-
3
-
-
34248190279
-
A beta oligomers-a decade of discovery
-
Walsh, D.M. & D.J. Selkoe 2007. A beta oligomers-a decade of discovery. J. Neurochem. 101: 1172-1184.
-
(2007)
J. Neurochem.
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
4
-
-
70450219539
-
Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
-
Martins, I.J. et al 2009. Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. J. Neurochem. 111: 1275-1308.
-
(2009)
J. Neurochem.
, vol.111
, pp. 1275-1308
-
-
Martins, I.J.1
-
5
-
-
33845286140
-
Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
-
Carter, C.J. 2007. Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. Neurochem. Int. 50: 12-38.
-
(2007)
Neurochem. Int.
, vol.50
, pp. 12-38
-
-
Carter, C.J.1
-
6
-
-
77953271492
-
Cholesterol-related genes in Alzheimer's disease
-
Wollmer, M.A. 2010. Cholesterol-related genes in Alzheimer's disease. Biochim. Biophys. Acta 1801: 762-773.
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 762-773
-
-
Wollmer, M.A.1
-
7
-
-
58149396136
-
Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle
-
Ghribi, O. 2008. Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. J. Alzheimers Dis. 15: 673-684.
-
(2008)
J. Alzheimers Dis.
, vol.15
, pp. 673-684
-
-
Ghribi, O.1
-
8
-
-
79955051063
-
Linking lipids to Alzheimer's disease: cholesterol and beyond
-
Di Paolo, G. & T.W. Kim 2011. Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat. Rev. Neurosci. 12: 284-296.
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 284-296
-
-
Di Paolo, G.1
Kim, T.W.2
-
10
-
-
33746909435
-
Lipid metabolism in cognitive decline and dementia
-
Panza, F. et al 2006. Lipid metabolism in cognitive decline and dementia. Brain Res. Rev. 51: 275-292.
-
(2006)
Brain Res. Rev.
, vol.51
, pp. 275-292
-
-
Panza, F.1
-
11
-
-
12444340438
-
Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
-
Pappolla, M.A. et al 2003. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology 61: 199-205.
-
(2003)
Neurology
, vol.61
, pp. 199-205
-
-
Pappolla, M.A.1
-
12
-
-
0034638746
-
Statins and the risk of dementia
-
Jick, H. et al 2000. Statins and the risk of dementia. Lancet 356: 1627-1631.
-
(2000)
Lancet
, vol.356
, pp. 1627-1631
-
-
Jick, H.1
-
13
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin, B. et al 2000. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57: 1439-1443.
-
(2000)
Arch. Neurol.
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
-
14
-
-
0942278990
-
Association between statin use and Alzheimer's disease
-
Zamrini, E., G. McGwin & J.M. Roseman 2004. Association between statin use and Alzheimer's disease. Neuroepidemiology 23: 94-98.
-
(2004)
Neuroepidemiology
, vol.23
, pp. 94-98
-
-
Zamrini, E.1
McGwin, G.2
Roseman, J.M.3
-
15
-
-
67650128395
-
Therapeutic potential of statins in Alzheimer's disease
-
Kandiah, N. & H.H. Feldman 2009. Therapeutic potential of statins in Alzheimer's disease. J. Neurol. Sci. 283: 230-234.
-
(2009)
J. Neurol. Sci.
, vol.283
, pp. 230-234
-
-
Kandiah, N.1
Feldman, H.H.2
-
16
-
-
77952583554
-
Cholesterol and statins in Alzheimer's disease: current controversies
-
Fonseca, A.C. et al 2010. Cholesterol and statins in Alzheimer's disease: current controversies. Exp. Neurol. 223: 282-293.
-
(2010)
Exp. Neurol.
, vol.223
, pp. 282-293
-
-
Fonseca, A.C.1
-
17
-
-
43249094747
-
Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
-
Arvanitakis, Z. et al 2008. Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology 70: 1795-1802.
