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Volumn 4, Issue 12, 2005, Pages 841-852

Cholesterol in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; ATORVASTATIN; CERIVASTATIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; MEVINOLIN; PLACEBO; SIMVASTATIN;

EID: 27744602604     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(05)70248-9     Document Type: Review
Times cited : (288)

References (150)
  • 1
    • 0032916242 scopus 로고    scopus 로고
    • Aging and the occurrence of dementia: Findings from a population-based cohort with a large sample of nonagenarians
    • E Von Strauss, M Viitanen, D De Ronchi, B Winblad, L Fratiglioni Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians Arch Neurol 56 1999 587 592
    • (1999) Arch Neurol , vol.56 , pp. 587-592
    • Von Strauss, E.1    Viitanen, M.2    De Ronchi, D.3    Winblad, B.4    Fratiglioni, L.5
  • 2
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
    • R Brookmeyer, S Gray, C Kawas Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset Am J Public Health 88 1998 1337 1342
    • (1998) Am J Public Health , vol.88 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 3
    • 1242331823 scopus 로고    scopus 로고
    • Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    • JC De la Torre Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics Lancet Neurol 3 2004 184 190
    • (2004) Lancet Neurol , vol.3 , pp. 184-190
    • De La Torre, J.C.1
  • 4
    • 0036130159 scopus 로고    scopus 로고
    • Small vessel disease and Alzheimer's dementia: Pathological considerations
    • RN Kalaria Small vessel disease and Alzheimer's dementia: pathological considerations Cerebrovasc Dis 13 suppl 2 2002 48 52
    • (2002) Cerebrovasc Dis , vol.13 , Issue.2 SUPPL. , pp. 48-52
    • Kalaria, R.N.1
  • 5
    • 0036144081 scopus 로고    scopus 로고
    • Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
    • SE Vermeer, PJ Koudstaal, M Oudkerk, A Hofman, MM Breteler Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study Stroke 33 2002 21 25
    • (2002) Stroke , vol.33 , pp. 21-25
    • Vermeer, S.E.1    Koudstaal, P.J.2    Oudkerk, M.3    Hofman, A.4    Breteler, M.M.5
  • 6
    • 0034021375 scopus 로고    scopus 로고
    • Vascular involvement in cognitive decline and dementia: Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study
    • MM Breteler Vascular involvement in cognitive decline and dementia: epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study Ann N Y Acad Sci 903 2000 457 465
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 457-465
    • Breteler, M.M.1
  • 7
    • 0034603524 scopus 로고    scopus 로고
    • Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia
    • JS Meyer, G Rauch, RA Rauch, A Haque Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia Neurobiol Aging 21 2000 161 169
    • (2000) Neurobiol Aging , vol.21 , pp. 161-169
    • Meyer, J.S.1    Rauch, G.2    Rauch, R.A.3    Haque, A.4
  • 9
    • 4444313311 scopus 로고    scopus 로고
    • Effect of vascular lesions on cognition in Alzheimer's disease: A community-based study
    • RG Riekse, JB Leverenz, W McCormick Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study J Am Geriatr Soc 52 2004 1442 1448
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1442-1448
    • Riekse, R.G.1    Leverenz, J.B.2    McCormick, W.3
  • 10
    • 3142758462 scopus 로고    scopus 로고
    • Links between the pathology of Alzheimer's disease and vascular dementia
    • M Sadowski, J Pankiewicz, H Scholtzova Links between the pathology of Alzheimer's disease and vascular dementia Neurochem Res 29 2004 1257 1266
    • (2004) Neurochem Res , vol.29 , pp. 1257-1266
    • Sadowski, M.1    Pankiewicz, J.2    Scholtzova, H.3
  • 11
    • 0035954333 scopus 로고    scopus 로고
    • Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
    • M Kivipelto, EL Helkala, T Hanninen Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study Neurology 56 2001 1683 1689
    • (2001) Neurology , vol.56 , pp. 1683-1689
    • Kivipelto, M.1    Helkala, E.L.2    Hanninen, T.3
  • 12
    • 0037322079 scopus 로고    scopus 로고
    • Dietary fats and the risk of incident Alzheimer disease
    • MC Morris, DA Evans, JL Bienias Dietary fats and the risk of incident Alzheimer disease Arch Neurol 60 2003 194 200
    • (2003) Arch Neurol , vol.60 , pp. 194-200
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3
  • 13
    • 0031976318 scopus 로고    scopus 로고
    • Serum total cholesterol, apolipoprotein e epsilon 4 allele, and Alzheimer's disease
    • IL Notkola, R Sulkava, J Pekkanen Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease Neuroepidemiology 17 1998 14 20
    • (1998) Neuroepidemiology , vol.17 , pp. 14-20
    • Notkola, I.L.1    Sulkava, R.2    Pekkanen, J.3
  • 14
    • 0035160066 scopus 로고    scopus 로고
    • A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
    • LM Refolo, MA Pappolla, J LaFrancois A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease Neurobiol Dis 8 2001 890 899
    • (2001) Neurobiol Dis , vol.8 , pp. 890-899
    • Refolo, L.M.1    Pappolla, M.A.2    Lafrancois, J.3
  • 15
    • 0842303768 scopus 로고    scopus 로고
    • Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
    • M Heverin, N Bogdanovic, D Lutjohann Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease J Lipid Res 45 2004 186 193
    • (2004) J Lipid Res , vol.45 , pp. 186-193
    • Heverin, M.1    Bogdanovic, N.2    Lutjohann, D.3
  • 16
    • 12244255799 scopus 로고    scopus 로고
    • ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    • MA Wollmer, JR Streffer, D Lutjohann ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease Neurobiol Aging 24 2003 421 426
    • (2003) Neurobiol Aging , vol.24 , pp. 421-426
    • Wollmer, M.A.1    Streffer, J.R.2    Lutjohann, D.3
  • 17
    • 0036138648 scopus 로고    scopus 로고
    • 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
    • A Papassotiropoulos, D Lutjohann, M Bagli 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia J Psychiatr Res 36 2002 27 32
    • (2002) J Psychiatr Res , vol.36 , pp. 27-32
    • Papassotiropoulos, A.1    Lutjohann, D.2    Bagli, M.3
  • 18
    • 0035856407 scopus 로고    scopus 로고
    • On the turnover of brain cholesterol in patients with Alzheimer's disease: Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
    • N Bogdanovic, L Bretillon, EG Lund On the turnover of brain cholesterol in patients with Alzheimer's disease: abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells Neurosci Lett 314 2001 45 48
