메뉴 건너뛰기




Volumn 33, Issue 2, 2012, Pages 240-252

Current understanding of the mechanism of benzene-induced leukemia in humans: Implications for risk assessment

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZOQUINONE; ALKYLATING AGENT; AROMATIC HYDROCARBON RECEPTOR; BENZENE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD135 ANTIGEN; CYTOCHROME P450; CYTOCHROME P450 2E1; GLYCOPHORIN A; GYRASE INHIBITOR; HYDROQUINONE; MELANOMA ANTIGEN 1; NUCLEOPHOSMIN; OXEPINE DERIVATIVE; PHENOL; PROTEIN P15; PROTEIN P53; RAS PROTEIN; TRANSCRIPTION FACTOR RUNX1;

EID: 84863011500     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr297     Document Type: Article
Times cited : (261)

References (215)
  • 1
    • 0003815886 scopus 로고    scopus 로고
    • ATSDR. U.S. Department Of Health And Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, GA
    • ATSDR. (2007) Toxicological Profile For Benzene. http://www.atsdr. cdc.gov/toxprofiles/tp3.html. U.S. Department Of Health And Human Services. Agency for Toxic Substances and Disease Registry, Atlanta, GA.
    • (2007) Toxicological Profile For Benzene
  • 2
    • 0003827210 scopus 로고
    • NIOSH. National Institute for Occupational Safety and Health Cincinnati, OH
    • NIOSH. (1990) National Occupational Exposure Survey (1981-83). http://www.cdc.gov/noes/noes3/empl0003.html. National Institute for Occupational Safety and Health Cincinnati, OH.
    • (1990) National Occupational Exposure Survey (1981-83)
  • 3
    • 77950627467 scopus 로고    scopus 로고
    • Benzene exposure: an overview of monitoring methods and their findings
    • Weisel, C.P. (2010) Benzene exposure: an overview of monitoring methods and their findings. Chem. Biol. Interact., 184, 58-66.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 58-66
    • Weisel, C.P.1
  • 4
    • 33749261012 scopus 로고    scopus 로고
    • Benzene exposure in the shoemaking industry in China, a literature survey, 1978-2004
    • Wang, L. et al. (2006) Benzene exposure in the shoemaking industry in China, a literature survey, 1978-2004. Regul. Toxicol. Pharmacol., 46, 149-156.
    • (2006) Regul. Toxicol. Pharmacol. , vol.46 , pp. 149-156
    • Wang, L.1
  • 5
    • 67449128753 scopus 로고    scopus 로고
    • Evidence that humans metabolize benzene via two pathways
    • Rappaport, S.M. et al. (2009) Evidence that humans metabolize benzene via two pathways. Environ. Health Perspect., 117, 946-952.
    • (2009) Environ. Health Perspect. , vol.117 , pp. 946-952
    • Rappaport, S.M.1
  • 6
    • 0030460979 scopus 로고    scopus 로고
    • Environmental exposure to benzene: an update
    • Wallace, L. (1996) Environmental exposure to benzene: an update. Environ. Health Perspect., 104 (suppl. 6), 1129-1136.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1129-1136
    • Wallace, L.1
  • 7
    • 77953871119 scopus 로고    scopus 로고
    • A biomarker approach to estimate the daily intake of benzene in non-smoking and smoking individuals in Germany
    • Schettgen, T. et al. (2009) A biomarker approach to estimate the daily intake of benzene in non-smoking and smoking individuals in Germany. J. Expo. Sci. Environ. Epidemiol., 20, 427-433.
    • (2009) J. Expo. Sci. Environ. Epidemiol. , vol.20 , pp. 427-433
    • Schettgen, T.1
  • 8
    • 10044280326 scopus 로고    scopus 로고
    • Hematotoxicity in workers exposed to low levels of benzene
    • Lan, Q. et al. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science, 306, 1774-1776.
    • (2004) Science , vol.306 , pp. 1774-1776
    • Lan, Q.1
  • 9
    • 0036789239 scopus 로고    scopus 로고
    • Hematological changes among Chinese workers with a broad range of benzene exposures
    • Qu, Q. et al. (2002) Hematological changes among Chinese workers with a broad range of benzene exposures. Am. J. Ind. Med., 42, 275-285.
    • (2002) Am. J. Ind. Med. , vol.42 , pp. 275-285
    • Qu, Q.1
  • 10
    • 0029879987 scopus 로고    scopus 로고
    • Risk of low red or white blood cell count related to estimated benzene exposure in a rubberworker cohort (1940-1975)
    • Ward, E. et al. (1996) Risk of low red or white blood cell count related to estimated benzene exposure in a rubberworker cohort (1940-1975). Am. J. Ind. Med., 29, 247-257.
    • (1996) Am. J. Ind. Med. , vol.29 , pp. 247-257
    • Ward, E.1
  • 11
    • 0030132576 scopus 로고    scopus 로고
    • Investigation of health status in workers exposed to lowlevel benzene
    • Zhang, B. (1996) [Investigation of health status in workers exposed to lowlevel benzene]. Zhonghua Yu Fang Yi Xue Za Zhi, 30, 164-166.
    • (1996) Zhonghua Yu Fang Yi Xue Za Zhi , vol.30 , pp. 164-166
    • Zhang, B.1
  • 12
    • 77950628240 scopus 로고    scopus 로고
    • Peripheral blood effects in benzene-exposed workers
    • Schnatter, R.A. et al. (2010) Peripheral blood effects in benzene-exposed workers. Chem. Biol. Interact., 184, 174-181.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 174-181
    • Schnatter, R.A.1
  • 13
    • 77950629361 scopus 로고    scopus 로고
    • Low level occupational benzene exposure and hematological parameters
    • Swaen, G.M. et al. (2010) Low level occupational benzene exposure and hematological parameters. Chem. Biol. Interact., 184, 94-100.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 94-100
    • Swaen, G.M.1
  • 14
    • 0031003261 scopus 로고    scopus 로고
    • Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection
    • Collins, J.J. et al. (1997) Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection. J. Occup. Environ. Med., 39, 232-237.
    • (1997) J. Occup. Environ. Med. , vol.39 , pp. 232-237
    • Collins, J.J.1
  • 15
    • 3242705759 scopus 로고    scopus 로고
    • A hematology surveillance study of petrochemical workers exposed to benzene
    • Tsai, S.P. et al. (2004) A hematology surveillance study of petrochemical workers exposed to benzene. Regul. Toxicol. Pharmacol., 40, 67-73.
    • (2004) Regul. Toxicol. Pharmacol. , vol.40 , pp. 67-73
    • Tsai, S.P.1
  • 16
    • 63149105969 scopus 로고    scopus 로고
    • Early effects of low benzene exposure on blood cell counts in Bulgarian petrochemical workers
    • Pesatori, A.C. et al. (2009) Early effects of low benzene exposure on blood cell counts in Bulgarian petrochemical workers. Med. Lav., 100, 83-90.
    • (2009) Med. Lav. , vol.100 , pp. 83-90
    • Pesatori, A.C.1
  • 17
    • 20444409830 scopus 로고    scopus 로고
    • Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzeneexposed workers
    • Forrest, M.S. et al. (2005) Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzeneexposed workers. Environ. Health Perspect., 113, 801-807.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 801-807
    • Forrest, M.S.1
  • 18
    • 61849158240 scopus 로고    scopus 로고
    • Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by crosscomparison on two microarray platforms
    • McHale, C.M. et al. (2009) Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by crosscomparison on two microarray platforms. Genomics, 93, 343-349.
    • (2009) Genomics , vol.93 , pp. 343-349
    • McHale, C.M.1
  • 19
    • 79953680906 scopus 로고    scopus 로고
    • Global gene expression profiling of a population exposed to a range of benzene levels
    • McHale, C.M. et al. (2010) Global gene expression profiling of a population exposed to a range of benzene levels. Environ. Health Perspect., 119, 628-634.
    • (2010) Environ. Health Perspect. , vol.119 , pp. 628-634
    • McHale, C.M.1
  • 20
    • 77950628562 scopus 로고    scopus 로고
    • Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair
    • Bi, Y. et al. (2009) Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem. Biol. Interact., 184, 207-211.
    • (2009) Chem. Biol. Interact. , vol.184 , pp. 207-211
    • Bi, Y.1
  • 21
    • 28044448487 scopus 로고    scopus 로고
    • Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics
    • Vermeulen, R. et al. (2005) Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics. Proc. Natl. Acad. Sci. USA. 102, 17041-17046.
    • (2005) Proc. Natl. Acad. Sci. USA. , vol.102 , pp. 17041-17046
    • Vermeulen, R.1
  • 22
    • 1242317101 scopus 로고    scopus 로고
    • Proteomic analysis of plasma proteins of workers exposed to benzene
    • Joo, W.A. et al. (2004) Proteomic analysis of plasma proteins of workers exposed to benzene. Mutat. Res., 558, 35-44.
    • (2004) Mutat. Res. , vol.558 , pp. 35-44
    • Joo, W.A.1
  • 23
    • 77950627558 scopus 로고    scopus 로고
    • Systems biology of human benzene exposure
    • Zhang, L. et al. (2010) Systems biology of human benzene exposure. Chem. Biol. Interact., 184, 86-93.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 86-93
    • Zhang, L.1
  • 24
    • 33847026146 scopus 로고    scopus 로고
    • Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    • Bollati, V. et al. (2007) Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res., 67, 876-880.
