메뉴 건너뛰기




Volumn 15, Issue 5, 2011, Pages 535-555

Neurobiological aspects of Alzheimer's disease

Author keywords

Alzheimer's disease; animal models; pathobiology; pharmacotherapy

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; AMYLOID BETA VACCINE; ANTIAMYLOID AGENT; ANTIOXIDANT; BERBERINE; CANNABINOID DERIVATIVE; CHOLINESTERASE INHIBITOR; CURCUMIN; DIMEBON; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DONEPEZIL; ESTROGEN; FERULIC ACID; GALANTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; MEMANTINE; NERVE GROWTH FACTOR; NEUROTOXIN; NEUROTROPHIC FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE INHIBITOR; RESVERATROL; RIVASTIGMINE; SELEGELINE; TACRINE; THIOCTIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; XALIPRODEN;

EID: 79954473644     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.2011.557363     Document Type: Review
Times cited : (50)

References (121)
  • 1
    • 35648944275 scopus 로고    scopus 로고
    • Alzheimer's disease; Taking the edge off with cannabinoids?
    • Campbell VA, Gowran A. Alzheimer's disease; taking the edge off with cannabinoids? Br J Pharmacol 2007;152:655-61
    • (2007) Br J Pharmacol , vol.152 , pp. 655-61
    • Campbell, V.A.1    Gowran, A.2
  • 2
    • 31544438866 scopus 로고    scopus 로고
    • Pathophysiology of Alzheimer's disease
    • DOI 10.1016/j.nic.2005.09.009, PII S1052514905001036, Alzheimer's Disease: 100 Years of Progress
    • Imbimbo BP, Lombard J, Pomara N. Pathophysiology of Alzheimer's disease. Neuroimaging Clin N Am 2005;15:727-53 (Pubitemid 43162374)
    • (2005) Neuroimaging Clinics of North America , vol.15 , Issue.4 , pp. 727-753
    • Imbimbo, B.P.1    Lombard, J.2    Pomara, N.3
  • 3
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • LaFerla FM, Green KN, Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 2007;8:499-509
    • (2007) Nat Rev Neurosci , vol.8 , pp. 499-509
    • Laferla, F.M.1    Green, K.N.2    Oddo, S.3
  • 4
    • 37449020071 scopus 로고    scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Yates D, McLoughlin DM. The molecular pathology of Alzheimer's disease. Psychiatry 2008;7:1-5
    • (2008) Psychiatry , vol.7 , pp. 1-5
    • Yates, D.1    McLoughlin, D.M.2
  • 5
    • 77049107343 scopus 로고    scopus 로고
    • Acetyl-L-Carnitine attenuates okadaic acid induced Tau hyperphosphorylation and spatial memory impairment in rats
    • Yin YY, Liu H, Cong XB, et al. Acetyl-L-Carnitine attenuates okadaic acid induced Tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimer Dis 2010;19(2):735-46
    • (2010) J Alzheimer Dis , vol.19 , Issue.2 , pp. 735-46
    • Yin, Y.Y.1    Liu, H.2    Cong, X.B.3
  • 6
    • 77951867859 scopus 로고    scopus 로고
    • Oxidative stress and Alzheimers disease: Dietary polyphenols as potential therapeutic agents
    • Darvesh AS, Carroll RT, Bishayee A, et al. Oxidative stress and Alzheimers disease: dietary polyphenols as potential therapeutic agents. Expert Rev Neurother 2010;10:729-45
    • (2010) Expert Rev Neurother , vol.10 , pp. 729-45
    • Darvesh, A.S.1    Carroll, R.T.2    Bishayee, A.3
  • 7
    • 45549109796 scopus 로고    scopus 로고
    • Inflammation, genes and zinc in Alzheimer's disease
    • Vasto S, Candore G, List F, et al. Inflammation, genes and zinc in Alzheimer's disease. Brain Res Rev 2008;58:96-105
    • (2008) Brain Res Rev , vol.58 , pp. 96-105
    • Vasto, S.1    Candore, G.2    List, F.3
  • 8
    • 27144511230 scopus 로고    scopus 로고
    • Beta-Amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease
    • Buttini M, Masliah E, Barbour R, et al. beta-Amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J Neurosci 2005;25(40):9096-10007
    • (2005) J Neurosci , vol.25 , Issue.40 , pp. 9096-10007
    • Buttini, M.1    Masliah, E.2    Barbour, R.3
  • 9
    • 34547667531 scopus 로고    scopus 로고
    • Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics
    • Cacabelos R Donepezil in Alzheimer's disease: from conventional trials to pharmacogenetics. Neuropsychiatr Dis Treat 2007;3:303-10
    • (2007) Neuropsychiatr Dis Treat , vol.3 , pp. 303-10
    • Cacabelos, R.1
  • 11
    • 1642358352 scopus 로고    scopus 로고
    • Alzheimer's disease: The two-hit hypothesis
    • DOI 10.1016/S1474-4422(04)00707-0, PII S1474442204007070
    • Zhu X, Raina AK, Perry G, et al. Alzheimer's disease: the two-hit hypothesis. Lancet Neurol 2004;3:219-26 (Pubitemid 38373660)
    • (2004) Lancet Neurology , vol.3 , Issue.4 , pp. 219-226
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4
  • 12
    • 41149153224 scopus 로고    scopus 로고
    • Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose: A potential contribution to Alzheimer's disease processes
    • Hua X, Lei M, Ding J, et al. Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose: a potential contribution to Alzheimer's disease processes. Exp Neurol 2008;210:709-18
    • (2008) Exp Neurol , vol.210 , pp. 709-18
    • Hua, X.1    Lei, M.2    Ding, J.3
  • 13
    • 0038103811 scopus 로고    scopus 로고
    • Altered hippocampal muscarinic receptors in acetylcholinesterase- deficient mice
    • DOI 10.1002/ana.10589
    • Volpicelli-Daley LA, Duysen EG, Lockridge O, et al. Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice. Ann Neurol 2003;53:788-96 (Pubitemid 36622517)
    • (2003) Annals of Neurology , vol.53 , Issue.6 , pp. 788-796
    • Volpicelli-Daley, L.A.1    Duysen, E.G.2    Lockridge, O.3    Levey, A.I.4
  • 14
    • 0037183534 scopus 로고    scopus 로고
    • Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
    • Darreh-Shori T, Almkvist O, Guan ZZ, et al. Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months. Neurology 2002;59:563-71
    • (2002) Neurology , vol.59 , pp. 563-71
    • Darreh-Shori, T.1    Almkvist, O.2    Guan, Z.Z.3
  • 15
    • 27744443298 scopus 로고    scopus 로고
    • Inhibition of hippocampal function in mild cognitive impairment: Targeting the cholinergic hypothesis
    • DOI 10.1016/j.neurobiolaging.2004.12.005, PII S0197458005000060
    • Gron G, Brandenburg I, Wunderlich AP, et al. Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiol Aging 2006;27:78-87 (Pubitemid 41627952)
    • (2006) Neurobiology of Aging , vol.27 , Issue.1 , pp. 78-87
    • Gron, G.1    Brandenburg, I.2    Wunderlich, A.P.3    Riepe, M.W.4
  • 16
    • 34447598807 scopus 로고
    • Zur cellulose-frage
    • Virchow R Zur cellulose-frage. Virchows Arch 1854;6:416-26
    • (1854) Virchows Arch , vol.6 , pp. 416-26
    • Virchow, R.1
  • 17
  • 18
    • 8744220663 scopus 로고    scopus 로고
    • Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases
    • Kayed R, Sokolov Y, Edmonds B, et al. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem 2004;279:46363-74
    • (2004) J Biol Chem , vol.279 , pp. 46363-74
    • Kayed, R.1    Sokolov, Y.2    Edmonds, B.3
  • 19
    • 0035297712 scopus 로고    scopus 로고
    • Targeting small A β oligomers: The solution to an Alzheimer's disease conundrum?
    • DOI 10.1016/S0166-2236(00)01749-5, PII S0166223600017495
    • Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? TRENDS Neurosci 2001;24:219-24 (Pubitemid 32204378)
    • (2001) Trends in Neurosciences , vol.24 , Issue.4 , pp. 219-224
    • Klein, W.L.1    Krafft, G.A.2    Finch, C.E.3
  • 20
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12:383-8
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-8
    • Hardy, J.1    Allsop, D.2
  • 21
    • 0033850407 scopus 로고    scopus 로고
    • Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
    • Buee L, Bussiere T, Buee-Scherrer V, et al. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 2000;33:95-130
    • (2000) Brain Res Rev , vol.33 , pp. 95-130
    • Buee, L.1    Bussiere, T.2    Buee-Scherrer, V.3
  • 22
    • 0344688272 scopus 로고    scopus 로고
    • Tau Phosphorylation tangles, and neurodegeneration: The chicken or the egg?