    • (2001) Neurosci Lett , vol.314 , pp. 45-48
    • Bogdanovic, N.1    Bretillon, L.2    Lund, E.G.3
  • 19
    • 0037052771 scopus 로고    scopus 로고
    • Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls
    • P Schonknecht, D Lutjohann, J Pantel Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls Neurosci Lett 324 2002 83 85
    • (2002) Neurosci Lett , vol.324 , pp. 83-85
    • Schonknecht, P.1    Lutjohann, D.2    Pantel, J.3
  • 21
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    • K Rockwood, S Kirkland, DB Hogan Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people Arch Neurol 59 2002 223 227
    • (2002) Arch Neurol , vol.59 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.B.3
  • 22
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme a reductase inhibitors
    • B Wolozin, W Kellman, P Ruosseau, GG Celesia, G Siegel Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors Arch Neurol 57 2000 1439 1443
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 23
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • K Yaffe, E Barrett-Connor, F Lin, D Grady Serum lipoprotein levels, statin use, and cognitive function in older women Arch Neurol 59 2002 378 384
    • (2002) Arch Neurol , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Connor, E.2    Lin, F.3    Grady, D.4
  • 24
    • 13244295723 scopus 로고    scopus 로고
    • Do statins reduce risk of incident dementia and Alzheimer disease? the Cache County Study
    • PP Zandi, DL Sparks, AS Khachaturian Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study Arch Gen Psychiatry 62 2005 217 224
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 217-224
    • Zandi, P.P.1    Sparks, D.L.2    Khachaturian, A.S.3
  • 25
    • 22844431778 scopus 로고    scopus 로고
    • Statin use and the risk of incident dementia: The Cardiovascular Health Study
    • TD Rea, JC Breitner, BM Psaty Statin use and the risk of incident dementia: the Cardiovascular Health Study Arch Neurol 62 2005 1047 1051
    • (2005) Arch Neurol , vol.62 , pp. 1047-1051
    • Rea, T.D.1    Breitner, J.C.2    Psaty, B.M.3
  • 26
    • 8644239495 scopus 로고    scopus 로고
    • Statin therapy and risk of dementia in the elderly: A community-based prospective cohort study
    • G Li, R Higdon, WA Kukull Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study Neurology 63 2004 1624 1628
    • (2004) Neurology , vol.63 , pp. 1624-1628
    • Li, G.1    Higdon, R.2    Kukull, W.A.3
  • 27
    • 0036305918 scopus 로고    scopus 로고
    • The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment
    • I Hajjar, J Schumpert, V Hirth, D Wieland, GP Eleazer The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment J Gerontol A Biol Sci Med Sci 57 2002 M414 M418
    • (2002) J Gerontol a Biol Sci Med Sci , vol.57
    • Hajjar, I.1    Schumpert, J.2    Hirth, V.3    Wieland, D.4    Eleazer, G.P.5
  • 28
    • 0037710127 scopus 로고    scopus 로고
    • Cholesterol homeostasis and function in neurons of the central nervous system
    • FW Pfrieger Cholesterol homeostasis and function in neurons of the central nervous system Cell Mol Life Sci 60 2003 1158 1171
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1158-1171
    • Pfrieger, F.W.1
  • 29
    • 0027298061 scopus 로고
    • Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats
    • J Poirier, A Baccichet, D Dea, S Gauthier Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats Neuroscience 55 1993 81 90
    • (1993) Neuroscience , vol.55 , pp. 81-90
    • Poirier, J.1    Baccichet, A.2    Dea, D.3    Gauthier, S.4
  • 31
    • 23444447665 scopus 로고    scopus 로고
    • Pleiotropic effects of statins in atherosclerosis: Role on endothelial function, inflammation and immunomodulation
    • C Arnaud, F Mach Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation Arch Mal Coeur Vaiss 98 2005 661 666
    • (2005) Arch Mal Coeur Vaiss , vol.98 , pp. 661-666
    • Arnaud, C.1    MacH, F.2
  • 32
    • 14044278778 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors and coenzyme Q10
    • JJ Nawarskas HMG-CoA reductase inhibitors and coenzyme Q10 Cardiol Rev 13 2005 76 79
    • (2005) Cardiol Rev , vol.13 , pp. 76-79
    • Nawarskas, J.J.1
  • 33
    • 21844435776 scopus 로고    scopus 로고
    • High-dose statins and skeletal muscle metabolism in humans: A randomized, controlled trial
    • H Paiva, KM Thelen, R Van Coster High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial Clin Pharmacol Ther 78 2005 60 68
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 60-68
    • Paiva, H.1    Thelen, K.M.2    Van Coster, R.3
  • 34
    • 0035826795 scopus 로고    scopus 로고
    • A fluid connection: Cholesterol and Abeta
    • B Wolozin A fluid connection: cholesterol and Abeta Proc Natl Acad Sci USA 98 2001 5371 5373
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5371-5373
    • Wolozin, B.1
  • 35
    • 0037359765 scopus 로고    scopus 로고
    • Apolipoprotein e and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease
    • J Poirier Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease Trends Mol Med 9 2003 94 101
    • (2003) Trends Mol Med , vol.9 , pp. 94-101
    • Poirier, J.1
  • 36
    • 0028801536 scopus 로고
    • Cholesterol for synthesis of myelin is made locally, not imported into brain
    • H Jurevics, P Morell Cholesterol for synthesis of myelin is made locally, not imported into brain J Neurochem 64 1995 895 901
    • (1995) J Neurochem , vol.64 , pp. 895-901
    • Jurevics, H.1    Morell, P.2
  • 37
    • 0004982358 scopus 로고
    • Apolipoprotein e mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets
    • NA Elshourbagy, WS Liao, RW Mahley, JM Taylor Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets Proc Natl Acad Sci USA 82 1985 203 207
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 203-207
    • Elshourbagy, N.A.1    Liao, W.S.2    Mahley, R.W.3    Taylor, J.M.4
  • 38
    • 0034663336 scopus 로고    scopus 로고
    • Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo
    • AM Fagan, DM Holtzman Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo Microsc Res Tech 50 2000 297 304
    • (2000) Microsc Res Tech , vol.50 , pp. 297-304
    • Fagan, A.M.1    Holtzman, D.M.2
  • 40
    • 0004821712 scopus 로고    scopus 로고
    • Plasma 24S-hydroxycholesterol: A peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease
    • A Papassotiropoulos, D Lutjohann, M Bagli Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease Neuroreport 11 2000 1959 1962
    • (2000) Neuroreport , vol.11 , pp. 1959-1962
    • Papassotiropoulos, A.1    Lutjohann, D.2    Bagli, M.3
  • 41
    • 4544282709 scopus 로고    scopus 로고
    • Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
    • H Kolsch, R Heun, A Kerksiek Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients Neurosci Lett 368 2004 303 308
    • (2004) Neurosci Lett , vol.368 , pp. 303-308
    • Kolsch, H.1    Heun, R.2    Kerksiek, A.3
  • 42
    • 0242384924 scopus 로고    scopus 로고
    • Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: Formation of nascent high density lipoprotein particles
    • L Liu, AE Bortnick, M Nickel Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles J Biol Chem 278 2003 42976 42984
    • (2003) J Biol Chem , vol.278 , pp. 42976-42984
    • Liu, L.1    Bortnick, A.E.2    Nickel, M.3
  • 43
    • 0036301461 scopus 로고    scopus 로고
    • Increased ABCA1 activity protects against atherosclerosis
    • RR Singaraja, C Fievet, G Castro Increased ABCA1 activity protects against atherosclerosis J Clin Invest 110 2002 35 42
    • (2002) J Clin Invest , vol.110 , pp. 35-42
    • Singaraja, R.R.1    Fievet, C.2    Castro, G.3
  • 44
    • 0036488074 scopus 로고    scopus 로고
    • ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels
    • KY Zwarts, SM Clee, AH Zwinderman ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels Clin Genet 61 2002 115 125
    • (2002) Clin Genet , vol.61 , pp. 115-125
    • Zwarts, K.Y.1    Clee, S.M.2    Zwinderman, A.H.3
  • 45
    • 13244278285 scopus 로고    scopus 로고
    • Genotypic effect of the -565C→T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis
    • T Kyriakou, C Hodgkinson, DE Pontefract Genotypic effect of the -565C→T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis Arterioscler Thromb Vasc Biol 25 2005 418 423
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 418-423
    • Kyriakou, T.1    Hodgkinson, C.2    Pontefract, D.E.3
  • 46
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    • RP Koldamova, IM Lefterov, MD Ikonomovic 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion J Biol Chem 278 2003 13244 13256
    • (2003) J Biol Chem , vol.278 , pp. 13244-13256
    • Koldamova, R.P.1    Lefterov, I.M.2    Ikonomovic, M.D.3
  • 47
    • 4644295495 scopus 로고    scopus 로고
    • Deficiency of ABCA1 impairs apolipoprotein e metabolism in brain
    • V Hirsch-Reinshagen, S Zhou, BL Burgess Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain J Biol Chem 279 2004 41197 41207
    • (2004) J Biol Chem , vol.279 , pp. 41197-41207
    • Hirsch-Reinshagen, V.1    Zhou, S.2    Burgess, B.L.3
  • 48
    • 4644361588 scopus 로고    scopus 로고
    • ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE
    • SE Wahrle, H Jiang, M Parsadanian ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE J Biol Chem 279 2004 40987 40993
    • (2004) J Biol Chem , vol.279 , pp. 40987-40993
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3
  • 49
    • 14844319827 scopus 로고    scopus 로고
    • MRNA expression of the ATP-binding cassette transporter subfamily a (ABCA) in rat and human brain capillary endothelial cells
    • S Ohtsuki, Y Watanabe, S Hori mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells Biol Pharm Bull 27 2004 1437 1440
    • (2004) Biol Pharm Bull , vol.27 , pp. 1437-1440
    • Ohtsuki, S.1    Watanabe, Y.2    Hori, S.3
  • 50
    • 0037044840 scopus 로고    scopus 로고
    • ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells
    • U Panzenboeck, Z Balazs, A Sovic ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells J Biol Chem 277 2002 42781 42789
    • (2002) J Biol Chem , vol.277 , pp. 42781-42789
    • Panzenboeck, U.1    Balazs, Z.2    Sovic, A.3
  • 51
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • M Ujiie, DL Dickstein, DA Carlow, WA Jefferies Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model Microcirculation 10 2003 463 470
    • (2003) Microcirculation , vol.10 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 52
    • 23744498856 scopus 로고    scopus 로고
    • Crossing the barrier: Net flux of 27-hydroxycholesterol into the human brain
    • M Heverin, S Meaney, D Lutjohann Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain J Lipid Res 46 2005 1047 1052
    • (2005) J Lipid Res , vol.46 , pp. 1047-1052
    • Heverin, M.1    Meaney, S.2    Lutjohann, D.3
  • 53
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • D Lutjohann, O Breuer, G Ahlborg Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation Proc Natl Acad Sci USA 93 1996 9799 9804
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3
  • 54
    • 0141700567 scopus 로고    scopus 로고
    • Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
    • V Leoni, T Masterman, P Patel Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers J Lipid Res 44 2003 793 799
    • (2003) J Lipid Res , vol.44 , pp. 793-799
    • Leoni, V.1    Masterman, T.2    Patel, P.3
  • 55
    • 0343775806 scopus 로고    scopus 로고
    • Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
    • D Lutjohann, A Papassotiropoulos, I Bjorkhem Plasma 24S- hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients J Lipid Res 41 2000 195 198
    • (2000) J Lipid Res , vol.41 , pp. 195-198
    • Lutjohann, D.1    Papassotiropoulos, A.2    Bjorkhem, I.3
  • 56
    • 0036128358 scopus 로고    scopus 로고
    • Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: Evidence that simvastatin affects cholesterol metabolism in the human brain
    • S Locatelli, D Lutjohann, HH Schmidt Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain Arch Neurol 59 2002 213 216
    • (2002) Arch Neurol , vol.59 , pp. 213-216
    • Locatelli, S.1    Lutjohann, D.2    Schmidt, H.H.3
  • 57
    • 1642525647 scopus 로고    scopus 로고
    • Diagnostic use of cerebral and extracerebral oxysterols
    • V Leoni, T Masterman, FS Mousavi Diagnostic use of cerebral and extracerebral oxysterols Clin Chem Lab Med 42 2004 186 191
    • (2004) Clin Chem Lab Med , vol.42 , pp. 186-191
    • Leoni, V.1    Masterman, T.2    Mousavi, F.S.3
  • 58
    • 0033833354 scopus 로고    scopus 로고
    • Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
    • LM Refolo, B Malester, J LaFrancois Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model Neurobiol Dis 7 2000 321 331