    • (2007) Cancer Res , vol.67 , pp. 876-880
    • Bollati, V.1
  • 25
    • 77952426255 scopus 로고    scopus 로고
    • A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide
    • Ji, Z. et al. (2010) A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia, 24, 986-991.
    • (2010) Leukemia , vol.24 , pp. 986-991
    • Ji, Z.1
  • 26
    • 84863039934 scopus 로고    scopus 로고
    • Utilizing functional genomics in yeast to discover novel biomarkers of benzene toxicity in humans
    • Abstracts of the 46th Congress of the European Societies of Toxicology
    • North, M. et al. (2009) Utilizing functional genomics in yeast to discover novel biomarkers of benzene toxicity in humans. Toxicol. Lett., 189Abstracts of the 46th Congress of the European Societies of Toxicology, S93.
    • (2009) Toxicol. Lett. , vol.189
    • North, M.1
  • 27
    • 36849041045 scopus 로고    scopus 로고
    • Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone
    • Galvan, N. et al. (2008) Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone. Mutat. Res., 649, 54-61.
    • (2008) Mutat. Res. , vol.649 , pp. 54-61
    • Galvan, N.1
  • 28
    • 59349116567 scopus 로고    scopus 로고
    • Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone
    • Ren, X. et al. (2009) Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol. Sci., 107, 367-375.
    • (2009) Toxicol. Sci. , vol.107 , pp. 367-375
    • Ren, X.1
  • 29
    • 59049095168 scopus 로고    scopus 로고
    • Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    • Lan, Q. et al. (2009) Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis, 30, 50-58.
    • (2009) Carcinogenesis , vol.30 , pp. 50-58
    • Lan, Q.1
  • 30
    • 27144553722 scopus 로고    scopus 로고
    • Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    • Lan, Q. et al. (2005) Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res., 65, 9574-9581.
    • (2005) Cancer Res , vol.65 , pp. 9574-9581
    • Lan, Q.1
  • 31
    • 33744464558 scopus 로고    scopus 로고
    • Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    • Shen, M. et al. (2006) Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. Hum. Genet., 119, 659-668.
    • (2006) Hum. Genet. , vol.119 , pp. 659-668
    • Shen, M.1
  • 32
    • 72449122919 scopus 로고    scopus 로고
    • Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity
    • Hosgood, H.D. III et al. (2009) Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Occup. Environ. Med., 66, 848-853.
    • (2009) Occup. Environ. Med. , vol.66 , pp. 848-853
    • Hosgood III, H.D.1
  • 33
    • 67449085953 scopus 로고    scopus 로고
    • Association of genetic polymorphisms, mRNA Expression of p53 and p21 with chronic benzene Poisoning in a Chinese occupational population
    • Sun, P. et al. (2009) Association of genetic polymorphisms, mRNA Expression of p53 and p21 with chronic benzene Poisoning in a Chinese occupational population. Cancer Epidemiol. Biomarkers Prev., 18, 1821-1828.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 1821-1828
    • Sun, P.1
  • 34
    • 56249092393 scopus 로고    scopus 로고
    • Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational population
    • Wu, F. et al. (2008) Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational population. Toxicol. Appl. Pharmacol., 233, 447-453.
    • (2008) Toxicol. Appl. Pharmacol. , vol.233 , pp. 447-453
    • Wu, F.1
  • 35
    • 57449088674 scopus 로고    scopus 로고
    • Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population
    • Sun, P. et al. (2008) Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. Carcinogenesis, 29, 2325-2329.
    • (2008) Carcinogenesis , vol.29 , pp. 2325-2329
    • Sun, P.1
  • 36
    • 28644444705 scopus 로고    scopus 로고
    • Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population
    • Zhang, Z. et al. (2005) Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population. Cancer Epidemiol. Biomarkers Prev., 14, 2614-2619.
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , pp. 2614-2619
    • Zhang, Z.1
  • 37
    • 20444380759 scopus 로고    scopus 로고
    • Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzeneexposed workers
    • Zhang, L. et al. (2005) Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzeneexposed workers. Chem. Biol. Interact., 153-154, 117-122.
    • (2005) Chem. Biol. Interact. , vol.153-154 , pp. 117-122
    • Zhang, L.1
  • 38
    • 79953678389 scopus 로고    scopus 로고
    • Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    • Zhang, L. et al. (2011) Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene. Carcinogenesis, 32, 605-612.
    • (2011) Carcinogenesis , vol.32 , pp. 605-612
    • Zhang, L.1
  • 39
    • 77953943742 scopus 로고    scopus 로고
    • Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis
    • Khalade, A. et al. (2010) Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis. Environ. Health, 9, 31
    • (2010) Environ. Health , vol.9 , pp. 31
    • Khalade, A.1
  • 40
    • 77952720805 scopus 로고    scopus 로고
    • Advances in understanding benzene health effects and susceptibility
    • Smith, M.T. (2010) Advances in understanding benzene health effects and susceptibility. Annu. Rev. Public Health, 31, 133-148.
    • (2010) Annu. Rev. Public Health , vol.31 , pp. 133-148
    • Smith, M.T.1
  • 41
    • 44449175111 scopus 로고    scopus 로고
    • Meta-analysis of benzene exposure and non-Hodgkin lymphoma: biases could mask an important association
    • Steinmaus, C. et al. (2008) Meta-analysis of benzene exposure and non-Hodgkin lymphoma: biases could mask an important association. Occup. Environ. Med., 65, 371-378.
    • (2008) Occup. Environ. Med. , vol.65 , pp. 371-378
    • Steinmaus, C.1
  • 42
    • 77953023425 scopus 로고    scopus 로고
    • Aetiology of childhood leukaemia
    • Eden, T. (2010) Aetiology of childhood leukaemia. Cancer Treat. Rev., 36, 286-297.
    • (2010) Cancer Treat. Rev. , vol.36 , pp. 286-297
    • Eden, T.1
  • 43
    • 77957953377 scopus 로고    scopus 로고
    • Benzene and human health: a historical review and appraisal of associations with various diseases
    • Galbraith, D. et al. (2010) Benzene and human health: a historical review and appraisal of associations with various diseases. Crit. Rev. Toxicol., 40 (suppl. 2), 1-46.
    • (2010) Crit. Rev. Toxicol. , vol.40 , Issue.SUPPL. 2 , pp. 1-46
    • Galbraith, D.1
  • 44
    • 4444302315 scopus 로고    scopus 로고
    • Benzene and hematopoietic malignancies
    • vii
    • Pyatt, D. (2004) Benzene and hematopoietic malignancies. Clin. Occup. Environ. Med., 4, 529-555, vii.
    • (2004) Clin. Occup. Environ. Med. , vol.4 , pp. 529-555
    • Pyatt, D.1
  • 45
    • 35748972379 scopus 로고    scopus 로고
    • Benzene-induced acute myeloid leukemia: a clinician's perspective
    • Natelson, E.A. (2007) Benzene-induced acute myeloid leukemia: a clinician's perspective. Am. J. Hematol., 82, 826-830.
    • (2007) Am. J. Hematol. , vol.82 , pp. 826-830
    • Natelson, E.A.1
  • 46
    • 48749090278 scopus 로고    scopus 로고
    • Therapy-related myeloid leukemia
    • Godley, L.A. et al. (2008) Therapy-related myeloid leukemia. Semin. Oncol., 35, 418-429.
    • (2008) Semin. Oncol. , vol.35 , pp. 418-429
    • Godley, L.A.1
  • 47
    • 0019445309 scopus 로고
    • Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease
    • Rowley, J.D. et al. (1981) Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease. Blood, 58, 759-767.
    • (1981) Blood , vol.58 , pp. 759-767
    • Rowley, J.D.1
  • 48
    • 0038305924 scopus 로고    scopus 로고
    • Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series
    • Smith, S.M. et al. (2003) Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood, 102, 43-52.
    • (2003) Blood , vol.102 , pp. 43-52
    • Smith, S.M.1
  • 49
    • 0023269281 scopus 로고
    • Cytogenetic characteristics of therapyrelated acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive cases
    • Pedersen-Bjergaard, J. et al. (1987) Cytogenetic characteristics of therapyrelated acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive cases. Br. J. Haematol., 66, 199-207.
    • (1987) Br. J. Haematol. , vol.66 , pp. 199-207
    • Pedersen-Bjergaard, J.1
  • 50
    • 33747873409 scopus 로고    scopus 로고
    • Chromatin structural elements and chromosomal translocations in leukemia
    • Zhang, Y. et al. (2006) Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair (Amst.), 5, 1282-1297.
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 1282-1297
    • Zhang, Y.1
  • 51
    • 39149093029 scopus 로고    scopus 로고
    • Genetics of therapy-related myelodysplasia and acute myeloid leukemia
    • Pedersen-Bjergaard, J. et al. (2008) Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia, 22, 240-248.
    • (2008) Leukemia , vol.22 , pp. 240-248
    • Pedersen-Bjergaard, J.1
  • 52
    • 33750326207 scopus 로고    scopus 로고
    • Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia
    • Pedersen-Bjergaard, J. et al. (2006) Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia, 20, 1943-1949.
    • (2006) Leukemia , vol.20 , pp. 1943-1949
    • Pedersen-Bjergaard, J.1
  • 53
    • 84863078604 scopus 로고    scopus 로고
    • Benzene induces cytotoxicity without metabolic activation
    • Nishikawa, T. et al. (2011) Benzene induces cytotoxicity without metabolic activation. J. Occup. Health, 11, 11
    • (2011) J. Occup. Health , vol.11 , pp. 11
    • Nishikawa, T.1
  • 54
    • 0033784614 scopus 로고    scopus 로고
    • The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues
    • Ross, D. (2000) The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J. Toxicol. Environ. Health, 61, 357-372.