    • Geschwind DH. Tau Phosphorylation, tangles, and neurodegeneration: the chicken or the egg? Neuron 2003;40:457-60
    • (2003) Neuron , vol.40 , pp. 457-60
    • Geschwind, D.H.1
  • 23
    • 0033981060 scopus 로고    scopus 로고
    • The Oregon brain aging study: Neuropathology accompanying healthy aging in the oldest old
    • Green MS, Kaye JA, Ball MJ. The Oregon brain aging study: neuropathology accompanying healthy aging in the oldest old. Neurology 2000;54:105-13 (Pubitemid 30038746)
    • (2000) Neurology , vol.54 , Issue.1 , pp. 105-113
    • Green, M.S.1    Kaye, J.A.2    Ball, M.J.3
  • 25
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • DOI 10.1016/S0896-6273(02)00706-7
    • Jackson GR, Wiedau-Pazos M, Sang TK, et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 2002;34:509-19 (Pubitemid 34628749)
    • (2002) Neuron , vol.34 , Issue.4 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.-K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 26
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • DOI 10.1016/S0896-6273(03)00627-5
    • Cruz JC, Tseng HC, Goldman JA, et al. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 2003;40:471-83 (Pubitemid 37494698)
    • (2003) Neuron , vol.40 , Issue.3 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.-C.2    Goldman, J.A.3    Shih, H.4    Tsai, L.-H.5
  • 32
    • 20044367108 scopus 로고    scopus 로고
    • Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • DOI 10.1523/JNEUROSCI.4637-04.2005
    • Andorfer C, Acker CM, Kress Y, et al. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 2005;25:5446-54 (Pubitemid 40770926)
    • (2005) Journal of Neuroscience , vol.25 , Issue.22 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3    Hof, P.R.4    Duff, K.5    Davies, P.6
  • 33
    • 0035851175 scopus 로고    scopus 로고
    • Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice
    • Kins S, Crameri A, Evans DRH, et al. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem 2001;276:38193-206
    • (2001) J Biol Chem , vol.276 , pp. 38193-206
    • Kins, S.1    Crameri, A.2    Drh, E.3
  • 34
    • 77958114712 scopus 로고    scopus 로고
    • Some current insights into oxidative stress
    • Durakova Z. Some current insights into oxidative stress. Physiol Res 2010;59:459-69
    • (2010) Physiol Res , vol.59 , pp. 459-69
    • Durakova, Z.1
  • 35
    • 84899547370 scopus 로고    scopus 로고
    • Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors
    • Guglielmotto M, Giliberto L, Tamagno E, et al. Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front Aging Neurosci 2010;2:3
    • (2010) Front Aging Neurosci , vol.2 , pp. 3
    • Guglielmotto, M.1    Giliberto, L.2    Tamagno, E.3
  • 36
    • 45249120152 scopus 로고    scopus 로고
    • Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice
    • Gu F, Zhu M, Shi J, et al. Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice. Neurosci Lett 2008;440:44-8
    • (2008) Neurosci Lett , vol.440 , pp. 44-8
    • Gu, F.1    Zhu, M.2    Shi, J.3
  • 38
    • 0025670273 scopus 로고
    • Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: A case-control study
    • Perrin R, Briancon S, Jeandel C, et al. Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study. Gerontology 1990;36:306-13
    • (1990) Gerontology , vol.36 , pp. 306-13
    • Perrin, R.1    Briancon, S.2    Jeandel, C.3
  • 39
    • 0035875690 scopus 로고    scopus 로고
    • Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
    • Pratico D, Uryu K, Leight S, et al. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci 2001;21:4183-92
    • (2001) J Neurosci , vol.21 , pp. 4183-92
    • Pratico, D.1    Uryu, K.2    Leight, S.3
  • 40
    • 0031944692 scopus 로고    scopus 로고
    • Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
    • Pappolla MA, Chyan YJ, Omar RA, et al. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am J Pathol 1998;152:871-83
    • (1998) Am J Pathol , vol.152 , pp. 871-83
    • Pappolla, M.A.1    Chyan, Y.J.2    Omar, R.A.3
  • 41
    • 0034213186 scopus 로고    scopus 로고
    • The evolution of free radicals and oxidative stress
    • DOI 10.1016/S0002-9343(00)00412-5, PII S0002934300004125
    • McCord JM. The evolution of free radicals and oxidative stress. Am J Med 2000;108:652-9 (Pubitemid 30336605)
    • (2000) American Journal of Medicine , vol.108 , Issue.8 , pp. 652-659
    • McCord, J.M.1
  • 42
    • 0036145348 scopus 로고    scopus 로고
    • Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB
    • DOI 10.1046/j.1523-1755.2002.00123.x
    • Onozato ML, Tojo A, Goto A, et al. Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney Int 2002;61:186-94 (Pubitemid 34075146)
