메뉴 건너뛰기




Volumn 19, Issue 1, 2010, Pages 353-372

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

Author keywords

Alzheimer's disease; Chelator; Diagnostic; Free radicals; Iron; Mild cognitive impairment (MCI); Oxidative stress; Pre clinical; Redox activity

Indexed keywords

AMYLOID BETA PROTEIN; CHELATING AGENT; FREE RADICAL; IRON;

EID: 75149152568     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1239     Document Type: Article
Times cited : (342)

References (88)
  • 1
    • 0031614624 scopus 로고    scopus 로고
    • Alzheimer disease
    • Smith MA (1998) Alzheimer disease. Int Rev Neurobiol 42, 1-54.
    • (1998) Int Rev Neurobiol , vol.42 , pp. 1-54
    • Smith, M.A.1
  • 3
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal
    • Hardy J (2006) Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J Alzheimers Dis 9, 151-153.
    • (2006) J Alzheimers Dis , vol.9 , pp. 151-153
    • Hardy, J.1
  • 4
    • 84880185178 scopus 로고    scopus 로고
    • Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now
    • Lee VM, Trojanowski JQ (2006) Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. J Alzheimers Dis 9, 257-262.
    • (2006) J Alzheimers Dis , vol.9 , pp. 257-262
    • Lee, V.M.1    Trojanowski, J.Q.2
  • 7
    • 0036829434 scopus 로고    scopus 로고
    • Amyloidbeta and tau serve antioxidant functions in the aging and Alzheimer brain
    • Smith MA, Casadesus G, Joseph JA, Perry G (2002) Amyloidbeta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med 33, 1194-1199.
    • (2002) Free Radic Biol Med , vol.33 , pp. 1194-1199
    • Smith, M.A.1    Casadesus, G.2    Joseph, J.A.3    Perry, G.4
  • 12
    • 27544484846 scopus 로고    scopus 로고
    • Are mitochondria critical in the pathogenesis of Alzheimer's disease?
    • Reddy PH, Beal MF (2005) Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res Brain Res Rev 49, 618-632.
    • (2005) Brain Res Brain Res Rev , vol.49 , pp. 618-632
    • Reddy, P.H.1    Beal, M.F.2
  • 13
    • 48749085779 scopus 로고    scopus 로고
    • Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients
    • Wang X, Su B, Fujioka H, Zhu X (2008) Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol 173, 470-482.
    • (2008) Am J Pathol , vol.173 , pp. 470-482
    • Wang, X.1    Su, B.2    Fujioka, H.3    Zhu, X.4
  • 14
    • 33747425960 scopus 로고    scopus 로고
    • Tau protein, the main component of paired helical filaments
    • Avila J (2006) Tau protein, the main component of paired helical filaments. J Alzheimers Dis 9, 171-175.
    • (2006) J Alzheimers Dis , vol.9 , pp. 171-175
    • Avila, J.1
  • 15
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA (1997) Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 150, 1933-1939.
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 16
    • 0036592637 scopus 로고    scopus 로고
    • Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle
    • Bowser R, Smith MA (2002) Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. J Alzheimers Dis 4, 249-254.
    • (2002) J Alzheimers Dis , vol.4 , pp. 249-254
    • Bowser, R.1    Smith, M.A.2
  • 17
    • 0033037948 scopus 로고    scopus 로고
    • Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer disease
    • McShea A, Wahl AF, Smith MA (1999) Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease. Med Hypotheses 52, 525-527.
    • (1999) Med Hypotheses , vol.52 , pp. 525-527
    • McShea, A.1    Wahl, A.F.2    Smith, M.A.3
  • 19
    • 0031776586 scopus 로고    scopus 로고
    • Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4- dinitrophenylhydrazine
    • Smith MA, Sayre LM, Anderson VE, Harris PL, Beal MF, Kowall N, Perry G (1998) Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4- dinitrophenylhydrazine. J Histochem Cytochem 46, 731-735.
    • (1998) J Histochem Cytochem , vol.46 , pp. 731-735
    • Smith, M.A.1    Sayre, L.M.2    Anderson, V.E.3    Harris, P.L.4    Beal, M.F.5    Kowall, N.6    Perry, G.7
  • 21
    • 0030989545 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
    • Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68, 2092-2097.
    • (1997) J Neurochem , vol.68 , pp. 2092-2097