    • (2000) Neurobiol Dis , vol.7 , pp. 321-331
    • Refolo, L.M.1    Malester, B.2    Lafrancois, J.3
  • 59
    • 0037171095 scopus 로고    scopus 로고
    • Diet-induced hypercholesterolemia enhances brain a beta accumulation in transgenic mice
    • FS Shie, LW Jin, DG Cook, JB Leverenz, RC LeBoeuf Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice Neuroreport 13 2002 455 459
    • (2002) Neuroreport , vol.13 , pp. 455-459
    • Shie, F.S.1    Jin, L.W.2    Cook, D.G.3    Leverenz, J.B.4    Leboeuf, R.C.5
  • 60
    • 0034098980 scopus 로고    scopus 로고
    • Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation: Preliminary observations
    • DL Sparks, YM Kuo, A Roher, T Martin, RJ Lukas Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation: preliminary observations Ann N Y Acad Sci 903 2000 335 344
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 335-344
    • Sparks, D.L.1    Kuo, Y.M.2    Roher, A.3    Martin, T.4    Lukas, R.J.5
  • 61
    • 0035826909 scopus 로고    scopus 로고
    • Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10
    • E Kojro, G Gimpl, S Lammich, W Marz, F Fahrenholz Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10 Proc Natl Acad Sci USA 98 2001 5815 5820
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5815-5820
    • Kojro, E.1    Gimpl, G.2    Lammich, S.3    Marz, W.4    Fahrenholz, F.5
  • 62
    • 0032568552 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    • M Simons, P Keller, B De Strooper Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons Proc Natl Acad Sci USA 95 1998 6460 6464
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6460-6464
    • Simons, M.1    Keller, P.2    De Strooper, B.3
  • 63
    • 0036180950 scopus 로고    scopus 로고
    • Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains
    • S Wahrle, P Das, AC Nyborg Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains Neurobiol Dis 9 2002 11 23
    • (2002) Neurobiol Dis , vol.9 , pp. 11-23
    • Wahrle, S.1    Das, P.2    Nyborg, A.C.3
  • 64
    • 17644429206 scopus 로고    scopus 로고
    • Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content
    • M Racchi, R Baetta, N Salvietti Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content Biochem J 322 1997 893 898
    • (1997) Biochem J , vol.322 , pp. 893-898
    • Racchi, M.1    Baetta, R.2    Salvietti, N.3
  • 65
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
    • S Bodovitz, WL Klein Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein J Biol Chem 271 1996 4436 4440
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 66
    • 0344288278 scopus 로고    scopus 로고
    • Amyloid beta-protein interactions with membranes and cholesterol: Causes or casualties of Alzheimer's disease
    • W Gibson Wood, GP Eckert, U Igbavboa, WE Muller Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease Biochim Biophys Acta 1610 2003 281 290
    • (2003) Biochim Biophys Acta , vol.1610 , pp. 281-290
    • Gibson Wood, W.1    Eckert, G.P.2    Igbavboa, U.3    Muller, W.E.4
  • 67
    • 0037171006 scopus 로고    scopus 로고
    • Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice
    • H Hayashi, U Igbavboa, H Hamanaka Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice Neuroreport 13 2002 383 386
    • (2002) Neuroreport , vol.13 , pp. 383-386
    • Hayashi, H.1    Igbavboa, U.2    Hamanaka, H.3
  • 68
    • 0029935694 scopus 로고    scopus 로고
    • Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice
    • U Igbavboa, NA Avdulov, F Schroeder, WG Wood Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice J Neurochem 66 1996 1717 1725
    • (1996) J Neurochem , vol.66 , pp. 1717-1725
    • Igbavboa, U.1    Avdulov, N.A.2    Schroeder, F.3    Wood, W.G.4
  • 69
    • 0037333737 scopus 로고    scopus 로고
    • Statin effects on cholesterol micro-domains in brain plasma membranes
    • C Kirsch, GP Eckert, WE Mueller Statin effects on cholesterol micro-domains in brain plasma membranes Biochem Pharmacol 65 2003 843 856
    • (2003) Biochem Pharmacol , vol.65 , pp. 843-856
    • Kirsch, C.1    Eckert, G.P.2    Mueller, W.E.3
  • 70
    • 0142241380 scopus 로고    scopus 로고
    • Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain
    • K Zou, D Kim, A Kakio Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain J Neurochem 87 2003 609 619
    • (2003) J Neurochem , vol.87 , pp. 609-619
    • Zou, K.1    Kim, D.2    Kakio, A.3
  • 71
    • 0242383360 scopus 로고    scopus 로고
    • Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis
    • J McLaurin, AA Darabie, MR Morrison Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis Pharmacopsychiatry 36 suppl 2 2003 S130 S135
    • (2003) Pharmacopsychiatry , vol.36 , Issue.2 SUPPL.
    • McLaurin, J.1    Darabie, A.A.2    Morrison, M.R.3
  • 73
    • 0141886877 scopus 로고    scopus 로고
    • Niemann-Pick disease type C
    • MT Vanier, G Millat Niemann-Pick disease type C Clin Genet 64 2003 269 281
    • (2003) Clin Genet , vol.64 , pp. 269-281
    • Vanier, M.T.1    Millat, G.2
  • 74
    • 0032923260 scopus 로고    scopus 로고
    • Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia
    • MG Spillantini, M Tolnay, S Love, M Goedert Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia Acta Neuropathol (Berl) 97 1999 585 594
    • (1999) Acta Neuropathol (Berl) , vol.97 , pp. 585-594
    • Spillantini, M.G.1    Tolnay, M.2    Love, S.3    Goedert, M.4
  • 75
    • 1842615071 scopus 로고    scopus 로고
    • Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease
    • Y Saito, K Suzuki, CM Hulette, S Murayama Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease J Neuropathol Exp Neurol 63 2004 323 328
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 323-328
    • Saito, Y.1    Suzuki, K.2    Hulette, C.M.3    Murayama, S.4
  • 76
    • 0034925263 scopus 로고    scopus 로고
    • Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons
    • R Distl, V Meske, TG Ohm Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons Acta Neuropathol (Berl) 101 2001 547 554
    • (2001) Acta Neuropathol (Berl) , vol.101 , pp. 547-554
    • Distl, R.1    Meske, V.2    Ohm, T.G.3
  • 77
    • 0038701804 scopus 로고    scopus 로고
    • Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain
    • R Distl, S Treiber-Held, F Albert Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain J Pathol 200 2003 104 111
    • (2003) J Pathol , vol.200 , pp. 104-111
    • Distl, R.1    Treiber-Held, S.2    Albert, F.3