    • (2002) Kidney International , vol.61 , Issue.1 , pp. 186-194
    • Onozato, M.L.1    Tojo, A.2    Goto, A.3    Fujita, T.4    Wilcox, C.S.5
  • 43
    • 0034986361 scopus 로고    scopus 로고
    • Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier
    • DOI 10.1016/S0028-3908(01)00019-3, PII S0028390801000193
    • Gilgun-Sherki Y, Melamed E, Offen D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 2001;40:959-75 (Pubitemid 32530602)
    • (2001) Neuropharmacology , vol.40 , Issue.8 , pp. 959-975
    • Gilgun-Sherki, Y.1    Melamed, E.2    Offen, D.3
  • 44
    • 0036804710 scopus 로고    scopus 로고
    • Free radicals, antioxidants, and nutrition
    • DOI 10.1016/S0899-9007(02)00916-4, PII S0899900702009164
    • Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition 2002;18:872-9 (Pubitemid 35292261)
    • (2002) Nutrition , vol.18 , Issue.10 , pp. 872-879
    • Fang, Y.-Z.1    Yang, S.2    Wu, G.3
  • 45
    • 0035186746 scopus 로고    scopus 로고
    • Antioxidant activity and phenolic compounds in selected herbs
    • DOI 10.1021/jf010697n
    • Zheng W, Wang SY. Antioxidant activity and phenolic compounds in selected herbs. J Agric Food Chem 2001;49:5165-70 (Pubitemid 33089648)
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , Issue.11 , pp. 5165-5170
    • Zheng, W.1    Wang, S.Y.2
  • 46
    • 25444500410 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    • Rezai-Zadeh K, Shytle D, Sun N, et al. Green tea epigallocatechin-3- gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 2005;25:8807-18
    • (2005) J Neurosci , vol.25 , pp. 8807-18
    • Rezai-Zadeh, K.1    Shytle, D.2    Sun, N.3
  • 47
    • 33745209915 scopus 로고    scopus 로고
    • ADAM10 activation is required for green tea (-)-epigallocatechin-3- gallate-induced alpha-secretase cleavage of amyloid precursor protein
    • Obregon DF, Rezai-Zadeh K, Bai Y, et al. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. J Biol Chem 2006;281:16419-28
    • (2006) J Biol Chem , vol.281 , pp. 16419-28
    • Obregon, D.F.1    Rezai-Zadeh, K.2    Bai, Y.3
  • 48
    • 63049091276 scopus 로고    scopus 로고
    • Flavonoid mediated presenilin 1 phosphorylation reduces Alzheimer's disease amyloid production
    • Rezai Zadeh K, Douglas Shytle R, Bai Y, et al. Flavonoid mediated presenilin 1 phosphorylation reduces Alzheimer's disease amyloid production. J Cell Mol Med 2009;13:574-88
    • (2009) J Cell Mol Med , vol.13 , pp. 574-88
    • Rezai Zadeh, K.1    Douglas Shytle, R.2    Bai, Y.3
  • 49
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • DOI 10.1038/nrn2038, PII NRN2038
    • Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007;8:57-69 (Pubitemid 46011999)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 50
    • 0034785349 scopus 로고    scopus 로고
    • The benefits and hazards of antioxidants: Controlling apoptosis and other protective mechanisms in cancer patients and the human population
    • Salganik RI. The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr 2001;20(Suppl 5):464-77
    • (2001) J Am Coll Nutr , vol.20 , Issue.SUPPL. 5 , pp. 464-77
    • Salganik, R.I.1
  • 51
    • 0036753272 scopus 로고    scopus 로고
    • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
    • DOI 10.1016/S0197-4580(01)00340-2, PII S0197458001003402
    • Allan Butterfield D, Castegna A, Lauderback CM. Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 2002;23:655-64 (Pubitemid 35217687)
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 655-664
    • Allan Butterfield, D.1    Castegna, A.2    Lauderback, C.M.3    Drake, J.4
  • 52
    • 0026647763 scopus 로고    scopus 로고
    • Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress
    • Floyd RA, Carney JM. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 2004;32:S22-7
    • (2004) Ann Neurol , vol.32
    • Floyd, R.A.1    Carney, J.M.2
  • 53
    • 34047173074 scopus 로고    scopus 로고
    • Mitochondrial bioenergetics and structural network organization
    • Benard G, Bellance N, James D, et al. Mitochondrial bioenergetics and structural network organization. J Cell Sci 2007;120:838-49
    • (2007) J Cell Sci , vol.120 , pp. 838-49
    • Benard, G.1    Bellance, N.2    James, D.3
  • 54
    • 0032502866 scopus 로고    scopus 로고
    • Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: The impact of irreversible permeability transition
    • DOI 10.1016/S0014-5793(98)00318-4, PII S0014579398003184
    • Petit PX, Goubern M, Diolez P, et al. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett 1998;426:111-16 (Pubitemid 28198166)
    • (1998) FEBS Letters , vol.426 , Issue.1 , pp. 111-116
    • Petit, P.X.1    Goubern, M.2    Diolez, P.3    Susin, S.A.4    Zamzami, N.5    Kroemer, G.6