-
(2008)
Neurology
, vol.70
, pp. 1795-1802
-
-
Arvanitakis, Z.1
-
18
-
-
0345669752
-
Alzheimer's disease: the cholesterol connection
-
Puglielli, L., R.E. Tanzi & D.M. Kovacs 2003. Alzheimer's disease: the cholesterol connection. Nat. Neurosci. 6: 345-351.
-
(2003)
Nat. Neurosci.
, vol.6
, pp. 345-351
-
-
Puglielli, L.1
Tanzi, R.E.2
Kovacs, D.M.3
-
19
-
-
2442684094
-
Cholesterol and APOE genotype interact to influence Alzheimer disease progression
-
Evans, R.M. et al 2004. Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology 62: 1879-1881.
-
(2004)
Neurology
, vol.62
, pp. 1879-1881
-
-
Evans, R.M.1
-
20
-
-
67349270965
-
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
-
Bu, G. 2009. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 10: 333-344.
-
(2009)
Nat. Rev. Neurosci.
, vol.10
, pp. 333-344
-
-
Bu, G.1
-
21
-
-
68249134074
-
The role of apolipoprotein E in Alzheimer's disease
-
Kim, J., J.M. Basak & D.M. Holtzman 2009. The role of apolipoprotein E in Alzheimer's disease. Neuron 63: 287-303.
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
22
-
-
63949084694
-
Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
-
Marzolo, M.P. & G. Bu 2009. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Semin. Cell. Dev. Biol. 20: 191-200.
-
(2009)
Semin. Cell. Dev. Biol.
, vol.20
, pp. 191-200
-
-
Marzolo, M.P.1
Bu, G.2
-
23
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
Jiang, Q. et al 2008. ApoE promotes the proteolytic degradation of Abeta. Neuron 58: 681-693.
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
-
24
-
-
34948888151
-
Clearance of amyloid-beta by circulating lipoprotein receptors
-
Sagare, A. et al 2007. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat. Med. 13: 1029-1031.
-
(2007)
Nat. Med.
, vol.13
, pp. 1029-1031
-
-
Sagare, A.1
-
25
-
-
34248202513
-
Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
-
Cam, J.A. & G. Bu 2006. Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Mol. Neurodegener. 18: 1-8.
-
(2006)
Mol. Neurodegener.
, vol.18
, pp. 1-8
-
-
Cam, J.A.1
Bu, G.2
-
26
-
-
0034305790
-
Apolipoprotein E receptors: linking brain development and Alzheimer's disease
-
Herz, J. & U. Beffert 2000. Apolipoprotein E receptors: linking brain development and Alzheimer's disease. Nat. Rev. Neurosci. 1: 51-58.
-
(2000)
Nat. Rev. Neurosci.
, vol.1
, pp. 51-58
-
-
Herz, J.1
Beffert, U.2
-
27
-
-
34748897213
-
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
-
Liu, Q. et al 2007. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56: 66-78.
-
(2007)
Neuron
, vol.56
, pp. 66-78
-
-
Liu, Q.1
-
28
-
-
77953812642
-
The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice
-
Jenner, A.M. et al 2010. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience 169: 109-115.
-
(2010)
Neuroscience
, vol.169
, pp. 109-115
-
-
Jenner, A.M.1
-
29
-
-
0037710127
-
Cholesterol homeostasis and function in neurons of the central nervous system
-
Pfrieger, F.W. 2003. Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60: 1158-1171.
-
(2003)
Cell. Mol. Life Sci.
, vol.60
, pp. 1158-1171
-
-
Pfrieger, F.W.1
-
30
-
-
2442557294
-
Brain cholesterol: long secret life behind a barrier
-
Björkhem, I. & S. Meaney 2004. Brain cholesterol: long secret life behind a barrier. Arterioscler. Thromb. Vasc. Biol. 24: 806-815.
-
(2004)
Arterioscler. Thromb. Vasc. Biol.
, vol.24
, pp. 806-815
-
-
Björkhem, I.1
Meaney, S.2
-
31
-
-
0037230328
-
Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?
-
Pfrieger, F.W. 2003. Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? Bioessays 25: 72-78.