  • 78
    • 0028840239 scopus 로고
    • Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease
    • IA Auer, ML Schmidt, VM Lee Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease Acta Neuropathol (Berl) 90 1995 547 551
    • (1995) Acta Neuropathol (Berl) , vol.90 , pp. 547-551
    • Auer, I.A.1    Schmidt, M.L.2    Lee, V.M.3
  • 79
    • 0141484478 scopus 로고    scopus 로고
    • Accumulation of flotillin-1 in tangle-bearing neurones of Alzheimer's disease
    • N Girardot, B Allinquant, D Langui Accumulation of flotillin-1 in tangle-bearing neurones of Alzheimer's disease Neuropathol Appl Neurobiol 29 2003 451 461
    • (2003) Neuropathol Appl Neurobiol , vol.29 , pp. 451-461
    • Girardot, N.1    Allinquant, B.2    Langui, D.3
  • 80
    • 14844321855 scopus 로고    scopus 로고
    • Cholesterol homeostasis failure as a unifying cause of synaptic degeneration
    • AR Koudinov, NV Koudinova Cholesterol homeostasis failure as a unifying cause of synaptic degeneration J Neurol Sci 229-230 2005 233 240
    • (2005) J Neurol Sci , vol.229-230 , pp. 233-240
    • Koudinov, A.R.1    Koudinova, N.V.2
  • 81
    • 0037235059 scopus 로고    scopus 로고
    • Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: Implications for Alzheimer's disease
    • V Meske, F Albert, D Richter, J Schwarze, TG Ohm Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease Eur J Neurosci 17 2003 93 102
    • (2003) Eur J Neurosci , vol.17 , pp. 93-102
    • Meske, V.1    Albert, F.2    Richter, D.3    Schwarze, J.4    Ohm, T.G.5
  • 82
    • 0035142852 scopus 로고    scopus 로고
    • Cholesterol-dependent modulation of tau phosphorylation in cultured neurons
    • QW Fan, W Yu, T Senda, K Yanagisawa, M Michikawa Cholesterol-dependent modulation of tau phosphorylation in cultured neurons J Neurochem 76 2001 391 400
    • (2001) J Neurochem , vol.76 , pp. 391-400
    • Fan, Q.W.1    Yu, W.2    Senda, T.3    Yanagisawa, K.4    Michikawa, M.5
  • 83
    • 0031026879 scopus 로고    scopus 로고
    • Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
    • A Hofman, A Ott, MM Breteler Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study Lancet 349 1997 151 154
    • (1997) Lancet , vol.349 , pp. 151-154
    • Hofman, A.1    Ott, A.2    Breteler, M.M.3
  • 84
    • 0031054674 scopus 로고    scopus 로고
    • Brain infarction and the clinical expression of Alzheimer disease: The Nun Study
    • DA Snowdon, LH Greiner, JA Mortimer Brain infarction and the clinical expression of Alzheimer disease: the Nun Study JAMA 277 1997 813 817
    • (1997) JAMA , vol.277 , pp. 813-817
    • Snowdon, D.A.1    Greiner, L.H.2    Mortimer, J.A.3
  • 85
    • 0030610591 scopus 로고    scopus 로고
    • High frequency of apolipoprotein e epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy
    • JA Nicoll, C Burnett, S Love High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy Ann Neurol 41 1997 716 721
    • (1997) Ann Neurol , vol.41 , pp. 716-721
    • Nicoll, J.A.1    Burnett, C.2    Love, S.3
  • 86
    • 0034719506 scopus 로고    scopus 로고
    • Apolipoprotein e genotype and the risk of recurrent lobar intracerebral hemorrhage
    • HC O'Donnell, J Rosand, KA Knudsen Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage N Engl J Med 342 2000 240 245
    • (2000) N Engl J Med , vol.342 , pp. 240-245
    • O'Donnell, H.C.1    Rosand, J.2    Knudsen, K.A.3
  • 87
    • 0034123538 scopus 로고    scopus 로고
    • Apolipoprotein e facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
    • DM Holtzman, AM Fagan, B Mackey Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model Ann Neurol 47 2000 739 747
    • (2000) Ann Neurol , vol.47 , pp. 739-747
    • Holtzman, D.M.1    Fagan, A.M.2    MacKey, B.3
  • 88
    • 4143063440 scopus 로고    scopus 로고
    • Apolipoprotein e dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease
    • RB DeMattos Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease J Mol Neurosci 23 2004 255 262
    • (2004) J Mol Neurosci , vol.23 , pp. 255-262
    • Demattos, R.B.1
  • 89
    • 0030833577 scopus 로고    scopus 로고
    • Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: Implications for cerebral amyloid angiopathy
    • B Urmoneit, I Prikulis, G Wihl Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy Lab Invest 77 1997 157 166
    • (1997) Lab Invest , vol.77 , pp. 157-166
    • Urmoneit, B.1    Prikulis, I.2    Wihl, G.3
  • 90
    • 13544268338 scopus 로고    scopus 로고
    • Genetic-morphologic association study: Association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy
    • M Christoforidis, R Schober, K Krohn Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy Neuropathol Appl Neurobiol 31 2005 11 19
    • (2005) Neuropathol Appl Neurobiol , vol.31 , pp. 11-19
    • Christoforidis, M.1    Schober, R.2    Krohn, K.3
  • 91
    • 0037031125 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    • M Kivipelto, EL Helkala, MP Laakso Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease Ann Intern Med 137 2002 149 155
    • (2002) Ann Intern Med , vol.137 , pp. 149-155
    • Kivipelto, M.1    Helkala, E.L.2    Laakso, M.P.3
  • 92
    • 0029072551 scopus 로고
    • Interactions of apolipoprotein e genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
    • GP Jarvik, EM Wijsman, WA Kukull Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study Neurology 45 1995 1092 1096
    • (1995) Neurology , vol.45 , pp. 1092-1096
    • Jarvik, G.P.1    Wijsman, E.M.2    Kukull, W.A.3
  • 93
    • 12444340438 scopus 로고    scopus 로고
    • Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
    • MA Pappolla, TK Bryant-Thomas, D Herbert Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology Neurology 61 2003 199 205
    • (2003) Neurology , vol.61 , pp. 199-205
    • Pappolla, M.A.1    Bryant-Thomas, T.K.2    Herbert, D.3
  • 94
    • 12744273863 scopus 로고    scopus 로고
    • Midlife cardiovascular risk factors and risk of dementia in late life
    • RA Whitmer, S Sidney, J Selby, SC Johnston, K Yaffe Midlife cardiovascular risk factors and risk of dementia in late life Neurology 64 2005 277 281
    • (2005) Neurology , vol.64 , pp. 277-281
    • Whitmer, R.A.1    Sidney, S.2    Selby, J.3    Johnston, S.C.4    Yaffe, K.5
  • 95
    • 0038115068 scopus 로고    scopus 로고
    • Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    • MC Morris, DA Evans, JL Bienias Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease Arch Neurol 60 2003 940 946