  • 55
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • DOI 10.1016/S0092-8674(00)80085-9
    • Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c Cell 1996;86:147-57 (Pubitemid 26256586)
    • (1996) Cell , vol.86 , Issue.1 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 56
    • 18744431459 scopus 로고    scopus 로고
    • Mitochondrial control of neuron death and its role in neurodegenerative disorders
    • Jordan J, Cena V, Prehn JHM. Mitochondrial control of neuron death and its role in neurodegenerative disorders. J Physiol Biochem 2003;59:129-41
    • (2003) J Physiol Biochem , vol.59 , pp. 129-41
    • Jordan, J.1    Cena, V.2    Prehn, J.H.M.3
  • 58
    • 33745902534 scopus 로고    scopus 로고
    • Ca2+-dependent mechanisms of presynaptic control at central synapses
    • Rusakov DA. Ca2+-dependent mechanisms of presynaptic control at central synapses. Neuroscientist 2006;12:317-28
    • (2006) Neuroscientist , vol.12 , pp. 317-28
    • Rusakov, D.A.1
  • 59
    • 23044503665 scopus 로고    scopus 로고
    • Mitochondria and neurotransmission: Evacuating the synapse
    • DOI 10.1016/j.neuron.2005.07.017, PII S0896627305006112
    • Hollenbeck PJ. Mitochondria and neurotransmission: evacuating the synapse. Neuron 2005;47:331-3 (Pubitemid 41073874)
    • (2005) Neuron , vol.47 , Issue.3 , pp. 331-333
    • Hollenbeck, P.J.1
  • 60
    • 69249211284 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
    • Hauptmann S, Scherping I, Drose S, et al. Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 2009;30:1574-86
    • (2009) Neurobiol Aging , vol.30 , pp. 1574-86
    • Hauptmann, S.1    Scherping, I.2    Drose, S.3
  • 61
    • 17344371804 scopus 로고    scopus 로고
    • Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
    • Keller JN, Kindy MS, Holtsberg FW, et al. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 1998;18:687-98
    • (1998) J Neurosci , vol.18 , pp. 687-98
    • Keller, J.N.1    Kindy, M.S.2    Holtsberg, F.W.3
  • 64
    • 0030754962 scopus 로고    scopus 로고
    • 4-hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
    • DOI 10.1016/S0306-4522(97)00065-1, PII S0306452297000651
    • Keller JN, Mark RJ, Bruce AJ, et al. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience 1997;80:685-96 (Pubitemid 27334614)
    • (1997) Neuroscience , vol.80 , Issue.3 , pp. 685-696
    • Keller, J.N.1    Mark, R.J.2    Bruce, A.J.3    Blanc, E.4    Rothstein, J.D.5    Uchida, K.6    Waeg, G.7    Mattson, M.P.8
  • 65
    • 77954755957 scopus 로고    scopus 로고
    • Mitochondrial biology in Alzheimer's disease pathogenesis
    • Galindo MF, Ikuta I, Zhu X, et al. Mitochondrial biology in Alzheimer's disease pathogenesis. J Neurochem 2010;114:933-45
    • (2010) J Neurochem , vol.114 , pp. 933-45
    • Galindo, M.F.1    Ikuta, I.2    Zhu, X.3
  • 66
    • 51449084024 scopus 로고    scopus 로고
    • Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease
    • Maczurek A, Hager K, Kenklies M, et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev 2008;60:1463-70
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1463-70
    • MacZurek, A.1    Hager, K.2    Kenklies, M.3
  • 67
    • 34848890388 scopus 로고    scopus 로고
    • Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
    • Mini-Forum "Mitochondria in Alzheimer Disease"
    • Moreira PI, Harris PLR, Zhu X, et al. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimer Dis 2007;12:195-206 (Pubitemid 47509369)
    • (2007) Journal of Alzheimer's Disease , vol.12 , Issue.2 , pp. 195-206
    • Moreira, P.I.1    Harris, P.L.R.2    Zhu, X.3    Santos, M.S.4    Oliveira, C.R.5    Smith, M.A.6    Perry, G.7
  • 71
    • 0041784698 scopus 로고    scopus 로고
    • Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria
    • DOI 10.1385/MN:27:3:325
    • Brown GC, Bal-PriceA. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 2003;27:325-55 (Pubitemid 38156291)
    • (2003) Molecular Neurobiology , vol.27 , Issue.3 , pp. 325-355
    • Brown, G.C.1    Bal-Price, A.2
  • 73
    • 22244458574 scopus 로고    scopus 로고
    • Neuroscience: Brain under surveillance: The microglia patrol
    • Fetler L, Amigorena S. Neuroscience: brain under surveillance: the microglia patrol. Science 2005;309:392-402
    • (2005) Science , vol.309 , pp. 392-402
    • Fetler, L.1    Amigorena, S.2
  • 74
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
    • Liu B, Hong JS. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 2003;304:1-11
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1-11
    • Liu, B.1    Hong, J.S.2
  • 76
    • 44149083565 scopus 로고    scopus 로고
    • Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease: Alzheimer's Review Series