    • (2000) J. Toxicol. Environ. Health , vol.61 , pp. 357-372
    • Ross, D.1
  • 55
    • 0018637646 scopus 로고
    • Partial hepatectomy reduces both metabolism and toxicity of benzene
    • Sammett, D. et al. (1979) Partial hepatectomy reduces both metabolism and toxicity of benzene. J. Toxicol. Environ. Health, 5, 785-792.
    • (1979) J. Toxicol. Environ. Health , vol.5 , pp. 785-792
    • Sammett, D.1
  • 56
    • 0030296583 scopus 로고    scopus 로고
    • Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression
    • Valentine, J.L. et al. (1996) Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol., 141, 205-213.
    • (1996) Toxicol. Appl. Pharmacol. , vol.141 , pp. 205-213
    • Valentine, J.L.1
  • 57
    • 0017363794 scopus 로고
    • Effects of toluene on the metabolism, disposition and hemopoietic toxicity of [3H]benzene
    • Andrews, L.S. et al. (1977) Effects of toluene on the metabolism, disposition and hemopoietic toxicity of [3H]benzene. Biochem. Pharmacol., 26, 293-300.
    • (1977) Biochem. Pharmacol. , vol.26 , pp. 293-300
    • Andrews, L.S.1
  • 58
    • 44649124119 scopus 로고    scopus 로고
    • Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
    • Wetmore, B.A. et al. (2008) Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice. Chem. Biol. Interact., 173, 166-178.
    • (2008) Chem. Biol. Interact. , vol.173 , pp. 166-178
    • Wetmore, B.A.1
  • 59
    • 77950628478 scopus 로고    scopus 로고
    • Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures
    • Bird, M.G. et al. (2010) Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures. Chem. Biol. Interact., 184, 233-239.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 233-239
    • Bird, M.G.1
  • 60
    • 0030445486 scopus 로고    scopus 로고
    • An overview of benzene metabolism
    • Snyder, R. et al. (1996) An overview of benzene metabolism. Environ. Health Perspect., 104 (suppl. 6), 1165-1171.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1165-1171
    • Snyder, R.1
  • 61
    • 0036297175 scopus 로고    scopus 로고
    • Benzene metabolism by the isolated perfused lung
    • Powley, M.W. et al. (2002) Benzene metabolism by the isolated perfused lung. Inhal. Toxicol., 14, 569-584.
    • (2002) Inhal. Toxicol. , vol.14 , pp. 569-584
    • Powley, M.W.1
  • 62
    • 1242320311 scopus 로고    scopus 로고
    • Kinetic factors involved in the metabolism of benzene in mouse lung and liver
    • Sheets, P. et al. (2004) Kinetic factors involved in the metabolism of benzene in mouse lung and liver. J. Toxicol. Environ. Health A, 67, 421-430.
    • (2004) J. Toxicol. Environ. Health A , vol.67 , pp. 421-430
    • Sheets, P.1
  • 63
    • 0018654390 scopus 로고
    • 3H-Benzene metabolism in rabbit bone marrow
    • Andrews, L.S. et al. (1979) 3H-Benzene metabolism in rabbit bone marrow. Life Sci., 25, 567-572.
    • (1979) Life Sci , vol.25 , pp. 567-572
    • Andrews, L.S.1
  • 64
    • 0018833552 scopus 로고
    • Benzene is metabolized and covalently bound in bone marrow in situ
    • Irons, R.D. et al. (1980) Benzene is metabolized and covalently bound in bone marrow in situ. Chem. Biol. Interact., 30, 241-245.
    • (1980) Chem. Biol. Interact. , vol.30 , pp. 241-245
    • Irons, R.D.1
  • 65
    • 0025323357 scopus 로고
    • Phenol-induced stimulation of hydroquinone bioactivation in mouse bone marrow in vivo: possible implications in benzene myelotoxicity
    • Subrahmanyam, V.V. et al. (1990) Phenol-induced stimulation of hydroquinone bioactivation in mouse bone marrow in vivo: possible implications in benzene myelotoxicity. Toxicology, 62, 107-116.
    • (1990) Toxicology , vol.62 , pp. 107-116
    • Subrahmanyam, V.V.1
  • 66
    • 0026346039 scopus 로고
    • Hydroxylation of phenol to hydroquinone catalyzed by a human myeloperoxidase-superoxide complex: possible implications in benzene-induced myelotoxicity
    • Subrahmanyam, V.V. et al. (1991) Hydroxylation of phenol to hydroquinone catalyzed by a human myeloperoxidase-superoxide complex: possible implications in benzene-induced myelotoxicity. Free Radic. Res. Commun., 15, 285-296.
    • (1991) Free Radic. Res. Commun. , vol.15 , pp. 285-296
    • Subrahmanyam, V.V.1
  • 67
    • 0032892913 scopus 로고    scopus 로고
    • Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression
    • Nedelcheva, V. et al. (1999) Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression. Arch. Toxicol., 73, 33-40.
    • (1999) Arch. Toxicol. , vol.73 , pp. 33-40
    • Nedelcheva, V.1
  • 68
    • 0034567095 scopus 로고    scopus 로고
    • Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes
    • Powley, M.W. et al. (2000) Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes. J. Biochem. Mol. Toxicol., 14, 303-309.
    • (2000) J. Biochem. Mol. Toxicol. , vol.14 , pp. 303-309
    • Powley, M.W.1
  • 69
    • 0032939647 scopus 로고    scopus 로고
    • Expression of CYP2A genes in human liver and extrahepatic tissues
    • Koskela, S. et al. (1999) Expression of CYP2A genes in human liver and extrahepatic tissues. Biochem. Pharmacol., 57, 1407-1413.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 1407-1413
    • Koskela, S.1
  • 70
    • 0034665139 scopus 로고    scopus 로고
    • Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Su, T. et al. (2000) Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 60, 5074-5079.
    • (2000) Cancer Res , vol.60 , pp. 5074-5079
    • Su, T.1
  • 71
    • 77950629024 scopus 로고    scopus 로고
    • Human benzene metabolism following occupational and environmental exposures
    • Rappaport, S.M. et al. (2009) Human benzene metabolism following occupational and environmental exposures. Chem. Biol. Interact., 184, 189-195.
    • (2009) Chem. Biol. Interact. , vol.184 , pp. 189-195
    • Rappaport, S.M.1
  • 72
    • 0024377946 scopus 로고
    • Excretion of 1,2,4-benzenetriol in the urine of workers exposed to benzene
    • Inoue, O. et al. (1989) Excretion of 1,2,4-benzenetriol in the urine of workers exposed to benzene. Br. J. Ind. Med., 46, 559-565.
    • (1989) Br. J. Ind. Med. , vol.46 , pp. 559-565
    • Inoue, O.1
  • 73
    • 0030464771 scopus 로고    scopus 로고
    • Reactive ring-opened aldehyde metabolites in benzene hematotoxicity
    • Witz, G. et al. (1996) Reactive ring-opened aldehyde metabolites in benzene hematotoxicity. Environ. Health Perspect., 104 (suppl. 6), 1195-1199.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1195-1199
    • Witz, G.1
  • 74
    • 0030473213 scopus 로고    scopus 로고
    • The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia
    • Smith, M.T. (1996) The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia. Environ. Health Perspect., 104 (suppl. 6), 1219-1225.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1219-1225
    • Smith, M.T.1
  • 75
    • 0026046826 scopus 로고
    • Potential role of free radicals in benzene-induced myelotoxicity and leukemia
    • Subrahmanyam, V.V. et al. (1991) Potential role of free radicals in benzene-induced myelotoxicity and leukemia. Free Radic. Biol. Med., 11, 495-515.
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 495-515
    • Subrahmanyam, V.V.1
  • 76
    • 20444396613 scopus 로고    scopus 로고
    • Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity
    • Iskander, K. et al. (2005) Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. Chem. Biol. Interact., 153-154, 147-157.
    • (2005) Chem. Biol. Interact. , vol.153-154 , pp. 147-157
    • Iskander, K.1
  • 77
    • 0036605993 scopus 로고    scopus 로고
    • Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia
    • Long, D.J. II et al. (2002) Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia. Cancer Res., 62, 3030-3036.
    • (2002) Cancer Res , vol.62 , pp. 3030-3036
    • Long II, D.J.1
  • 78
    • 0030849791 scopus 로고    scopus 로고
    • Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C->T mutation and rapid fractional excretion of chlorzoxazone
    • Rothman, N. et al. (1997) Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C->T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res., 57, 2839-2842.
    • (1997) Cancer Res , vol.57 , pp. 2839-2842
    • Rothman, N.1
  • 79
    • 0027287801 scopus 로고
    • Cell proliferation and differentiation in chemical leukemogenesis
    • Irons, R.D. et al. (1993) Cell proliferation and differentiation in chemical leukemogenesis. Stem Cells, 11, 235-242.