-
(2003)
Bioessays
, vol.25
, pp. 72-78
-
-
Pfrieger, F.W.1
-
32
-
-
33645299023
-
The involvement of lipid rafts in Alzheimer's disease
-
Cordy, J.M., N.M. Hooper & A.J. Turner 2006. The involvement of lipid rafts in Alzheimer's disease. Mol. Membr. Biol. 23: 111-122.
-
(2006)
Mol. Membr. Biol.
, vol.23
, pp. 111-122
-
-
Cordy, J.M.1
Hooper, N.M.2
Turner, A.J.3
-
33
-
-
77953280950
-
Membrane rafts in Alzheimer's disease beta-amyloid production
-
Vetrivel, K.S. & G. Thinakaran 2010. Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim. Biophys. Acta 1801: 860-867.
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 860-867
-
-
Vetrivel, K.S.1
Thinakaran, G.2
-
34
-
-
77953282057
-
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?
-
Beel, A.J. et al 2010. Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Biochim. Biophys. Acta 1801: 975-982.
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 975-982
-
-
Beel, A.J.1
-
35
-
-
0036180950
-
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains
-
Wahrle, S. et al 2002. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis. 9: 11-23.
-
(2002)
Neurobiol. Dis.
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
-
36
-
-
40349102241
-
Active gamma-secretase is localized to detergent-resistant membranes in human brain
-
Hur, J.Y. et al 2008. Active gamma-secretase is localized to detergent-resistant membranes in human brain. FEBS J. 275: 1174-1187.
-
(2008)
FEBS J.
, vol.275
, pp. 1174-1187
-
-
Hur, J.Y.1
-
37
-
-
45549093275
-
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels
-
Grimm, M.O. et al 2008. Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels. J. Biol. Chem. 283: 11302-11311.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 11302-11311
-
-
Grimm, M.O.1
-
38
-
-
39249084075
-
Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production
-
Xiong, H. et al 2008. Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol. Dis. 29: 422-437.
-
(2008)
Neurobiol. Dis.
, vol.29
, pp. 422-437
-
-
Xiong, H.1
-
39
-
-
34547315810
-
Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins
-
Reid, P.C. et al 2007. Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J. Cell. Mol. Med. 11: 383-392.
-
(2007)
J. Cell. Mol. Med.
, vol.11
, pp. 383-392
-
-
Reid, P.C.1
-
40
-
-
70349295148
-
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein
-
Harris, B., I. Pereira & E. Parkin 2009. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein. Brain Res. 1296: 203-215.
-
(2009)
Brain Res.
, vol.1296
, pp. 203-215
-
-
Harris, B.1
Pereira, I.2
Parkin, E.3
-
41
-
-
15944366574
-
Cholesterol and amyloid beta fibrillogenesis
-
Yanagisawa, K. 2005. Cholesterol and amyloid beta fibrillogenesis. Subcell. Biochem. 38: 179-202.
-
(2005)
Subcell. Biochem.
, vol.38
, pp. 179-202
-
-
Yanagisawa, K.1
-
42
-
-
0037062582
-
Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid
-
Kakio, A. et al 2002. Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 41: 7385-7390.
-
(2002)
Biochemistry
, vol.41
, pp. 7385-7390
-
-
Kakio, A.1
-
43
-
-
52049113661
-
Cholesterol binding to amyloid-beta fibrils: a TEM study
-
Harris, J.R. 2008. Cholesterol binding to amyloid-beta fibrils: a TEM study. Micron 9: 1192-1196.
-
(2008)
Micron
, vol.9
, pp. 1192-1196
-
-
Harris, J.R.1
-
44
-
-
0035816709
-
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid
-
Kakio, A. et al 2001. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid. J. Biol. Chem. 276: 24985-24990.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24985-24990
-
-
Kakio, A.1
-
45
-
-
33745246852
-
Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice
-
Burns, M.P. et al 2006. Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice. Neuromolecular Med. 8: 319-328.
-
(2006)
Neuromolecular Med.