    • DOI 10.1111/j.1582-4934.2008.00314.x
    • Farfara D, Lifshitz V, Frenkel D. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease. J Cell Mol Med 2008;12:762-80 (Pubitemid 351718063)
    • (2008) Journal of Cellular and Molecular Medicine , vol.12 , Issue.3 , pp. 762-780
    • Farfara, D.1    Lifshitz, V.2    Frenkel, D.3
  • 77
    • 0037089102 scopus 로고    scopus 로고
    • APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy
    • De Giorgio LA, Shimizu Y, Chun HS, et al. APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy. Glia 2002;38:174-8
    • (2002) Glia , vol.38 , pp. 174-8
    • De Giorgio, L.A.1    Shimizu, Y.2    Chun, H.S.3
  • 79
    • 0034667558 scopus 로고    scopus 로고
    • CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
    • Tan J, Town T, Mori T, et al. CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. J Neurosci 2000;20:7587-95
    • (2000) J Neurosci , vol.20 , pp. 7587-95
    • Tan, J.1    Town, T.2    Mori, T.3
  • 83
    • 0035866060 scopus 로고    scopus 로고
    • Beta-Amyloid stimulation of microglia and monocytes results in TNF alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs CK, Karlo JC, Kao SC. beta-Amyloid stimulation of microglia and monocytes results in TNF alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001;21:1179-85
    • (2001) J Neurosci , vol.21 , pp. 1179-85
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3
  • 85
    • 0037427384 scopus 로고    scopus 로고
    • Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    • DOI 10.1016/S0006-8993(03)02361-8
    • Nagele RG, D'Andrea MR, Lee H, et al. Astrocytes accumulate Abeta42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res 2003;971:197-209 (Pubitemid 36423321)
    • (2003) Brain Research , vol.971 , Issue.2 , pp. 197-209
    • Nagele, R.G.1    D'Andrea, M.R.2    Lee, H.3    Venkataraman, V.4    Wang, H.-Y.5
  • 86
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • DOI 10.1016/j.jneuroim.2006.11.017, PII S016557280600470X, Inflammation, Neurodegeneration and Neuroprotection in the Central Nervous System
    • Heneka MT, O'Banion MK. Inflammatory processes in Alzheimer's disease. J Neuroimmunol 2007;184:69-91 (Pubitemid 46365992)
    • (2007) Journal of Neuroimmunology , vol.184 , Issue.1-2 , pp. 69-91
    • Heneka, M.T.1    O'Banion, M.K.2
  • 87
    • 26044437911 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway
    • DOI 10.1016/j.bbi.2005.03.015, PII S0889159105000668
    • Pavlov VA, Tracey KJ. The cholinergic anti-inflammatory pathway. Brain Behav Immun 2005;19:493-9 (Pubitemid 41407697)
    • (2005) Brain, Behavior, and Immunity , vol.19 , Issue.6 , pp. 493-499
    • Pavlov, V.A.1    Tracey, K.J.2
  • 88
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • DOI 10.1016/j.neuron.2006.01.022, PII S0896627306000754
    • Simard AR, Soulet D, Gowing G, et al. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006;49:489-502 (Pubitemid 43221886)
    • (2006) Neuron , vol.49 , Issue.4 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 89
    • 0035283321 scopus 로고    scopus 로고
    • Expression and function of inducible nitric oxide synthase in neurons
    • DOI 10.1016/S0165-5728(01)00246-6, PII S0165572801002466
    • Heneka MT, Feinstein DL. Expression and function of inducible nitric oxide synthase in neurons. J Neuroimmunol 2001;114:8-18 (Pubitemid 32184720)
    • (2001) Journal of Neuroimmunology , vol.114 , Issue.1-2 , pp. 8-18
    • Heneka, M.T.1    Feinstein, D.L.2
  • 91
  • 92
    • 0034638270 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
    • DOI 10.1016/S0306-4522(00)00200-1, PII S0306452200002001
    • Lesort M, Johnson GVW. Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons. Neuroscience 2000;99:305-16 (Pubitemid 30628418)
    • (2000) Neuroscience , vol.99 , Issue.2 , pp. 305-316
    • Lesort, M.1    Johnson, G.V.W.2
  • 93
    • 0043127453 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
    • Schubert M, Brazil DP, Burks DJ, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003;23:7084-90
    • (2003) J Neurosci , vol.23 , pp. 7084-90
    • Schubert, M.1    Brazil, D.P.2    Burks, D.J.3
  • 94
    • 0034928074 scopus 로고    scopus 로고
    • Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPsw mice
    • Mori T, Paris D, Town T, et al. Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPsw mice. J Neuropathol Exp Neurol 2001;60:778-84
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 778-84
    • Mori, T.1    Paris, D.2    Town, T.3
  • 95
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer disease: Preliminary results
    • Sparks DL, Sabbagh MN, Connor DJ, et al. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 2005;62:753-60