    • (1993) Stem Cells , vol.11 , pp. 235-242
    • Irons, R.D.1
  • 80
    • 0030744058 scopus 로고    scopus 로고
    • Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity
    • Bratton, S.B. et al. (1997) Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity. Chem. Res. Toxicol., 10, 859-865.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 859-865
    • Bratton, S.B.1
  • 81
    • 77950627494 scopus 로고    scopus 로고
    • The fate of benzene-oxide
    • Monks, T.J. et al. (2010) The fate of benzene-oxide. Chem. Biol. Interact., 184, 201-206.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 201-206
    • Monks, T.J.1
  • 82
    • 77950626841 scopus 로고    scopus 로고
    • Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity
    • Ross, D. et al. (2010) Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity. Chem. Biol. Interact., 184, 222-228.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 222-228
    • Ross, D.1
  • 83
    • 84863054087 scopus 로고    scopus 로고
    • Low occupational exposure to benzene in a petrochemical plant: modulating effect of genetic polymorphisms and smoking habit on the urinary t, t-MA/SPMA ratio
    • Mansi, A. et al. (2011) Low occupational exposure to benzene in a petrochemical plant: modulating effect of genetic polymorphisms and smoking habit on the urinary t, t-MA/SPMA ratio. Toxicol. Lett., 15, 15
    • (2011) Toxicol. Lett. , vol.15 , pp. 15
    • Mansi, A.1
  • 84
    • 0030749561 scopus 로고    scopus 로고
    • Genotoxic effects in workers exposed to benzene: with special reference to exposure biomarkers and confounding factors
    • Bogadi-Soare, A. et al. (1997) Genotoxic effects in workers exposed to benzene: with special reference to exposure biomarkers and confounding factors. Ind. Health, 35, 367-373.
    • (1997) Ind. Health , vol.35 , pp. 367-373
    • Bogadi-Soare, A.1
  • 85
    • 0021066537 scopus 로고
    • Chromosome changes in patients with chronic benzene poisoning
    • Ding, X.J. et al. (1983) Chromosome changes in patients with chronic benzene poisoning. Chin. Med. J. (Engl.), 96, 681-685.
    • (1983) Chin. Med. J. (Engl.) , vol.96 , pp. 681-685
    • Ding, X.J.1
  • 86
    • 0015153488 scopus 로고
    • Chromosome changes and their evolution in subjects with past exposure to benzene
    • Forni, A.M. et al. (1971) Chromosome changes and their evolution in subjects with past exposure to benzene. Arch. Environ. Health, 23, 385-391.
    • (1971) Arch. Environ. Health , vol.23 , pp. 385-391
    • Forni, A.M.1
  • 87
    • 0342948599 scopus 로고    scopus 로고
    • Cytogenetic changes in subjects occupationally exposed to benzene
    • Kasuba, V. et al. (2000) Cytogenetic changes in subjects occupationally exposed to benzene. Chemosphere, 40, 307-310.
    • (2000) Chemosphere , vol.40 , pp. 307-310
    • Kasuba, V.1
  • 88
    • 0018745150 scopus 로고
    • Cytogenetic study of workers exposed to benzene
    • Picciano, D. (1979) Cytogenetic study of workers exposed to benzene. Environ. Res., 19, 33-38.
    • (1979) Environ. Res. , vol.19 , pp. 33-38
    • Picciano, D.1
  • 89
    • 0026728424 scopus 로고
    • Nonrandom distribution of breakpoints in the karyotypes of workers occupationally exposed to benzene
    • Sasiadek, M. (1992) Nonrandom distribution of breakpoints in the karyotypes of workers occupationally exposed to benzene. Environ. Health Perspect., 97, 255-257.
    • (1992) Environ. Health Perspect. , vol.97 , pp. 255-257
    • Sasiadek, M.1
  • 90
    • 0025563386 scopus 로고
    • Genotoxic effects observed in workers occupationally exposed to organic solvents
    • Sasiadek, M. et al. (1990) Genotoxic effects observed in workers occupationally exposed to organic solvents. Pol. J. Occup. Med., 3, 103-108.
    • (1990) Pol. J. Occup. Med. , vol.3 , pp. 103-108
    • Sasiadek, M.1
  • 91
    • 0024457803 scopus 로고
    • Localization of breakpoints in the karyotype of workers professionally exposed to benzene
    • Sasiadek, M. et al. (1989) Localization of breakpoints in the karyotype of workers professionally exposed to benzene. Mutat. Res., 224, 235-240.
    • (1989) Mutat. Res. , vol.224 , pp. 235-240
    • Sasiadek, M.1
  • 92
    • 0028009326 scopus 로고
    • Monitoring of benzene-exposed workers for genotoxic effects of benzene: improved-working-condition-related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes
    • Tompa, A. et al. (1994) Monitoring of benzene-exposed workers for genotoxic effects of benzene: improved-working-condition-related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes. Mutat. Res., 304, 159-165.
    • (1994) Mutat. Res. , vol.304 , pp. 159-165
    • Tompa, A.1
  • 93
    • 0000642510 scopus 로고
    • Chromosome aberrations and exposure to ambient benzene
    • Tough, I.M. et al. (1965) Chromosome aberrations and exposure to ambient benzene. Lancet, 1, 684
    • (1965) Lancet , vol.1 , pp. 684
    • Tough, I.M.1
  • 94
    • 0014733450 scopus 로고
    • Chromosome studies on workers exposed to atmospheric benzene. The possible influence of age
    • Tough, I.M. et al. (1970) Chromosome studies on workers exposed to atmospheric benzene. The possible influence of age. Eur. J. Cancer, 6, 49-55.
    • (1970) Eur. J. Cancer , vol.6 , pp. 49-55
    • Tough, I.M.1
  • 95
    • 0025176881 scopus 로고
    • Analysis of chromosomal aberrations in workers exposed to low level benzene
    • Yardley-Jones, A. et al. (1990) Analysis of chromosomal aberrations in workers exposed to low level benzene. Br. J. Ind. Med., 47, 48-51.
    • (1990) Br. J. Ind. Med. , vol.47 , pp. 48-51
    • Yardley-Jones, A.1
  • 96
    • 0031720844 scopus 로고    scopus 로고
    • Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene
    • Zhang, L. et al. (1998) Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis, 19, 1955-1961.
    • (1998) Carcinogenesis , vol.19 , pp. 1955-1961
    • Zhang, L.1
  • 97
    • 34547634185 scopus 로고    scopus 로고
    • Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers
    • Zhang, L. et al. (2007) Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environ. Mol. Mutagen., 48, 467-474.
    • (2007) Environ. Mol. Mutagen. , vol.48 , pp. 467-474
    • Zhang, L.1
  • 98
    • 0036172782 scopus 로고    scopus 로고
    • The nature of chromosomal aberrations detected in humans exposed to benzene
    • Zhang, L. et al. (2002) The nature of chromosomal aberrations detected in humans exposed to benzene. Crit. Rev. Toxicol., 32, 1-42.
    • (2002) Crit. Rev. Toxicol. , vol.32 , pp. 1-42
    • Zhang, L.1
  • 99
    • 15144357231 scopus 로고    scopus 로고
    • Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene
    • Smith, M.T. et al. (1998) Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res., 58, 2176-2181.
    • (1998) Cancer Res , vol.58 , pp. 2176-2181
    • Smith, M.T.1
  • 100
    • 0033374464 scopus 로고    scopus 로고
    • Benzene increases aneuploidy in the lymphocytes of exposed workers: a comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells
    • Zhang, L. et al. (1999) Benzene increases aneuploidy in the lymphocytes of exposed workers: a comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ. Mol. Mutagen., 34, 260-268.
    • (1999) Environ. Mol. Mutagen. , vol.34 , pp. 260-268
    • Zhang, L.1
  • 101
    • 0033852276 scopus 로고    scopus 로고
    • Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells
    • Smith, M.T. et al. (2000) Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells. Carcinogenesis, 21, 1485-1490.
    • (2000) Carcinogenesis , vol.21 , pp. 1485-1490
    • Smith, M.T.1
  • 102
    • 0033982687 scopus 로고    scopus 로고
    • The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells
    • Stillman, W.S. et al. (2000) The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34{thorn}CD19- bone marrow cells. Exp. Hematol., 28, 169-176.
    • (2000) Exp. Hematol. , vol.28 , pp. 169-176
    • Stillman, W.S.1
  • 104
    • 2042536159 scopus 로고
    • Chromosome changes by G-banding in patients with chronic benzene poisoning
    • Li, Y. et al. (1990) Chromosome changes by G-banding in patients with chronic benzene poisoning. Chinese J. Ind. Med., 3, 29-31.
    • (1990) Chinese J. Ind. Med. , vol.3 , pp. 29-31
    • Li, Y.1
  • 105
    • 77951159099 scopus 로고    scopus 로고
    • Micronucleus-centromere assay in workers occupationally exposed to low level of benzene
    • Kim, Y.J. et al. (2010) Micronucleus-centromere assay in workers occupationally exposed to low level of benzene. Hum. Exp. Toxicol., 29, 343-350.
    • (2010) Hum. Exp. Toxicol. , vol.29 , pp. 343-350
    • Kim, Y.J.1
  • 106
    • 0022323885 scopus 로고
    • Quinones as toxic metabolites of benzene
    • Irons, R.D. (1985) Quinones as toxic metabolites of benzene. J. Toxicol. Environ. Health, 16, 673-678.
    • (1985) J. Toxicol. Environ. Health , vol.16 , pp. 673-678
    • Irons, R.D.1
  • 107
    • 0027953131 scopus 로고
    • Detection of 1,2,4-benzenetriol induced aneuploidy and microtubule disruption by fluorescence in situ hybridization and immunocytochemistry
    • Zhang, L. et al. (1994) Detection of 1,2,4-benzenetriol induced aneuploidy and microtubule disruption by fluorescence in situ hybridization and immunocytochemistry. Mutat. Res., 320, 315-327.