, vol.8
, pp. 319-328
-
-
Burns, M.P.1
-
46
-
-
0034795651
-
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
-
Puglielli, L. et al 2001. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat. Cell Biol. 3: 905-912.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 905-912
-
-
Puglielli, L.1
-
48
-
-
0035884905
-
A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release
-
Michikawa, M. et al 2001. A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release. Neurosci. 21: 7226-7235.
-
(2001)
Neurosci.
, vol.21
, pp. 7226-7235
-
-
Michikawa, M.1
-
49
-
-
0037010287
-
Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade
-
Gong, J.S. et al 2002. Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade. J. Neurosci. Res. 70: 438-446.
-
(2002)
J. Neurosci. Res.
, vol.70
, pp. 438-446
-
-
Gong, J.S.1
-
50
-
-
0035142852
-
Cholesterol-dependent modulation of tau phosphorylation in cultured neurons
-
Fan, Q.W. et al 2001. Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J. Neurochem. 76: 391-400.
-
(2001)
J. Neurochem.
, vol.76
, pp. 391-400
-
-
Fan, Q.W.1
-
51
-
-
14844321855
-
Cholesterol homeostasis failure as a unifying cause of synaptic degeneration
-
Koudinov, A.R. & N.V. Koudinova 2005. Cholesterol homeostasis failure as a unifying cause of synaptic degeneration. J. Neurol. Sci. 229-230: 233-240.
-
(2005)
J. Neurol. Sci.
, vol.229-230
, pp. 233-240
-
-
Koudinov, A.R.1
Koudinova, N.V.2
-
52
-
-
0034928074
-
Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice
-
Mori, T. et al 2001. Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice. J. Neuropathol. Exp. Neurol. 60: 778-785.
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 778-785
-
-
Mori, T.1
-
53
-
-
0037474140
-
Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques
-
Burns, M.P. et al 2003. Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques. Brain Res. Mol. Brain Res. 110: 119-125.
-
(2003)
Brain Res. Mol. Brain Res.
, vol.110
, pp. 119-125
-
-
Burns, M.P.1
-
54
-
-
67349094556
-
Oxysterols and neurodegenerative diseases
-
Björkhem, I. et al 2009. Oxysterols and neurodegenerative diseases. Mol. Aspects Med. 30: 171-179.
-
(2009)
Mol. Aspects Med.
, vol.30
, pp. 171-179
-
-
Björkhem, I.1
-
55
-
-
33751096969
-
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain
-
Björkhem I. 2006. Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J. Intern. Med. 260: 493-508.
-
(2006)
J. Intern. Med.
, vol.260
, pp. 493-508
-
-
Björkhem, I.1
-
56
-
-
33744948883
-
24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux
-
Abildayeva, K. et al 2006. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J. Biol. Chem. 281: 12799-12808.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12799-12808
-
-
Abildayeva, K.1
-
57
-
-
34147141285
-
Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid
-
Meaney, S. et al 2007. Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. J. Lipid Res. 48: 944-951.
-
(2007)
J. Lipid Res.
, vol.48
, pp. 944-951
-
-
Meaney, S.1
-
58
-
-
23744498856
-
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
-
Heverin, M. et al 2005. Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. J. Lipid Res. 46: 1047-1052.
-
(2005)
J. Lipid Res.
, vol.46
, pp. 1047-1052
-
-
Heverin, M.1
-
59
-
-
14844304305
-
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide
-
Nelson, T.J. & D.L. Alkon 2005. Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. J. Biol. Chem. 280: 7377-7387.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7377-7387
-
-
Nelson, T.J.1
Alkon, D.L.2
-
60
-
-
0343775806
-
Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
-
Lütjohann, D. et al 2000. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J. Lipid Res. 41: 195-198.
-
(2000)
J. Lipid Res.
, vol.41
, pp. 195-198
-
-
Lütjohann, D.1
-
61
-
-
0036138648
-
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
-
Papassotiropoulos, A. et al 2002. 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J. Psychiatr. Res. 36: 27-32.
-
(2002)
J. Psychiatr. Res.
, vol.36
, pp. 27-32
-
-
Papassotiropoulos, A.1
-
62
-
-
4544282709
-
Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
-
Kölsch, H. et al 2004. Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. Neurosci. Lett. 368: 303-308.