    • (2005) Arch Neurol , vol.62 , pp. 753-60
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3
  • 96
    • 0029924266 scopus 로고    scopus 로고
    • Apolipoprotein E. structure, function, and possible roles in Alzheimer's disease
    • Mahley RW, Nathan BP, Pitas RE. Apolipoprotein E. structure, function, and possible roles in Alzheimer's disease. Ann NY Acad Sci 1996;777:139-45
    • (1996) Ann NY Acad Sci , vol.777 , pp. 139-45
    • Mahley, R.W.1    Nathan, B.P.2    Pitas, R.E.3
  • 97
    • 33750215920 scopus 로고    scopus 로고
    • Role of Amyloid precursor protein, amyloid-and-secretase in cholesterol maintenance
    • Hartmann T. Role of Amyloid precursor protein, amyloid-and-secretase in cholesterol maintenance. Cell Mech Alzheimer Dis 2006;3:305-10
    • (2006) Cell Mech Alzheimer Dis , vol.3 , pp. 305-10
    • Hartmann, T.1
  • 98
    • 3242701593 scopus 로고    scopus 로고
    • Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
    • DOI 10.1111/j.0009-9163.2004.00280.x
    • Wellington CL. Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism. Clin Genet 2004;66:1-16 (Pubitemid 38960816)
    • (2004) Clinical Genetics , vol.66 , Issue.1 , pp. 1-16
    • Wellington, C.L.1
  • 99
    • 31144450053 scopus 로고    scopus 로고
    • Current pharmacotherapy for Alzheimer's disease
    • DOI 10.1146/annurev.med.57.121304.131442
    • Lleo A, Greenberg SM, Growdon JH. Current pharmacotherapy for Alzheimer's disease. Annu Rev Med 2006;57:513-33 (Pubitemid 43262005)
    • (2006) Annual Review of Medicine , vol.57 , pp. 513-533
    • Lleo, A.1    Greenberg, S.M.2    Growdon, J.H.3
  • 100
    • 10044270820 scopus 로고    scopus 로고
    • Combination therapy in Alzheimer's disease: A review of current evidence
    • DOI 10.2165/00023210-200418130-00001
    • Schmitt B, Bernhardt T, Moeller HJ, et al. Combination therapy in Alzheimers disease: a review of current evidence. CNS Drugs 2004;18:827-44 (Pubitemid 39612014)
    • (2004) CNS Drugs , vol.18 , Issue.13 , pp. 827-844
    • Schmitt, B.1    Bernhardt, T.2    Moeller, H.-J.3    Heuser, I.4    Frolich, L.5
  • 101
    • 0021155081 scopus 로고
    • The variable topography of Alzheimer type changes in senile dementia and normal old age
    • Ulrich J, Stahelin HB. The variable topography of Alzheimer type changes in senile dementia and normal old age. Gerontology 1984;30:210-4 (Pubitemid 14089745)
    • (1984) Gerontology , vol.30 , Issue.4 , pp. 210-214
    • Ulrich, J.1    Stahelin, H.B.2
  • 103
    • 77954427486 scopus 로고    scopus 로고
    • Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease
    • Grothe M, Zaborszky L, Atienza M, et al. Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease. Cerebral Cortex 2010;20:1685-95
    • (2010) Cerebral Cortex , vol.20 , pp. 1685-95
    • Grothe, M.1    Zaborszky, L.2    Atienza, M.3
  • 104
    • 0024346318 scopus 로고    scopus 로고
    • Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats
    • Fischer W, Gage FH, Bjorklund A. Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. Eur J Neurosci 2006;1:34-45
    • (2006) Eur J Neurosci , vol.1 , pp. 34-45
    • Fischer, W.1    Gage, F.H.2    Bjorklund, A.3
  • 106
    • 0024529370 scopus 로고
    • Impaired sympathetic nervous system response to cognitive effort in early Alzheimer's disease
    • Borson S, Barnes RF, Veith RC, et al. Impaired sympathetic nervous system response to cognitive effort in early Alzheimer's disease. J Gerontology 1989;44:M8-12
    • (1989) J Gerontology , vol.44
    • Borson, S.1    Barnes, R.F.2    Veith, R.C.3
  • 107
    • 0008276623 scopus 로고
    • Interventional approaches to memory
    • In: Martinez JR Kesner RP editors Academic Press Orlando, FL
    • Olton DS. Interventional approaches to memory. In: Martinez JR, Kesner RP, editors, Lesions in learning and memory: a biological view. Academic Press, Orlando, FL; 1986. p. 379-97
    • (1986) Lesions in Learning and Memory: A Biological View , pp. 379-97
    • Olton, D.S.1
  • 108
    • 0019864493 scopus 로고
    • Recovery of function after neurotoxic damage to the hippocampal CA3 region: Importance of postoperative recovery interval and task experience
    • Handelmann GE, Olton DS. Recovery of function after neurotoxic damage to the hippocampal CA3 region: importance of postoperative recovery interval and task experience. Behav Neural Biol 1981;33:453-64 (Pubitemid 12175952)
    • (1981) Behavioral and Neural Biology , vol.33 , Issue.4 , pp. 453-464
    • Handelmann, G.E.1    Olton, D.S.2
  • 109
    • 0020640626 scopus 로고
    • Neurotoxic action of kainic acid
    • Coyle JT. Neurotoxic action of kainic acid. J Neurochem 1983;41:1-11 (Pubitemid 13064890)