    • (1994) Mutat. Res. , vol.320 , pp. 315-327
    • Zhang, L.1
  • 108
    • 0035378062 scopus 로고    scopus 로고
    • Characterization and mechanisms of chromosomal alterations induced by benzene in mice and humans
    • discussion, 69-80
    • Eastmond, D.A. et al. (2001) Characterization and mechanisms of chromosomal alterations induced by benzene in mice and humans. Res. Rep. Health Eff. Inst., 103, 1-68; discussion, 69-80.
    • (2001) Res. Rep. Health Eff. Inst. , vol.103 , pp. 1-68
    • Eastmond, D.A.1
  • 109
    • 17644390211 scopus 로고    scopus 로고
    • Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison
    • Lindsey, R.H. Jr et al. (2005) Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chem. Res. Toxicol., 18, 761-770.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 761-770
    • Lindsey Jr., R.H.1
  • 110
    • 0028799368 scopus 로고
    • Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects
    • Chen, H. et al. (1995) Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects. Carcinogenesis, 16, 2301-2307.
    • (1995) Carcinogenesis , vol.16 , pp. 2301-2307
    • Chen, H.1
  • 111
    • 0030446664 scopus 로고    scopus 로고
    • Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites
    • Frantz, C.E. et al. (1996) Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites. Environ. Health Perspect., 104 (suppl. 6), 1319-1323.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1319-1323
    • Frantz, C.E.1
  • 112
    • 0030445214 scopus 로고    scopus 로고
    • Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene
    • Hutt, A.M. et al. (1996) Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene. Environ. Health Perspect., 104 (suppl. 6), 1265-1269.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1265-1269
    • Hutt, A.M.1
  • 113
    • 3042665880 scopus 로고    scopus 로고
    • Inhibition of topoisomerase II in 32D.3(G) cells by hydroquinone is associated with cell death
    • Fung, J. et al. (2004) Inhibition of topoisomerase II in 32D.3(G) cells by hydroquinone is associated with cell death. J. Appl. Toxicol., 24, 183-188.
    • (2004) J. Appl. Toxicol. , vol.24 , pp. 183-188
    • Fung, J.1
  • 114
    • 2942555034 scopus 로고    scopus 로고
    • 1,4-Benzoquinone is a topoisomerase II poison
    • Lindsey, R.H.Jr. et al. (2004) 1,4-Benzoquinone is a topoisomerase II poison. Biochemistry, 43, 7563-7574.
    • (2004) Biochemistry , vol.43 , pp. 7563-7574
    • Lindsey Jr., R.H.1
  • 115
    • 0442279186 scopus 로고    scopus 로고
    • Genotoxicity of benzene and its metabolites
    • Whysner, J. et al. (2004) Genotoxicity of benzene and its metabolites. Mutat. Res., 566, 99-130.
    • (2004) Mutat. Res. , vol.566 , pp. 99-130
    • Whysner, J.1
  • 116
    • 20444414463 scopus 로고    scopus 로고
    • Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene
    • Eastmond, D.A. et al. (2005) Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene. Chem. Biol. Interact., 153-154, 207-216.
    • (2005) Chem. Biol. Interact. , vol.153-154 , pp. 207-216
    • Eastmond, D.A.1
  • 117
    • 0035437139 scopus 로고    scopus 로고
    • Benzene metabolites antagonize etoposidestabilized cleavable complexes of DNA topoisomerase IIalpha
    • Baker, R.K. et al. (2001) Benzene metabolites antagonize etoposidestabilized cleavable complexes of DNA topoisomerase IIalpha. Blood, 98, 830-833.
    • (2001) Blood , vol.98 , pp. 830-833
    • Baker, R.K.1
  • 118
    • 58549092955 scopus 로고    scopus 로고
    • In silico studies with human DNA topoisomerase-II alpha to unravel the mechanism of in vitro genotoxicity of benzene and its metabolites
    • Pandey, A.K. et al. (2009) In silico studies with human DNA topoisomerase-II alpha to unravel the mechanism of in vitro genotoxicity of benzene and its metabolites. Mutat. Res., 661, 57-70.
    • (2009) Mutat. Res. , vol.661 , pp. 57-70
    • Pandey, A.K.1
  • 119
    • 67650921922 scopus 로고    scopus 로고
    • The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells
    • Ji, Z. et al. (2009) The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells. Mutagenesis, 24, 367-372.
    • (2009) Mutagenesis , vol.24 , pp. 367-372
    • Ji, Z.1
  • 120
    • 0029069281 scopus 로고
    • Benzene induces gene-duplicating but not geneinactivating mutations at the glycophorin A locus in exposed humans
    • Rothman, N. et al. (1995) Benzene induces gene-duplicating but not geneinactivating mutations at the glycophorin A locus in exposed humans. Proc. Natl Acad. Sci. USA, 92, 4069-4073.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 4069-4073
    • Rothman, N.1
  • 121
    • 0007611734 scopus 로고    scopus 로고
    • An epidemiologic study of early biologic effects of benzene in Chinese workers
    • Rothman, N. et al. (1996) An epidemiologic study of early biologic effects of benzene in Chinese workers. Environ. Health Perspect., 104 (suppl. 6), 1365-1370.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 6 , pp. 1365-1370
    • Rothman, N.1
  • 122
    • 0029880076 scopus 로고    scopus 로고
    • Glycophorin A mutations and risk of secondary leukaemia in patients treated for childhood acute lymphoblastic leukaemia
    • Boyse, J. et al. (1996) Glycophorin A mutations and risk of secondary leukaemia in patients treated for childhood acute lymphoblastic leukaemia. Br. J. Haematol., 93, 117-124.
    • (1996) Br. J. Haematol. , vol.93 , pp. 117-124
    • Boyse, J.1
  • 123
    • 84863071697 scopus 로고    scopus 로고
    • Decreased topoisomerase IIalpha expression and altered histone and regulatory factors of topoisomerase IIalpha promoter in patients with chronic benzene poisoning
    • Yu, K. et al. (2011) Decreased topoisomerase IIalpha expression and altered histone and regulatory factors of topoisomerase IIalpha promoter in patients with chronic benzene poisoning. Toxicol. Lett., 5, 5
    • (2011) Toxicol. Lett. , vol.5 , pp. 5
    • Yu, K.1
  • 124
    • 0036197485 scopus 로고    scopus 로고
    • Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop
    • Andersen, M.K. et al. (2002) Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes Chromosomes Cancer, 33, 395-400.
    • (2002) Genes Chromosomes Cancer , vol.33 , pp. 395-400
    • Andersen, M.K.1
  • 125
    • 20144388623 scopus 로고    scopus 로고
    • DNA topoisomerase II in therapy-related acute promyelocytic leukemia
    • Mistry, A.R. et al. (2005) DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N. Engl. J. Med., 352, 1529-1538.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1529-1538
    • Mistry, A.R.1
  • 126
    • 39849095435 scopus 로고    scopus 로고
    • Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia
    • Pedersen-Bjergaard, J. et al. (2007) Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia. Hematology Am. Soc. Hematol. Educ. Program, 392-397.
    • (2007) Hematology Am. Soc. Hematol. Educ. Program , pp. 392-397
    • Pedersen-Bjergaard, J.1
  • 127
    • 4344569251 scopus 로고    scopus 로고
    • Mitoxantrone therapy in multiple sclerosis and acute leukaemia: a case report out of 644 treated patients
    • Voltz, R. et al. (2004) Mitoxantrone therapy in multiple sclerosis and acute leukaemia: a case report out of 644 treated patients. Mult. Scler., 10, 472-474.
    • (2004) Mult. Scler. , vol.10 , pp. 472-474
    • Voltz, R.1
  • 128
    • 21744435615 scopus 로고    scopus 로고
    • Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q
    • Schoch, C. et al. (2005) Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q. Leukemia, 19, 1224-1228.
    • (2005) Leukemia , vol.19 , pp. 1224-1228
    • Schoch, C.1
  • 129
    • 78649715229 scopus 로고    scopus 로고
    • Altered DNA methylation in leukocytes with trisomy 21
    • Kerkel, K. et al. (2010) Altered DNA methylation in leukocytes with trisomy 21 PLoS Genet., 6, e1001212
    • (2010) PLoS Genet , vol.6
    • Kerkel, K.1
  • 130
    • 33846876123 scopus 로고    scopus 로고
    • Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
    • Falini, B. et al. (2007) Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc{thorn} AML): biologic and clinical features. Blood, 109, 874-885.
    • (2007) Blood , vol.109 , pp. 874-885
    • Falini, B.1
  • 131
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis, E.R. et al. (2009) Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med., 361, 1058-1066.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1058-1066
    • Mardis, E.R.1
  • 132
    • 77950046087 scopus 로고    scopus 로고
    • Hprt mutant frequency and p53 gene status in mice chronically exposed by inhalation to benzene
    • Albertini, R.J. et al. (2010) Hprt mutant frequency and p53 gene status in mice chronically exposed by inhalation to benzene. Chem. Biol. Interact., 184, 77-85.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 77-85
    • Albertini, R.J.1
  • 133
    • 0028922843 scopus 로고
    • Inhalation of benzene leads to an increase in the mutant frequencies of a lacI transgene in lung and spleen tissues of mice
    • Mullin, A.H. et al. (1995) Inhalation of benzene leads to an increase in the mutant frequencies of a lacI transgene in lung and spleen tissues of mice. Mutat. Res., 327, 121-129.