-
(2004)
Neurosci. Lett.
, vol.368
, pp. 303-308
-
-
Kölsch, H.1
-
63
-
-
0034722108
-
Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
-
Bretillon, L. et al 2000. Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. Neurosci. Lett. 293: 87-90.
-
(2000)
Neurosci. Lett.
, vol.293
, pp. 87-90
-
-
Bretillon, L.1
-
64
-
-
0035856407
-
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
-
Bogdanovic, N. et al 2001. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci. Lett. Nov. 314: 45-48.
-
(2001)
Neurosci. Lett. Nov.
, vol.314
, pp. 45-48
-
-
Bogdanovic, N.1
-
65
-
-
4544255297
-
Differential expression of cholesterol hydroxylases in Alzheimer's disease
-
Brown, J. 3rd et al 2004. Differential expression of cholesterol hydroxylases in Alzheimer's disease. J. Biol. Chem. 13: 34674-34681.
-
(2004)
J. Biol. Chem.
, vol.13
, pp. 34674-34681
-
-
Brown 3rd, J.1
-
66
-
-
78650475565
-
Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease
-
Iuliano, L. et al 2010. Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease. J. Alzheimers Dis. 21: 1383-1392.
-
(2010)
J. Alzheimers Dis.
, vol.21
, pp. 1383-1392
-
-
Iuliano, L.1
-
67
-
-
0842303768
-
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
-
Heverin, M. et al 2004. Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J. Lipid Res. 45: 186-193.
-
(2004)
J. Lipid Res.
, vol.45
, pp. 186-193
-
-
Heverin, M.1
-
68
-
-
79955038570
-
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
-
Shafaati, M. et al 2011. Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. J. Lipid Res. 52: 1004-1010.
-
(2011)
J. Lipid Res.
, vol.52
, pp. 1004-1010
-
-
Shafaati, M.1
-
69
-
-
33846362273
-
Oxysterols and Alzheimer's disease
-
Björkhem, I. et al 2006. Oxysterols and Alzheimer's disease. Acta Neurol. Scand. Suppl. 185: 43-49.
-
(2006)
Acta Neurol. Scand. Suppl.
, vol.185
, pp. 43-49
-
-
Björkhem, I.1
-
70
-
-
0141700567
-
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
-
Leoni, V. et al 2003. Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. J. Lipid Res. 44: 793-799.
-
(2003)
J. Lipid Res.
, vol.44
, pp. 793-799
-
-
Leoni, V.1
-
71
-
-
0141533183
-
Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
-
Yau, J.L. et al 2003. Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease. Neuroscience 121: 307-314.
-
(2003)
Neuroscience
, vol.121
, pp. 307-314
-
-
Yau, J.L.1
-
72
-
-
1642525647
-
Diagnostic use of cerebral and extracerebral oxysterols
-
Leoni, V. et al 2004. Diagnostic use of cerebral and extracerebral oxysterols. Clin. Chem. Lab. Med. 42: 186-191.
-
(2004)
Clin. Chem. Lab. Med.
, vol.42
, pp. 186-191
-
-
Leoni, V.1
-
73
-
-
58849154028
-
Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons
-
Kim, W.S. et al 2009. Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. J. Alzheimers Dis. 16: 121-131.
-
(2009)
J. Alzheimers Dis.
, vol.16
, pp. 121-131
-
-
Kim, W.S.1
-
74
-
-
0037108819
-
Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration
-
Wang, L. et al 2002. Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc. Natl. Acad. Sci. USA 15: 13878-13883.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.15
, pp. 13878-13883
-
-
Wang, L.1
-
75
-
-
33947610707
-
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
-
Riddell, D.R. et al 2007. The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol. Cell. Neurosci. 34: 621-628.
-
(2007)
Mol. Cell. Neurosci.
, vol.34
, pp. 621-628
-
-
Riddell, D.R.1
-
76
-
-
34547531201
-
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
-
Zelcer, N. et al 2007. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc. Natl. Acad. Sci. USA 19: 10601-10606.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.19
, pp. 10601-10606
-
-
Zelcer, N.1
-
77
-
-
34147131740
-
Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics
-
Cao, G. et al 2007. Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. Curr. Alzheimer Res. 4: 179-184.