    • (1983) Journal of Neurochemistry , vol.41 , Issue.1 , pp. 1-11
    • Coyle, J.T.1
  • 110
    • 0022477025 scopus 로고
    • Effects of scopolamine and unilateral lesions of the basal forebrain on T-maze spatial discrimination and alternation in rats
    • Beninger RJ, Jhamandas K, Boegman RJ, et al. Effects of scopolamine and unilateral lesions of the basal forebrain on T-maze spatial discrimination and alternation in rats. Pharmacol Biochem Behav 1986;24:1353-60 (Pubitemid 16067421)
    • (1986) Pharmacology Biochemistry and Behavior , vol.24 , Issue.5 , pp. 1353-1360
    • Beninger, R.J.1    Jhamandas, K.2    Boegman, R.J.3    El-Defrawy, S.R.4
  • 111
    • 0019950117 scopus 로고    scopus 로고
    • Neurofibrillary axonal pathology in aluminum intoxication
    • Troncoso JC, Price DL, Griffin JW, et al. Neurofibrillary axonal pathology in aluminum intoxication. Ann Neurol 2004;12:278-83
    • (2004) Ann Neurol , vol.12 , pp. 278-83
    • Troncoso, J.C.1    Price, D.L.2    Griffin, J.W.3
  • 112
    • 0024447802 scopus 로고
    • An hypothesis on the role of glucose in the mechanism of action of cognitive enhancers
    • Wenk GL. An hypothesis on the role of glucose in the mechanism of action of cognitive enhancers. Psychopharmacology 1989;99:431-8 (Pubitemid 19273095)
    • (1989) Psychopharmacology , vol.99 , Issue.4 , pp. 431-438
    • Wenk, G.L.1
  • 113
    • 0037063709 scopus 로고    scopus 로고
    • Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats
    • DOI 10.1016/S0024-3205(02)02083-0, PII S0024320502020830
    • Sharma M, Gupta YK. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 2002;71:2489-98 (Pubitemid 35251893)
    • (2002) Life Sciences , vol.71 , Issue.21 , pp. 2489-2498
    • Sharma, M.1    Gupta, Y.K.2
  • 115
    • 0023691731 scopus 로고
    • Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics
    • Bialojan C, Takai A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem J 1988;256:283-90
    • (1988) Biochem J , vol.256 , pp. 283-90
    • Bialojan, C.1    Takai, A.2
  • 116
    • 0032924417 scopus 로고    scopus 로고
    • Effects of calyculin A and okadaic acid on acetylcholine release and subcellular distribution in rat hippocampal formation
    • Issa AM, Gauthier S, Collier B. Effects of calyculin A and okadaic acid on acetylcholine release and subcellular distribution in rat hippocampal formation. J Neurochem 2002;72:166-73
    • (2002) J Neurochem , vol.72 , pp. 166-73
    • Issa, A.M.1    Gauthier, S.2    Collier, B.3
  • 117
    • 0345700240 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices
    • DOI 10.1016/S0304-3940(03)00096-X
    • Gong CX, Wang JZ, Iqbal K, et al. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci Lett 2003;340:107-10 (Pubitemid 36369286)
    • (2003) Neuroscience Letters , vol.340 , Issue.2 , pp. 107-110
    • Gong, C.-X.1    Wang, J.-Z.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 118
    • 0028316539 scopus 로고
    • Intracerebroventricular but not intraperitoneal administration of aluminum attenuates vasopressin-enhanced retrieval of a passive avoidance task in rats
    • DOI 10.1016/0091-3057(94)90163-5
    • Bernstein HG, Schwartzberg H, Poeggel G, et al. Intracerebroventricular but not intraperitonial administration of aluminium attenuates vasopressin-enhanced retrieval of a passive avoidance task in rats. Pharmacol Biochem Behav 1994;47:587-90 (Pubitemid 24077729)
    • (1994) Pharmacology Biochemistry and Behavior , vol.47 , Issue.3 , pp. 587-590
    • Bernstein, H.-G.1    Schwarzberg, H.2    Poeggel, G.3    Reiser, M.4
  • 119
    • 0036344646 scopus 로고    scopus 로고
    • Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats
    • DOI 10.1016/S0091-3057(02)00838-9, PII S0091305702008389
    • Kumar MVK, Gupta YK. Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats. Pharmacol Biochem Behav 2002;73:565-71 (Pubitemid 34879162)
    • (2002) Pharmacology Biochemistry and Behavior , vol.73 , Issue.3 , pp. 565-571
    • Veerendra Kumar, M.H.1    Gupta, Y.K.2
  • 120
    • 34548142159 scopus 로고    scopus 로고
    • Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type
    • Kumar A, Seghal N, Naidu PS, et al. Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Pharmacol Rep 2007;59:274-82
    • (2007) Pharmacol Rep , vol.59 , pp. 274-82
    • Kumar, A.1    Seghal, N.2    Naidu, P.S.3
  • 121
    • 75649108560 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease
    • Elder GA, Sosa MAG, De Gasperi R. Transgenic mouse models of Alzheimer's disease. Mt Sinai J Med 2010;77:69-81
    • (2010) Mt Sinai J Med , vol.77 , pp. 69-81
    • Elder, G.A.1    Mag, S.2    De Gasperi, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.