    • (2003) Arch Neurol , vol.60 , pp. 940-946
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3
  • 96
    • 0030775948 scopus 로고    scopus 로고
    • Dietary fat intake and the risk of incident dementia in the Rotterdam Study
    • S Kalmijn, LJ Launer, A Ott Dietary fat intake and the risk of incident dementia in the Rotterdam Study Ann Neurol 42 1997 776 782
    • (1997) Ann Neurol , vol.42 , pp. 776-782
    • Kalmijn, S.1    Launer, L.J.2    Ott, A.3
  • 97
    • 0037180207 scopus 로고    scopus 로고
    • Fish, meat, and risk of dementia: Cohort study
    • P Barberger-Gateau, L Letenneur, V Deschamps Fish, meat, and risk of dementia: cohort study Bmj 325 2002 932 933
    • (2002) Bmj , vol.325 , pp. 932-933
    • Barberger-Gateau, P.1    Letenneur, L.2    Deschamps, V.3
  • 98
    • 4544306972 scopus 로고    scopus 로고
    • Dietary factors and Alzheimer's disease
    • JA Luchsinger, R Mayeux Dietary factors and Alzheimer's disease Lancet Neurol 3 2004 579 587
    • (2004) Lancet Neurol , vol.3 , pp. 579-587
    • Luchsinger, J.A.1    Mayeux, R.2
  • 99
  • 100
    • 11044221394 scopus 로고    scopus 로고
    • Novel omega-3-derived local mediators in anti-inflammation and resolution
    • CN Serhan Novel omega-3-derived local mediators in anti-inflammation and resolution Pharmacol Ther 105 2005 7 21
    • (2005) Pharmacol Ther , vol.105 , pp. 7-21
    • Serhan, C.N.1
  • 101
    • 0027227341 scopus 로고
    • N-3 fatty acids from fish oil: Effects on plasma lipoproteins and hypertriglyceridemic patients
    • WE Connor, CA DeFrancesco, SL Connor N-3 fatty acids from fish oil: effects on plasma lipoproteins and hypertriglyceridemic patients Ann N Y Acad Sci 683 1993 16 34
    • (1993) Ann N Y Acad Sci , vol.683 , pp. 16-34
    • Connor, W.E.1    Defrancesco, C.A.2    Connor, S.L.3
  • 102
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • EH Corder, AM Saunders, WJ Strittmatter Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 103
    • 0032926539 scopus 로고    scopus 로고
    • Apolipoprotein e genetic variation and Alzheimer's disease. a meta-analysis
    • DC Rubinsztein, DF Easton Apolipoprotein E genetic variation and Alzheimer's disease. a meta-analysis Dement Geriatr Cogn Disord 10 1999 199 209
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 199-209
    • Rubinsztein, D.C.1    Easton, D.F.2
  • 104
    • 0036384169 scopus 로고    scopus 로고
    • Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    • H Kolsch, D Lutjohann, M Ludwig Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease Mol Psychiatry 7 2002 899 902
    • (2002) Mol Psychiatry , vol.7 , pp. 899-902
    • Kolsch, H.1    Lutjohann, D.2    Ludwig, M.3
  • 105
    • 0037008389 scopus 로고    scopus 로고
    • Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
    • P Desai, ST DeKosky, MI Kamboh Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease Neurosci Lett 328 2002 9 12
    • (2002) Neurosci Lett , vol.328 , pp. 9-12
    • Desai, P.1    Dekosky, S.T.2    Kamboh, M.I.3
  • 106
    • 0037227538 scopus 로고    scopus 로고
    • Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    • A Papassotiropoulos, JR Streffer, M Tsolaki Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism Arch Neurol 60 2003 29 35
    • (2003) Arch Neurol , vol.60 , pp. 29-35
    • Papassotiropoulos, A.1    Streffer, J.R.2    Tsolaki, M.3
  • 107
    • 2942740962 scopus 로고    scopus 로고
    • Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease
    • A Johansson, H Katzov, H Zetterberg Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease Hum Genet 114 2004 581 587
    • (2004) Hum Genet , vol.114 , pp. 581-587
    • Johansson, A.1    Katzov, H.2    Zetterberg, H.3
  • 108
    • 11144357626 scopus 로고    scopus 로고
    • Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism
    • H Katzov, K Chalmers, J Palmgren Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism Hum Mutat 23 2004 358 367
    • (2004) Hum Mutat , vol.23 , pp. 358-367
    • Katzov, H.1    Chalmers, K.2    Palmgren, J.3
  • 109
    • 3543119039 scopus 로고    scopus 로고
    • Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study
    • Y Li, K Tacey, L Doil Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study Neurosci Lett 366 2004 268 271
    • (2004) Neurosci Lett , vol.366 , pp. 268-271
    • Li, Y.1    Tacey, K.2    Doil, L.3
  • 110
    • 0141891169 scopus 로고    scopus 로고
    • Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype
    • M Causevic, N Ramoz, V Haroutunian, KL Davis, JD Buxbaum Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype J Neuropathol Exp Neurol 62 2003 999 1005
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 999-1005
    • Causevic, M.1    Ramoz, N.2    Haroutunian, V.3    Davis, K.L.4    Buxbaum, J.D.5
  • 111
    • 0042821639 scopus 로고    scopus 로고
    • Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease
    • H Kolsch, U Ptok, I Mohamed Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease Am J Med Genet B Neuropsychiatr Genet 121 2003 128 130
    • (2003) Am J Med Genet B Neuropsychiatr Genet , vol.121 , pp. 128-130
    • Kolsch, H.1    Ptok, U.2    Mohamed, I.3
  • 112
    • 0035807760 scopus 로고    scopus 로고
    • Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease
    • M Sanchez-Guerra, O Combarros, J Infante Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease Neurosci Lett 316 2001 17 20
    • (2001) Neurosci Lett , vol.316 , pp. 17-20
    • Sanchez-Guerra, M.1    Combarros, O.2    Infante, J.3
  • 113
    • 0031042451 scopus 로고    scopus 로고
    • Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein e in a Caucasian population
    • CL Lendon, CJ Talbot, NJ Craddock Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population Neurosci Lett 222 1997 187 190
    • (1997) Neurosci Lett , vol.222 , pp. 187-190
    • Lendon, C.L.1    Talbot, C.J.2    Craddock, N.J.3
  • 114
    • 0027477297 scopus 로고
    • Apolipoprotein e polymorphism is associated with plasma cholesterol response in a 7-day hospitalization study for metabolic and dietary control in NIDDM
    • K Murakami, M Shimizu, N Yamada Apolipoprotein E polymorphism is associated with plasma cholesterol response in a 7-day hospitalization study for metabolic and dietary control in NIDDM Diabetes Care 16 1993 564 569
    • (1993) Diabetes Care , vol.16 , pp. 564-569
    • Murakami, K.1    Shimizu, M.2    Yamada, N.3
  • 115