-
(2007)
Curr. Alzheimer Res.
, vol.4
, pp. 179-184
-
-
Cao, G.1
-
78
-
-
34249828178
-
Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway
-
Famer, D. et al 2007. Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. Biochem. Biophys. Res. Commun. 359: 46-50.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.359
, pp. 46-50
-
-
Famer, D.1
-
79
-
-
62149140601
-
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
-
Prasanthi, J.R. et al 2009. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Mol. Neurodegener. 4: 1-8.
-
(2009)
Mol. Neurodegener.
, vol.4
, pp. 1-8
-
-
Prasanthi, J.R.1
-
80
-
-
77149145513
-
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices
-
Marwarha, G. et al 2010. Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. J. Alzheimers Dis. 19: 1007-1019.
-
(2010)
J. Alzheimers Dis.
, vol.19
, pp. 1007-1019
-
-
Marwarha, G.1
-
81
-
-
56349160982
-
Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling
-
Sharma, S. et al 2008. Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiol. Dis. 32: 426-432.
-
(2008)
Neurobiol. Dis.
, vol.32
, pp. 426-432
-
-
Sharma, S.1
-
82
-
-
57449119576
-
Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro
-
Mateos, L. et al 2009. Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. Brain Pathol. 19: 69-80.
-
(2009)
Brain Pathol.
, vol.19
, pp. 69-80
-
-
Mateos, L.1
-
83
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama, H. et al 2000. Inflammation and Alzheimer's disease. Neurobiol. Aging 21: 383-421.
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
-
84
-
-
84899547370
-
Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors
-
Guglielmotto, M. et al 2010. Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front. Aging Neurosci. 2: 1-8.
-
(2010)
Front. Aging Neurosci.
, vol.2
, pp. 1-8
-
-
Guglielmotto, M.1
-
85
-
-
80052827401
-
Inflammation in the early stages of neurodegenerative pathology
-
Khandelwal, P.J., A.M. Herman & C.E. Moussa 2011. Inflammation in the early stages of neurodegenerative pathology. J. Neuroimmunol. 15: 1-11.
-
(2011)
J. Neuroimmunol.
, vol.15
, pp. 1-11
-
-
Khandelwal, P.J.1
Herman, A.M.2
Moussa, C.E.3
-
86
-
-
79954553697
-
Inflammatory risk factors and pathologies associated with Alzheimer's disease.
-
Sastre, M. et al 2011. Inflammatory risk factors and pathologies associated with Alzheimer's disease. Curr. Alzheimer Res. 8: 132-141.
-
(2011)
Curr. Alzheimer Res
, vol.8
, pp. 132-141
-
-
Sastre, M.1
-
87
-
-
79954486783
-
Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?
-
Ferretti, M.T. & A.C. Cuello 2011. Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment? Curr. Alzheimer Res. 8: 164-174.
-
(2011)
Curr. Alzheimer Res.
, vol.8
, pp. 164-174
-
-
Ferretti, M.T.1
Cuello, A.C.2
-
88
-
-
2342495787
-
Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease
-
Verdier, Y., M. Zarándi & B. Penke 2004. Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease. J. Pept. Sci. 10: 229-248.
-
(2004)
J. Pept. Sci.
, vol.10
, pp. 229-248
-
-
Verdier, Y.1
Zarándi, M.2
Penke, B.3
-
89
-
-
47849127085
-
2008. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders
-
Schwab, C. & P.L. McGeer 2008. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. J. Alzheimers Dis. 13: 359-369.
-
J. Alzheimers Dis.
, vol.13
, pp. 359-369
-
-
Schwab, C.1
McGeer, P.L.2
-
90
-
-
20244364226
-
Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice
-
Abbas, N. et al 2002. Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice. J. Neuroimmunol. 126: 50-57.
-
(2002)
J. Neuroimmunol.
, vol.126
, pp. 50-57
-
-
Abbas, N.1
-
91
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura, A. et al 2001. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60: 759-767.