    • Sayre, L.M.1    Zelasko, D.A.2    Harris, P.L.3    Perry, G.4    Salomon, R.G.5    Smith, M.A.6
  • 26
    • 84880190029 scopus 로고    scopus 로고
    • Oxidative stress and iron imbalance in Alzheimer disease: How rust became the fuss!
    • Smith MA (2006) Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss! J Alzheimers Dis 9, 305-308.
    • (2006) J Alzheimers Dis , vol.9 , pp. 305-308
    • Smith, M.A.1
  • 29
    • 2342429093 scopus 로고    scopus 로고
    • Oxidative stress in mild cognitive impairment and Alzheimer disease: A continuum
    • Mecocci P (2004) Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J Alzheimers Dis 6, 159-163.
    • (2004) J Alzheimers Dis , vol.6 , pp. 159-163
    • Mecocci, P.1
  • 34
    • 34648859471 scopus 로고    scopus 로고
    • Oxidative damage in mild cognitive impairment and early Alzheimer's disease
    • Lovell MA, Markesbery WR(2007) Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res 85, 3036-3040.
    • (2007) J Neurosci Res , vol.85 , pp. 3036-3040
    • Lovell, M.A.1    Markesbery, W.R.2
  • 35
    • 34548588380 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: Insights into the pro gression of this dementing disorder
    • Butterfield DA, Sultana R (2007) Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the pro gression of this dementing disorder. J Alzheimers Dis 12, 61-72.
    • (2007) J Alzheimers Dis , vol.12 , pp. 61-72
    • Butterfield, D.A.1    Sultana, R.2
  • 36
    • 0033301784 scopus 로고    scopus 로고
    • Dietary links to Alzheimer's disease: 1999 update
    • Grant WB (1999) Dietary links to Alzheimer's disease: 1999 update. J Alzheimers Dis 1, 197-201.
    • (1999) J Alzheimers Dis , vol.1 , pp. 197-201
    • Grant, W.B.1
  • 37
    • 0033301717 scopus 로고    scopus 로고
    • Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease
    • Smith MA, Petot GJ, Perry G (1999) Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease. J Alzheimers Dis 1, 203-206.
    • (1999) J Alzheimers Dis , vol.1 , pp. 203-206
    • Smith, M.A.1    Petot, G.J.2    Perry, G.3
  • 38
    • 0030885482 scopus 로고    scopus 로고
    • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    • Smith MA, Harris PL, Sayre LM, Perry G (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A 94, 9866-9868.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9866-9868
    • Smith, M.A.1    Harris, P.L.2    Sayre, L.M.3    Perry, G.4
  • 39
    • 0033964859 scopus 로고    scopus 로고
    • Situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
    • Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, SmithMA (2000) In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J Neurochem 74, 270-279.
    • (2000) J Neurochem , vol.74 , pp. 270-279
    • Sayre, L.M.1    Perry, G.2    Harris, P.L.3    Liu, Y.4    Schubert, K.A.5    Smith, M.A.6
  • 41
    • 44849129360 scopus 로고    scopus 로고
    • Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron
    • Lavados M, Guillon M, Mujica MC, Rojo LE, Fuentes P, Maccioni RB (2008) Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron. J Alzheimers Dis 13, 225-232.
    • (2008) J Alzheimers Dis , vol.13 , pp. 225-232
    • Lavados, M.1    Guillon, M.2    Mujica, M.C.3    Rojo, L.E.4    Fuentes, P.5    MacCioni, R.B.6
  • 42
    • 0030239464 scopus 로고    scopus 로고
    • Brain samples from Alzheimer's patients have elevated levels of loosely bound iron
    • Kala SV, Hasinoff BB, Richardson JS (1996) Brain samples from Alzheimer's patients have elevated levels of loosely bound iron. Int J Neurosci 86, 263-269.
    • (1996) Int J Neurosci , vol.86 , pp. 263-269
    • Kala, S.V.1    Hasinoff, B.B.2    Richardson, J.S.3
  • 43
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
    • Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 45, 358-368.
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 45
    • 0027425211 scopus 로고
    • The Clinical Dementia Rating (CDR): Current version and scoring rules
    • Morris JC (1993) The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43, 2412-2414.
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 48