    • (1995) Mutat. Res. , vol.327 , pp. 121-129
    • Mullin, A.H.1
  • 134
    • 0031684217 scopus 로고    scopus 로고
    • Inhaled benzene increases the frequency and length of lacI deletion mutations in lung tissues of mice
    • Mullin, A.H. et al. (1998) Inhaled benzene increases the frequency and length of lacI deletion mutations in lung tissues of mice. Carcinogenesis, 19, 1723-1733.
    • (1998) Carcinogenesis , vol.19 , pp. 1723-1733
    • Mullin, A.H.1
  • 135
    • 76949106796 scopus 로고    scopus 로고
    • Benzene-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the functional analysis of separated alleles in yeast, in human lung cells
    • Billet, S. et al. (2010) Benzene-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the functional analysis of separated alleles in yeast, in human lung cells. Arch. Toxicol., 84, 99-107.
    • (2010) Arch. Toxicol. , vol.84 , pp. 99-107
    • Billet, S.1
  • 136
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
    • Petitjean, A. et al. (2007) Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat., 28, 622-629.
    • (2007) Hum. Mutat. , vol.28 , pp. 622-629
    • Petitjean, A.1
  • 137
    • 0031417429 scopus 로고    scopus 로고
    • Increased gene expression in human promyeloid leukemia cells exposed to trans, trans-muconaldehyde, a hematotoxic benzene metabolite
    • Ho, T.Y. et al. (1997) Increased gene expression in human promyeloid leukemia cells exposed to trans, trans-muconaldehyde, a hematotoxic benzene metabolite. Carcinogenesis, 18, 739-744.
    • (1997) Carcinogenesis , vol.18 , pp. 739-744
    • Ho, T.Y.1
  • 138
    • 0027408743 scopus 로고
    • Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo
    • Kolachana, P. et al. (1993) Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res., 53, 1023-1026.
    • (1993) Cancer Res , vol.53 , pp. 1023-1026
    • Kolachana, P.1
  • 139
    • 0033060036 scopus 로고    scopus 로고
    • Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species
    • Wiemels, J. et al. (1999) Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species. Free Radic. Res., 30, 93-103.
    • (1999) Free Radic. Res. , vol.30 , pp. 93-103
    • Wiemels, J.1
  • 140
    • 0037340868 scopus 로고    scopus 로고
    • Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress
    • Winn, L.M. (2003) Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress. Toxicol. Sci., 72, 143-149.
    • (2003) Toxicol. Sci. , vol.72 , pp. 143-149
    • Winn, L.M.1
  • 141
    • 48249084111 scopus 로고    scopus 로고
    • Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure
    • Shen, M. et al. (2008) Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure. Environ. Mol. Mutagen., 49, 453-457.
    • (2008) Environ. Mol. Mutagen. , vol.49 , pp. 453-457
    • Shen, M.1
  • 142
    • 2142655894 scopus 로고    scopus 로고
    • NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger
    • Siegel, D. et al. (2004) NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol. Pharmacol., 65, 1238-1247.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 1238-1247
    • Siegel, D.1
  • 143
    • 77950628479 scopus 로고    scopus 로고
    • The role of DNA repair in benzene-induced carcinogenesis
    • Hartwig, A. (2010) The role of DNA repair in benzene-induced carcinogenesis. Chem. Biol. Interact., 184, 269-272.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 269-272
    • Hartwig, A.1
  • 144
    • 77950629360 scopus 로고    scopus 로고
    • Role of DNA-PKcs in the biological effect of a benzene metabolite: phenol toxicity to human K562 cells in vitro
    • Xiao, X. et al. (2010) Role of DNA-PKcs in the biological effect of a benzene metabolite: phenol toxicity to human K562 cells in vitro. Chem. Biol. Interact., 184, 302-305.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 302-305
    • Xiao, X.1
  • 145
    • 55149113449 scopus 로고    scopus 로고
    • Generation of phosphorylated histone H2AX by benzene metabolites
    • Ishihama, M. et al. (2008) Generation of phosphorylated histone H2AX by benzene metabolites. Toxicol. In Vitro, 22, 1861-1868.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1861-1868
    • Ishihama, M.1
  • 146
    • 84863025368 scopus 로고    scopus 로고
    • Differential DNA repair in hematopoietic stem and progenitor cells following genotoxic damage by benzene metabolites
    • Alexander, D. et al. (2010) Differential DNA repair in hematopoietic stem and progenitor cells following genotoxic damage by benzene metabolites. Toxicol. Sci., 114, 29
    • (2010) Toxicol. Sci. , vol.114 , pp. 29
    • Alexander, D.1
  • 147
    • 77956251480 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    • Mohrin, M. et al. (2010) Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell, 7, 174-185.
    • (2010) Cell Stem Cell , vol.7 , pp. 174-185
    • Mohrin, M.1
  • 148
    • 77956233247 scopus 로고    scopus 로고
    • A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
    • Milyavsky, M. et al. (2010) A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell, 7, 186-197.
    • (2010) Cell Stem Cell , vol.7 , pp. 186-197
    • Milyavsky, M.1
  • 149
    • 77951080101 scopus 로고    scopus 로고
    • High-performance single cell genetic analysis using microfluidic emulsion generator arrays
    • Zeng, Y. et al. (2010) High-performance single cell genetic analysis using microfluidic emulsion generator arrays. Anal. Chem., 82, 3183-3190.
    • (2010) Anal. Chem. , vol.82 , pp. 3183-3190
    • Zeng, Y.1
  • 150
    • 55949134303 scopus 로고    scopus 로고
    • DNA methylomes, histone codes and miRNAs: tying it all together
    • Guil, S. et al. (2009) DNA methylomes, histone codes and miRNAs: tying it all together. Int. J. Biochem. Cell Biol., 41, 87-95.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 87-95
    • Guil, S.1
  • 151
    • 33847317873 scopus 로고    scopus 로고
    • DNA methylation in health, disease, and cancer
    • Shames, D.S. et al. (2007) DNA methylation in health, disease, and cancer. Curr. Mol. Med., 7, 85-102.
    • (2007) Curr. Mol. Med. , vol.7 , pp. 85-102
    • Shames, D.S.1
  • 152
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: dNA methylation and chromatin alterations in human tumours
    • Esteller, M. et al. (2002) Cancer as an epigenetic disease: dNA methylation and chromatin alterations in human tumours. J. Pathol., 196, 1-7.
    • (2002) J. Pathol. , vol.196 , pp. 1-7
    • Esteller, M.1
  • 153
    • 67749129297 scopus 로고    scopus 로고
    • Epigenetics and environmental chemicals
    • Baccarelli, A. et al. (2009) Epigenetics and environmental chemicals. Curr. Opin. Pediatr., 21, 243-251.
    • (2009) Curr. Opin. Pediatr. , vol.21 , pp. 243-251
    • Baccarelli, A.1
  • 154
    • 78751495821 scopus 로고    scopus 로고
    • An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    • Ren, X. et al. (2011) An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ. Health Perspect., 119, 11-19.
    • (2011) Environ. Health Perspect. , vol.119 , pp. 11-19
    • Ren, X.1
  • 155
    • 77950629617 scopus 로고    scopus 로고
    • Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning
    • Xing, C. et al. (2010) Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning. Chem. Biol. Interact., 184, 306-309.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 306-309
    • Xing, C.1
  • 156
    • 18144431719 scopus 로고    scopus 로고
    • Genotype-dependent induction of transmissible chromosomal instability by gamma-radiation and the benzene metabolite hydroquinone
    • Gowans, I.D. et al. (2005) Genotype-dependent induction of transmissible chromosomal instability by gamma-radiation and the benzene metabolite hydroquinone. Cancer Res., 65, 3527-3530.
    • (2005) Cancer Res , vol.65 , pp. 3527-3530
    • Gowans, I.D.1
  • 157
    • 79251580717 scopus 로고    scopus 로고
    • Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells
    • Ren, X. et al. (2011) Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One, 6, e14546
    • (2011) PLoS One , vol.6
    • Ren, X.1
  • 158
    • 33749553917 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in DNA doublestrand break repair pathway and susceptibility to benzene-induced hematotoxicity
    • Shen, M. et al. (2006) Polymorphisms in genes involved in DNA doublestrand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis, 27, 2083-2089.
    • (2006) Carcinogenesis , vol.27 , pp. 2083-2089
    • Shen, M.1
  • 159
    • 80051871652 scopus 로고    scopus 로고
    • Aneuploidy drives genomic instability in yeast
    • Sheltzer, J.M. et al. (2011) Aneuploidy drives genomic instability in yeast. Science, 333, 1026-1030.
    • (2011) Science , vol.333 , pp. 1026-1030
    • Sheltzer, J.M.1
  • 160
    • 80051874823 scopus 로고    scopus 로고
    • Mutational inactivation of STAG2 causes aneuploidy in human cancer
    • Solomon, D.A. et al. (2011) Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science, 333, 1039-1043.
    • (2011) Science , vol.333 , pp. 1039-1043
    • Solomon, D.A.1
  • 161
    • 59149098921 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells
    • Hirabayashi, Y. et al. (2009) Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells. Biochem. Pharmacol., 77, 521-535.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 521-535
    • Hirabayashi, Y.1
  • 162
    • 59149086493 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations
    • Singh, K.P. et al. (2009) The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochem. Pharmacol., 77, 577-587.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 577-587
    • Singh, K.P.1
  • 163
    • 67650739990 scopus 로고    scopus 로고
    • The benzene metabolite para -benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral bloodmononuclear cells at low concentrations
    • Westphal, G. et al. (2009) The benzene metabolite para -benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral bloodmononuclear cells at low concentrations. Arch. Toxicol., 83, 721-729.