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
-
92
-
-
34548356689
-
Causes of oxidative stress in Alzheimer disease
-
Zhu, X. et al 2007. Causes of oxidative stress in Alzheimer disease. Cell. Mol. Life Sci. 64: 2202-2210.
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 2202-2210
-
-
Zhu, X.1
-
93
-
-
75149152568
-
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
-
Smith, M.A. et al 2010. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J. Alzheimers Dis. 19: 363-372.
-
(2010)
J. Alzheimers Dis.
, vol.19
, pp. 363-372
-
-
Smith, M.A.1
-
94
-
-
77955917442
-
Oxidative stress in Alzheimer disease: a possibility for prevention
-
Bonda, D.J. et al 2010. Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology 59: 290-294.
-
(2010)
Neuropharmacology
, vol.59
, pp. 290-294
-
-
Bonda, D.J.1
-
95
-
-
33847192092
-
Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease
-
Ding, Q., E. Dimayuga & J.N. Keller 2007. Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease. Curr. Alzheimer Res. 4: 73-79.
-
(2007)
Curr. Alzheimer Res.
, vol.4
, pp. 73-79
-
-
Ding, Q.1
Dimayuga, E.2
Keller, J.N.3
-
96
-
-
0035875690
-
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
-
Praticò, D. et al 2001. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 21: 4183-4187.
-
(2001)
J. Neurosci.
, vol.21
, pp. 4183-4187
-
-
Praticò, D.1
-
97
-
-
39749113772
-
Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?
-
Naylor, R., A.F. Hill & K.J. Barnham 2008. Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible? Eur. Biophys. J. 37: 265-268.
-
(2008)
Eur. Biophys. J.
, vol.37
, pp. 265-268
-
-
Naylor, R.1
Hill, A.F.2
Barnham, K.J.3
-
98
-
-
33846811272
-
Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy
-
Arca, M. et al 2007. Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. Free Radic. Biol. Med. 42: 698-705.
-
(2007)
Free Radic. Biol. Med.
, vol.42
, pp. 698-705
-
-
Arca, M.1
-
99
-
-
38849150935
-
Mitochondrial oxidative stress causes hyperphosphorylation of tau
-
Melov, S. et al 2007. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS One 2: e536.
-
(2007)
PLoS One
, vol.2
-
-
Melov, S.1
-
100
-
-
84859496195
-
Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease
-
Cassano, T. et al 2011. Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiol. Aging 27. doi:
-
(2011)
Neurobiol. Aging
, vol.27
-
-
Cassano, T.1
-
101
-
-
73249128637
-
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity
-
Usui, K. et al 2009. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proc. Natl. Acad. Sci. USA 106: 18563-18568.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18563-18568
-
-
Usui, K.1
-
102
-
-
0033624797
-
7alpha-Hydroperoxycholesterol causes CNS neuronal cell death
-
Kolsch, H. et al 2000. 7alpha-Hydroperoxycholesterol causes CNS neuronal cell death. Neurochem. Int. 36: 507-512.
-
(2000)
Neurochem. Int.
, vol.36
, pp. 507-512
-
-
Kolsch, H.1
-
103
-
-
77953290487
-
Changes in brain cholesterol metabolome after excitotoxicity
-
Ong, W.Y. et al 2010. Changes in brain cholesterol metabolome after excitotoxicity. Mol. Neurobiol. 41: 299-313.
-
(2010)
Mol. Neurobiol.
, vol.41
, pp. 299-313
-
-
Ong, W.Y.1
-
104
-
-
46249124246
-
Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress
-
Ferrera, P. et al 2008. Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress. Neurochem. Res. 33: 1509-1517.
-
(2008)
Neurochem. Res.
, vol.33
, pp. 1509-1517
-
-
Ferrera, P.1
-
105
-
-
79955955895
-
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime
-
Gamba, P. et al 2011. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging Cell 10: 403-417.
-
(2011)
Aging Cell
, vol.10
, pp. 403-417
-
-
Gamba, P.1
|