    • 0023764870 scopus 로고
    • Familial hypercholesterolemia and apolipoprotein E4
    • M Eto, K Watanabe, N Chonan, K Ishii Familial hypercholesterolemia and apolipoprotein E4 Atherosclerosis 72 1988 123 128
    • (1988) Atherosclerosis , vol.72 , pp. 123-128
    • Eto, M.1    Watanabe, K.2    Chonan, N.3    Ishii, K.4
  • 116
    • 1542614534 scopus 로고    scopus 로고
    • Apolipoprotein e gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia
    • K Luthra, M Tripathi, R Grover Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia Dement Geriatr Cogn Disord 17 2004 132 135
    • (2004) Dement Geriatr Cogn Disord , vol.17 , pp. 132-135
    • Luthra, K.1    Tripathi, M.2    Grover, R.3
  • 117
    • 0036219565 scopus 로고    scopus 로고
    • Association between apolipoprotein e genotype and Alzheimer disease in African American subjects
    • NR Graff-Radford, RC Green, RC Go Association between apolipoprotein E genotype and Alzheimer disease in African American subjects Arch Neurol 59 2002 594 600
    • (2002) Arch Neurol , vol.59 , pp. 594-600
    • Graff-Radford, N.R.1    Green, R.C.2    Go, R.C.3
  • 118
    • 5644241911 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 genotype as a risk factor for cognitive decline and dementia: Data from the Canadian Study of Health and Aging
    • GY Hsiung, AD Sadovnick, H Feldman Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging CMAJ 171 2004 863 867
    • (2004) CMAJ , vol.171 , pp. 863-867
    • Hsiung, G.Y.1    Sadovnick, A.D.2    Feldman, H.3
  • 119
    • 0027339923 scopus 로고
    • The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease
    • R Mayeux, Y Stern, R Ottman The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease Ann Neurol 34 1993 752 754
    • (1993) Ann Neurol , vol.34 , pp. 752-754
    • Mayeux, R.1    Stern, Y.2    Ottman, R.3
  • 120
    • 0027178862 scopus 로고
    • Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease
    • AM Saunders, AD Roses Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease Stroke 24 1993 1416 1417
    • (1993) Stroke , vol.24 , pp. 1416-1417
    • Saunders, A.M.1    Roses, A.D.2
  • 121
    • 0031839545 scopus 로고    scopus 로고
    • Risk estimates of dementia by apolipoprotein e genotypes from a population-based incidence study: The Rotterdam Study
    • AJ Slooter, M Cruts, S Kalmijn Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study Arch Neurol 55 1998 964 968
    • (1998) Arch Neurol , vol.55 , pp. 964-968
    • Slooter, A.J.1    Cruts, M.2    Kalmijn, S.3
  • 122
    • 0041834646 scopus 로고    scopus 로고
    • Genetic variation of the APOE promoter and outcome after head injury
    • CL Lendon, JM Harris, AL Pritchard Genetic variation of the APOE promoter and outcome after head injury Neurology 61 2003 683 685
    • (2003) Neurology , vol.61 , pp. 683-685
    • Lendon, C.L.1    Harris, J.M.2    Pritchard, A.L.3
  • 123
    • 0030770308 scopus 로고    scopus 로고
    • Association of apolipoprotein e polymorphism with outcome after head injury
    • GM Teasdale, JA Nicoll, G Murray, M Fiddes Association of apolipoprotein E polymorphism with outcome after head injury Lancet 350 1997 1069 1071
    • (1997) Lancet , vol.350 , pp. 1069-1071
    • Teasdale, G.M.1    Nicoll, J.A.2    Murray, G.3    Fiddes, M.4
  • 124
    • 2542523048 scopus 로고    scopus 로고
    • Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: From risk factors to disease modulators
    • B Borroni, S Archetti, C Agosti Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators Neurobiol Aging 25 2004 747 751
    • (2004) Neurobiol Aging , vol.25 , pp. 747-751
    • Borroni, B.1    Archetti, S.2    Agosti, C.3
  • 125
    • 2542422805 scopus 로고    scopus 로고
    • Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population
    • A Kabbara, N Payet, D Cottel Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population Neurosci Lett 363 2004 139 143
    • (2004) Neurosci Lett , vol.363 , pp. 139-143
    • Kabbara, A.1    Payet, N.2    Cottel, D.3
  • 126
    • 4344576749 scopus 로고    scopus 로고
    • Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease
    • M Ingelsson, J Jesneck, MC Irizarry, BT Hyman, GW Rebeck Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease Neurosci Lett 367 2004 228 231
    • (2004) Neurosci Lett , vol.367 , pp. 228-231
    • Ingelsson, M.1    Jesneck, J.2    Irizarry, M.C.3    Hyman, B.T.4    Rebeck, G.W.5
  • 127
    • 0343632390 scopus 로고    scopus 로고
    • No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
    • D Fallin, A Kundtz, T Town No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample Neurosci Lett 233 1997 145 147
    • (1997) Neurosci Lett , vol.233 , pp. 145-147
    • Fallin, D.1    Kundtz, A.2    Town, T.3
  • 128
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    • K Fassbender, M Simons, C Bergmann Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo Proc Natl Acad Sci USA 98 2001 5856 5861
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5856-5861
    • Fassbender, K.1    Simons, M.2    Bergmann, C.3
  • 129
    • 0034990260 scopus 로고    scopus 로고
    • Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide
    • JD Buxbaum, NS Geoghagen, LT Friedhoff Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide J Alzheimers Dis 3 2001 221 229
    • (2001) J Alzheimers Dis , vol.3 , pp. 221-229
    • Buxbaum, J.D.1    Geoghagen, N.S.2    Friedhoff, L.T.3
  • 130
    • 4143063543 scopus 로고    scopus 로고
    • Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding
    • S Parvathy, M Ehrlich, S Pedrini Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding J Neurochem 90 2004 1005 1010
    • (2004) J Neurochem , vol.90 , pp. 1005-1010
    • Parvathy, S.1    Ehrlich, M.2    Pedrini, S.3
  • 131
    • 0036121232 scopus 로고    scopus 로고
    • Statins inhibit a beta-neurotoxicity in vitro and a beta-induced vasoconstriction and inflammation in rat aortae
    • D Paris, KP Townsend, J Humphrey Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae Atherosclerosis 161 2002 293 299
    • (2002) Atherosclerosis , vol.161 , pp. 293-299
    • Paris, D.1    Townsend, K.P.2    Humphrey, J.3
  • 132
    • 0037331420 scopus 로고    scopus 로고
    • Pravastatin inhibits pro-inflammatory effects of Alzheimer's peptide Abeta(1-42) in glioma cell culture in vitro
    • YX Sun, M Crisby, S Lindgren, S Janciauskiene Pravastatin inhibits pro-inflammatory effects of Alzheimer's peptide Abeta(1-42) in glioma cell culture in vitro Pharmacol Res 47 2003 119 126