    • (2009) Arch. Toxicol. , vol.83 , pp. 721-729
    • Westphal, G.1
  • 164
    • 0036848223 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor mediates benzeneinduced hematotoxicity
    • Yoon, B.I. et al. (2002) Aryl hydrocarbon receptor mediates benzeneinduced hematotoxicity. Toxicol. Sci, 70, 150-156.
    • (2002) Toxicol. Sci , vol.70 , pp. 150-156
    • Yoon, B.I.1
  • 165
    • 48849114370 scopus 로고    scopus 로고
    • Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells: time after benzene treatment and recovery
    • Hirabayashi, Y. et al. (2008) Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells: time after benzene treatment and recovery. Chemosphere, 73, S290-S294.
    • (2008) Chemosphere , vol.73
    • Hirabayashi, Y.1
  • 166
    • 77950628719 scopus 로고    scopus 로고
    • Benzene-induced bone-marrow toxicity: a hematopoietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect
    • Hirabayashi, Y. et al. (2010) Benzene-induced bone-marrow toxicity: a hematopoietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect. Chem. Biol. Interact., 184, 252-258.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 252-258
    • Hirabayashi, Y.1
  • 167
    • 77950630137 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzeneinduced hematopoietic toxicity
    • Gasiewicz, T.A. et al. (2010) The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzeneinduced hematopoietic toxicity. Chem. Biol. Interact., 184, 246-251.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 246-251
    • Gasiewicz, T.A.1
  • 168
    • 0029838152 scopus 로고    scopus 로고
    • Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells
    • Moran, J.L. et al. (1996) Induction of apoptosis by benzene metabolites in HL60 and CD34{thorn} human bone marrow progenitor cells. Mol. Pharmacol., 50, 610-615.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 610-615
    • Moran, J.L.1
  • 169
    • 33746378327 scopus 로고    scopus 로고
    • Benzene metabolites induce apoptosis in lymphocytes
    • Martínez-Velázquez, M. et al. (2006) Benzene metabolites induce apoptosis in lymphocytes. Exp. Toxicol. Pathol., 58, 65-70.
    • (2006) Exp. Toxicol. Pathol. , vol.58 , pp. 65-70
    • Martínez-Velázquez, M.1
  • 170
    • 0034847403 scopus 로고    scopus 로고
    • Regulation of hematopoiesis by gap junction-mediated intercellular communication
    • Montecino-Rodriguez, E. et al. (2001) Regulation of hematopoiesis by gap junction-mediated intercellular communication. J Leukoc Biol, 70, 341-347.
    • (2001) J Leukoc Biol , vol.70 , pp. 341-347
    • Montecino-Rodriguez, E.1
  • 171
    • 0033843162 scopus 로고    scopus 로고
    • Hematopoiesis: gap junction intercellular communication is likely to be involved in regulation of stroma-dependent proliferation of hemopoietic stem cells
    • Ploemacher, R.E. et al. (2000) Hematopoiesis: gap junction intercellular communication is likely to be involved in regulation of stroma-dependent proliferation of hemopoietic stem cells. Hematology, 5, 133-147.
    • (2000) Hematology , vol.5 , pp. 133-147
    • Ploemacher, R.E.1
  • 172
    • 0034254263 scopus 로고    scopus 로고
    • Expression of connexin 43 (Cx43) is critical for normal hematopoiesis
    • Montecino-Rodriguez, E. et al. (2000) Expression of connexin 43 (Cx43) is critical for normal hematopoiesis. Blood, 96, 917-924.
    • (2000) Blood , vol.96 , pp. 917-924
    • Montecino-Rodriguez, E.1
  • 173
    • 0034661521 scopus 로고    scopus 로고
    • Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells
    • Cancelas, J.A. et al. (2000) Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood, 96, 498-505.
    • (2000) Blood , vol.96 , pp. 498-505
    • Cancelas, J.A.1
  • 174
    • 20544433655 scopus 로고    scopus 로고
    • Metabolites of benzene are potent inhibitors of gap-junction intercellular communication
    • Rivedal, E. et al. (2005) Metabolites of benzene are potent inhibitors of gap-junction intercellular communication. Arch. Toxicol., 79, 303-311.
    • (2005) Arch. Toxicol. , vol.79 , pp. 303-311
    • Rivedal, E.1
  • 175
    • 77950627413 scopus 로고    scopus 로고
    • Gap junction intercellular communication and benzene toxicity
    • Rivedal, E. et al. (2009) Gap junction intercellular communication and benzene toxicity. Chem. Biol. Interact., 184, 229-232.
    • (2009) Chem. Biol. Interact. , vol.184 , pp. 229-232
    • Rivedal, E.1
  • 176
    • 33646435309 scopus 로고    scopus 로고
    • The stem cell niches in bone
    • Yin, T. et al. (2006) The stem cell niches in bone. J. Clin. Invest., 116, 1195-1201.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1195-1201
    • Yin, T.1
  • 177
    • 44349096923 scopus 로고    scopus 로고
    • Stem cell niche: microenvironment and beyond
    • Zhang, J. et al. (2008) Stem cell niche: microenvironment and beyond. J. Biol. Chem., 283, 9499-9503.
    • (2008) J. Biol. Chem. , vol.283 , pp. 9499-9503
    • Zhang, J.1
  • 178
    • 35448948735 scopus 로고    scopus 로고
    • The TNF-a 238A polymorphism is associated with susceptibility to persistent bone marrow dysplasia following chronic exposure to benzene
    • Lv, L. et al. (2007) The TNF-a 238A polymorphism is associated with susceptibility to persistent bone marrow dysplasia following chronic exposure to benzene. Leuk. Res., 31, 1479-1485.
    • (2007) Leuk. Res. , vol.31 , pp. 1479-1485
    • Lv, L.1
  • 179
    • 77953778885 scopus 로고    scopus 로고
    • NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion
    • Zhou, H. et al. (2010) NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J. Pharmacol. Exp. Ther., 334, 260-268.
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 260-268
    • Zhou, H.1
  • 180
    • 0021133491 scopus 로고
    • DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene
    • Smart, R.C. et al. (1984) DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene. Mol. Pharmacol., 26, 105-111.
    • (1984) Mol. Pharmacol. , vol.26 , pp. 105-111
    • Smart, R.C.1
  • 181
    • 0025017521 scopus 로고
    • Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells
    • Thomas, D.J. et al. (1990) Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells. Mol. Pharmacol., 37, 255-262.
    • (1990) Mol. Pharmacol. , vol.37 , pp. 255-262
    • Thomas, D.J.1
  • 182
    • 69549083468 scopus 로고    scopus 로고
    • Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells
    • Zhou, H. et al. (2009) Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells. Mol. Pharmacol., 76, 579-587.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 579-587
    • Zhou, H.1
  • 183
    • 70350685238 scopus 로고    scopus 로고
    • Oxidative stress regulation of stem and progenitor cells
    • Pervaiz, S. et al. (2009) Oxidative stress regulation of stem and progenitor cells. Antioxid. Redox Signal., 11, 2777-2789.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2777-2789
    • Pervaiz, S.1
  • 184
    • 51349117161 scopus 로고    scopus 로고
    • Oxidative stress in the regulation of normal and neoplastic hematopoiesis
    • Ghaffari, S. (2008) Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid. Redox Signal., 10, 1923-1940.
    • (2008) Antioxid. Redox Signal. , vol.10 , pp. 1923-1940
    • Ghaffari, S.1
  • 185
    • 75249083919 scopus 로고    scopus 로고
    • In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species
    • Badham, H.J. et al. (2010) In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species. Toxicol. Sci., 113, 207-215.
    • (2010) Toxicol. Sci. , vol.113 , pp. 207-215
    • Badham, H.J.1
  • 186
    • 77950490138 scopus 로고    scopus 로고
    • In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species
    • Badham, H.J. et al. (2010) In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species. Toxicol. Appl. Pharmacol., 244, 273-279.
    • (2010) Toxicol. Appl. Pharmacol. , vol.244 , pp. 273-279
    • Badham, H.J.1
  • 187
    • 33745888434 scopus 로고    scopus 로고
    • PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokinedependent clonogenic response in human CD34(+) hematopoietic progenitor cells
    • Gross, S.A. et al. (2006) PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokinedependent clonogenic response in human CD34(+) hematopoietic progenitor cells. Cell Biol. Toxicol., 22, 229-241.
    • (2006) Cell Biol. Toxicol. , vol.22 , pp. 229-241
    • Gross, S.A.1
  • 188
    • 77449121923 scopus 로고    scopus 로고
    • Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
    • Butler, J.M. et al. (2010) Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell, 6, 251-264.
    • (2010) Cell Stem Cell , vol.6 , pp. 251-264
    • Butler, J.M.1
  • 189
    • 78449232489 scopus 로고    scopus 로고
    • Toward modeling the bone marrow niche using scaffold-based 3D culture systems
    • Di Maggio, N. et al. (2011) Toward modeling the bone marrow niche using scaffold-based 3D culture systems. Biomaterials, 32, 321-329.