    • 33947178563 scopus 로고    scopus 로고
    • Alzheimer disease, the two-hit hypothesis: An update
    • Zhu X, Lee HG, Perry G, SmithMA(2007) Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 1772, 494-502.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 494-502
    • Zhu, X.1    Lee, H.G.2    Perry, G.3    Smith, M.A.4
  • 50
    • 34848890388 scopus 로고    scopus 로고
    • Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
    • Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G (2007) Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis 12, 195-206.
    • (2007) J Alzheimers Dis , vol.12 , pp. 195-206
    • Moreira, P.I.1    Harris, P.L.2    Zhu, X.3    Santos, M.S.4    Oliveira, C.R.5    Smith, M.A.6    Perry, G.7
  • 54
    • 0029032632 scopus 로고
    • Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
    • Schipper HM, Cisse S, Stopa EG (1995) Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann Neurol 37, 758-768.
    • (1995) Ann Neurol , vol.37 , pp. 758-768
    • Schipper, H.M.1    Cisse, S.2    Stopa, E.G.3
  • 55
    • 0026590705 scopus 로고
    • Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease
    • Connor JR, Snyder BS, Beard JL, Fine RE, Mufson EJ (1992) Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease. J Neurosci Res 31, 327-335.
    • (1992) J Neurosci Res , vol.31 , pp. 327-335
    • Connor, J.R.1    Snyder, B.S.2    Beard, J.L.3    Fine, R.E.4    Mufson, E.J.5
  • 58
    • 0030709194 scopus 로고    scopus 로고
    • Inherent abnormalities in oxidative metabolism in Alzheimer's disease: Interaction with vascular abnormalities
    • Blass JP, Sheu KF, Piacentini S, Sorbi S (1997) Inherent abnormalities in oxidative metabolism in Alzheimer's disease: interaction with vascular abnormalities. Ann N Y Acad Sci 826, 382-385.
    • (1997) Ann N y Acad Sci , vol.826 , pp. 382-385
    • Blass, J.P.1    Sheu, K.F.2    Piacentini, S.3    Sorbi, S.4
  • 60
    • 0033569839 scopus 로고    scopus 로고
    • Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease
    • Russell RL, Siedlak SL, Raina AK, Bautista JM, Smith MA, Perry G (1999) Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Arch Biochem Biophys 370, 236-239.
    • (1999) Arch Biochem Biophys , vol.370 , pp. 236-239
    • Russell, R.L.1    Siedlak, S.L.2    Raina, A.K.3    Bautista, J.M.4    Smith, M.A.5    Perry, G.6
  • 61
    • 58049218922 scopus 로고    scopus 로고
    • Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    • Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105, 19318-19323.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19318-19323
    • Wang, X.1    Su, B.2    Siedlak, S.L.3    Moreira, P.I.4    Fujioka, H.5    Wang, Y.6    Casadesus, G.7    Zhu, X.8
  • 63
    • 34447286620 scopus 로고    scopus 로고
    • Molecular imaging of brain amyloid in mild cognitive impairment and Alzheimer's disease
    • Matthews PM (2007) Molecular imaging of brain amyloid in mild cognitive impairment and Alzheimer's disease. Nat Clin Pract Neurol 3, 366-367.
    • (2007) Nat Clin Pract Neurol , vol.3 , pp. 366-367
    • Matthews, P.M.1
  • 64
    • 0030466582 scopus 로고    scopus 로고
    • Neuroimaging and genetic assessment for early diagnosis of Alzheimer's disease
    • Small GW (1996) Neuroimaging and genetic assessment for early diagnosis of Alzheimer's disease. J Clin Psychiatry 57 Suppl 14, 9-13.
    • (1996) J Clin Psychiatry , vol.57 , Issue.SUPPL. 14 , pp. 9-13
    • Small, G.W.1
  • 66
    • 0035003439 scopus 로고    scopus 로고
    • Chemistry and biochemistry of oxidative stress in neurodegenerative disease
    • Sayre LM, Smith MA, Perry G (2001) Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8, 721-738.
    • (2001) Curr Med Chem , vol.8 , pp. 721-738
    • Sayre, L.M.1    Smith, M.A.2    Perry, G.3
  • 68
    • 0029076397 scopus 로고
    • Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
    • Yan SD, Yan SF, Chen X, Fu J, Chen M, Kuppusamy P, Smith MA, Perry G, Godman GC, Nawroth P, et al. (1995) Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat Med 1, 693-699.
    • (1995) Nat Med , vol.1 , pp. 693-699