    • (2003) Pharmacol Res , vol.47 , pp. 119-126
    • Sun, Y.X.1    Crisby, M.2    Lindgren, S.3    Janciauskiene, S.4
  • 133
    • 0030832526 scopus 로고    scopus 로고
    • Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets
    • H Osamah, R Mira, S Sorina, K Shlomo, A Michael Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets Br J Clin Pharmacol 44 1997 77 83
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 77-83
    • Osamah, H.1    Mira, R.2    Sorina, S.3    Shlomo, K.4    Michael, A.5
  • 134
    • 2942558528 scopus 로고    scopus 로고
    • Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties
    • E Ongini, F Impagnatiello, A Bonazzi Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties Proc Natl Acad Sci USA 101 2004 8497 8502
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8497-8502
    • Ongini, E.1    Impagnatiello, F.2    Bonazzi, A.3
  • 135
    • 0034694774 scopus 로고    scopus 로고
    • Pravastatin down-regulates inflammatory mediators in human monocytes in vitro
    • O Grip, S Janciauskiene, S Lindgren Pravastatin down-regulates inflammatory mediators in human monocytes in vitro Eur J Pharmacol 410 2000 83 92
    • (2000) Eur J Pharmacol , vol.410 , pp. 83-92
    • Grip, O.1    Janciauskiene, S.2    Lindgren, S.3
  • 136
    • 4143102291 scopus 로고    scopus 로고
    • Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: A novel vasculoprotective function of statins
    • J Haendeler, J Hoffmann, AM Zeiher, S Dimmeler Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins Circulation 110 2004 856 861
    • (2004) Circulation , vol.110 , pp. 856-861
    • Haendeler, J.1    Hoffmann, J.2    Zeiher, A.M.3    Dimmeler, S.4
  • 137
    • 0036322869 scopus 로고    scopus 로고
    • Isoprenoids as mediators of the biological effects of statins
    • JK Liao Isoprenoids as mediators of the biological effects of statins J Clin Invest 110 2002 285 288
    • (2002) J Clin Invest , vol.110 , pp. 285-288
    • Liao, J.K.1
  • 138
    • 0141841612 scopus 로고    scopus 로고
    • High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    • S Kinlay, GG Schwartz, AG Olsson High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study Circulation 108 2003 1560 1566
    • (2003) Circulation , vol.108 , pp. 1560-1566
    • Kinlay, S.1    Schwartz, G.G.2    Olsson, A.G.3
  • 139
    • 0038443056 scopus 로고    scopus 로고
    • Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke
    • J Chen, ZG Zhang, Y Li Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke Ann Neurol 53 2003 743 751
    • (2003) Ann Neurol , vol.53 , pp. 743-751
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3
  • 140
    • 0348048790 scopus 로고    scopus 로고
    • Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: Evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase
    • G Tringali, M Vairano, C Dello Russo, P Preziosi, P Navarra Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase Neurosci Lett 354 2004 107 110
    • (2004) Neurosci Lett , vol.354 , pp. 107-110
    • Tringali, G.1    Vairano, M.2    Dello Russo, C.3    Preziosi, P.4    Navarra, P.5
  • 141
    • 3042640736 scopus 로고    scopus 로고
    • High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
    • D Lutjohann, M Stroick, T Bertsch High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs Steroids 69 2004 431 438
    • (2004) Steroids , vol.69 , pp. 431-438
    • Lutjohann, D.1    Stroick, M.2    Bertsch, T.3
  • 142
    • 4644308807 scopus 로고    scopus 로고
    • Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain
    • NB Chauhan, GJ Siegel, DL Feinstein Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain Neurochem Res 29 2004 1897 1911
    • (2004) Neurochem Res , vol.29 , pp. 1897-1911
    • Chauhan, N.B.1    Siegel, G.J.2    Feinstein, D.L.3
  • 143
    • 0037388527 scopus 로고    scopus 로고
    • Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease
    • GL Vega, MF Weiner, AM Lipton Reduction in levels of 24S- hydroxycholesterol by statin treatment in patients with Alzheimer disease Arch Neurol 60 2003 510 515
    • (2003) Arch Neurol , vol.60 , pp. 510-515
    • Vega, G.L.1    Weiner, M.F.2    Lipton, A.M.3
  • 144
    • 0036714243 scopus 로고    scopus 로고
    • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
    • M Simons, F Schwarzler, D Lutjohann Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial Ann Neurol 52 2002 346 350
    • (2002) Ann Neurol , vol.52 , pp. 346-350
    • Simons, M.1    Schwarzler, F.2    Lutjohann, D.3
  • 145
    • 20844457621 scopus 로고    scopus 로고
    • The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease
    • K Hoglund, KM Thelen, S Syversen The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease Dement Geriatr Cogn Disord 19 2005 256 265
    • (2005) Dement Geriatr Cogn Disord , vol.19 , pp. 256-265
    • Hoglund, K.1    Thelen, K.M.2    Syversen, S.3
  • 146
    • 0037262480 scopus 로고    scopus 로고
    • Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
    • M Sjogren, K Gustafsson, S Syversen Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein Dement Geriatr Cogn Disord 16 2003 25 30
    • (2003) Dement Geriatr Cogn Disord , vol.16 , pp. 25-30
    • Sjogren, M.1    Gustafsson, K.2    Syversen, S.3
  • 147
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 2002 7 22
    • (2002) Lancet , vol.360 , pp. 7-22
  • 148
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • J Shepherd, GJ Blauw, MB Murphy Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial Lancet 360 2002 1623 1630
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 149
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer disease: Preliminary results
    • DL Sparks, MN Sabbagh, DJ Connor Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results Arch Neurol 62 2005 753 757
    • (2005) Arch Neurol , vol.62 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3
  • 150
    • 0038381775 scopus 로고    scopus 로고
    • Statin-associated memory loss: Analysis of 60 case reports and review of the literature
    • LR Wagstaff, MW Mitton, BM Arvik, PM Doraiswamy Statin-associated memory loss: analysis of 60 case reports and review of the literature Pharmacotherapy 23 2003 871 880
    • (2003) Pharmacotherapy , vol.23 , pp. 871-880
    • Wagstaff, L.R.1    Mitton, M.W.2    Arvik, B.M.3    Doraiswamy, P.M.4


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