    • (2011) Biomaterials , vol.32 , pp. 321-329
    • Di Maggio, N.1
  • 190
    • 74149093609 scopus 로고    scopus 로고
    • Challenge assay: a functional biomarker for exposure-induced DNA repair deficiency and for risk of cancer
    • Au, W.W. et al. (2010) Challenge assay: a functional biomarker for exposure-induced DNA repair deficiency and for risk of cancer. Int. J. Hyg. Environ. Health, 213, 32-39.
    • (2010) Int. J. Hyg. Environ. Health , vol.213 , pp. 32-39
    • Au, W.W.1
  • 191
    • 78349264149 scopus 로고    scopus 로고
    • Selected technologies for measuring acquired genetic damage in humans
    • Shuga, J. et al. (2010) Selected technologies for measuring acquired genetic damage in humans. Environ. Mol. Mutagen., 51, 851-870.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 851-870
    • Shuga, J.1
  • 192
    • 61849165197 scopus 로고    scopus 로고
    • Decreased T-cell receptor excision DNA circles in peripheral blood mononuclear cells among benzene-exposed workers
    • Li, B. et al. (2009) Decreased T-cell receptor excision DNA circles in peripheral blood mononuclear cells among benzene-exposed workers. Int. J. Immunogenet., 36, 107-111.
    • (2009) Int. J. Immunogenet. , vol.36 , pp. 107-111
    • Li, B.1
  • 193
    • 84857993170 scopus 로고    scopus 로고
    • Commentary: does immune suppression increase risk of developing acute myeloid leukemia?
    • doi:10.1038/ leu.2011.224
    • Gale, R.P. et al. (2011) Commentary: does immune suppression increase risk of developing acute myeloid leukemia? Leukemia. doi:10.1038/ leu.2011.224
    • (2011) Leukemia
    • Gale, R.P.1
  • 194
    • 74949126713 scopus 로고    scopus 로고
    • A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants
    • Guyton, K.Z. et al. (2009) A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants. Environ. Health Perspect., 117, 1664-1672.
    • (2009) Environ. Health Perspect. , vol.117 , pp. 1664-1672
    • Guyton, K.Z.1
  • 195
    • 28144434924 scopus 로고    scopus 로고
    • Guidelines for carcinogen risk assessment and supplemental guidance for assessing susceptibility from early-life exposure to carcinogens
    • US Environmental Protection Agency
    • US Environmental Protection Agency (2005) Guidelines for carcinogen risk assessment and supplemental guidance for assessing susceptibility from early-life exposure to carcinogens. Fed. Regist., vol. 70, 17765-17817.
    • (2005) Fed. Regist. , vol.70 , pp. 17765-17817
  • 196
    • 9144238300 scopus 로고    scopus 로고
    • A framework for human relevance analysis of information on carcinogenic modes of action
    • Meek, M.E. et al. (2003) A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol., 33, 591-653.
    • (2003) Crit. Rev. Toxicol. , vol.33 , pp. 591-653
    • Meek, M.E.1
  • 197
    • 33751283298 scopus 로고    scopus 로고
    • IPCS framework for analyzing the relevance of a cancer mode of action for humans
    • Boobis, A.R. et al. (2006) IPCS framework for analyzing the relevance of a cancer mode of action for humans. Crit. Rev. Toxicol., 36, 781-792.
    • (2006) Crit. Rev. Toxicol. , vol.36 , pp. 781-792
    • Boobis, A.R.1
  • 198
    • 77950630300 scopus 로고    scopus 로고
    • Proposed mode of action of benzene-induced leukemia: interpreting available data and identifying critical data gaps for risk assessment
    • Meek, M.E. et al. (2010) Proposed mode of action of benzene-induced leukemia: interpreting available data and identifying critical data gaps for risk assessment. Chem. Biol. Interact., 184, 279-285.
    • (2010) Chem. Biol. Interact. , vol.184 , pp. 279-285
    • Meek, M.E.1
  • 199
    • 0018818239 scopus 로고
    • The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in ARK/J and C57BL/6J mice
    • Snyder, C.A. et al. (1980) The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in ARK/J and C57BL/6J mice. Toxicol. Appl. Pharmacol., 54, 323-331.
    • (1980) Toxicol. Appl. Pharmacol. , vol.54 , pp. 323-331
    • Snyder, C.A.1
  • 200
    • 0024438477 scopus 로고
    • Hematotoxicity and carcinogenicity of inhaled benzene
    • Cronkite, E.P. et al. (1989) Hematotoxicity and carcinogenicity of inhaled benzene. Environ. Health Perspect., 82, 97-108.
    • (1989) Environ. Health Perspect. , vol.82 , pp. 97-108
    • Cronkite, E.P.1
  • 201
    • 0038032435 scopus 로고    scopus 로고
    • NTP. Department of Health and Human Services, Research Triangle Park, NC
    • NTP. (2011) Report on Carcinogens. ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/Benzene.pdf, Department of Health and Human Services, Research Triangle Park, NC.
    • (2011) Report on Carcinogens
  • 202
    • 0024449146 scopus 로고
    • Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice
    • Huff, J.E. et al. (1989) Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. Environ. Health Perspect., 82, 125-163.
    • (1989) Environ. Health Perspect. , vol.82 , pp. 125-163
    • Huff, J.E.1
  • 203
    • 84863075801 scopus 로고
    • NTP. NTP Toxicology and Carcinogenesis Studies of Benzene (CAS No. 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Technical Report Series. U.S. Department Of Health And Human Services, Public Health Service, National Institutes of Health Bethesda, MD
    • NTP. (1986) NTP Toxicology and Carcinogenesis Studies of Benzene (CAS No. 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Technical Report Series. U.S. Department Of Health And Human Services, Public Health Service, National Institutes of Health Bethesda, MD, Vol. 289, pp. 1-277
    • (1986) , vol.289 , pp. 1-277
  • 204
    • 78650231595 scopus 로고    scopus 로고
    • Toxicogenomic profiling of chemically exposed humans in risk assessment
    • McHale, C.M. et al. (2010) Toxicogenomic profiling of chemically exposed humans in risk assessment. Mutat. Res., 705, 172-183.
    • (2010) Mutat. Res. , vol.705 , pp. 172-183
    • McHale, C.M.1
  • 205
    • 82255163899 scopus 로고    scopus 로고
    • Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment
    • Wilson, V.S. et al. (2011) Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment. Toxicol. Appl. Pharmacol., 2, 2
    • (2011) Toxicol. Appl. Pharmacol. , vol.2 , pp. 2
    • Wilson, V.S.1
  • 206
    • 2142825649 scopus 로고    scopus 로고
    • Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene
    • Faiola, B. et al. (2004) Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene. Mutat. Res., 549, 195-212.
    • (2004) Mutat. Res. , vol.549 , pp. 195-212
    • Faiola, B.1
  • 207
    • 10744222470 scopus 로고    scopus 로고
    • Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue
    • Yoon, B.I. et al. (2003) Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue. Environ. Health Perspect., 111, 1411-1420.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1411-1420
    • Yoon, B.I.1
  • 208
    • 67650723486 scopus 로고    scopus 로고
    • Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice
    • Kawasaki, Y. et al. (2009) Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice. Toxicol. Sci., 110, 293-306.
    • (2009) Toxicol. Sci. , vol.110 , pp. 293-306
    • Kawasaki, Y.1
  • 209
    • 80051672855 scopus 로고    scopus 로고
    • Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites
    • Sarma, S.N. et al. (2011) Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites. Environ. Toxicol. Pharmacol., 32, 285-295.
    • (2011) Environ. Toxicol. Pharmacol. , vol.32 , pp. 285-295
    • Sarma, S.N.1
  • 210
    • 34547394837 scopus 로고    scopus 로고
    • Identification of human cell responses to benzene and benzene metabolites
    • Gillis, B. et al. (2007) Identification of human cell responses to benzene and benzene metabolites. Genomics, 90, 324-333.
    • (2007) Genomics , vol.90 , pp. 324-333
    • Gillis, B.1
  • 211
    • 79953701610 scopus 로고    scopus 로고
    • Towards a quantitative understanding of stem cellniche interaction: experiments, models, and technologies
    • Roeder, I. et al. (2011) Towards a quantitative understanding of stem cellniche interaction: experiments, models, and technologies. Blood Cells Mol. Dis., 46, 308-317.
    • (2011) Blood Cells Mol. Dis. , vol.46 , pp. 308-317
    • Roeder, I.1
  • 212
    • 77954071829 scopus 로고    scopus 로고
    • High-throughput methods to define complex stem cell niches
    • Kobel, S. et al. (2010) High-throughput methods to define complex stem cell niches. Biotechniques, 48, ix-xxii.
    • (2010) Biotechniques , vol.48
    • Kobel, S.1
  • 213
    • 59749092462 scopus 로고    scopus 로고
    • Patterning mouse and human embryonic stem cells using micro-contact printing
    • Peerani, R. et al. (2009) Patterning mouse and human embryonic stem cells using micro-contact printing. Methods Mol. Biol., 482, 21-33.
    • (2009) Methods Mol. Biol. , vol.482 , pp. 21-33
    • Peerani, R.1
  • 214
    • 68149087810 scopus 로고    scopus 로고
    • Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens
    • Peerani, R. et al. (2009) Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens. PLoS One, 4, e6438
    • (2009) PLoS One , vol.4
    • Peerani, R.1
  • 215
    • 33646732840 scopus 로고    scopus 로고
    • Benzene exposure and hematotoxicity: response
    • Lan, Q. et al. (2006) Benzene exposure and hematotoxicity: response. Science, 312, 998-998.
    • (2006) Science , vol.312 , pp. 998-1998
    • Lan, Q.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.