    • Yan, S.D.1    Yan, S.F.2    Chen, X.3    Fu, J.4    Chen, M.5    Kuppusamy, P.6    Smith, M.A.7    Perry, G.8    Godman, G.C.9    Nawroth, P.10
  • 69
    • 33645775687 scopus 로고    scopus 로고
    • Antioxidant protection and neurodegenerative disease: The role of amyloidbeta and tau
    • Castellani RJ, Lee HG, Perry G, SmithMA(2006) Antioxidant protection and neurodegenerative disease: the role of amyloidbeta and tau. Am J Alzheimers Dis Other Demen 21, 126-130.
    • (2006) Am J Alzheimers Dis Other Demen , vol.21 , pp. 126-130
    • Castellani, R.J.1    Lee, H.G.2    Perry, G.3    Smith, M.A.4
  • 74
  • 76
    • 75149146158 scopus 로고    scopus 로고
    • Neuropathology of preclinical and clinical Alzheimer's disease
    • McKeel Jr. DW, Burns JM, Meuser TM, Morris JC, eds. Clinical Publishing, Oxford, UK
    • McKeel Jr. DW, Burns JM, Meuser TM, Morris JC (2007) Neuropathology of preclinical and clinical Alzheimer's disease In Dementia: an Atlas of Investigation and Diagnosis, McKeel Jr. DW, Burns JM, Meuser TM, Morris JC, eds. Clinical Publishing, Oxford, UK, pp. 71-94.
    • (2007) Dementia: An Atlas of Investigation and Diagnosis , pp. 71-94
    • McKeel Jr., D.W.1    Burns, J.M.2    Meuser, T.M.3    Morris, J.C.4
  • 78
    • 0030681383 scopus 로고    scopus 로고
    • Impaired dynamic morphology of cerebellar mitochondria in physiological aging and Alzheimer's disease
    • Bertoni-Freddari C, Fattoretti P, Paoloni R, Caselli U, Meier- Ruge W (1997) Impaired dynamic morphology of cerebellar mitochondria in physiological aging and Alzheimer's disease. Ann N Y Acad Sci 826, 479-482.
    • (1997) Ann N y Acad Sci , vol.826 , pp. 479-482
    • Bertoni-Freddari, C.1    Fattoretti, P.2    Paoloni, R.3    Caselli, U.4    Meier-Ruge, W.5
  • 79
    • 52149119873 scopus 로고    scopus 로고
    • The cerebellum in mild cognitive impairment and Alzheimer's disease - A structural MRI study
    • Thomann PA, Schlafer C, Seidl U, Santos VD, Essig M, Schroder J (2008) The cerebellum in mild cognitive impairment and Alzheimer's disease - a structural MRI study. J Psychiatr Res 42, 1198-1202.
    • (2008) J Psychiatr Res , vol.42 , pp. 1198-1202
    • Thomann, P.A.1    Schlafer, C.2    Seidl, U.3    Santos, V.D.4    Essig, M.5    Schroder, J.6
  • 80
    • 33645106680 scopus 로고    scopus 로고
    • Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment
    • Wang J, Markesbery WR, Lovell MA (2006) Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment. J Neurochem 96, 825-832.
    • (2006) J Neurochem , vol.96 , pp. 825-832
    • Wang, J.1    Markesbery, W.R.2    Lovell, M.A.3
  • 83
    • 64049104164 scopus 로고    scopus 로고
    • Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease
    • Liu G, Men P, Kudo W, Perry G, Smith MA (2009) Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease. Neurosci Lett 455, 187-190.
    • (2009) Neurosci Lett , vol.455 , pp. 187-190
    • Liu, G.1    Men, P.2    Kudo, W.3    Perry, G.4    Smith, M.A.5
  • 85
    • 33748202940 scopus 로고    scopus 로고
    • Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance
    • Liu G, Men P, Harris PL, Rolston RK, Perry G, Smith MA (2006) Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance. Neurosci Lett 406, 189-193.
    • (2006) Neurosci Lett , vol.406 , pp. 189-193
    • Liu, G.1    Men, P.2    Harris, P.L.3    Rolston, R.K.4    Perry, G.5    Smith, M.A.6
  • 87
    • 43249100611 scopus 로고    scopus 로고
    • Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
    • Amit T, Avramovich-Tirosh Y, Youdim MB, Mandel S (2008) Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators. FASEB J 22, 1296-1305.
    • (2008) FASEB J , vol.22 , pp. 1296-1305
    • Amit, T.1    Avramovich-Tirosh, Y.2    Youdim, M.B.3    Mandel, S.4
  • 88
    • 54249103057 scopus 로고    scopus 로고
    • Drug development based on the metals hypothesis of Alzheimer's disease
    • Bush AI (2008) Drug development based on the metals hypothesis of Alzheimer's disease. J Alzheimers Dis 15, 223-240.
    • (2008) J Alzheimers Dis , vol.15 , pp. 223-240
    • Bush, A.I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.