R. (1992). Rapid induction in regenerating liver of RL/IF-I (an IκB that inhibits NF-κB, RelB-p50, and c-rel-p50) and PHF, a novel κB site-binding complex. Mol. Cell. Biol. 12, 2898-2908.
38. Vernet, M., Bonnerot, C., Briand P. and Nicolas, J. F. (1993) Application of lacZ gene fusion to preimplantation development. Methods in Enzymology (ed. P. M. Wassarman and M. L. DePamphilis) 225, 434-451.
39. Weih, F., Carrasco, D. and Bravo, R. (1994). Constitutive and inducible Rel/NF-κB activities in mouse thymus and spleen. Oncogens 9, 3289-3297.
40. Weih, F., Carrasco, D., Durham, S. K., Barton, D. S., Rizzo, C. A., Ryseck, R.-P., Lira, S. A. and Bravo, R. (1995). Multiorgan inflammation and hemopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80, 331-340.
41. Whelan, J., Ghersa, P., Hooft van Huijsduijnen, R., Gray, J., Chandra, G., Talabot, F. and DeLamarter, J. F. (1991). An NF-κB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule (ELAM) gene transcription. Nucleic Acids Res. 19, 2645-2653.